Publication Date:
1983-09-23
Description:
Noise analysis of rabbit bladder revealed two components: Lorentzian noise, arising from interaction of amiloride with the Na+ channel, and flicker noise (l/f, where f is frequency), as in other biological membranes. Hydrostatic pressure, which causes exchange between intracellular vesicular membrane and apical membrane, increases the number but not the single-channel current of the amiloride-sensitive channels. Flicker noise arises from degraded channels that have lost amiloride sensitivity and Na+ to K+ selectivity. The degraded channels were selectively removed by washing the mucosal surface. These results imply channel turnover by intracellular synthesis, transfer from vesicular to apical membrane, degradation, and elimination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loo, D D -- Lewis, S A -- Ifshin, M S -- Diamond, J M -- AM17327/AM/NIADDK NIH HHS/ -- AM20851/AM/NIADDK NIH HHS/ -- GM14772/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1288-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612343" target="_blank"〉PubMed〈/a〉
Keywords:
Amiloride/pharmacology
;
Animals
;
Cell Membrane/metabolism
;
Cytoplasmic Granules/metabolism
;
Epithelium/physiology
;
Rabbits
;
Sodium/*metabolism
;
Urinary Bladder/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink