Publication Date:
1980-02-08
Description:
Cell death, inflammation, and repair in rabbits' aortas and pulmonary arteries were observed at 3-, 7-, and 10-day periods after the intravenous injection of oxygenated sterols. Thus, oxygenated sterols, not cholesterol, may play the primary role in arterial wall injury and lesion development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Imai, H -- Werthessen, N T -- Subramanyam, V -- LeQuesne, P W -- Soloway, A H -- Kanisawa, M -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):651-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352277" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Aorta/drug effects
;
Blood Vessels/*drug effects/pathology
;
Cholesterol/*analogs & derivatives/toxicity
;
Epoxy Compounds/*toxicity
;
Ethers, Cyclic/*toxicity
;
Female
;
Hydroxycholesterols/toxicity
;
Lanosterol/analogs & derivatives/toxicity
;
Male
;
Necrosis
;
Oxidation-Reduction
;
Pulmonary Artery/drug effects
;
Rabbits
;
Structure-Activity Relationship
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
