Publication Date:
2009-05-16
Description:
The neural mechanisms supporting the ability to recognize and respond to fictive outcomes, outcomes of actions that one has not taken, remain obscure. We hypothesized that neurons in the anterior cingulate cortex (ACC), which monitors the consequences of actions and mediates subsequent changes in behavior, would respond to fictive reward information. We recorded responses of single neurons during performance of a choice task that provided information about the reward values of options that were not chosen. We found that ACC neurons signal fictive reward information and use a coding scheme similar to that used to signal experienced outcomes. Thus, individual ACC neurons process both experienced and fictive rewards.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096846/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096846/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hayden, Benjamin Y -- Pearson, John M -- Platt, Michael L -- 013496/PHS HHS/ -- 023338/PHS HHS/ -- F32 DA023338/DA/NIDA NIH HHS/ -- F32 DA023338-01A1/DA/NIDA NIH HHS/ -- F32 DA023338-02/DA/NIDA NIH HHS/ -- K99 DA027718/DA/NIDA NIH HHS/ -- K99 DA027718-01/DA/NIDA NIH HHS/ -- K99 DA027718-02/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 2009 May 15;324(5929):948-50. doi: 10.1126/science.1168488.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Duke University School of Medicine, Center for Neuroeconomic Studies, Center for Cognitive Neuroscience, Duke University, Durham, NC 27701, USA. hayden@neuro.duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19443783" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Animals
;
Behavior, Animal
;
Brain Mapping
;
*Choice Behavior
;
Cues
;
Fixation, Ocular
;
Gyrus Cinguli/*physiology
;
Macaca mulatta
;
Male
;
Neural Pathways
;
Neurons/*physiology
;
Reaction Time
;
*Reward
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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