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  • 1
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    Sensitivities of marine macrozoobenthos to environmental pressures in the Netherlands (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.79
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: The relative sensitivities of 309 common invertebrate species in Dutch marine waters are presented for environmental and anthropogenic pressures like organic enrichment, sedimentation and fisheries. The species were furthermore appointed to trophic groups like suspension and deposit feeders. The Dutch Ministry of Infrastructure and the Environment uses these data when calculating the Benthic Ecosystem Quality Index 2 and the Infaunal Trophic Index. These metrics aid in the mandatory monitoring of ecological quality for example for the European Water Framework Directive. The common Dutch species were selected based on their abundance according to, 1. the mwtl dataset including results of on-going monitoring programs issued by the Ministry, 2. the monitoring by volunteer scuba-divers for the anemoon Foundation and 3. the monitoring of fouling plates for the project setl.
    Schlagwort(e): macrozoobenthos ; marine ; Netherlands ; environment ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 2
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    De zeepissebed Uromunna spec, de eerste waarneming van de familie Munnidae in Nederland (Isopoda) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.43
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: Onze fauna verandert en de mariene fauna is daarop geen uitzondering. Zuidelijke soorten koloniseren onze kustwateren en exotische soorten worden door de mens aangevoerd. Voor sommige soorten is niet duidelijk waarom ze hier opduiken. De sterk veranderende kustbiotopen spelen ongetwijfeld eveneens een rol. Een niet-aflatende stroom onverwachte soorten, soms zelfs behorend tot nieuwe genera en zelfs families maken faunistisch onderzoek in de kustwateren verrassend en boeiend. In het kader van een inventarisatie van kreeftachtigen in het Deltagebied werden in de Oosterschelde bij Zierikzee verscheidene kleine monsters genomen van diverse substraten. De monsters van roodwieren bevatten een aantal opmerkelijke soorten. Dit artikel behandelt Uromunna spec., een zeepissebeddensoort van een familie die in ons land nog niet was aangetroffen.
    Schlagwort(e): Isopoda ; Munnidae ; Nederland ; Uromunna ; verspreiding ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 3
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    First record of a settled stomatopod Platysquilla eusebia in the North Sea (Malacostraca: Stomatopoda) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.31
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: This paper describes the discovery of a settled juvenile specimen of the stomatopod Platysquilla eusebia on the Dutch part of the Dogger Bank in the central North Sea. This is the northernmost record in Europe. The species is native to the Mediterranean and to the Atlantic coast from Portugal up to France. Further investigations have to show if the species already forms populations this far north. As the planktonic stages of P. eusebia have already been recorded in prior years, the establishment of the species should not be a problem, providing the circumstances are favourable.
    Schlagwort(e): Malacostraca ; Stomatopoda ; Platysquilla eusebia ; distribution ; Netherlands ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 4
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    De springstaart Fasciosminthurus quinquefasciatus nieuw voor de Nederlandse fauna (Collembola: Bourletiellidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.40 (2013) p.1
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: Met enige regelmaat duiken nieuwe springstaartsoorten op in ons land. Het vinden van een nieuwe soort is soms op toeval gebaseerd. Op een foto van een sprinkhaan was naast de linker voorpoot een klein, donker vlekje te zien. Uitvergroot bleek het om een klein springstaartje te gaan. Het zwart-wit gestreepte patroon liet geen ruimte voor twijfel over de determinatie: Fasciosminthurus quinquefasciatus, een nieuwe springstaart voor de Nederlandse fauna. In dit artikel wordt het genus en de soort voorgesteld, beschrijven we de habitat en geven we informatie over de verspreiding in de rest van Europa.
    Schlagwort(e): Collembola ; Bourletiellidae ; Fasciosminthurus quinquefasciatus ; Nederland ; verspreiding ; herkenning ; biologie ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 5
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    Duistere heiderouwzwever Exoprosopa cleomene duikt op in Nederlandse wolzwevercollectie (Diptera: Bombyliidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.49
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: De roodbruine heiderouwzwever Exoprosopa capucina is een fraaie en karakteristieke koffiebruine verschijning op de Nederlandse heideterreinen. Zoals veel wolzwevers is deze te herkennen aan de vleugeltekening en de kleur van de lichaamsbeharing. Echter naarmate de dieren ouder worden verliezen ze deze beharing en wordt de determinatie lastiger. Vermoedelijk heeft het verfomfaaide uiterlijk van een vrouwtje Exoprosopa cleomene er voor gezorgd dat deze ruim 50 jaar onopgemerkt tussen de exemplaren van E. capucina heeft gestaan.
    Schlagwort(e): Diptera ; Bombyliidae ; Exoprosopa cleomene ; Nederland ; verspreiding ; herkenning ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 6
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    Sulcacis bidentulus, een nieuwe houtzwamkever voor de Nederlandse fauna (Coleoptera: Ciidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.7
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: In de afgelopen jaren werd op verschillende plekken in Nederland een houtzwamkever gevonden die tot nu toe niet officieel gemeld werd: Sulcacis bidentulus. Deze soort valt binnen de zeer eenvormige familie Ciidae op door de kleur van de dekschilden, die duidelijk iets lichter bruin zijn dan de rest van het lichaam. De soort zou zich ontwikkelen in de bleke borstelkurkzwam, die voornamelijk op populieren groeit. Oudere vondsten ontbreken en de ontdekking van deze soort op meerdere locaties duidt op een recente vestiging in ons land. Dit sluit aan bij de geconstateerde uitbreiding in Midden-Europa.
    Schlagwort(e): Coleoptera ; Ciidae ; Sulcacis bidentulus ; Nederland ; verspreiding ; biologie ; herkenning ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 7
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    Vestiging van de boomkrekel Oecanthus pellucens in het rivierengebied (Orthoptera) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.35
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: De boomkrekel is een slanke geelbruine krekel, die vooral opvalt door zijn melodieuze zang. Vroeger moest je naar Frankrijk om dit geluid te horen, maar tegenwoordig heerst ook in het rivierengebied bij Nijmegen een mediterrane sfeer. De boomkrekel is in 2004 voor het eerst langs de Waal gevonden en heeft zich daarna uitgebreid. In 2010 en 2011 heeft de Flora- en faunawerkgroep Gelderse Poort met vele vrijwilligers onderzoek gedaan naar de precieze verspreiding. In totaal werd de boomkrekel in 57 kilometerhokken gevonden en de verwachting is dat de soort zich de komende jaren verder zal uitbreiden.
    Schlagwort(e): Orthoptera ; Oecanthus pellucens ; Nederland ; verspreiding ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 8
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    De Nederlandse hongerwespen (Hymenoptera: Evanioidea: Gasteruptiidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.55
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: Hongerwespen behoren tot de grote groep van de sluipwespen. Het zijn slanke wespjes die typisch met hangende pootjes vliegen, waarbij de verbrede achterschenen opvallen. Ze parasiteren bijen en mogelijk ook bepaalde angeldragende wespen en worden daarom vaak bij bijenhotels waargenomen. In het kader van dit artikel zijn de meldingen van Nederlandse hongerwespen kritisch beschouwd. In totaal zijn nu negen soorten uit ons land bekend, waarvan er hier maar liefst zes voor het eerst worden gemeld.
    Schlagwort(e): Hymenoptera ; Evanioidea ; Gasteruptiidae ; Nederland ; verspreiding ; herkenning ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 9
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    Marine fauna of hard substrata of the Cleaver bank and Dogger bank (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.69
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: As most of the sea bottom in the Dutch part of the North Sea consists of sand, marine fauna that live in association with hard substrates are rarely monitored. We report here on the results of a species inventory in June 2011 done by scuba-diving while focusing on a wreck on the Dogger Bank and on rocky bottoms on the Cleaver Bank. This resulted in various new records of species for the Dutch part of the North Sea. This result appeared for a large part linked to the added value of monitoring with scuba-divers. It is therefore concluded that scuba-divers should be used in addition to the more traditional monitoring methods in which dredges and grabs are used, if one aims at getting an accurate view of the biodiversity present in marine regions like the North Sea.
    Schlagwort(e): biodiversity ; hard substrata ; Netherlands ; marine ; scuba-diving ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 10
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    Benthic communities on hard substrates within the first Dutch offshore wind farm (OWEZ) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.59
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: Five years after the commissioning of the offshore wind farm Egmond aan Zee, the monopiles and the rocks of the scour protection layers were covered by a wide variety of marine organisms. This paper describes the results of qualitative and quantitative assessments carried out in 2008 and 2011. The assessments were based on video footage, pictures and samples collected by divers at three different wind turbines. The ecological relevance of identified taxa is also discussed.
    Schlagwort(e): offshore wind farms ; Netherlands ; biodiversity ; benthic zone ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 11
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    De gouden kegelbij Coelioxys aurolimbata teruggevonden in het rivierengebied (Hymenoptera: Apoidea: Megachilidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.40 (2013) p.39
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    Publikationsdatum: 2015-12-09
    Beschreibung: De gouden kegelbij Coelioxys aurolimbata is uit ons land recent alleen bekend uit de zuidelijke helft van Limburg. Vóór 1960 kwam deze parasiet van de lathyrusbij Chalicodoma ericetorum ook in het rivierengebied voor. In juli van dit jaar werd de gouden kegelbij gevangen in Duiven. Mogelijk is dit de voorbode van een herovering van het rivierengebied door deze bedreigde soort.
    Schlagwort(e): Hymenoptera ; Apoidea ; Megachilidae ; Nederland ; Coelioxys aurolimbata ; verspreiding ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 12
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    The juwel anemone Corynactis viridis, a new order for the Netherlands (Cnidaria: Corallimorpharia) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.35
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    Publikationsdatum: 2015-12-09
    Beschreibung: During an expedition with scuba-divers to the Dutch part of the Brown Ridge in the central North Sea in June 2013, two colonies of the jewel anemone Corynactis viridis were found on the wreck Anna Graebe. With the jewel anemone both a new species and a new animal order, the Corallimorpharia, are added to the autochthonous fauna of the Netherlands. This species typically occurs in the Mediterranean and along the Atlantic coast from Portugal and the west British Isles up to Shetland. As other records of settled colonies of C. viridis in the North Sea were recently reported from Belgian, German and English waters, it is concluded that the jewel anemone, which used to be known as an occasional visitor, should now be considered autochthonous in the North Sea.
    Schlagwort(e): Cnidaria ; Corallimorpharia ; Netherlands ; Corynactis viridis ; distribution ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 13
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    De molkreeften Upogebia deltaura en U. stellata en geassocieerde soorten in de Noordzee (Decapoda: Upogebiidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.15
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    Publikationsdatum: 2015-12-09
    Beschreibung: In de bodem van de Noordzee leeft een bijzondere groep van kreeften. Zij brengen hun leven door in een ondergronds gangenstelsel: de molkreeften. Het zijn algemene bewoners van het Friese Front, de Oestergronden en de Klaverbank. In, op en bij deze kreeften leven verschillende andere diersoorten: parasitaire pissebedden, een mosdiertje en twee soorten tweekleppigen. Deze bijdrage gaat in op de ecologie van de molkreeften en hun symbionten.
    Schlagwort(e): Decapoda ; Upogebiidae ; Upogebia ; Nederland ; biology ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 14
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    Moss animals of the Dutch part of the North Sea and coastal waters of the Netherlands (Bryozoa) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.1
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    Publikationsdatum: 2015-12-09
    Beschreibung: Bryozoa or moss animals constitute a conspicuous and species-rich component of hardsubstrate benthic communities in marine and estuarine habitats. To gain insight into the biodiversity of these habitats, knowledge of bryozoan species is indispensable. Since the last comprehensive publication on Dutch species in 2004 much new information has become available. Particularly from the Dutch part of the Continental Flat of the North Sea, the largest natural area of the Netherlands, many new records have been collected. Other reasons to present an updated review are changes in nomenclature, the arrival of some exotic species and identification issues.
    Schlagwort(e): Bryozoa ; Netherlands ; checklist ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 15
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    Tephrochlaena oraria, een nieuwe afvalvlieg voor de Nederlandse fauna (Diptera: Heleomyzidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.40 (2013) p.35
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    Publikationsdatum: 2015-12-09
    Beschreibung: Heleomyzidae zijn kleine tot middelgrote vliegen. Ze krijgen niet veel aandacht, omdat de meeste soorten een nogal verborgen leven leiden en bovendien niet opvallend gekleurd of getekend zijn. De Nederlandse familienaam, afvalvliegen, is voor de meeste soorten niet echt passend, maar veel soorten van de subfamilie Heteromyzinae, waartoe Tephrochlaena oraria behoort, worden dan wel weer vaker rond afval aangetroffen. Tephrochlaena oraria is echter in meerdere opzichten een buitenbeentje. Met deze soort komt de lijst van Nederlandse Heleomyzidae op 49.
    Schlagwort(e): Diptera ; Heleomyzidae ; Tephrochlaena oraria ; Nederland ; verspreiding ; herkenning ; biologie ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 16
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    Komt de vermiljoenkever Cucujus cinnaberinus in azijnzuurvallen (Coleoptera: Cucujidae)? (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.40 (2013) p.9
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: Cucujus cinnaberinus is een recent voor Nederland ontdekte soort. De kever staat op de Habitatrichtlijn, wat onder meer betekent dat hij beschermd is en dat de populatie gemonitord dient te worden. Inventarisatie en monitoring gebeurt in het algemeen door het weghalen van schors van recent gestorven bomen. Hierdoor wordt het leefgebied van de kever echter flink aangetast. Wij voerden een klein onderzoek uit naar de mogelijkheden om C. cinnaberinus te vangen in azijnzuurvallen, zodat de habitat intact gelaten kan worden en de soort toch geïnventariseerd kan worden. Tijdens het voorjaar van 2013 werden vier vallen opgehangen op een locatie waar zich een populatie van deze soort bevindt. Er werden slechts twee individuen verzameld; de vangmethode lijkt dus niet bijzonder geschikt.
    Schlagwort(e): Coleoptera ; Cucujidae ; Cucujus cinnaberinus ; methode ; inventarisatie ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 17
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    Northward dispersal of the tanaid Zeuxo holdichi to the Netherlands (Crustacea: Tanaidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.95
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: The tanaid Zeuxo holdichi, described in 1990 from Arcachon Bay in southwest France, has since then been recorded from west Portugal to northern Brittany and southwest England. The species is recorded here from the Netherlands, a further northward expansion of the range. It is hypothesised that Z. holdichi may be non-native to Europe.
    Schlagwort(e): Crustacea ; Tanaidae ; Zeuxo holdichi ; Netherlands ; distribution ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 18
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    Ecological relevance of shipwrecks in the North Sea (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.41 (2013) p.49
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: This paper reports on observations made during wreck dive expeditions in 2010-2012, in order to investigate the ecological relevance of shipwrecks on the Dutch Continental Shelf (dcs). Shipwrecks are biodiversity hotspots. The number of species recorded on shipwrecks is similar to the number of species found in soft bottoms of the entire dcs. The soft substrates, however, represent a vastly larger habitat on the dcs than the shipwrecks. Amongst many other taxa, juvenile and large Atlantic cod, linear skeleton shrimp, goldsinny wrasses and leopard spotted gobies were found in the shipwreck habitats. The presence of these important species and their absence from many other habitats, illustrate that shipwrecks function as key habitats, nurseries, and refugia that are rare or absent anywhere else in the Netherlands.
    Schlagwort(e): shipwrecks ; Netherlands ; biodiversity ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 19
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    De hottentottenvilla Villa hottentotta toch op de Nederlandse lijst (Diptera: Bombyliidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.40 (2013) p.23
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: Wolzwevers zijn vliegen waarvan de larven parasitair leven bij andere insecten. Wolzwevers van het genus Villa veroorzaken vaak determinatieproblemen. Deze problemen lijken verleden tijd met recent gepubliceerde taxonomische inzichten. Eindelijk konden nu ook de Nederlandse exemplaren van dit genus op naam gebracht worden. Deze bleken te behoren tot vier soorten, waarvan er twee vermoedelijk reeds zijn verdwenen.
    Schlagwort(e): Diptera ; Bombyliidae ; Villa hottentotta ; Nederland ; verspreiding ; herkenning ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 20
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    De bijzondere levensloop van de sluipwesp Acrodactyla quadrisculpta op de schaduwstrekspin Tetragnatha montana (Hymenoptera: Ichneumonidae, Araneae: Tetragnathidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.1
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    Publikationsdatum: 2015-12-09
    Beschreibung: Sluipwespen van de groep van de Polysphinctini hebben een bijzondere levenswijze. Het vrouwtje van wesp legt een eitje op het achterlijf van een spin. Wanneer het eitje is uitgekomen brengt de larve haar hele leven op het achterlijf van de spin door. Ze maakt kleine wondjes in de huid en voedt zich met lichaamsvloeistof van de spin. Na verloop van tijd ontwikkelt de larve bulten op de rug, een teken dat ze bijna volgroeid is. Ze zuigt dan de spin leeg, de ‘grote slurp’ genaamd, en verpopt zich in het web. In dit artikel wordt de levenswijze van één van deze soorten, Acrodactyla quadrisculpta, voor het eerst beschreven en geïllustreerd.
    Schlagwort(e): Hymenoptera ; Ichneumonidae ; Araneae ; Tetragnathidae ; biologie ; Nederland ; Acrodactyla quadrisculpta ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 21
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    Galvormende bladwespen op wilg in Nederland (Hymenoptera: Tenthredinidae: Nematinae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.15
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: De bladwespgenera Phyllocolpa, Tubpontania, Pontania en Euura hebben gemeenschappelijk dat ze gallen vormen op wilg. Recentelijk is er veel vernieuwend taxonomisch werk verricht aan deze groepen. In dit artikel wordt de Nederlandse situatie samengevat. Uit oudere literatuur waren 18 soorten bekend en in het recent gepubliceerde gallenboek worden nog eens 11 soorten voor het eerst voor ons land vermeld. In dit artikel worden nog acht soorten aan de lijst toegevoegd en twee soorten worden van de lijst afgevoerd. In totaal zijn nu 35 soorten galvormende bladwespen van wilg uit Nederland bekend.
    Schlagwort(e): Hymenoptera ; Tenthredinidae ; Nematinae ; Nederland ; verspreiding ; herkenning ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
    Format: application/pdf
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  • 22
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    De rode snuitvlieg Rhingia rostrata terug in Nederland (Diptera: Syrphidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.40 (2013) p.15
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: Snuitvliegen zijn rare snuiters onder de zweefvliegen. Ze hebben een verlengd gezicht en een lange tong. Hiermee kunnen ze foerageren op bloemen met diepliggende nectar, in tegenstelling tot de meeste andere zweefvliegen. Als genus zijn de vliegen makkelijk herkenbaar, maar de zeer zeldzame soorten tussen de zeer algemene gewone snuitvlieg uithalen was niet altijd even makkelijk. In dit artikel wordt de herontdekking van de rode snuitvlieg beschreven en een tabel gegeven voor de drie Noordwest-Europese soorten.
    Schlagwort(e): Diptera ; Syrphidae ; Rhingia rostrata ; Nederland ; verspreiding ; herkenning ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
    Format: application/pdf
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  • 23
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    Eerste waarneming van de schietmot Ecclisopteryx dalecarlica in Nederland en nieuwe vondsten in België (Trichoptera: Limnephilidae) (2013)
    In:  Nederlandse Faunistische Mededelingen (0169-2453) vol.39 (2013) p.89
    Details
    Publikationsdatum: 2015-12-09
    Beschreibung: De larven van Trichoptera heten kokerjuffers en leven in het water. Veel soorten bouwen een kokertje van zand, takjes of ander materiaal, vandaar de Nederlandse naam. De volwassen dieren lijken wel wat op nachtvlinders en worden schietmotten genoemd. De laatste jaren heeft het onderzoek naar deze dieren een grote vlucht genomen. Enerzijds spelen ze een rol als indicator voor de waterkwaliteit. De larven worden dan ook veel verzameld tijdens macrofaunabemonsteringen door waterschappen. Anderzijds is er een groeiende groep entomologen die schietmotten bestudeert. In dit artikel wordt Ecclisopteryx dalecarlica voorgesteld, een nieuwe soort voor Nederland.
    Schlagwort(e): Trichoptera ; Limnephilidae ; Ecclisopteryx dalecarlica ; Nederland ; Belgie ; verspreiding ; herkenning ; 42.75
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: Article / Letter to the editor
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  • 24
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    Little emperors: behavioral impacts of China's One-Child Policy (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-01-12
    Beschreibung: We document that China's One-Child Policy (OCP), one of the most radical approaches to limiting population growth, has produced significantly less trusting, less trustworthy, more risk-averse, less competitive, more pessimistic, and less conscientious individuals. Our data were collected from economics experiments conducted with 421 individuals born just before and just after the OCP's introduction in 1979. Surveys to elicit personality traits were also used. We used the exogenous imposition of the OCP to identify the causal impact of being an only child, net of family background effects. The OCP thus has significant ramifications for Chinese society.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cameron, L -- Erkal, N -- Gangadharan, L -- Meng, X -- New York, N.Y. -- Science. 2013 Feb 22;339(6122):953-7. doi: 10.1126/science.1230221. Epub 2013 Jan 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Econometrics, Monash University, Clayton, Victoria 3800, Australia. lisa.cameron@monash.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23306438" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Altruism ; Anxiety Disorders ; *Attitude ; *Behavior ; China ; Competitive Behavior ; Family ; *Family Planning Policy ; Female ; Games, Experimental ; Humans ; Male ; Only Child/*psychology ; *Personality ; Risk-Taking ; Trust ; Urban Population
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 25
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    Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-03-23
    Beschreibung: Glycosylated alpha-dystroglycan (alpha-DG) serves as cellular entry receptor for multiple pathogens, and defects in its glycosylation cause hereditary Walker-Warburg syndrome (WWS). At least eight proteins are critical to glycosylate alpha-DG, but many genes mutated in WWS remain unknown. To identify modifiers of alpha-DG, we performed a haploid screen for Lassa virus entry, a hemorrhagic fever virus causing thousands of deaths annually that hijacks glycosylated alpha-DG to enter cells. In complementary screens, we profiled cells for absence of alpha-DG carbohydrate chains or biochemically related glycans. This revealed virus host factors and a suite of glycosylation units, including all known Walker-Warburg genes and five additional factors critical for the modification of alpha-DG. Our findings accentuate the complexity of this posttranslational feature and point out genes defective in dystroglycanopathies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919138/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919138/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jae, Lucas T -- Raaben, Matthijs -- Riemersma, Moniek -- van Beusekom, Ellen -- Blomen, Vincent A -- Velds, Arno -- Kerkhoven, Ron M -- Carette, Jan E -- Topaloglu, Haluk -- Meinecke, Peter -- Wessels, Marja W -- Lefeber, Dirk J -- Whelan, Sean P -- van Bokhoven, Hans -- Brummelkamp, Thijn R -- AI057159/AI/NIAID NIH HHS/ -- AI081842/AI/NIAID NIH HHS/ -- R01 AI081842/AI/NIAID NIH HHS/ -- U54 AI057159/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2013 Apr 26;340(6131):479-83. doi: 10.1126/science.1233675. Epub 2013 Mar 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23519211" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Cell Line ; Dystroglycans/*metabolism ; Female ; Glycosylation ; Haploidy ; Host-Pathogen Interactions/*genetics ; Humans ; Infant ; Lassa Fever/*genetics/virology ; Lassa virus/*physiology ; Male ; Membrane Proteins/*genetics ; Molecular Sequence Data ; Mutation ; Pedigree ; Proteome/*metabolism ; *Virus Internalization ; Walker-Warburg Syndrome/*genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 26
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    Comment on "ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models" (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-05-25
    Beschreibung: Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) reported that bexarotene rapidly reduces beta-amyloid (Abeta) levels and plaque burden in two mouse models of Abeta deposition in Alzheimer's disease (AD). We now report that, although bexarotene reduces soluble Abeta40 levels in one of the mouse models, the drug has no impact on plaque burden in three strains that exhibit Abeta amyloidosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Veeraraghavalu, Karthikeyan -- Zhang, Can -- Miller, Sean -- Hefendehl, Jasmin K -- Rajapaksha, Tharinda W -- Ulrich, Jason -- Jucker, Mathias -- Holtzman, David M -- Tanzi, Rudolph E -- Vassar, Robert -- Sisodia, Sangram S -- New York, N.Y. -- Science. 2013 May 24;340(6135):924-f. doi: 10.1126/science.1235505.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23704555" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alzheimer Disease/*drug therapy/*metabolism ; Amyloid beta-Peptides/*metabolism ; Animals ; Apolipoproteins E/*metabolism ; Brain/*metabolism ; Male ; Tetrahydronaphthalenes/*pharmacology/*therapeutic use
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 27
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    The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-09-28
    Beschreibung: The growing prevalence of overeating disorders is a key contributor to the worldwide obesity epidemic. Dysfunction of particular neural circuits may trigger deviations from adaptive feeding behaviors. The lateral hypothalamus (LH) is a crucial neural substrate for motivated behavior, including feeding, but the precise functional neurocircuitry that controls LH neuronal activity to engage feeding has not been defined. We observed that inhibitory synaptic inputs from the extended amygdala preferentially innervate and suppress the activity of LH glutamatergic neurons to control food intake. These findings help explain how dysregulated activity at a number of unique nodes can result in a cascading failure within a defined brain network to produce maladaptive feeding.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131546/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131546/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jennings, Joshua H -- Rizzi, Giorgio -- Stamatakis, Alice M -- Ung, Randall L -- Stuber, Garret D -- AA011605/AA/NIAAA NIH HHS/ -- AA022234/AA/NIAAA NIH HHS/ -- DA032750/DA/NIDA NIH HHS/ -- DA034472/DA/NIDA NIH HHS/ -- F31 DA034472/DA/NIDA NIH HHS/ -- NS007431/NS/NINDS NIH HHS/ -- P30 NS045892/NS/NINDS NIH HHS/ -- P50 AA011605/AA/NIAAA NIH HHS/ -- R01 DA032750/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 2013 Sep 27;341(6153):1517-21. doi: 10.1126/science.1241812.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24072922" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adaptation, Physiological ; Amygdala/physiology ; Animals ; Bacterial Proteins/genetics/metabolism ; Eating/*physiology ; Feeding Behavior/*physiology ; GABAergic Neurons/*physiology ; Hypothalamus/*physiology ; Luminescent Proteins/genetics/metabolism ; Male ; Mice ; Mice, Mutant Strains ; Obesity/physiopathology ; Rhodopsin/genetics/metabolism ; Septal Nuclei/physiology ; Synapses/physiology ; gamma-Aminobutyric Acid/metabolism/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 28
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    Topology of feather melanocyte progenitor niche allows complex pigment patterns to emerge (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-04-27
    Beschreibung: Color patterns of bird plumage affect animal behavior and speciation. Diverse patterns are present in different species and within the individual. Here, we study the cellular and molecular basis of feather pigment pattern formation. Melanocyte progenitors are distributed as a horizontal ring in the proximal follicle, sending melanocytes vertically up into the epithelial cylinder, which gradually emerges as feathers grow. Different pigment patterns form by modulating the presence, arrangement, or differentiation of melanocytes. A layer of peripheral pulp further regulates pigmentation via patterned agouti expression. Lifetime feather cyclic regeneration resets pigment patterns for physiological needs. Thus, the evolution of stem cell niche topology allows complex pigment patterning through combinatorial co-option of simple regulatory mechanisms.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144997/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144997/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, S J -- Foley, J -- Jiang, T X -- Yeh, C Y -- Wu, P -- Foley, A -- Yen, C M -- Huang, Y C -- Cheng, H C -- Chen, C F -- Reeder, B -- Jee, S H -- Widelitz, R B -- Chuong, C M -- AR060306/AR/NIAMS NIH HHS/ -- AR42177/AR/NIAMS NIH HHS/ -- AR47364/AR/NIAMS NIH HHS/ -- R01 AR042177/AR/NIAMS NIH HHS/ -- R01 AR047364/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2013 Jun 21;340(6139):1442-5. doi: 10.1126/science.1230374. Epub 2013 Apr 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23618762" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Agouti Signaling Protein/metabolism ; Animals ; Birds/*anatomy & histology/physiology ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Chickens/anatomy & histology/physiology ; Columbidae/anatomy & histology/physiology ; Feathers/*cytology/growth & development ; Female ; Galliformes/anatomy & histology/physiology ; Male ; Melanocytes/*cytology/physiology ; Models, Biological ; *Pigmentation ; Regeneration ; *Stem Cell Niche ; Stem Cells/*cytology/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Two dimensions of value: dopamine neurons represent reward but not aversiveness (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-08-03
    Beschreibung: Whereas reward (appetitiveness) and aversiveness (punishment) have been distinguished as two discrete dimensions within psychology and behavior, physiological and computational models of their neural representation have treated them as opposite sides of a single continuous dimension of "value." Here, I show that although dopamine neurons of the primate ventral midbrain are activated by evidence for reward and suppressed by evidence against reward, they are insensitive to aversiveness. This indicates that reward and aversiveness are represented independently as two dimensions, even by neurons that are closely related to motor function. Because theory and experiment support the existence of opponent neural representations for value, the present results imply four types of value-sensitive neurons corresponding to reward-ON (dopamine), reward-OFF, aversive-ON, and aversive-OFF.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fiorillo, Christopher D -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Aug 2;341(6145):546-9. doi: 10.1126/science.1238699.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Bio and Brain Engineering, KAIST (Korea Advanced Institute of Science and Technology), Yuseong-gu, Daejeon, Republic of Korea. fiorillo@kaist.ac.kr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23908236" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Appetitive Behavior/*physiology ; Conditioning, Classical/physiology ; Dopaminergic Neurons/*physiology ; Female ; Macaca mulatta ; Male ; Mesencephalon/cytology/*physiology ; Punishment/*psychology ; *Reward
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 30
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    Comment on "ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models" (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-05-25
    Beschreibung: Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) demonstrated in a mouse model for Alzheimer's disease (AD) that treatment of APP/PS1DeltaE9 mice with bexarotene decreased Abeta pathology and ameliorated memory deficits. We confirm the reversal of memory deficits in APP/PS1DeltaE9 mice expressing human APOE3 or APOE4 to the levels of their nontransgenic controls and the significant decrease of interstitial fluid Abeta, but not the effects on amyloid deposition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086452/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086452/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fitz, Nicholas F -- Cronican, Andrea A -- Lefterov, Iliya -- Koldamova, Radosveta -- F32AG034031/AG/NIA NIH HHS/ -- R01 AG037481/AG/NIA NIH HHS/ -- R01 AG037919/AG/NIA NIH HHS/ -- R01AG037481/AG/NIA NIH HHS/ -- R01AG037919/AG/NIA NIH HHS/ -- R21 ES021243/ES/NIEHS NIH HHS/ -- R21ES021243/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2013 May 24;340(6135):924-c. doi: 10.1126/science.1235809.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23704552" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alzheimer Disease/*drug therapy/*metabolism ; Amyloid beta-Peptides/*metabolism ; Animals ; Apolipoproteins E/*metabolism ; Brain/*metabolism ; Male ; Tetrahydronaphthalenes/*pharmacology/*therapeutic use
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 31
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    Comment on "In monkeys making value-based decisions, LIP neurons encode cue salience and not action value" (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-04-27
    Beschreibung: Leathers and Olson (Reports, 5 October 2012, p. 132) draw the strong conclusion that neurons in the monkey lateral intraparietal (LIP) cortical area encode only cue salience, and not action value, during value-based decision-making. Although their findings regarding cue salience are interesting, their broader conclusions are problematic because (i) their primary conclusion is based on responses observed during a brief interval at the beginning of behavioral trials but is extended to all subsequent temporal epochs and (ii) the authors failed to replicate basic hallmarks of LIP physiology observed in those subsequent temporal epochs by many laboratories.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045496/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045496/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newsome, William T -- Glimcher, Paul W -- Gottlieb, Jacqueline -- Lee, Daeyeol -- Platt, Michael L -- R01 MH096875/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2013 Apr 26;340(6131):430. doi: 10.1126/science.1233214.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23620037" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Cues ; Decision Making/*physiology ; Male ; Motivation/*physiology ; Neurons/*physiology ; Saccades/*physiology ; *Social Values
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 32
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    Immunology. Welcome to the microgenderome (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-03-02
    Beschreibung: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005781/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005781/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flak, Magdalena B -- Neves, Joana F -- Blumberg, Richard S -- DK0034854/DK/NIDDK NIH HHS/ -- DK044319/DK/NIDDK NIH HHS/ -- DK051362/DK/NIDDK NIH HHS/ -- DK053056/DK/NIDDK NIH HHS/ -- DK088199/DK/NIDDK NIH HHS/ -- R01 DK088199/DK/NIDDK NIH HHS/ -- R37 DK044319/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2013 Mar 1;339(6123):1044-5. doi: 10.1126/science.1236226.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23449586" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Autoimmunity ; Diabetes Mellitus, Type 1/*microbiology ; Female ; Gonadal Steroid Hormones/*immunology ; Intestines/*microbiology ; Male ; *Metagenome ; *Sex Characteristics
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Prediction error governs pharmacologically induced amnesia for learned fear (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-02-16
    Beschreibung: Although reconsolidation opens up new avenues to erase excessive fear memory, subtle boundary conditions put constraints on retrieval-induced plasticity. Reconsolidation may only take place when memory reactivation involves an experience that engages new learning (prediction error). Thus far, it has not been possible to determine the optimal degree of novelty required for destabilizing the memory. The occurrence of prediction error could only be inferred from the observation of a reconsolidation process itself. Here, we provide a noninvasive index of memory destabilization that is independent from the occurrence of reconsolidation. Using this index, we show in humans that prediction error is (i) a necessary condition for reconsolidation of associative fear memory and (ii) determined by the interaction between original learning and retrieval. Insight into the process of memory updating is crucial for understanding the optimal and boundary conditions on reconsolidation and provides a clear guide for the development of reconsolidation-based treatments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sevenster, Dieuwke -- Beckers, Tom -- Kindt, Merel -- New York, N.Y. -- Science. 2013 Feb 15;339(6121):830-3. doi: 10.1126/science.1231357.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Clinical Psychology, University of Amsterdam, Amsterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23413355" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 1-Propanol/administration & dosage ; Amnesia/chemically induced/*psychology ; Conditioning (Psychology)/drug effects ; Fear/drug effects/*psychology ; Female ; Humans ; Learning/drug effects/*physiology ; Male ; Mental Recall/drug effects/physiology ; Models, Psychological ; Reinforcement Schedule ; Young Adult
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 34
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    IBI series winner. Exploring the evolution of human mate preference (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-11-30
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Foster, Valerie -- New York, N.Y. -- Science. 2013 Nov 29;342(6162):1060-1. doi: 10.1126/science.1230005.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Natural Sciences Division, Pasadena City College, 1570 East Colorado Boulevard, Pasadena, CA 91106, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24288326" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Courtship/*psychology ; Female ; Humans ; Male ; Marriage/*psychology ; Personality ; Problem-Based Learning/*methods ; Selection, Genetic ; Voice Quality ; Young Adult
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 35
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    Immunology. Guilty by association (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-03-09
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Joshi, Nikhil S -- Jacks, Tyler -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Mar 8;339(6124):1160-1. doi: 10.1126/science.1235528.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Koch Institute for Integrative Cancer Research, Department of Biology, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23471395" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Female ; *Immune Tolerance ; Male ; Prostate/*immunology ; Prostatic Neoplasms/*immunology ; T-Lymphocytes, Regulatory/*immunology ; Thymus Gland/*growth & development/*immunology ; Transcription Factors/*immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 36
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    Comment on "Bateman in nature: predation on offspring reduces the potential for sexual selection" (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-05-04
    Beschreibung: Byers and Dunn (Reports, 9 November 2012, p. 802) reported that sexual selection and natural selection are closely related in a wild population of pronghorns. Here, I argue that this conclusion is incorrect. Their main finding is due to the fact that, unsurprisingly, juvenile mortality and juvenile survival are negatively related across years.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arnqvist, Goran -- 294333/European Research Council/International -- New York, N.Y. -- Science. 2013 May 3;340(6132):549. doi: 10.1126/science.1233413.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Animal Ecology, Department of Ecology and Genetics, Uppsala University, Norbyvagen 18D, SE75236 Uppsala, Sweden. goran.arnqvist@ebc.uu.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23641095" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antelopes/*physiology ; Female ; Male ; *Mating Preference, Animal ; *Predatory Behavior ; *Sexual Behavior, Animal
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 37
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    Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-07-23
    Beschreibung: Melanocortin receptor accessory proteins (MRAPs) modulate signaling of melanocortin receptors in vitro. To investigate the physiological role of brain-expressed melanocortin 2 receptor accessory protein 2 (MRAP2), we characterized mice with whole-body and brain-specific targeted deletion of Mrap2, both of which develop severe obesity at a young age. Mrap2 interacts directly with melanocortin 4 receptor (Mc4r), a protein previously implicated in mammalian obesity, and it enhances Mc4r-mediated generation of the second messenger cyclic adenosine monophosphate, suggesting that alterations in Mc4r signaling may be one mechanism underlying the association between Mrap2 disruption and obesity. In a study of humans with severe, early-onset obesity, we found four rare, potentially pathogenic genetic variants in MRAP2, suggesting that the gene may also contribute to body weight regulation in humans.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788688/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788688/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Asai, Masato -- Ramachandrappa, Shwetha -- Joachim, Maria -- Shen, Yuan -- Zhang, Rong -- Nuthalapati, Nikhil -- Ramanathan, Visali -- Strochlic, David E -- Ferket, Peter -- Linhart, Kirsten -- Ho, Caroline -- Novoselova, Tatiana V -- Garg, Sumedha -- Ridderstrale, Martin -- Marcus, Claude -- Hirschhorn, Joel N -- Keogh, Julia M -- O'Rahilly, Stephen -- Chan, Li F -- Clark, Adrian J -- Farooqi, I Sadaf -- Majzoub, Joseph A -- 098497/Wellcome Trust/United Kingdom -- G0802796/Medical Research Council/United Kingdom -- G0900554/Medical Research Council/United Kingdom -- G9824984/Medical Research Council/United Kingdom -- P30-HD18655/HD/NICHD NIH HHS/ -- R01 DK075787/DK/NIDDK NIH HHS/ -- R01DK075787/DK/NIDDK NIH HHS/ -- T32 DK007699/DK/NIDDK NIH HHS/ -- T32 MH020017/MH/NIMH NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2013 Jul 19;341(6143):275-8. doi: 10.1126/science.1233000.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Endocrinology, Department of Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23869016" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Animals ; Body Mass Index ; Body Weight/*genetics ; Carrier Proteins/*genetics ; Child ; Child, Preschool ; Energy Metabolism/genetics ; Female ; Gene Deletion ; Humans ; Male ; Mice ; Mice, Knockout ; Obesity/*genetics/metabolism ; Receptor Activity-Modifying Proteins/genetics/*metabolism ; Receptor, Melanocortin, Type 4/genetics/*metabolism ; Young Adult
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Poverty impedes cognitive function (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-08-31
    Beschreibung: The poor often behave in less capable ways, which can further perpetuate poverty. We hypothesize that poverty directly impedes cognitive function and present two studies that test this hypothesis. First, we experimentally induced thoughts about finances and found that this reduces cognitive performance among poor but not in well-off participants. Second, we examined the cognitive function of farmers over the planting cycle. We found that the same farmer shows diminished cognitive performance before harvest, when poor, as compared with after harvest, when rich. This cannot be explained by differences in time available, nutrition, or work effort. Nor can it be explained with stress: Although farmers do show more stress before harvest, that does not account for diminished cognitive performance. Instead, it appears that poverty itself reduces cognitive capacity. We suggest that this is because poverty-related concerns consume mental resources, leaving less for other tasks. These data provide a previously unexamined perspective and help explain a spectrum of behaviors among the poor. We discuss some implications for poverty policy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mani, Anandi -- Mullainathan, Sendhil -- Shafir, Eldar -- Zhao, Jiaying -- New York, N.Y. -- Science. 2013 Aug 30;341(6149):976-80. doi: 10.1126/science.1238041.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Economics, University of Warwick, Coventry, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23990553" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Agriculture ; *Cognition ; Female ; Financial Management ; Humans ; Male ; Poverty/*psychology ; Public Policy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 39
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    Bayes' confidence (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-09-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fraser, D A S -- New York, N.Y. -- Science. 2013 Sep 27;341(6153):1452. doi: 10.1126/science.341.6153.1452-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24072906" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Algorithms ; *Bayes Theorem ; Humans ; Male
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 40
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    Immunology. Pasteur approach to a malaria vaccine may take the lead (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-09-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Good, Michael F -- New York, N.Y. -- Science. 2013 Sep 20;341(6152):1352-3. doi: 10.1126/science.1244157.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Glycomics, Griffith University, Gold Coast 4222, Australia. michael.good@griffith.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24052298" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Female ; Humans ; Malaria Vaccines/*administration & dosage/*immunology ; Malaria, Falciparum/*prevention & control ; Male ; Plasmodium falciparum/*immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Psychiatric research. Severe autism, often slighted, now targeted for study (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-10-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmidt, Charles -- New York, N.Y. -- Science. 2013 Oct 11;342(6155):179. doi: 10.1126/science.342.6155.179.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24115416" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Autistic Disorder/*genetics/*psychology ; Behavioral Research/*economics ; Biomedical Research/*economics ; Child ; Child, Preschool ; Financing, Organized ; Humans ; Male ; Severity of Illness Index ; Young Adult
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 42
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    Repeated cortico-striatal stimulation generates persistent OCD-like behavior (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-06-08
    Beschreibung: Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics in mice to simulate CSTC hyperactivation observed in OCD patients. Whereas acute orbitofrontal cortex (OFC)-ventromedial striatum (VMS) stimulation did not produce repetitive behaviors, repeated hyperactivation over multiple days generated a progressive increase in grooming, a mouse behavior related to OCD. Increased grooming persisted for 2 weeks after stimulation cessation. The grooming increase was temporally coupled with a progressive increase in light-evoked firing of postsynaptic VMS cells. Both increased grooming and evoked firing were reversed by chronic fluoxetine, a first-line OCD treatment. Brief but repeated episodes of abnormal circuit activity may thus set the stage for the development of persistent psychopathology.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954809/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954809/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahmari, Susanne E -- Spellman, Timothy -- Douglass, Neria L -- Kheirbek, Mazen A -- Simpson, H Blair -- Deisseroth, Karl -- Gordon, Joshua A -- Hen, Rene -- K01 MH099371/MH/NIMH NIH HHS/ -- K01MH099371/MH/NIMH NIH HHS/ -- K08 MH087718/MH/NIMH NIH HHS/ -- K08MH087718/MH/NIMH NIH HHS/ -- K24 MH091555/MH/NIMH NIH HHS/ -- R01 MH096274/MH/NIMH NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Jun 7;340(6137):1234-9. doi: 10.1126/science.1234733.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. sea2103@columbia.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23744948" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenoviridae ; Animals ; Artificial Gene Fusion ; Bacterial Proteins/genetics ; Behavior, Animal ; Corpus Striatum/drug effects/*physiopathology ; Electric Stimulation ; Fluoxetine/pharmacology ; Frontal Lobe/drug effects/*physiopathology ; Luminescent Proteins/genetics ; Male ; Mice ; Obsessive-Compulsive Disorder/*physiopathology/*psychology ; Optogenetics ; Rhodopsin/biosynthesis/genetics ; Serotonin Uptake Inhibitors/pharmacology ; Thalamus/drug effects/*physiopathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-07-13
    Beschreibung: Wiskott-Aldrich syndrome (WAS) is an inherited immunodeficiency caused by mutations in the gene encoding WASP, a protein regulating the cytoskeleton. Hematopoietic stem/progenitor cell (HSPC) transplants can be curative, but, when matched donors are unavailable, infusion of autologous HSPCs modified ex vivo by gene therapy is an alternative approach. We used a lentiviral vector encoding functional WASP to genetically correct HSPCs from three WAS patients and reinfused the cells after a reduced-intensity conditioning regimen. All three patients showed stable engraftment of WASP-expressing cells and improvements in platelet counts, immune functions, and clinical scores. Vector integration analyses revealed highly polyclonal and multilineage haematopoiesis resulting from the gene-corrected HSPCs. Lentiviral gene therapy did not induce selection of integrations near oncogenes, and no aberrant clonal expansion was observed after 20 to 32 months. Although extended clinical observation is required to establish long-term safety, lentiviral gene therapy represents a promising treatment for WAS.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375961/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375961/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aiuti, Alessandro -- Biasco, Luca -- Scaramuzza, Samantha -- Ferrua, Francesca -- Cicalese, Maria Pia -- Baricordi, Cristina -- Dionisio, Francesca -- Calabria, Andrea -- Giannelli, Stefania -- Castiello, Maria Carmina -- Bosticardo, Marita -- Evangelio, Costanza -- Assanelli, Andrea -- Casiraghi, Miriam -- Di Nunzio, Sara -- Callegaro, Luciano -- Benati, Claudia -- Rizzardi, Paolo -- Pellin, Danilo -- Di Serio, Clelia -- Schmidt, Manfred -- Von Kalle, Christof -- Gardner, Jason -- Mehta, Nalini -- Neduva, Victor -- Dow, David J -- Galy, Anne -- Miniero, Roberto -- Finocchi, Andrea -- Metin, Ayse -- Banerjee, Pinaki P -- Orange, Jordan S -- Galimberti, Stefania -- Valsecchi, Maria Grazia -- Biffi, Alessandra -- Montini, Eugenio -- Villa, Anna -- Ciceri, Fabio -- Roncarolo, Maria Grazia -- Naldini, Luigi -- R01 AI067946/AI/NIAID NIH HHS/ -- TGT11D01/Telethon/Italy -- TGT11D02/Telethon/Italy -- New York, N.Y. -- Science. 2013 Aug 23;341(6148):1233151. doi: 10.1126/science.1233151. Epub 2013 Jul 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Scientific Institute, 20132 Milan, Italy. aiuti.alessandro@hsr.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23845947" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Child ; Genetic Therapy/*methods ; Genetic Vectors ; *Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/*metabolism ; Humans ; Lentivirus ; Male ; Transduction, Genetic ; Virus Integration ; Wiskott-Aldrich Syndrome/*therapy ; Wiskott-Aldrich Syndrome Protein/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Comment on "Poverty impedes cognitive function" (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-12-07
    Beschreibung: Mani et al. (Research Articles, 30 August, p. 976) presented laboratory experiments that aimed to show that poverty-related worries impede cognitive functioning. A reanalysis without dichotomization of income fails to corroborate their findings and highlights spurious interactions between income and experimental manipulation due to ceiling effects caused by short and easy tests. This suggests that effects of financial worries are not limited to the poor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wicherts, Jelte M -- Scholten, Annemarie Zand -- New York, N.Y. -- Science. 2013 Dec 6;342(6163):1169. doi: 10.1126/science.1246680.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Jelte Wicherts, Department of Methodology and Statistics, Tilburg University, P.O. Box 90153, 5000 LE, Tilburg, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24311665" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Cognition ; Female ; Humans ; Male ; Poverty/*psychology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Genomics. Initiative aims to minister to Mexico's unique genetic heritage (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-11-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, Lizzie -- New York, N.Y. -- Science. 2013 Nov 15;342(6160):788. doi: 10.1126/science.342.6160.788.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24233700" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Alleles ; Diabetes Mellitus/epidemiology/genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genetic Variation ; Genome, Human/*genetics ; Humans ; Male ; Mexico/epidemiology ; Pedigree ; Population/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Compartmentalization of GABAergic inhibition by dendritic spines (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-05-11
    Beschreibung: gamma-aminobutyric acid-mediated (GABAergic) inhibition plays a critical role in shaping neuronal activity in the neocortex. Numerous experimental investigations have examined perisomatic inhibitory synapses, which control action potential output from pyramidal neurons. However, most inhibitory synapses in the neocortex are formed onto pyramidal cell dendrites, where theoretical studies suggest they may focally regulate cellular activity. The precision of GABAergic control over dendritic electrical and biochemical signaling is unknown. By using cell type-specific optical stimulation in combination with two-photon calcium (Ca(2+)) imaging, we show that somatostatin-expressing interneurons exert compartmentalized control over postsynaptic Ca(2+) signals within individual dendritic spines. This highly focal inhibitory action is mediated by a subset of GABAergic synapses that directly target spine heads. GABAergic inhibition thus participates in localized control of dendritic electrical and biochemical signaling.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752161/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752161/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chiu, Chiayu Q -- Lur, Gyorgy -- Morse, Thomas M -- Carnevale, Nicholas T -- Ellis-Davies, Graham C R -- Higley, Michael J -- DC009977/DC/NIDCD NIH HHS/ -- GM053395/GM/NIGMS NIH HHS/ -- K01 MH097961/MH/NIMH NIH HHS/ -- MH099045/MH/NIMH NIH HHS/ -- NS011613/NS/NINDS NIH HHS/ -- NS069720/NS/NINDS NIH HHS/ -- R01 DC009977/DC/NIDCD NIH HHS/ -- R01 GM053395/GM/NIGMS NIH HHS/ -- R01 MH099045/MH/NIMH NIH HHS/ -- R01 NS011613/NS/NINDS NIH HHS/ -- R01 NS069720/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2013 May 10;340(6133):759-62. doi: 10.1126/science.1234274.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Yale School of Medicine, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23661763" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Calcium/metabolism ; Computer Simulation ; Dendritic Spines/*physiology ; Female ; Glutamic Acid/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Models, Neurological ; Neocortex/*physiology ; *Neural Inhibition ; Photic Stimulation ; Pyramidal Cells/*physiology ; Rhodopsin/metabolism ; Synapses/physiology ; gamma-Aminobutyric Acid/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Treatment as prevention, real world (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-02-23
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2013 Feb 22;339(6122):901. doi: 10.1126/science.339.6122.901.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23430630" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anti-HIV Agents/*therapeutic use ; *Antiretroviral Therapy, Highly Active ; Female ; HIV Infections/*drug therapy/*prevention & control ; Humans ; Male ; *Rural Health
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Multiple fitness peaks on the adaptive landscape drive adaptive radiation in the wild (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-01-12
    Beschreibung: The relationship between phenotype and fitness can be visualized as a rugged landscape. Multiple fitness peaks on this landscape are predicted to drive early bursts of niche diversification during adaptive radiation. We measured the adaptive landscape in a nascent adaptive radiation of Cyprinodon pupfishes endemic to San Salvador Island, Bahamas, and found multiple coexisting high-fitness regions driven by increased competition at high densities, supporting the early burst model. Hybrids resembling the generalist phenotype were isolated on a local fitness peak separated by a valley from a higher-fitness region corresponding to trophic specialization. This complex landscape could explain both the rarity of specialists across many similar environments due to stabilizing selection on generalists and the rapid morphological diversification rate of specialists due to their higher fitness.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, Christopher H -- Wainwright, Peter C -- New York, N.Y. -- Science. 2013 Jan 11;339(6116):208-11. doi: 10.1126/science.1227710.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Evolution and Ecology and Center for Population Biology, University of California, One Shields Avenue, Davis, CA, USA. chmartin@ucdavis.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23307743" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adaptation, Physiological/*genetics ; Animals ; Bahamas ; *Biological Evolution ; Crosses, Genetic ; Ecosystem ; Environment ; Female ; *Genetic Fitness ; Genetic Speciation ; Hybridization, Genetic ; Killifishes/*genetics/*physiology ; Lakes ; Male ; Models, Biological ; Phenotype ; Selection, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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    Following the males' trail, 1.5 million years later (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-04-27
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, Michael -- New York, N.Y. -- Science. 2013 Apr 26;340(6131):426-7. doi: 10.1126/science.340.6131.426-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23620031" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anthropology, Physical/*history ; Female ; Foot/*anatomy & histology/*physiology ; Fossils ; History, Ancient ; Humans ; Kenya ; Male ; Social Behavior/*history ; Walking/*history
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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    Immunology. An interferon paradox (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-04-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Odorizzi, Pamela M -- Wherry, E John -- T32 AI007632/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2013 Apr 12;340(6129):155-6. doi: 10.1126/science.1237568.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Immunology and Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23580520" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arenaviridae Infections/*immunology/*virology ; Female ; Interferon Type I/*immunology/*metabolism ; Lymphocytic choriomeningitis virus/*immunology/*physiology ; Male ; *Signal Transduction
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-08-10
    Beschreibung: Consistent, high-level, vaccine-induced protection against human malaria has only been achieved by inoculation of Plasmodium falciparum (Pf) sporozoites (SPZ) by mosquito bites. We report that the PfSPZ Vaccine--composed of attenuated, aseptic, purified, cryopreserved PfSPZ--was safe and well tolerated when administered four to six times intravenously (IV) to 40 adults. Zero of six subjects receiving five doses and three of nine subjects receiving four doses of 1.35 x 10(5) PfSPZ Vaccine and five of six nonvaccinated controls developed malaria after controlled human malaria infection (P = 0.015 in the five-dose group and P = 0.028 for overall, both versus controls). PfSPZ-specific antibody and T cell responses were dose-dependent. These data indicate that there is a dose-dependent immunological threshold for establishing high-level protection against malaria that can be achieved with IV administration of a vaccine that is safe and meets regulatory standards.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seder, Robert A -- Chang, Lee-Jah -- Enama, Mary E -- Zephir, Kathryn L -- Sarwar, Uzma N -- Gordon, Ingelise J -- Holman, LaSonji A -- James, Eric R -- Billingsley, Peter F -- Gunasekera, Anusha -- Richman, Adam -- Chakravarty, Sumana -- Manoj, Anita -- Velmurugan, Soundarapandian -- Li, MingLin -- Ruben, Adam J -- Li, Tao -- Eappen, Abraham G -- Stafford, Richard E -- Plummer, Sarah H -- Hendel, Cynthia S -- Novik, Laura -- Costner, Pamela J M -- Mendoza, Floreliz H -- Saunders, Jamie G -- Nason, Martha C -- Richardson, Jason H -- Murphy, Jittawadee -- Davidson, Silas A -- Richie, Thomas L -- Sedegah, Martha -- Sutamihardja, Awalludin -- Fahle, Gary A -- Lyke, Kirsten E -- Laurens, Matthew B -- Roederer, Mario -- Tewari, Kavita -- Epstein, Judith E -- Sim, B Kim Lee -- Ledgerwood, Julie E -- Graham, Barney S -- Hoffman, Stephen L -- VRC 312 Study Team -- 3R44AI055229-06S1/AI/NIAID NIH HHS/ -- 4R44AI055229-08/AI/NIAID NIH HHS/ -- 5R44AI058499-05/AI/NIAID NIH HHS/ -- N01-AI-40096/AI/NIAID NIH HHS/ -- Intramural NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Sep 20;341(6152):1359-65. doi: 10.1126/science.1241800. Epub 2013 Aug 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA. rseder@mail.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23929949" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Administration, Intravenous ; Adult ; Animals ; Cytokines/immunology ; Female ; Humans ; Immunity, Cellular ; Malaria Vaccines/*administration & dosage/adverse effects/*immunology ; Malaria, Falciparum/*prevention & control ; Male ; Mice ; Plasmodium falciparum/*immunology ; Sporozoites/immunology ; T-Lymphocytes/immunology ; Vaccination/adverse effects/methods
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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    Network-based diffusion analysis reveals cultural transmission of lobtail feeding in humpback whales (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-04-27
    Beschreibung: We used network-based diffusion analysis to reveal the cultural spread of a naturally occurring foraging innovation, lobtail feeding, through a population of humpback whales (Megaptera novaeangliae) over a period of 27 years. Support for models with a social transmission component was 6 to 23 orders of magnitude greater than for models without. The spatial and temporal distribution of sand lance, a prey species, was also important in predicting the rate of acquisition. Our results, coupled with existing knowledge about song traditions, show that this species can maintain multiple independently evolving traditions in its populations. These insights strengthen the case that cetaceans represent a peak in the evolution of nonhuman culture, independent of the primate lineage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allen, Jenny -- Weinrich, Mason -- Hoppitt, Will -- Rendell, Luke -- New York, N.Y. -- Science. 2013 Apr 26;340(6131):485-8. doi: 10.1126/science.1231976.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sea Mammal Research Unit and Centre for Social Learning and Cognitive Evolution, School of Biology, University of St Andrews, Fife, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23620054" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Cultural Evolution ; *Feeding Behavior ; Female ; Humpback Whale/*psychology ; Male ; Population ; *Social Behavior ; Social Networking ; *Transfer (Psychology)
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Evolution. Why male mammals are monogamous (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-08-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kappeler, Peter M -- New York, N.Y. -- Science. 2013 Aug 2;341(6145):469-70. doi: 10.1126/science.1242001.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Behavioral Ecology and Sociobiology Unit, German Primate Center (DPZ), and Department of Sociobiology/Anthropology, University of Gottingen, Gottingen, Germany. pkappel@gwdg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23908214" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Biological Evolution ; Female ; Male ; *Marriage ; *Sexual Behavior, Animal
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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    Genetics. Our fallen genomes (2013)
    American Association for the Advancement of Science (AAAS)
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    Publikationsdatum: 2013-11-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macosko, Evan Z -- McCarroll, Steven A -- New York, N.Y. -- Science. 2013 Nov 1;342(6158):564-5. doi: 10.1126/science.1246942.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24179207" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *DNA Copy Number Variations ; Frontal Lobe/*cytology ; Humans ; Male ; *Mosaicism ; Neural Stem Cells/*cytology ; Neurons/*cytology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Behavioral ecology. At home on the range: prairie rodents yield their secrets to a dogged observer (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-03-09
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2013 Mar 8;339(6124):1136-7. doi: 10.1126/science.339.6124.1136.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23471380" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Animal Distribution ; Animals ; *Competitive Behavior ; Female ; Male ; *Reproduction ; Sciuridae/*physiology ; *Territoriality
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Gut microbiomes of Malawian twin pairs discordant for kwashiorkor (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-02-01
    Beschreibung: Kwashiorkor, an enigmatic form of severe acute malnutrition, is the consequence of inadequate nutrient intake plus additional environmental insults. To investigate the role of the gut microbiome, we studied 317 Malawian twin pairs during the first 3 years of life. During this time, half of the twin pairs remained well nourished, whereas 43% became discordant, and 7% manifested concordance for acute malnutrition. Both children in twin pairs discordant for kwashiorkor were treated with a peanut-based, ready-to-use therapeutic food (RUTF). Time-series metagenomic studies revealed that RUTF produced a transient maturation of metabolic functions in kwashiorkor gut microbiomes that regressed when administration of RUTF was stopped. Previously frozen fecal communities from several discordant pairs were each transplanted into gnotobiotic mice. The combination of Malawian diet and kwashiorkor microbiome produced marked weight loss in recipient mice, accompanied by perturbations in amino acid, carbohydrate, and intermediary metabolism that were only transiently ameliorated with RUTF. These findings implicate the gut microbiome as a causal factor in kwashiorkor.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667500/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667500/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, Michelle I -- Yatsunenko, Tanya -- Manary, Mark J -- Trehan, Indi -- Mkakosya, Rajhab -- Cheng, Jiye -- Kau, Andrew L -- Rich, Stephen S -- Concannon, Patrick -- Mychaleckyj, Josyf C -- Liu, Jie -- Houpt, Eric -- Li, Jia V -- Holmes, Elaine -- Nicholson, Jeremy -- Knights, Dan -- Ursell, Luke K -- Knight, Rob -- Gordon, Jeffrey I -- DK078669/DK/NIDDK NIH HHS/ -- DK30292/DK/NIDDK NIH HHS/ -- F32 DK091044/DK/NIDDK NIH HHS/ -- P01 DK078669/DK/NIDDK NIH HHS/ -- P30 DK056341/DK/NIDDK NIH HHS/ -- R37 DK030292/DK/NIDDK NIH HHS/ -- T32 HD049338/HD/NICHD NIH HHS/ -- T32-HD049338/HD/NICHD NIH HHS/ -- T35 DK074375/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2013 Feb 1;339(6119):548-54. doi: 10.1126/science.1229000. Epub 2013 Jan 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Genome Sciences and Systems Biology, Washington University in St. Louis, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23363771" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acids/metabolism ; Animals ; Arachis ; Carbohydrate Metabolism ; Child, Preschool ; Diseases in Twins/*microbiology ; Feces/microbiology ; Female ; Gastrointestinal Tract/*microbiology ; Germ-Free Life ; Humans ; Infant ; Kwashiorkor/diet therapy/epidemiology/*microbiology ; Longitudinal Studies ; Malawi/epidemiology ; Male ; *Metagenome ; Mice ; Mice, Inbred C57BL
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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    Autonomic nerve development contributes to prostate cancer progression (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-07-13
    Beschreibung: Nerves are a common feature of the microenvironment, but their role in tumor growth and progression remains unclear. We found that the formation of autonomic nerve fibers in the prostate gland regulates prostate cancer development and dissemination in mouse models. The early phases of tumor development were prevented by chemical or surgical sympathectomy and by genetic deletion of stromal beta2- and beta3-adrenergic receptors. Tumors were also infiltrated by parasympathetic cholinergic fibers that promoted cancer dissemination. Cholinergic-induced tumor invasion and metastasis were inhibited by pharmacological blockade or genetic disruption of the stromal type 1 muscarinic receptor, leading to improved survival of the mice. A retrospective blinded analysis of prostate adenocarcinoma specimens from 43 patients revealed that the densities of sympathetic and parasympathetic nerve fibers in tumor and surrounding normal tissue, respectively, were associated with poor clinical outcomes. These findings may lead to novel therapeutic approaches for prostate cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Magnon, Claire -- Hall, Simon J -- Lin, Juan -- Xue, Xiaonan -- Gerber, Leah -- Freedland, Stephen J -- Frenette, Paul S -- DK056638/DK/NIDDK NIH HHS/ -- HL069438/HL/NHLBI NIH HHS/ -- HL097819/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2013 Jul 12;341(6142):1236361. doi: 10.1126/science.1236361.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA. clairemagnon@free.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23846904" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/*pathology ; Adrenergic Fibers/physiology ; Animals ; Autonomic Nervous System/*growth & development ; Cell Line, Tumor ; Cell Transformation, Neoplastic/pathology ; Cholinergic Fibers/physiology ; Disease Progression ; Genes, myc/genetics ; Humans ; Male ; Mice ; Mice, Transgenic ; Neoplasm Invasiveness ; Neoplasm Transplantation ; Nerve Net/pathology/physiology ; *Neurogenesis ; Parasympathetic Nervous System/growth & development ; Promoter Regions, Genetic ; Prostate/*innervation/*pathology ; Prostatic Neoplasms/*pathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Fear learning enhances neural responses to threat-predictive sensory stimuli (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-12-18
    Beschreibung: The central nervous system rapidly learns that particular stimuli predict imminent danger. This learning is thought to involve associations between neutral and harmful stimuli in cortical and limbic brain regions, though associative neuroplasticity in sensory structures is increasingly appreciated. We observed the synaptic output of olfactory sensory neurons (OSNs) in individual mice before and after they learned that a particular odor indicated an impending foot shock. OSNs are the first cells in the olfactory system, physically contacting the odor molecules in the nose and projecting their axons to the brain's olfactory bulb. OSN output evoked by the shock-predictive odor was selectively facilitated after fear conditioning. These results indicate that affective information about a stimulus can be encoded in its very earliest representation in the nervous system.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011636/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011636/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kass, Marley D -- Rosenthal, Michelle C -- Pottackal, Joseph -- McGann, John P -- DC009442/DC/NIDCD NIH HHS/ -- DC013090/DC/NIDCD NIH HHS/ -- MH101293/MH/NIMH NIH HHS/ -- R00 DC009442/DC/NIDCD NIH HHS/ -- R01 DC013090/DC/NIDCD NIH HHS/ -- R01 MH101293/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2013 Dec 13;342(6164):1389-92. doi: 10.1126/science.1244916.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Behavioral and Systems Neuroscience Section, Department of Psychology, Rutgers, The State University of New Jersey, 152 Frelinghuysen Road, Piscataway, NJ 08854, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24337299" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Conditioning, Classical/physiology ; Fear/*psychology ; Learning/*physiology ; Male ; Mice ; Mice, Inbred C57BL ; Neuronal Plasticity ; *Odors ; Olfactory Receptor Neurons/*physiology ; Smell/*physiology ; Synapses/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Sleep drives metabolite clearance from the adult brain (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-10-19
    Beschreibung: The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of beta-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880190/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880190/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xie, Lulu -- Kang, Hongyi -- Xu, Qiwu -- Chen, Michael J -- Liao, Yonghong -- Thiyagarajan, Meenakshisundaram -- O'Donnell, John -- Christensen, Daniel J -- Nicholson, Charles -- Iliff, Jeffrey J -- Takano, Takahiro -- Deane, Rashid -- Nedergaard, Maiken -- NS028642/NS/NINDS NIH HHS/ -- NS078167/NS/NINDS NIH HHS/ -- NS078304/NS/NINDS NIH HHS/ -- R01 DE022743/DE/NIDCR NIH HHS/ -- R01 NS075177/NS/NINDS NIH HHS/ -- R01 NS078167/NS/NINDS NIH HHS/ -- R01 NS078304/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2013 Oct 18;342(6156):373-7. doi: 10.1126/science.1241224.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24136970" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenergic Antagonists/administration & dosage ; Amyloid beta-Peptides/*metabolism ; Animals ; Brain/*metabolism/physiology ; Cerebral Cortex/metabolism/physiology ; Cerebrospinal Fluid/metabolism ; Diffusion ; Electroencephalography ; Extracellular Space ; Intracellular Space ; Male ; Mice ; Mice, Inbred C57BL ; Neurodegenerative Diseases/*metabolism ; Quaternary Ammonium Compounds/chemistry ; Receptors, Adrenergic/metabolism ; Sleep/*physiology ; Wakefulness/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Mosaic copy number variation in human neurons (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-11-02
    Beschreibung: We used single-cell genomic approaches to map DNA copy number variation (CNV) in neurons obtained from human induced pluripotent stem cell (hiPSC) lines and postmortem human brains. We identified aneuploid neurons, as well as numerous subchromosomal CNVs in euploid neurons. Neurotypic hiPSC-derived neurons had larger CNVs than fibroblasts, and several large deletions were found in hiPSC-derived neurons but not in matched neural progenitor cells. Single-cell sequencing of endogenous human frontal cortex neurons revealed that 13 to 41% of neurons have at least one megabase-scale de novo CNV, that deletions are twice as common as duplications, and that a subset of neurons have highly aberrant genomes marked by multiple alterations. Our results show that mosaic CNV is abundant in human neurons.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975283/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975283/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McConnell, Michael J -- Lindberg, Michael R -- Brennand, Kristen J -- Piper, Julia C -- Voet, Thierry -- Cowing-Zitron, Chris -- Shumilina, Svetlana -- Lasken, Roger S -- Vermeesch, Joris R -- Hall, Ira M -- Gage, Fred H -- DP2 OD006493/OD/NIH HHS/ -- DP20D006493-01/DP/NCCDPHP CDC HHS/ -- HHSN2752009000011C/PHS HHS/ -- N01-HD-9-011/HD/NICHD NIH HHS/ -- R01 MH095741/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2013 Nov 1;342(6158):632-7. doi: 10.1126/science.1243472.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24179226" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aneuploidy ; *DNA Copy Number Variations ; Frontal Lobe/*cytology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Male ; *Mosaicism ; Neural Stem Cells/*cytology ; Neurogenesis ; Neurons/*cytology ; Sequence Analysis, DNA ; Sequence Deletion ; Single-Cell Analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    A neural circuit for memory specificity and generalization (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-03-16
    Beschreibung: Increased fear memory generalization is associated with posttraumatic stress disorder, but the circuit mechanisms that regulate memory specificity remain unclear. Here, we define a neural circuit-composed of the medial prefrontal cortex, the nucleus reuniens (NR), and the hippocampus-that controls fear memory generalization. Inactivation of prefrontal inputs into the NR or direct silencing of NR projections enhanced fear memory generalization, whereas constitutive activation of NR neurons decreased memory generalization. Direct optogenetic activation of phasic and tonic action-potential firing of NR neurons during memory acquisition enhanced or reduced memory generalization, respectively. We propose that the NR determines the specificity and generalization of memory attributes for a particular context by processing information from the medial prefrontal cortex en route to the hippocampus.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651700/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651700/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Wei -- Sudhof, Thomas C -- K99 MH099153/MH/NIMH NIH HHS/ -- NS077906/NS/NINDS NIH HHS/ -- P50 MH086403/MH/NIMH NIH HHS/ -- R01 NS077906/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Mar 15;339(6125):1290-5. doi: 10.1126/science.1229534.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94304-5453, USA. weixu@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23493706" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain Mapping ; Dependovirus ; Fear/*physiology ; *Generalization (Psychology) ; Green Fluorescent Proteins/genetics/metabolism ; Hippocampus/physiology ; Male ; Memory/*physiology ; Mice ; Mice, Inbred C57BL ; Midline Thalamic Nuclei/physiology ; Neural Pathways ; Prefrontal Cortex/*physiology ; Synapses/physiology ; Vesicle-Associated Membrane Protein 2/genetics/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    The dizzying journey to a new cancer arsenal (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-07-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2013 Jun 28;340(6140):1514-8. doi: 10.1126/science.340.6140.1514.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23812696" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Engineering ; Child ; Female ; Genetic Engineering ; Humans ; Leukemia/*therapy ; Male ; Middle Aged ; Pennsylvania ; T-Lymphocytes/*transplantation ; Treatment Outcome
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-05-25
    Beschreibung: CD8(+) T cell responses focus on a small fraction of pathogen- or vaccine-encoded peptides, and for some pathogens, these restricted recognition hierarchies limit the effectiveness of antipathogen immunity. We found that simian immunodeficiency virus (SIV) protein-expressing rhesus cytomegalovirus (RhCMV) vectors elicit SIV-specific CD8(+) T cells that recognize unusual, diverse, and highly promiscuous epitopes, including dominant responses to epitopes restricted by class II major histocompatibility complex (MHC) molecules. Induction of canonical SIV epitope-specific CD8(+) T cell responses is suppressed by the RhCMV-encoded Rh189 gene (corresponding to human CMV US11), and the promiscuous MHC class I- and class II-restricted CD8(+) T cell responses occur only in the absence of the Rh157.5, Rh157.4, and Rh157.6 (human CMV UL128, UL130, and UL131) genes. Thus, CMV vectors can be genetically programmed to achieve distinct patterns of CD8(+) T cell epitope recognition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816976/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816976/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hansen, Scott G -- Sacha, Jonah B -- Hughes, Colette M -- Ford, Julia C -- Burwitz, Benjamin J -- Scholz, Isabel -- Gilbride, Roxanne M -- Lewis, Matthew S -- Gilliam, Awbrey N -- Ventura, Abigail B -- Malouli, Daniel -- Xu, Guangwu -- Richards, Rebecca -- Whizin, Nathan -- Reed, Jason S -- Hammond, Katherine B -- Fischer, Miranda -- Turner, John M -- Legasse, Alfred W -- Axthelm, Michael K -- Edlefsen, Paul T -- Nelson, Jay A -- Lifson, Jeffrey D -- Fruh, Klaus -- Picker, Louis J -- P01 AI094417/AI/NIAID NIH HHS/ -- P51 OD 011092/OD/NIH HHS/ -- R01 AI059457/AI/NIAID NIH HHS/ -- R01 AI060392/AI/NIAID NIH HHS/ -- U24 OD010850/OD/NIH HHS/ -- New York, N.Y. -- Science. 2013 May 24;340(6135):1237874. doi: 10.1126/science.1237874.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23704576" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; CD8-Positive T-Lymphocytes/*immunology ; Cytokines/immunology ; Cytomegalovirus/genetics/*immunology ; Epitopes, T-Lymphocyte/*immunology ; Female ; Genetic Vectors/genetics/*immunology ; Histocompatibility Antigens Class II/immunology ; Humans ; Macaca mulatta ; Male ; Membrane Glycoproteins/genetics ; SAIDS Vaccines/administration & dosage/*immunology ; Viral Envelope Proteins/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Global health. The global prevalence of intimate partner violence against women (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-06-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Devries, K M -- Mak, J Y T -- Garcia-Moreno, C -- Petzold, M -- Child, J C -- Falder, G -- Lim, S -- Bacchus, L J -- Engell, R E -- Rosenfeld, L -- Pallitto, C -- Vos, T -- Abrahams, N -- Watts, C H -- New York, N.Y. -- Science. 2013 Jun 28;340(6140):1527-8. doi: 10.1126/science.1240937. Epub 2013 Jun 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gender Violence and Health Centre, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK. karen.devries@lshtm.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23788730" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Female ; Global Health ; Humans ; Male ; Prevalence ; Primary Prevention/methods ; Spouse Abuse/*prevention & control/*statistics & numerical data
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Neural decoding of visual imagery during sleep (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-04-06
    Beschreibung: Visual imagery during sleep has long been a topic of persistent speculation, but its private nature has hampered objective analysis. Here we present a neural decoding approach in which machine-learning models predict the contents of visual imagery during the sleep-onset period, given measured brain activity, by discovering links between human functional magnetic resonance imaging patterns and verbal reports with the assistance of lexical and image databases. Decoding models trained on stimulus-induced brain activity in visual cortical areas showed accurate classification, detection, and identification of contents. Our findings demonstrate that specific visual experience during sleep is represented by brain activity patterns shared by stimulus perception, providing a means to uncover subjective contents of dreaming using objective neural measurement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horikawa, T -- Tamaki, M -- Miyawaki, Y -- Kamitani, Y -- New York, N.Y. -- Science. 2013 May 3;340(6132):639-42. doi: 10.1126/science.1234330. Epub 2013 Apr 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉ATR Computational Neuroscience Laboratories, Kyoto 619-0288, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23558170" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Artificial Intelligence ; Brain/*physiology ; Brain Mapping ; Databases, Factual ; Dreams/*physiology ; Electroencephalography ; Humans ; Magnetic Resonance Imaging ; Male ; Photic Stimulation ; Sleep/*physiology ; Sleep Stages ; *Support Vector Machine ; Visual Cortex/*physiology ; Visual Perception ; Wakefulness
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-09-07
    Beschreibung: Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone modification. Although several transcription factors play crucial roles in mammalian sex determination, how epigenetic regulation contributes to this process remains unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuroki, Shunsuke -- Matoba, Shogo -- Akiyoshi, Mika -- Matsumura, Yasuko -- Miyachi, Hitoshi -- Mise, Nathan -- Abe, Kuniya -- Ogura, Atsuo -- Wilhelm, Dagmar -- Koopman, Peter -- Nozaki, Masami -- Kanai, Yoshiakira -- Shinkai, Yoichi -- Tachibana, Makoto -- New York, N.Y. -- Science. 2013 Sep 6;341(6150):1106-9. doi: 10.1126/science.1239864.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, 53 Shogoin, Kawara-cho, Sakyo-ku, Kyoto, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24009392" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Epididymis/abnormalities ; *Epigenesis, Genetic ; Female ; *Gene Expression Regulation, Developmental ; Histones/*metabolism ; Jumonji Domain-Containing Histone Demethylases/genetics/*metabolism ; Male ; Methylation ; Mice ; Mice, Mutant Strains ; Mice, Transgenic ; Ovary/abnormalities/enzymology ; *Protein Processing, Post-Translational ; Sex Determination Processes/*genetics ; Testis/abnormalities/enzymology ; Uterus/abnormalities
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Multisensory control of hippocampal spatiotemporal selectivity (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-05-04
    Beschreibung: The hippocampal cognitive map is thought to be driven by distal visual cues and self-motion cues. However, other sensory cues also influence place cells. Hence, we measured rat hippocampal activity in virtual reality (VR), where only distal visual and nonvestibular self-motion cues provided spatial information, and in the real world (RW). In VR, place cells showed robust spatial selectivity; however, only 20% were track active, compared with 45% in the RW. This indicates that distal visual and nonvestibular self-motion cues are sufficient to provide selectivity, but vestibular and other sensory cues present in RW are necessary to fully activate the place-cell population. In addition, bidirectional cells preferentially encoded distance along the track in VR, while encoding absolute position in RW. Taken together, these results suggest the differential contributions of these sensory cues in shaping the hippocampal population code. Theta frequency was reduced, and its speed dependence was abolished in VR, but phase precession was unaffected, constraining mechanisms governing both hippocampal theta oscillations and temporal coding. These results reveal cooperative and competitive interactions between sensory cues for control over hippocampal spatiotemporal selectivity and theta rhythm.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049564/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049564/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ravassard, Pascal -- Kees, Ashley -- Willers, Bernard -- Ho, David -- Aharoni, Daniel -- Cushman, Jesse -- Aghajan, Zahra M -- Mehta, Mayank R -- 5R01MH092925-02/MH/NIMH NIH HHS/ -- R01 MH092925/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2013 Jun 14;340(6138):1342-6. doi: 10.1126/science.1232655. Epub 2013 May 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23641063" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain Mapping ; Cues ; Hippocampus/*physiology ; Male ; Rats ; Rats, Inbred LEC ; *Space Perception ; *Spatial Behavior ; Theta Rhythm ; *Time Perception ; User-Computer Interface
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 68
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    Island of the snakes (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-12-07
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2013 Dec 6;342(6163):1166-7. doi: 10.1126/science.342.6163.1166.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24311659" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Behavior, Animal ; *Colubridae/physiology ; *Ecosystem ; Female ; Guam ; *Introduced Species ; Male ; Mice ; Pest Control ; Population Density
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 69
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    China's rapid urbanization (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-10-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, X Jin -- New York, N.Y. -- Science. 2013 Oct 18;342(6156):310. doi: 10.1126/science.342.6156.310-a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24136949" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aged ; Aged, 80 and over ; Animal Diseases/epidemiology ; Animals ; Child, Preschool ; China ; Female ; Humans ; Male ; Neoplasms/epidemiology ; Plant Diseases/statistics & numerical data ; Rural Population/statistics & numerical data/trends ; Transients and Migrants/statistics & numerical data ; Unemployment/statistics & numerical data/trends ; Urban Population/statistics & numerical data/*trends ; Urbanization/*trends
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 70
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    Genetics. Genealogy databases enable naming of anonymous DNA donors (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-01-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2013 Jan 18;339(6117):262. doi: 10.1126/science.339.6117.262.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23329025" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anonymous Testing/*methods ; DNA/*genetics ; *Databases, Genetic ; Genetic Markers ; *Genetic Privacy ; Humans ; Male ; Names ; *Pedigree
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 71
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    High coverage of ART associated with decline in risk of HIV acquisition in rural KwaZulu-Natal, South Africa (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-02-23
    Beschreibung: The landmark HIV Prevention Trials Network (HPTN) 052 trial in HIV-discordant couples demonstrated unequivocally that treatment with antiretroviral therapy (ART) substantially lowers the probability of HIV transmission to the HIV-uninfected partner. However, it has been vigorously debated whether substantial population-level reductions in the rate of new HIV infections could be achieved in "real-world" sub-Saharan African settings where stable, cohabiting couples are often not the norm and where considerable operational challenges exist to the successful and sustainable delivery of treatment and care to large numbers of patients. We used data from one of Africa's largest population-based prospective cohort studies (in rural KwaZulu-Natal, South Africa) to follow up a total of 16,667 individuals who were HIV-uninfected at baseline, observing individual HIV seroconversions over the period 2004 to 2011. Holding other key HIV risk factors constant, individual HIV acquisition risk declined significantly with increasing ART coverage in the surrounding local community. For example, an HIV-uninfected individual living in a community with high ART coverage (30 to 40% of all HIV-infected individuals on ART) was 38% less likely to acquire HIV than someone living in a community where ART coverage was low (〈10% of all HIV-infected individuals on ART).〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255272/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255272/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tanser, Frank -- Barnighausen, Till -- Grapsa, Erofili -- Zaidi, Jaffer -- Newell, Marie-Louise -- 082384/Z/07/Z/Wellcome Trust/United Kingdom -- 097410/Wellcome Trust/United Kingdom -- 1R01-HD058482-01/HD/NICHD NIH HHS/ -- R01 HD058482/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2013 Feb 22;339(6122):966-71. doi: 10.1126/science.1228160.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Africa Centre for Health and Population Studies, University of KwaZulu-Natal, South Africa. tanserf@africacentre.ac.za〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23430656" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Anti-HIV Agents/*therapeutic use ; *Antiretroviral Therapy, Highly Active ; Delivery of Health Care ; Female ; HIV Infections/*drug therapy/epidemiology/*prevention & control/transmission ; HIV Seropositivity ; Humans ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Risk Factors ; *Rural Health ; South Africa/epidemiology ; Young Adult
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 72
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    Neuroscience. Why adults need new brain cells (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-05-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergmann, Olaf -- Frisen, Jonas -- New York, N.Y. -- Science. 2013 May 10;340(6133):695-6. doi: 10.1126/science.1237976.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23661750" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Behavior, Animal ; Female ; Hippocampus/*embryology ; *Individuality ; Male ; *Neurogenesis ; Neuronal Plasticity/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 73
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    Anthropology. Latest skirmish over ancestral violence strikes blow for peace (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-07-23
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2013 Jul 19;341(6143):224. doi: 10.1126/science.341.6143.224.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23868993" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aggression/*psychology ; Agriculture/*history ; Animal Husbandry/*history ; Female ; Homicide/*psychology ; Humans ; Male ; *Warfare
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 74
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    Persistent LCMV infection is controlled by blockade of type I interferon signaling (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-04-13
    Beschreibung: During persistent viral infections, chronic immune activation, negative immune regulator expression, an elevated interferon signature, and lymphoid tissue destruction correlate with disease progression. We demonstrated that blockade of type I interferon (IFN-I) signaling using an IFN-I receptor neutralizing antibody reduced immune system activation, decreased expression of negative immune regulatory molecules, and restored lymphoid architecture in mice persistently infected with lymphocytic choriomeningitis virus. IFN-I blockade before and after establishment of persistent virus infection resulted in enhanced virus clearance and was CD4 T cell-dependent. Hence, we demonstrate a direct causal link between IFN-I signaling, immune activation, negative immune regulator expression, lymphoid tissue disorganization, and virus persistence. Our results suggest that therapies targeting IFN-I may help control persistent virus infections.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640797/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640797/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teijaro, John R -- Ng, Cherie -- Lee, Andrew M -- Sullivan, Brian M -- Sheehan, Kathleen C F -- Welch, Megan -- Schreiber, Robert D -- de la Torre, Juan Carlos -- Oldstone, Michael B A -- AI007354/AI/NIAID NIH HHS/ -- AI047140/AI/NIAID NIH HHS/ -- AI077719/AI/NIAID NIH HHS/ -- AI09484/AI/NIAID NIH HHS/ -- CA43059/CA/NCI NIH HHS/ -- HL007195/HL/NHLBI NIH HHS/ -- NS041219/NS/NINDS NIH HHS/ -- R01 AI009484/AI/NIAID NIH HHS/ -- R01 AI047140/AI/NIAID NIH HHS/ -- R01 AI077719/AI/NIAID NIH HHS/ -- U54 AI057160/AI/NIAID NIH HHS/ -- U54AI057160/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2013 Apr 12;340(6129):207-11. doi: 10.1126/science.1235214.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23580529" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Viral/blood ; Antigens, CD274/metabolism ; Arenaviridae Infections/*immunology/pathology/*virology ; CD4-Positive T-Lymphocytes/immunology ; Cytokines/metabolism ; Dendritic Cells/immunology/virology ; Female ; Immune Tolerance ; Interferon Type I/immunology/*metabolism ; Interleukin-10/metabolism ; Lymphocytes/immunology/virology ; Lymphocytic choriomeningitis virus/*immunology/*physiology ; Male ; Mice ; Mice, Inbred C57BL ; Receptor, Interferon alpha-beta/immunology/metabolism ; *Signal Transduction ; Spleen/immunology/pathology ; Viremia
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 75
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    Response to comments on "ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models" (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-05-25
    Beschreibung: The data reported in the Technical Comments by Fitz et al., Price et al., Tesseur et al., and Veeraraghavalu et al. replicate and validate our central conclusion that bexarotene stimulates the clearance of soluble beta-amyloid peptides and results in the reversal of behavioral deficits in mouse models of Alzheimer's disease (AD). The basis of the inability to reproduce the drug-stimulated microglial-mediated reduction in plaque burden is unexplained. However, we concluded that plaque burden is functionally unrelated to improved cognition and memory elicited by bexarotene.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714602/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714602/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Landreth, Gary E -- Cramer, Paige E -- Lakner, Mitchell M -- Cirrito, John R -- Wesson, Daniel W -- Brunden, Kurt R -- Wilson, Donald A -- AG030482-03S1/AG/NIA NIH HHS/ -- DC003906/DC/NIDCD NIH HHS/ -- K01 AG029524/AG/NIA NIH HHS/ -- P50-AG005681/AG/NIA NIH HHS/ -- R01 AG037693/AG/NIA NIH HHS/ -- R01 DC003906/DC/NIDCD NIH HHS/ -- R01-AG037693/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2013 May 24;340(6135):924-g. doi: 10.1126/science.1234114.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Alzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. gel2@case.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23704556" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alzheimer Disease/*drug therapy/*metabolism ; Amyloid beta-Peptides/*metabolism ; Animals ; Apolipoproteins E/*metabolism ; Brain/*metabolism ; Male ; Tetrahydronaphthalenes/*pharmacology/*therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Microbiology. Undernutrition--looking within for answers (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-02-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Relman, David A -- DP1 OD000964/OD/NIH HHS/ -- New York, N.Y. -- Science. 2013 Feb 1;339(6119):530-2. doi: 10.1126/science.1234723. Epub 2013 Jan 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Medicine and of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. relman@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23363770" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Female ; Gastrointestinal Tract/*microbiology ; Humans ; Kwashiorkor/*microbiology ; Male ; *Metagenome
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 77
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    Increases in adult life expectancy in rural South Africa: valuing the scale-up of HIV treatment (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-02-23
    Beschreibung: The scale-up of antiretroviral therapy (ART) is expected to raise adult life expectancy in populations with high HIV prevalence. Using data from a population cohort of over 101,000 individuals in rural KwaZulu-Natal, South Africa, we measured changes in adult life expectancy for 2000-2011. In 2003, the year before ART became available in the public-sector health system, adult life expectancy was 49.2 years; by 2011, adult life expectancy had increased to 60.5 years--an 11.3-year gain. Based on standard monetary valuation of life, the survival benefits of ART far outweigh the costs of providing treatment in this community. These gains in adult life expectancy signify the social value of ART and have implications for the investment decisions of individuals, governments, and donors.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860268/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860268/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bor, Jacob -- Herbst, Abraham J -- Newell, Marie-Louise -- Barnighausen, Till -- 097410/Wellcome Trust/United Kingdom -- 1R01MH083539-01/MH/NIMH NIH HHS/ -- R01 HD058482-01/HD/NICHD NIH HHS/ -- R01 MH083539/MH/NIMH NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2013 Feb 22;339(6122):961-5. doi: 10.1126/science.1230413.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Post Office Box 198, Mtubatuba, KwaZulu-Natal 3935, South Africa. jbor@hsph.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23430655" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Anti-HIV Agents/economics/*therapeutic use ; *Antiretroviral Therapy, Highly Active/economics ; Cohort Studies ; Cost-Benefit Analysis ; Delivery of Health Care ; Female ; HIV Infections/*drug therapy/*mortality ; Humans ; Kaplan-Meier Estimate ; *Life Expectancy/trends ; Male ; Middle Aged ; *Mortality ; Prevalence ; Public Sector ; *Rural Health ; South Africa/epidemiology ; Value of Life ; Young Adult
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Neuroscience. Sleep it out (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-10-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herculano-Houzel, Suzana -- New York, N.Y. -- Science. 2013 Oct 18;342(6156):316-7. doi: 10.1126/science.1245798.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Comparative Neuroanatomy, Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, Brazil.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24136954" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amyloid beta-Peptides/*metabolism ; Animals ; Brain/*metabolism ; Male ; Neurodegenerative Diseases/*metabolism ; Sleep/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Neuroscience. The promise and perils of oxytocin (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-01-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2013 Jan 18;339(6117):267-9. doi: 10.1126/science.339.6117.267.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23329028" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arvicolinae ; Autistic Disorder/*drug therapy/physiopathology ; Child Development/*drug effects ; Child, Preschool ; Clinical Trials as Topic ; Cognition ; Female ; Humans ; Hypothalamus/metabolism ; Male ; Mental Disorders/drug therapy/physiopathology ; Mother-Child Relations ; Oxytocin/*adverse effects/metabolism/*therapeutic use ; Social Behavior
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 80
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    Mathematics. Bayes' theorem in the 21st century (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-06-08
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Efron, Bradley -- R37 EB002784/EB/NIBIB NIH HHS/ -- New York, N.Y. -- Science. 2013 Jun 7;340(6137):1177-8. doi: 10.1126/science.1236536.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Statistics, Stanford University, Stanford, CA 94305, USA. brad@stat.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23744934" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Algorithms ; *Bayes Theorem ; Clinical Trials as Topic/statistics & numerical data ; Humans ; Male ; Oligonucleotide Array Sequence Analysis/statistics & numerical data ; Prostatic Neoplasms/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 81
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    Wolbachia invades Anopheles stephensi populations and induces refractoriness to Plasmodium infection (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-05-11
    Beschreibung: Wolbachia is a maternally transmitted symbiotic bacterium of insects that has been proposed as a potential agent for the control of insect-transmitted diseases. One of the major limitations preventing the development of Wolbachia for malaria control has been the inability to establish inherited infections of Wolbachia in anopheline mosquitoes. Here, we report the establishment of a stable Wolbachia infection in an important malaria vector, Anopheles stephensi. In A. stephensi, Wolbachia strain wAlbB displays both perfect maternal transmission and the ability to induce high levels of cytoplasmic incompatibility. Seeding of naturally uninfected A. stephensi populations with infected females repeatedly resulted in Wolbachia invasion of laboratory mosquito populations. Furthermore, wAlbB conferred resistance in the mosquito to the human malaria parasite Plasmodium falciparum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bian, Guowu -- Joshi, Deepak -- Dong, Yuemei -- Lu, Peng -- Zhou, Guoli -- Pan, Xiaoling -- Xu, Yao -- Dimopoulos, George -- Xi, Zhiyong -- R01AI061576/AI/NIAID NIH HHS/ -- R01AI080597/AI/NIAID NIH HHS/ -- R21AI082141/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2013 May 10;340(6133):748-51. doi: 10.1126/science.1236192.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23661760" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Anopheles/*microbiology ; Female ; Humans ; Malaria, Falciparum/parasitology/*prevention & control ; Male ; *Pest Control, Biological ; Plasmodium falciparum/*growth & development ; Reactive Oxygen Species/metabolism ; Wolbachia/*growth & development
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 82
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    Mandibular remains support taxonomic validity of Australopithecus sediba (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-04-13
    Beschreibung: Since the announcement of the species Australopithecus sediba, questions have been raised over whether the Malapa fossils represent a valid taxon or whether inadequate allowance was made for intraspecific variation, in particular with reference to the temporally and geographically proximate species Au. africanus. The morphology of mandibular remains of Au. sediba, including newly recovered material discussed here, shows that it is not merely a late-surviving morph of Au. africanus. Rather-as is seen elsewhere in the cranium, dentition, and postcranial skeleton-these mandibular remains share similarities with other australopiths but can be differentiated from the hypodigm of Au. africanus in both size and shape as well as in their ontogenetic growth trajectory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Ruiter, Darryl J -- DeWitt, Thomas J -- Carlson, Keely B -- Brophy, Juliet K -- Schroeder, Lauren -- Ackermann, Rebecca R -- Churchill, Steven E -- Berger, Lee R -- New York, N.Y. -- Science. 2013 Apr 12;340(6129):1232997. doi: 10.1126/science.1232997.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anthropology, Texas A&M University, College Station, TX 77843, USA. deruiter@tamu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23580533" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Dentition ; Female ; *Fossils ; Hominidae/*anatomy & histology/*classification/growth & development ; Male ; Mandible/*anatomy & histology/growth & development ; Paleodontology ; South Africa ; Tooth/anatomy & histology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 83
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    Bat and rat neurons differ in theta-frequency resonance despite similar coding of space (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-04-20
    Beschreibung: Both bats and rats exhibit grid cells in medial entorhinal cortex that fire as they visit a regular array of spatial locations. In rats, grid-cell firing field properties correlate with theta-frequency rhythmicity of spiking and membrane-potential resonance; however, bat grid cells do not exhibit theta rhythmic spiking, generating controversy over the role of theta rhythm. To test whether this discrepancy reflects differences in rhythmicity at a cellular level, we performed whole-cell patch recordings from entorhinal neurons in both species to record theta-frequency resonance. Bat neurons showed no theta-frequency resonance, suggesting grid-cell coding via different mechanisms in bats and rats or lack of theta rhythmic contributions to grid-cell firing in either species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heys, James G -- MacLeod, Katrina M -- Moss, Cynthia F -- Hasselmo, Michael E -- New York, N.Y. -- Science. 2013 Apr 19;340(6130):363-7. doi: 10.1126/science.1233831.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Graduate Program for Neuroscience, Center for Memory and Brain, Boston University, 2 Cummington Street, Boston, MA 02215, USA. jimheys@bu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23599495" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Chiroptera ; Entorhinal Cortex/cytology/*physiology ; Female ; Male ; Membrane Potentials ; Models, Neurological ; Neurons/cytology/*physiology ; Patch-Clamp Techniques ; Rats ; Rats, Long-Evans ; *Theta Rhythm
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 84
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    The human animal (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-06-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Quillin, Kim -- New York, N.Y. -- Science. 2013 Jun 14;340(6138):1288. doi: 10.1126/science.340.6138.1288-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23766313" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cercopithecus aethiops/*physiology ; *Cultural Evolution ; *Feeding Behavior ; Female ; Food Preferences/*psychology ; Humpback Whale/*psychology ; Male ; *Social Behavior ; *Social Conformity ; *Transfer (Psychology)
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 85
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    The end of history illusion (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-01-05
    Beschreibung: We measured the personalities, values, and preferences of more than 19,000 people who ranged in age from 18 to 68 and asked them to report how much they had changed in the past decade and/or to predict how much they would change in the next decade. Young people, middle-aged people, and older people all believed they had changed a lot in the past but would change relatively little in the future. People, it seems, regard the present as a watershed moment at which they have finally become the person they will be for the rest of their lives. This "end of history illusion" had practical consequences, leading people to overpay for future opportunities to indulge their current preferences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Quoidbach, Jordi -- Gilbert, Daniel T -- Wilson, Timothy D -- P01 AG020166/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2013 Jan 4;339(6115):96-8. doi: 10.1126/science.1229294.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Fund for Scientific Research, Brussels, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23288539" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Aged ; Female ; *Forecasting ; History ; Humans ; *Illusions ; Male ; Middle Aged ; Personality ; Self Report ; *Time Perception ; Young Adult
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 86
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    The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-07-06
    Beschreibung: Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. We investigated the localization mechanisms of the Xist lncRNA during X-chromosome inactivation (XCI), a paradigm of lncRNA-mediated chromatin regulation. During the maintenance of XCI, Xist binds broadly across the X chromosome. During initiation of XCI, Xist initially transfers to distal regions across the X chromosome that are not defined by specific sequences. Instead, Xist identifies these regions by exploiting the three-dimensional conformation of the X chromosome. Xist requires its silencing domain to spread across actively transcribed regions and thereby access the entire chromosome. These findings suggest a model in which Xist coats the X chromosome by searching in three dimensions, modifying chromosome structure, and spreading to newly accessible locations.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778663/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778663/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Engreitz, Jesse M -- Pandya-Jones, Amy -- McDonel, Patrick -- Shishkin, Alexander -- Sirokman, Klara -- Surka, Christine -- Kadri, Sabah -- Xing, Jeffrey -- Goren, Alon -- Lander, Eric S -- Plath, Kathrin -- Guttman, Mitchell -- 1F32GM103139-01/GM/NIGMS NIH HHS/ -- DP5 OD012190/OD/NIH HHS/ -- DP5OD012190/OD/NIH HHS/ -- P01 GM099134/GM/NIGMS NIH HHS/ -- P01GM099134/GM/NIGMS NIH HHS/ -- P50HG006193/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2013 Aug 16;341(6147):1237973. doi: 10.1126/science.1237973. Epub 2013 Jul 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23828888" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Differentiation ; Cell Line ; Chromatin/chemistry/metabolism ; Female ; *Genome ; Male ; Mice ; Models, Genetic ; RNA, Long Noncoding/chemistry/*metabolism ; Transcription, Genetic ; X Chromosome/*metabolism/ultrastructure ; *X Chromosome Inactivation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 87
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    GWAS of 126,559 individuals identifies genetic variants associated with educational attainment (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-06-01
    Beschreibung: A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) approximately 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for approximately 2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751588/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751588/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rietveld, Cornelius A -- Medland, Sarah E -- Derringer, Jaime -- Yang, Jian -- Esko, Tonu -- Martin, Nicolas W -- Westra, Harm-Jan -- Shakhbazov, Konstantin -- Abdellaoui, Abdel -- Agrawal, Arpana -- Albrecht, Eva -- Alizadeh, Behrooz Z -- Amin, Najaf -- Barnard, John -- Baumeister, Sebastian E -- Benke, Kelly S -- Bielak, Lawrence F -- Boatman, Jeffrey A -- Boyle, Patricia A -- Davies, Gail -- de Leeuw, Christiaan -- Eklund, Niina -- Evans, Daniel S -- Ferhmann, Rudolf -- Fischer, Krista -- Gieger, Christian -- Gjessing, Hakon K -- Hagg, Sara -- Harris, Jennifer R -- Hayward, Caroline -- Holzapfel, Christina -- Ibrahim-Verbaas, Carla A -- Ingelsson, Erik -- Jacobsson, Bo -- Joshi, Peter K -- Jugessur, Astanand -- Kaakinen, Marika -- Kanoni, Stavroula -- Karjalainen, Juha -- Kolcic, Ivana -- Kristiansson, Kati -- Kutalik, Zoltan -- Lahti, Jari -- Lee, Sang H -- Lin, Peng -- Lind, Penelope A -- Liu, Yongmei -- Lohman, Kurt -- Loitfelder, Marisa -- McMahon, George -- Vidal, Pedro Marques -- Meirelles, Osorio -- Milani, Lili -- Myhre, Ronny -- Nuotio, Marja-Liisa -- Oldmeadow, Christopher J -- Petrovic, Katja E -- Peyrot, Wouter J -- Polasek, Ozren -- Quaye, Lydia -- Reinmaa, Eva -- Rice, John P -- Rizzi, Thais S -- Schmidt, Helena -- Schmidt, Reinhold -- Smith, Albert V -- Smith, Jennifer A -- Tanaka, Toshiko -- Terracciano, Antonio -- van der Loos, Matthijs J H M -- Vitart, Veronique -- Volzke, Henry -- Wellmann, Jurgen -- Yu, Lei -- Zhao, Wei -- Allik, Juri -- Attia, John R -- Bandinelli, Stefania -- Bastardot, Francois -- Beauchamp, Jonathan -- Bennett, David A -- Berger, Klaus -- Bierut, Laura J -- Boomsma, Dorret I -- Bultmann, Ute -- Campbell, Harry -- Chabris, Christopher F -- Cherkas, Lynn -- Chung, Mina K -- Cucca, Francesco -- de Andrade, Mariza -- De Jager, Philip L -- De Neve, Jan-Emmanuel -- Deary, Ian J -- Dedoussis, George V -- Deloukas, Panos -- Dimitriou, Maria -- Eiriksdottir, Guethny -- Elderson, Martin F -- Eriksson, Johan G -- Evans, David M -- Faul, Jessica D -- Ferrucci, Luigi -- Garcia, Melissa E -- Gronberg, Henrik -- Guethnason, Vilmundur -- Hall, Per -- Harris, Juliette M -- Harris, Tamara B -- Hastie, Nicholas D -- Heath, Andrew C -- Hernandez, Dena G -- Hoffmann, Wolfgang -- Hofman, Adriaan -- Holle, Rolf -- Holliday, Elizabeth G -- Hottenga, Jouke-Jan -- Iacono, William G -- Illig, Thomas -- Jarvelin, Marjo-Riitta -- Kahonen, Mika -- Kaprio, Jaakko -- Kirkpatrick, Robert M -- Kowgier, Matthew -- Latvala, Antti -- Launer, Lenore J -- Lawlor, Debbie A -- Lehtimaki, Terho -- Li, Jingmei -- Lichtenstein, Paul -- Lichtner, Peter -- Liewald, David C -- Madden, Pamela A -- Magnusson, Patrik K E -- Makinen, Tomi E -- Masala, Marco -- McGue, Matt -- Metspalu, Andres -- Mielck, Andreas -- Miller, Michael B -- Montgomery, Grant W -- Mukherjee, Sutapa -- Nyholt, Dale R -- Oostra, Ben A -- Palmer, Lyle J -- Palotie, Aarno -- Penninx, Brenda W J H -- Perola, Markus -- Peyser, Patricia A -- Preisig, Martin -- Raikkonen, Katri -- Raitakari, Olli T -- Realo, Anu -- Ring, Susan M -- Ripatti, Samuli -- Rivadeneira, Fernando -- Rudan, Igor -- Rustichini, Aldo -- Salomaa, Veikko -- Sarin, Antti-Pekka -- Schlessinger, David -- Scott, Rodney J -- Snieder, Harold -- St Pourcain, Beate -- Starr, John M -- Sul, Jae Hoon -- Surakka, Ida -- Svento, Rauli -- Teumer, Alexander -- LifeLines Cohort Study -- Tiemeier, Henning -- van Rooij, Frank J A -- Van Wagoner, David R -- Vartiainen, Erkki -- Viikari, Jorma -- Vollenweider, Peter -- Vonk, Judith M -- Waeber, Gerard -- Weir, David R -- Wichmann, H-Erich -- Widen, Elisabeth -- Willemsen, Gonneke -- Wilson, James F -- Wright, Alan F -- Conley, Dalton -- Davey-Smith, George -- Franke, Lude -- Groenen, Patrick J F -- Hofman, Albert -- Johannesson, Magnus -- Kardia, Sharon L R -- Krueger, Robert F -- Laibson, David -- Martin, Nicholas G -- Meyer, Michelle N -- Posthuma, Danielle -- Thurik, A Roy -- Timpson, Nicholas J -- Uitterlinden, Andre G -- van Duijn, Cornelia M -- Visscher, Peter M -- Benjamin, Daniel J -- Cesarini, David -- Koellinger, Philipp D -- AA09367/AA/NIAAA NIH HHS/ -- AA11886/AA/NIAAA NIH HHS/ -- BB/F019394/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- CZB/4/710/Chief Scientist Office/United Kingdom -- DA024417/DA/NIDA NIH HHS/ -- DA029377/DA/NIDA NIH HHS/ -- DA05147/DA/NIDA NIH HHS/ -- DA13240/DA/NIDA NIH HHS/ -- ETM/55/Chief Scientist Office/United Kingdom -- F31 DA029377/DA/NIDA NIH HHS/ -- G0600705/Medical Research Council/United Kingdom -- G0700704/Medical Research Council/United Kingdom -- G9815508/Medical Research Council/United Kingdom -- K05 AA017688/AA/NIAAA NIH HHS/ -- MC_PC_U127561128/Medical Research Council/United Kingdom -- MC_UU_12013/1/Medical Research Council/United Kingdom -- MC_UU_12013/3/Medical Research Council/United Kingdom -- MC_UU_12013/5/Medical Research Council/United Kingdom -- MH016880/MH/NIMH NIH HHS/ -- MH066140/MH/NIMH NIH HHS/ -- MR/K026992/1/Medical Research Council/United Kingdom -- P01 AG005842/AG/NIA NIH HHS/ -- P01 CA089392/CA/NCI NIH HHS/ -- P01 GM099568/GM/NIGMS NIH HHS/ -- P01-AG005842/AG/NIA NIH HHS/ -- P01-AG005842-20S2/AG/NIA NIH HHS/ -- P30 AG012810/AG/NIA NIH HHS/ -- P30-AG012810/AG/NIA NIH HHS/ -- R01 AA009367/AA/NIAAA NIH HHS/ -- R01 AA011886/AA/NIAAA NIH HHS/ -- R01 DA013240/DA/NIDA NIH HHS/ -- R01 HL090620/HL/NHLBI NIH HHS/ -- R01 HL105756/HL/NHLBI NIH HHS/ -- R01 HL111314/HL/NHLBI NIH HHS/ -- R01 MH066140/MH/NIMH NIH HHS/ -- R37 DA005147/DA/NIDA NIH HHS/ -- T32 AG000186/AG/NIA NIH HHS/ -- T32 MH016880/MH/NIMH NIH HHS/ -- T32-AG000186-23/AG/NIA NIH HHS/ -- U01 AG009740/AG/NIA NIH HHS/ -- U01 DA024417/DA/NIDA NIH HHS/ -- Z01 AG001050-01/Intramural NIH HHS/ -- ZIA AG000196-03/Intramural NIH HHS/ -- ZIA AG000196-04/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2013 Jun 21;340(6139):1467-71. doi: 10.1126/science.1235488. Epub 2013 May 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23722424" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cognition ; *Educational Status ; Endophenotypes ; Female ; Genetic Loci ; *Genome-Wide Association Study ; Humans ; Male ; Multifactorial Inheritance ; *Polymorphism, Single Nucleotide
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Behavior. Animal conformists (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-04-27
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Waal, Frans B M -- P51 OD011132/OD/NIH HHS/ -- New York, N.Y. -- Science. 2013 Apr 26;340(6131):437-8. doi: 10.1126/science.1237521.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Living Links, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. dewaal@emory.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23620041" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cercopithecus aethiops/*physiology ; *Cultural Evolution ; *Feeding Behavior ; Female ; Food Preferences/*psychology ; Humpback Whale/*psychology ; Male ; *Social Behavior ; *Social Conformity ; *Transfer (Psychology)
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Glutamate-dependent neuroglial calcium signaling differs between young and adult brain (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-01-12
    Beschreibung: An extensive literature shows that astrocytes exhibit metabotropic glutamate receptor 5 (mGluR5)-dependent increases in cytosolic calcium ions (Ca(2+)) in response to glutamatergic transmission and, in turn, modulate neuronal activity by their Ca(2+)-dependent release of gliotransmitters. These findings, based on studies of young rodents, have led to the concept of the tripartite synapse, in which astrocytes actively participate in neurotransmission. Using genomic analysis, immunoelectron microscopy, and two-photon microscopy of astrocytic Ca(2+) signaling in vivo, we found that astrocytic expression of mGluR5 is developmentally regulated and is undetectable after postnatal week 3. In contrast, mGluR3, whose activation inhibits adenylate cyclase but not calcium signaling, was expressed in astrocytes at all developmental stages. Neuroglial signaling in the adult brain may therefore occur in a manner fundamentally distinct from that exhibited during development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569008/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569008/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Wei -- McConnell, Evan -- Pare, Jean-Francois -- Xu, Qiwu -- Chen, Michael -- Peng, Weiguo -- Lovatt, Ditte -- Han, Xiaoning -- Smith, Yoland -- Nedergaard, Maiken -- NS075177/NS/NINDS NIH HHS/ -- NS078304/NS/NINDS NIH HHS/ -- P51OD011132/OD/NIH HHS/ -- P51RR000165/RR/NCRR NIH HHS/ -- R01 NS075177/NS/NINDS NIH HHS/ -- R01 NS078167/NS/NINDS NIH HHS/ -- R01 NS078304/NS/NINDS NIH HHS/ -- RR00165/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2013 Jan 11;339(6116):197-200. doi: 10.1126/science.1226740.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23307741" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; *Aging ; Animals ; Astrocytes/*metabolism ; Calcium/metabolism ; *Calcium Signaling ; Cerebral Cortex/cytology/*metabolism/ultrastructure ; Female ; Glutamic Acid/*metabolism ; Hippocampus/cytology/metabolism/ultrastructure ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Receptor, Metabotropic Glutamate 5 ; Receptors, Metabotropic Glutamate/agonists/*metabolism ; Synaptic Transmission
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 90
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    Infectious diseases. Bacterial meningitis finds new niche in gay communities (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-07-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2013 Jul 26;341(6144):328. doi: 10.1126/science.341.6144.328.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23888010" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Disease Outbreaks ; Genome, Bacterial ; *Homosexuality, Male ; Humans ; Male ; Meningitis, Meningococcal/*epidemiology/microbiology/prevention & ; control/transmission ; Meningococcal Vaccines ; Neisseria meningitidis/genetics/isolation & purification/*pathogenicity ; Risk Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 91
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    China's little emperors show signs of success (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-02-23
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhao, Xudong -- Ma, Xiquan -- Yao, Yuhong -- Wan, Chonghua -- Ng, Emily -- New York, N.Y. -- Science. 2013 Feb 22;339(6122):905-6. doi: 10.1126/science.339.6122.905-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23430636" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Attitude ; *Behavior ; *Family Planning Policy ; Female ; Humans ; Male ; Only Child/*psychology ; *Personality
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 92
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    China. Making a selfish generation by fiat (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-01-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hvistendahl, Mara -- New York, N.Y. -- Science. 2013 Jan 11;339(6116):131. doi: 10.1126/science.339.6116.131.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23307715" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; China ; Family Characteristics ; *Family Planning Policy ; Female ; Games, Experimental ; Humans ; *Interpersonal Relations ; Male ; Only Child/*psychology ; *Personality ; *Social Behavior ; Young Adult
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 93
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    Public health. China partners with gay groups on HIV screening (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-01-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hvistendahl, Mara -- New York, N.Y. -- Science. 2013 Jan 4;339(6115):17-8. doi: 10.1126/science.339.6115.17.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23288517" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Communicable Disease Control/economics/*methods ; HIV Infections/*epidemiology/*prevention & control ; Homosexuality, Male ; Hong Kong/epidemiology ; Humans ; Male ; *Mass Screening ; United Nations
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 94
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    A worm vaccine, coming at a snail's pace (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-02-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kupferschmidt, Kai -- New York, N.Y. -- Science. 2013 Feb 1;339(6119):502-3. doi: 10.1126/science.339.6119.502.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23371989" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Anthelmintics/therapeutic use ; Biomedical Research/*economics ; Brazil ; Drug Resistance ; Female ; Humans ; Male ; Praziquantel/therapeutic use ; *Research Support as Topic ; Schistosoma/*immunology ; Schistosomiasis/*drug therapy/prevention & control ; Vaccines/adverse effects/*therapeutic use
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 95
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    Neuroscience. Sleep: the brain's housekeeper? (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-10-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Underwood, Emily -- New York, N.Y. -- Science. 2013 Oct 18;342(6156):301. doi: 10.1126/science.342.6156.301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24136944" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amyloid beta-Peptides/*metabolism ; Animals ; Brain/*metabolism ; Male ; Neurodegenerative Diseases/*metabolism ; Sleep/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 96
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    Males shorten the life span of C. elegans hermaphrodites via secreted compounds (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2013-12-03
    Beschreibung: How an individual's longevity is affected by the opposite sex is still largely unclear. In the nematode Caenorhabditis elegans, the presence of males accelerated aging and shortened the life span of individuals of the opposite sex (hermaphrodites), including long-lived or sterile hermaphrodites. The male-induced demise could occur without mating and required only exposure of hermaphrodites to medium in which males were once present. Such communication through pheromones or other diffusible substances points to a nonindividual autonomous mode of aging regulation. The male-induced demise also occurred in other species of nematodes, suggesting an evolutionary conserved process whereby males may induce the disposal of the opposite sex to save resources for the next generation or to prevent competition from other males.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126796/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126796/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maures, Travis J -- Booth, Lauren N -- Benayoun, Berenice A -- Izrayelit, Yevgeniy -- Schroeder, Frank C -- Brunet, Anne -- DP1 AG044848/AG/NIA NIH HHS/ -- DP1AG044848/AG/NIA NIH HHS/ -- F32AG37254/AG/NIA NIH HHS/ -- R01 AG031198/AG/NIA NIH HHS/ -- R01 GM088290/GM/NIGMS NIH HHS/ -- R01AG031198/AG/NIA NIH HHS/ -- R01GM088290/GM/NIGMS NIH HHS/ -- T32 GM008500/GM/NIGMS NIH HHS/ -- T32 HG000044/HG/NHGRI NIH HHS/ -- T32GM008500/GM/NIGMS NIH HHS/ -- T32HG000044/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2014 Jan 31;343(6170):541-4. doi: 10.1126/science.1244160. Epub 2013 Nov 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Stanford University, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24292626" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biological Evolution ; Caenorhabditis elegans/drug effects/genetics/*physiology ; Caenorhabditis elegans Proteins/genetics ; Carrier Proteins/genetics ; Culture Media, Conditioned/metabolism/pharmacology ; Female ; Gene Expression Regulation ; Genes, Helminth/genetics ; Longevity/drug effects/genetics/*physiology ; Male ; Peptide Hormones/genetics ; RNA Interference
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 97
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    Molecular biology: Circles reshape the RNA world (2013)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2013-03-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kosik, Kenneth S -- England -- Nature. 2013 Mar 21;495(7441):322-4. doi: 10.1038/nature11956. Epub 2013 Feb 27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23446351" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Female ; *Gene Expression Regulation ; Humans ; Male ; MicroRNAs/*metabolism ; RNA/*metabolism
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
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  • 98
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    SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties (2013)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2013-10-25
    Beschreibung: Mutations in SHANK3 and large duplications of the region spanning SHANK3 both cause a spectrum of neuropsychiatric disorders, indicating that proper SHANK3 dosage is critical for normal brain function. However, SHANK3 overexpression per se has not been established as a cause of human disorders because 22q13 duplications involve several genes. Here we report that Shank3 transgenic mice modelling a human SHANK3 duplication exhibit manic-like behaviour and seizures consistent with synaptic excitatory/inhibitory imbalance. We also identified two patients with hyperkinetic disorders carrying the smallest SHANK3-spanning duplications reported so far. These findings indicate that SHANK3 overexpression causes a hyperkinetic neuropsychiatric disorder. To probe the mechanism underlying the phenotype, we generated a Shank3 in vivo interactome and found that Shank3 directly interacts with the Arp2/3 complex to increase F-actin levels in Shank3 transgenic mice. The mood-stabilizing drug valproate, but not lithium, rescues the manic-like behaviour of Shank3 transgenic mice raising the possibility that this hyperkinetic disorder has a unique pharmacogenetic profile.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923348/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923348/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Han, Kihoon -- Holder, J Lloyd Jr -- Schaaf, Christian P -- Lu, Hui -- Chen, Hongmei -- Kang, Hyojin -- Tang, Jianrong -- Wu, Zhenyu -- Hao, Shuang -- Cheung, Sau Wai -- Yu, Peng -- Sun, Hao -- Breman, Amy M -- Patel, Ankita -- Lu, Hui-Chen -- Zoghbi, Huda Y -- 1R01NS070302/NS/NINDS NIH HHS/ -- 2T32NS043124/NS/NINDS NIH HHS/ -- P30HD024064/HD/NICHD NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2013 Nov 7;503(7474):72-7. doi: 10.1038/nature12630. Epub 2013 Oct 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA [2] Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA [3] Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24153177" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Actin-Related Protein 2-3 Complex/metabolism ; Actins/metabolism ; Adult ; Animals ; Behavior, Animal ; Bipolar Disorder/*drug therapy/genetics/*physiopathology ; Chromosomes, Human, Pair 22/genetics ; Disease Models, Animal ; Excitatory Postsynaptic Potentials ; Female ; Gene Dosage/genetics ; Gene Expression/genetics ; Genes, Duplicate/genetics ; Humans ; Hyperkinesis/genetics/physiopathology ; Inhibitory Postsynaptic Potentials ; Lithium/pharmacology ; Male ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/*genetics/*metabolism ; Seizures/genetics ; Valproic Acid/pharmacology/therapeutic use
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
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    CLP1 links tRNA metabolism to progressive motor-neuron loss (2013)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2013-03-12
    Beschreibung: CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo function has been elusive. Here we generated kinase-dead Clp1 (Clp1(K/K)) mice that show a progressive loss of spinal motor neurons associated with axonal degeneration in the peripheral nerves and denervation of neuromuscular junctions, resulting in impaired motor function, muscle weakness, paralysis and fatal respiratory failure. Transgenic rescue experiments show that CLP1 functions in motor neurons. Mechanistically, loss of CLP1 activity results in accumulation of a novel set of small RNA fragments, derived from aberrant processing of tyrosine pre-transfer RNA. These tRNA fragments sensitize cells to oxidative-stress-induced p53 (also known as TRP53) activation and p53-dependent cell death. Genetic inactivation of p53 rescues Clp1(K/K) mice from the motor neuron loss, muscle denervation and respiratory failure. Our experiments uncover a mechanistic link between tRNA processing, formation of a new RNA species and progressive loss of lower motor neurons regulated by p53.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674495/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674495/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hanada, Toshikatsu -- Weitzer, Stefan -- Mair, Barbara -- Bernreuther, Christian -- Wainger, Brian J -- Ichida, Justin -- Hanada, Reiko -- Orthofer, Michael -- Cronin, Shane J -- Komnenovic, Vukoslav -- Minis, Adi -- Sato, Fuminori -- Mimata, Hiromitsu -- Yoshimura, Akihiko -- Tamir, Ido -- Rainer, Johannes -- Kofler, Reinhard -- Yaron, Avraham -- Eggan, Kevin C -- Woolf, Clifford J -- Glatzel, Markus -- Herbst, Ruth -- Martinez, Javier -- Penninger, Josef M -- K99NS077435-01A1/NS/NINDS NIH HHS/ -- NS038253/NS/NINDS NIH HHS/ -- P 19223/Austrian Science Fund FWF/Austria -- P 21667/Austrian Science Fund FWF/Austria -- R00 NS077435/NS/NINDS NIH HHS/ -- R01 NS038253/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2013 Mar 28;495(7442):474-80. doi: 10.1038/nature11923. Epub 2013 Mar 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna 1030, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23474986" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amyotrophic Lateral Sclerosis ; Animals ; Animals, Newborn ; Axons/metabolism/pathology ; Cell Death ; Diaphragm/innervation ; Embryo Loss ; Embryo, Mammalian/metabolism/pathology ; Exons/genetics ; Female ; Fibroblasts ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Motor Neurons/*metabolism/*pathology ; Muscular Atrophy, Spinal ; Neuromuscular Diseases/metabolism/pathology ; Oxidative Stress ; RNA Processing, Post-Transcriptional ; RNA, Transfer, Tyr/genetics/*metabolism ; Respiration ; Spinal Nerves/cytology ; Transcription Factors/deficiency/*metabolism ; Tumor Suppressor Protein p53/metabolism ; Tyrosine/genetics/metabolism
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
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  • 100
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    Global health: One million deaths (2013)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2013-12-07
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Westly, Erica -- England -- Nature. 2013 Dec 5;504(7478):22-3. doi: 10.1038/504022a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24305135" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Cause of Death ; Female ; Global Health/*statistics & numerical data ; Humans ; India/epidemiology ; Interviews as Topic ; Male ; Rural Population ; Urban Population
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
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