Publication Date:
1980-08-01
Description:
Antibody to platelet factor 4 was used to demonstrate permeation of this factor into the blood vessel wall after endothelial injury in rabbits. The presence of platelet factor 4 antigen in the vessel wall after removal of the endothelium was shown by immunofluorescence 10 and 30 minutes after injury but not 240 minutes afterward. This study demonstrates that factors carried by platelets can enter the vessel wall and that the movement of these platelet products into the vasculature is a short-lived, self-limiting process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldberg, I D -- Stemerman, M B -- Handin, R I -- New York, N.Y. -- Science. 1980 Aug 1;209(4456):611-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6994228" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Blood Coagulation Factors/*physiology
;
Endothelium/physiology
;
Fluorescent Antibody Technique
;
Immune Sera
;
Muscle, Smooth, Vascular/*physiopathology
;
Permeability
;
Platelet Factor 4/*physiology
;
Rabbits
;
Wounds and Injuries/*physiopathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
