Publication Date:
2005-02-26
Description:
Shigella, the leading cause of bacillary dysentery, uses a type III secretion system (TTSS) to inject proteins into human cells, leading to bacterial invasion and a vigorous inflammatory response. The bacterium is protected against the response by the O antigen of lipopolysaccharide (LPS) on its surface. We show that bacteriophage-encoded glucosylation of Shigella O antigen, the basis of different serotypes, shortens the LPS molecule by around half. This enhances TTSS function without compromising the protective properties of the LPS. Thus, LPS glucosylation promotes bacterial invasion and evasion of innate immunity, which may have contributed to the emergence of serotype diversity in Shigella.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉West, Nicholas P -- Sansonetti, Philippe -- Mounier, Joelle -- Exley, Rachel M -- Parsot, Claude -- Guadagnini, Stephanie -- Prevost, Marie-Christine -- Prochnicka-Chalufour, Ada -- Delepierre, Muriel -- Tanguy, Myriam -- Tang, Christoph M -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1313-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Flowers Building, Imperial College London, London SW7 2AZ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731456" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bacterial Adhesion
;
Bacteriophages/genetics
;
Carbohydrate Conformation
;
Dysentery, Bacillary/immunology/*microbiology/pathology
;
Glucose/*metabolism
;
Glycosylation
;
Hydrophobic and Hydrophilic Interactions
;
Immunity, Innate
;
Intestinal Mucosa/microbiology/pathology
;
Lipopolysaccharides/chemistry/*metabolism
;
Microscopy, Electron, Scanning
;
Microscopy, Electron, Transmission
;
Mutation
;
Neutrophils
;
O Antigens/chemistry/*metabolism
;
Operon
;
Rabbits
;
Serotyping
;
Shigella flexneri/classification/metabolism/*pathogenicity/ultrastructure
;
Virulence
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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