Publication Date:
2013-05-25
Description:
Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) demonstrated in a mouse model for Alzheimer's disease (AD) that treatment of APP/PS1DeltaE9 mice with bexarotene decreased Abeta pathology and ameliorated memory deficits. We confirm the reversal of memory deficits in APP/PS1DeltaE9 mice expressing human APOE3 or APOE4 to the levels of their nontransgenic controls and the significant decrease of interstitial fluid Abeta, but not the effects on amyloid deposition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086452/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086452/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fitz, Nicholas F -- Cronican, Andrea A -- Lefterov, Iliya -- Koldamova, Radosveta -- F32AG034031/AG/NIA NIH HHS/ -- R01 AG037481/AG/NIA NIH HHS/ -- R01 AG037919/AG/NIA NIH HHS/ -- R01AG037481/AG/NIA NIH HHS/ -- R01AG037919/AG/NIA NIH HHS/ -- R21 ES021243/ES/NIEHS NIH HHS/ -- R21ES021243/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2013 May 24;340(6135):924-c. doi: 10.1126/science.1235809.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23704552" target="_blank"〉PubMed〈/a〉
Keywords:
Alzheimer Disease/*drug therapy/*metabolism
;
Amyloid beta-Peptides/*metabolism
;
Animals
;
Apolipoproteins E/*metabolism
;
Brain/*metabolism
;
Male
;
Tetrahydronaphthalenes/*pharmacology/*therapeutic use
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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