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  • 1
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    Localization of a Plasmodium surface antigen epitope by Tn5 mutagenesis mapping of a recombinant cDNA clone (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-17
    Description: A recombinant complementary DNA clone from Plasmodium knowlesi makes a beta-lactamase fusion polypeptide in Escherichia coli that reacts with a monoclonal antibody to a Plasmodium surface antigen. An epitope of the surface antigen was localized by transposon Tn5 mutagenesis mapping of the complementary DNA clone. The Tn5 mutation having the farthest 5' insert into the complementary DNA portion of the chimeric gene, giving the shortest truncated protein that maintained the ability to bind monoclonal antibody, defined the location of the epitope.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lupski, J R -- Ozaki, L S -- Ellis, J -- Godson, G N -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1285-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6190227" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal/immunology ; Antigens, Surface/genetics/*immunology ; Cloning, Molecular ; DNA, Recombinant/immunology/*metabolism ; Epitopes/genetics/*immunology ; Escherichia coli/genetics ; Plasmodium/*genetics/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Plasmodium knowlesi sporozoite antigen: expression by infectious recombinant vaccinia virus (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-27
    Description: The gene coding for the circumsporozoite antigen of the malaria parasite Plasmodium knowlesi was inserted into the vaccinia virus genome under the control of a defined vaccinia virus promoter. Cells infected with the recombinant virus synthesized polypeptides of 53,000 to 56,000 daltons that reacted with monoclonal antibody against the repeating epitope of the malaria protein. Furthermore, rabbits vaccinated with the recombinant virus produced antibodies that bound specifically to sporozoites. These data provide evidence for expression of a cloned malaria gene in mammalian cells and illustrate the potential of vaccinia virus recombinants as live malaria vaccines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, G L -- Godson, G N -- Nussenzweig, V -- Nussenzweig, R S -- Barnwell, J -- Moss, B -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):397-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6200932" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Formation ; Antigens, Surface/analysis/*genetics/immunology ; *Cloning, Molecular ; *DNA, Recombinant ; Epitopes/immunology ; Genes ; Genes, Viral ; Genetic Vectors ; Operon ; Plasmodium/*genetics/immunology ; Rabbits ; Vaccination ; Vaccinia virus/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Diversity of circumsporozoite antigen genes from two strains of the malarial parasite Plasmodium knowlesi (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-23
    Description: The complete nucleotide sequence of the coding region of the circumsporozoite antigen gene (CS gene) of the Nuri strain of the malarial parasite Plasmodium knowlesi is presented. The gene from the Nuri strain exhibits a novel form of sequence diversity when compared to the CS gene from the H strain. Instead of the 12 tandem repeating 36-base pair units of the H strain, the Nuri strain contains 16 tandem repeating 27-base pair units of a different nucleotide sequence that encodes a different repeating peptide. In contrast, the 5' and 3' coding and noncoding sequences flanking the repeats are 98 percent conserved in both strains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sharma, S -- Svec, P -- Mitchell, G H -- Godson, G N -- 1 R01 AI21496-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):779-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023712" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antigens, Protozoan/*genetics ; Antigens, Surface/genetics ; Base Sequence ; Genes ; Molecular Sequence Data ; Plasmodium/*genetics/immunology ; Protozoan Proteins/*genetics ; Repetitive Sequences, Nucleic Acid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Expression of the major surface antigen of Plasmodium knowlesi sporozoites in yeast (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-17
    Description: The circumsporozite protein, a surface antigen of the sporozoite stage of the monkey malarial parasite Plasmodium knowlesi, was expressed in the yeast Saccharomyces cerevisiae by using an expression vector containing the 5' regulatory region of the yeast alcohol dehydrogenase I gene. It was necessary to eliminate the entire 5' upstream region of the parasite DNA to obtain the expression of this protein. Only the circumsporozoite precursor was produced by the yeast transformants, as detected by immunoblotting. About 55 and 20 percent of the circumsporozoite protein produced in yeast was associated wtih the 25,000 g and 150,000 g particulate fractions, respectively. The protein could be solubilized in Triton X-100 and was stable in solubilized extracts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sharma, S -- Godson, G N -- 1 R01 AI21496-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1985 May 17;228(4701):879-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3890178" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Protozoan/*genetics ; Antigens, Surface/*genetics ; Cloning, Molecular ; DNA, Recombinant ; Genes ; Molecular Weight ; Plasmodium/genetics/*immunology ; Protein Precursors/biosynthesis/genetics ; Protozoan Proteins/*genetics ; Saccharomyces cerevisiae/*genetics ; Transformation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    Preparation of a Nuclear Fraction from Bacillus Megatherium and its Role in Biosynthesis of Ribonucleic Acid (1962)
    [s.l.] : Nature Publishing Group
    Nature 193 (1962), S. 655-656 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SO-called 'chromatin bodies' have been observed in a variety of bacteria by cytological and electron microscopic techniques. In only one instance, however, has a discrete nuclear body been isolated by a biochemical technique. Spiegelman, Aronson and Fitzjames1 reported that when the cytoplasmic ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/193655a0
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  • 6
    Electronic Resource
    Electronic Resource
    Later Stages of Protein Synthesis and the Role of Phospholipids in the Process (1961)
    [s.l.] : Nature Publishing Group
    Nature 189 (1961), S. 140-141 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] On the other hand, the evidence that ribonucleic acid (RNA) plays an active part in protein biosynthesis is overwhelming, and it is the purpose of this communication to provide a hypothesis whereby these surprising results may be reconciled with current ideas on the mechanism of protein ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/189140a0
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  • 7
    Electronic Resource
    Electronic Resource
    ‘Nuclear’ and Cytoplasmic Ribosomes in B. MEGATERIUM (1964)
    [s.l.] : Nature Publishing Group
    Nature 201 (1964), S. 876-878 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IT has been shown in recent papers1'2 that on lysis with a neutral detergent, lubral W, protoplasts of B. mega-terium yield: (a) nuclear fraction containing all the DNA with some 'nuclear' ribosomes as well as the cytoplasmic membranes of the cell; (b) a cytoplasmic fraction containing most of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/201876b0
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  • 8
    Electronic Resource
    Electronic Resource
    Radiation-induced base substitution mutagenesis in single-stranded DNA phage M13 (1981)
    [s.l.] : Nature Publishing Group
    Nature 294 (1981), S. 180-182 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We used single-stranded DNA phage Ml 3 to study independently the effects of target DNA irradiation and the consequences of induction of the SOS repair system. M13 is particularly useful in such an investigation because (1) mutagenesis of single-stranded DNA phages by UV and y irradiation is ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/294180a0
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  • 9
    Electronic Resource
    Electronic Resource
    Gene K , a new overlapping gene in bacteriophage G4 (1978)
    [s.l.] : Nature Publishing Group
    Nature 272 (1978), S. 510-515 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A third overlapping gene in the isometric bacteriophages has been identified by nucleotide sequence analysis of the G4 genome and by isolation and microsequence analysis of the new protein. Five nucleotides are used in all three translational reading frames of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/272510a0
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  • 10
    Electronic Resource
    Electronic Resource
    Nucleotide sequence of bacteriophage G4 DNA (1978)
    [s.l.] : Nature Publishing Group
    Nature 276 (1978), S. 236-247 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The 5,577 nucleotide long sequence of bacteriophage G4 DNA has been determined using the ‘plus and minus’ and chain termination methods of DNA sequencing. This sequence has been compared with that of the closely related bacteriophage ΦX174 (refs 1, 55). In the coding regions there ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/276236a0
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