Abstract
Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Bone Development*
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Bone Matrix / drug effects
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Bone Matrix / physiology
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Bone Morphogenetic Proteins
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Bone Neoplasms / physiopathology
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Cattle
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Cell Differentiation
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DNA, Neoplasm / metabolism
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Dogs
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Growth Substances / physiology*
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Guinea Pigs
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Haplorhini
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Humans
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Insulin-Like Growth Factor II
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Mice
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Osteogenesis*
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Osteosarcoma / physiopathology
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Proteins / pharmacology
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Proteins / physiology
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Rabbits
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Rats
Substances
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Bone Morphogenetic Proteins
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DNA, Neoplasm
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Growth Substances
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IGF2 protein, human
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Proteins
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Insulin-Like Growth Factor II