Publication Date:
1978-06-09
Description:
The calf lens epithelium contains a specific cytoplasmic receptor for glucocorticoids. This binding protein has a high affinity for dexamethasone (average dissociation constant, 8 x 10(-9) mole per liter), a low capacity (average, 550 femtomoles per milligram of protein), extreme heat sensitivity, and exhibits a pattern of competition similar to that of glucocorticoid receptors in other tissues. This provides direct biochemical evidence that these tissues may function as a target organ for glucocorticoids.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Southren, A L -- Gordon, G G -- Yeh, H S -- Dunn, M W -- Weinstein, B I -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1177-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653363" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Binding, Competitive
;
Cattle
;
Cytoplasm/metabolism
;
Dexamethasone/metabolism
;
Epithelium/metabolism
;
Hot Temperature
;
Hydrocortisone/metabolism
;
Lens, Crystalline/*metabolism
;
Receptors, Glucocorticoid/*metabolism
;
Receptors, Steroid/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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