Publication Date:
1984-08-17
Description:
Active and passive sensitization, both in vivo and in vitro, caused significant hyperpolarization of airway smooth muscle cell preparations isolated from guinea pigs. An increase in the contribution of the electrogenic Na+ pump to the resting membrane potential was responsible for this change. Hyperpolarization, as induced by passive sensitization, was not prevented by agents that inhibit specific mediators of anaphylaxis but was abolished when serum from sensitized animals was heated. The heat-sensitive serum factor, presumably reaginic antibodies, appears to be responsible for the membrane hyperpolarization of airway smooth muscle cells after sensitization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Souhrada, M -- Souhrada, J F -- HL-28063/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 17;225(4663):723-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6087455" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Membrane/*immunology
;
Immunization
;
Immunization, Passive
;
Ion Channels/immunology
;
Male
;
Mast Cells/immunology
;
Membrane Potentials
;
Mice
;
Muscle, Smooth/*immunology
;
Rabbits
;
Rats
;
Respiratory System/*immunology
;
Sodium/metabolism
;
Trachea/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
