Publication Date:
1983-05-13
Description:
Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Urist, M R -- DeLange, R J -- Finerman, G A -- DEO2103-17/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1983 May 13;220(4598):680-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6403986" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Bone Development
;
Bone Matrix/drug effects/physiology
;
Bone Morphogenetic Proteins
;
Bone Neoplasms/physiopathology
;
Cattle
;
Cell Differentiation
;
DNA, Neoplasm/metabolism
;
Dogs
;
Growth Substances/*physiology
;
Guinea Pigs
;
Haplorhini
;
Humans
;
Insulin-Like Growth Factor II
;
Mice
;
*Osteogenesis
;
Osteosarcoma/physiopathology
;
Proteins/pharmacology/physiology
;
Rabbits
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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