Publication Date:
1982-07-23
Description:
Serotonin-containing enterochromaffin cells in the rabbit duodenal mucosa span the tissue contacting both the luminal and serosal sides. When the serosal surface is stimulated with carbachol in vitro, serotonin is secreted on the serosal side but not the mucosal side. Carbachol added to the luminal side is ineffective. Atropine but not hexamethonium blocks the effect of carbachol. Acetylcholine on the serosal surface also stimulates serotonin release on the serosal side. These findings indicate that enterochromaffin cells possess on their serosal surfaces muscarinic receptors that mediate vectorial release of serotonin when activated by cholinergic agonists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Forsberg, E J -- Miller, R J -- DA 02121/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):355-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089569" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylcholine/pharmacology
;
Animals
;
Atropine/pharmacology
;
Carbachol/pharmacology
;
Chromaffin System/*secretion
;
Duodenum/physiology
;
Enterochromaffin Cells/*secretion
;
Hexamethonium Compounds/pharmacology
;
In Vitro Techniques
;
Intestinal Mucosa/drug effects
;
Parasympathomimetics/*pharmacology
;
Rabbits
;
Receptors, Muscarinic/metabolism
;
Serotonin/*secretion
;
Serous Membrane/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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