Publication Date:
1980-05-02
Description:
The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase activity associated with early embryogenesis in the mouse and arrests embryonic development at that stage. Contragestational effects were confirmed in the rat and rabbit. An increase in L-ornithine decarboxylase activity that leads to a rapid increase in putrescine concentration appears to be essential during a critical period after implantation for continued mammalian embryonal growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fozard, J R -- Part, M L -- Prakash, N J -- Grove, J -- Schechter, P J -- Sjoerdsma, A -- Koch-Weser, J -- New York, N.Y. -- Science. 1980 May 2;208(4443):505-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6768132" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosylmethionine Decarboxylase/metabolism
;
Animals
;
Carboxy-Lyases/*physiology
;
Eflornithine
;
Embryo, Mammalian/drug effects/*physiology
;
Female
;
Gestational Age
;
Mice
;
Ornithine/*analogs & derivatives/pharmacology
;
Ornithine Decarboxylase/*physiology
;
Ornithine Decarboxylase Inhibitors
;
Polyamines/metabolism
;
Pregnancy
;
Rabbits
;
Rats
;
Uterus/drug effects/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
