Publication Date:
1980-05-02
Description:
Analysis of extracts of the bloodstream forms of Trypanosoma brucei showed that both DNA polymerase-alpha and DNA polymerase-beta activities were present. The detection of DNA polymerase-beta in T. brucei demonstrates the presence of this enzyme in unicellular organisms. DNA polymerase-beta is present also in Leishmania mexicana. The DNA polymerases in T. brucei are immunologically distinct from the host enzymes. The structural differences between the parasite and the host enzymes could be exploited for the development of agents to combat parasitic diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chang, L M -- Cheriathundam, E -- Mahoney, E M -- Cerami, A -- New York, N.Y. -- Science. 1980 May 2;208(4443):510-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367875" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Centrifugation, Density Gradient
;
Chickens
;
DNA Polymerase I/analysis
;
DNA Polymerase II/analysis
;
DNA Polymerase III/analysis
;
DNA-Directed DNA Polymerase/*analysis
;
Fishes
;
Immune Sera
;
Leishmania/*enzymology
;
Molecular Weight
;
Rabbits
;
Rats
;
Species Specificity
;
Trypanosoma brucei brucei/*enzymology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
