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  • Analytical Chemistry and Spectroscopy  (12,813)
  • General Chemistry  (12,386)
  • Cell & Developmental Biology  (12,126)
  • Animals  (8,343)
  • Fisheries
  • 2020-2023  (33)
  • 2000-2004  (4,620)
  • 1990-1994  (21,924)
  • 1985-1989  (17,890)
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  • 1
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    The International Collective in Support of Fishworkers (ICSF) | India
    Publication Date: 2022-02-21
    Description: Yemaya No. 63, dated May 2021, features articles from US, The Netherlands, Myanmar, Senegal, and an article on women in fisheries and human rights. The article from the US by Linda Behnken argues that a growing coalition of small-scale, community-based fishers is calling for the recognition and protection of Alaska’s invaluable coastal fisheries during COVID-19. The article from the Netherlands by Cornelie Quist looks at the challenges facing women engaged in small-scale fishing and supplying fish through retailers and how they found new ways to directly reach consumers. The conversation between Miranda Bout and Cornelie Quist focuses on how they combined new product development with the use of social media to contact their customer base during the pandemic-induced disruption of traditional marketing chains. The article by Elena Finkbeiner, Juno Fitzpatrick and Whitney Yadao-Evans looks at recent media revelations and scientific research that have brought increased attention to human-rights violations and the myriad social issues facing fisheries, but with a disproportionate focus on labour-rights violations at sea and in industrial fishing operations. The systemic inequalities combined with the effects of COVID-19 exacerbated vulnerabilities of women to health risks, food and livelihood security. The article from Senegal by Aby Dia from Lumière Synergie pour le Développement (LSD), in collaboration with WoMin African Alliance, South Africa, narrates the story of traditional women fish processors from the Bargny who have been, for more than a decade, struggling against development projects that jeopardise their environment, health and livelihoods. In order to preserve their livelihoods, women processors in Senegal have come together to oppose the Tosyali steel project. The European Network of Women in Fisheries and Aquaculture in Europe (AKTEA) urges the Office of the Commissioner for the Environment, Oceans and Fisheries to integrate gender into all aspects of European fishing policy. The Profile column looks at how Linda Behnken became a fisher in Alaska and how fishing has shaped her individuality and work. Natalie Sattler says that fishing for halibut, sablefish and salmon from the sparkling waters of the Pacific along with her children and at the same time passion for working with the Alaska Longline Fishermen’s Association and the Alaska Sustainable Fisheries Trust is an immense challenge.
    Description: Published
    Description: Refereed
    Keywords: Fishing Communities ; Women in fisheries ; Gender ; Small-scale fisheries ; Aquaculture ; Fisheries
    Repository Name: AquaDocs
    Type: Book/Monograph/Conference Proceedings
    Format: 12p.
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  • 2
    Publication Date: 2022-06-28
    Description: Las pesquerías basadas en las agregaciones reproductivas pueden amenazar a especies como los pargos que tienen conductas gregarias durante el período reproductivo. Esta nota ofrece elementos que sugieren la existencia de sitios de agregación no registrados previamente y no protegidos en el Parque Nacional Cayos de San Felipe (PNCSF), región suroccidental de Cuba. La información tradicional obtenida de pescadores locales y trabajadores del parque se corroboró con muestreos cualitativos y cuantitativos de peces de arrecifes y datos de pesquerías locales del 2014. En la época de reproducción de pargos (mayo a julio) se observaron grupos de entre 40-100 ejemplares de Lutjanus cyanopterus, Lutjanus synagris y Lutjanus jocu en los arrecifes de la zona occidental del PNCSF (camellones entre 15-30 m de profundidad cerca del borde de la plataforma). Dentro de esa área, se señalan dos sitios que parecen ser utilizados para agregaciones de predesove, por lo que requieren protección y ser estudiados. Los censos cuantitativos confirmaron que en mayo y junio la zona occidental tiene densidad alta de pargos adultos. También, el pico de captura de estas especies ocurrió en la época reproductiva. Se comprobó que las pesquerías se realizaron durante las migraciones de peces hacia el borde de la plataforma en áreas de la zona occidental del PNCSF, y que más del 60% de los individuos tuvieron gónadas maduras (antes de desovar). Esta información debe incentivar el estudio de las agregaciones de desove en esta región de Cuba, la protección de especies amenazadas y áreas de alta significación ecológica y la implementación de pesquerías sostenibles.
    Description: Fisheries based on reproductive aggregations can threaten species such as snappers that have gregarious behavior during the reproductive period. This note provides evidence to support the existence of aggregation sites, not previously registered and unprotected, in the National Park San Felipe Keys (NPSFK), southwestern region of Cuba. Traditionalinformation obtained from local fishermen and from the park staff was complemented with qualitative and quantitative fish reef censuses and local fisheries data in 2014. In the reproductive season of snappers (May to July) groups of between 40-100 specimens of Lutjanus cyanopterus, Lutja- nus synagris and Lutjanus jocu were observed in the western area of the NPSFK on the reefs (spoor and grove between 20-30 m deep close to the platform edge). Within that area two sites are indicated that can be used for prespawning aggregation, so they require protection and study. Quanti- tative censuses confirmed that in May and June the western zone has high density of adult snappers. Also, the peak of capture of these snapper species occurred in the reproduc- tive season. It was found that fisheries carried out during fish migrations to the edge of the shelf in areas of the western area of the NPSFK and more than 60% of the individuals had mature gonads (before spawning). This information should promote the study of spawning aggregations in this region of Cuba, the protection of threatened species and areas of high ecological significance and the implementation of sustainable fisheries.
    Description: Published
    Description: Refereed
    Keywords: Región suroccidental de Cuba ; Desove ; Pesquerías ; Migration routes ; Spawning ; Fisheries ; Rutas migraciones
    Repository Name: AquaDocs
    Type: Journal Contribution
    Format: pp.54-65
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  • 3
    Publication Date: 2022-09-14
    Description: The ICES Workshop on ICES reference points (WKREF2) was tasked review the WKREF1 report and based on the outcome develop updated guidelines for the ICES reference points system and recommendations for ACOM consideration. The WKREF1 report has suggested 5 key recom- mendations to simplify and harmonise the ICES reference points framework representing a ma- jor change to the current guidelines. At WKREF2, we detailed discussions and four key concerns were raised about the proposed approach. The first related to the simplification of rules to define Blim. Around two thirds of category 1 stocks would end up as WKREF1 “Blim Type 2” where Blim would be set as a fraction of B0. The Allee effect or “depensation” maybe more important than previously thought and should be furthered explored for ICES stocks since it has important consequences for Blim. A number of challenges and issues around defining Blim using the current guidelines were documented. Some suggestions on improvement criteria were discussed including using classifiers to define spas- modic stocks and using change point algorithms to address non-stationary productivity regimes. However, further work is need to make these approaches operational and there was no consen- sus that the WKREF1 Blim types should replace the current guidelines. WKREF1 recommended that the FMSY proxy should be based on a biological proxies and should be less than the deterministic FMSY. It was pointed out that the stochastic FMSY estimated in EqSim for example, is lower than the deterministic FMSY and that the current guidelines ensure that the FMSY should not pose a more than 5% risk to Blim. A large amount of work described in WD 1 was carried out to develop an MSE framework to consistency and robustness test a candidate refer- ence point system for North East Atlantic stocks. However, WKREF2 recommended that further work needs to be carried out to condition and test the simulation framework before the conclu- sions could be adopted by ICES and incorporated into the guidelines. A number of considerations for defining MSY related reference points were discussed including using model validation and prediction skill to ensure that ICES provide robust and credible ad- vice. There is evidence that density dependence (DD) is important in the majority of ICES stocks (68% in recruitment and 54% in growth). The correct prediction of the shape and strength of density-dependence in productivity is key to predicting future stock development and providing the best possible long-term fisheries management advice. A suggested approach to use surplus production models (SPMs) to account for DD in FMSY was suggested and discussed but there was no consensus on whether that approach was appropriate. There was consensus that the FECO approach as a means of adapting target fishing mortality to medium-term changes in productiv- ity should be included in the guidelines subject to a benchmark and ACOM approval. While WKREF1 and 2 focused mainly on Category 1 stocks ToR c) called for a “simplified and harmonised set of guidelines for estimating MSY and precautionary reference points applicable in the advice framework across various ICES stock categories.” Ideally the ICES assessment cat- egories should provide equivalent risk across all stocks. This issue was discussed but no recom- mendations emerged. There was no consensus a revised reference point framework was proposed at WKREF2. How- ever, it was agreed that it should be presented here for further discussion at ACOM and other fora. The key feature of the suggested approach is that the stock status evaluation is treated in- dependent of the Advice Rule (AR). The main feature of the system is that the biomass trigger is not linked to a stock status evaluation, it is linked to the expected biomass when fishing at the target fishing mortality, in contrast to the current ICES approach. It also entailed that FMSY would also become an upper limit of fishing mortality and that the advised fishing mortality would be set at or lower than that level. WKREF2 did not discuss what to do in situations where SSB〈 Blim or alternative forms of HCR for the advice rule. Building community understanding and con- sensus around simplified and harmonised guidelines has yet to be achieved. A further workshop WKREF3 will be required to achieve that aim. The report includes 6 recommendations for ACOM consideration.
    Description: ICES
    Description: The main objective of the workshop was to review the recommendations of WKREF1 and con- sider how these might feed into a new reference points framework and guidelines for ICES. There were a number of presentations on the wider issues of best practice for reference points, the Allee effect, density dependence and the WKIRISH approach. The starting point was to try and develop a set of simplified and harmonised guidelines based on the WKREF1 report rather than evolving the current guidelines to include the WKREF1 conclusions. A key aspect of the meeting was to allow for discussions in order to build a shared understanding of the strengths and weakness of the current framework and of the new framework emerging from WKREF1.
    Description: Published
    Description: Non Refereed
    Keywords: ICES ; Reference points ; Management advice ; Fisheries ; Fishery management reference points
    Repository Name: AquaDocs
    Type: Report
    Format: 103pp
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  • 4
    Publication Date: 2022-10-26
    Description: © The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Dowd, S., Chapman, M., Koehn, L., & Hoagland, P. The economic tradeoffs and ecological impacts associated with a potential mesopelagic fishery in the California Current. Ecological Applications, 32(4), (2022): e2578, https://doi.org/10.1002/eap.2578.
    Description: The ocean's mesopelagic zone (200–1000 m) remains one of the most understudied parts of the ocean despite knowledge that mesopelagic fishes are highly abundant. Apex predators from the surface waters are known to consume these fishes, constituting an important ecological interaction. Some countries have begun exploring the potential harvest of mesopelagic fishes to supply fishmeal and fish oil markets due to the high fish abundance in the mesopelagic zone compared with overfished surface waters. This study explored the economic and ecological implications of a moratorium on the harvest of mesopelagic fishes such as lanternfish off the US West Coast, one of the few areas where such resources are managed. We adapted a bioeconomic decision model to examine the tradeoffs between the values gained from a hypothetical mesopelagic fishery with the potential values lost from declines in predators of mesopelagic fishes facing a reduced prey resource. The economic rationale for a moratorium on harvesting mesopelagics was sensitive both to ecological relationships and the scale of the nonmarket values attributed to noncommercial predators. Using a California Current-based ecological simulation model, we found that most modeled predators of mesopelagic fishes increased in biomass even under high mesopelagic harvest rates, but the changes (either increases or decreases) were small, with relatively few predators responding with more than a 10% change in their biomass. While the ecological simulations implied that a commercial mesopelagic fishery might not have large biomass impacts for many species in the California Current system, there is still a need to further explore the various roles of the mesopelagic zone in the ocean.
    Description: Sally Dowd acknowledges sponsorship from the WHOI Summer Student Fellowship and the Rausser College of Natural Resources Honors Program at UC Berkeley. This project would not have been possible without the guidance provided by Kama Thieler and Carl Boettiger. Porter Hoagland acknowledges funding from the Audacious Project, a collaborative endeavor, housed at TED and the J. Seward Johnson Fund in support of the Marine Policy Center at WHOI.
    Keywords: Bioeconomic model ; Fisheries ; Mesopelagic fishes ; Moratorium ; Nonmarket value ; Predators ; Rpath ; Willingness-to-pay values
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 5
    Publication Date: 2022-05-27
    Description: Buesseler, K., Jin, D., Kourantidou, M., Levin, D., Ramakrishna, K., Renaud, P., Ausubel, J., Baltes, K., Gjerde, K., Holland, M., Kostel, K., LaCapra, V., Martin, A., Sosik, H., Thorrold, S., Tierney, T., Joyce, K., Renier, N., Taylor, E. (2022). The Ocean Twilight Zone’s Role in Climate Change. Woods Hole Oceanographic Institution, 32 pp.
    Description: The ocean twilight zone (more formally known as the mesopelagic zone) plays a fundamental role in global climate. It is the mid-ocean region roughly 100 to 1000 meters below the surface, encompassing a half-mile deep belt of water that spans more than two-thirds of our planet. The top of the ocean twilight zone only receives 1% of incident sunlight and the bottom level is void of sunlight. Life in the ocean twilight zone helps to transport billions of metric tons (gigatonnes) of carbon annually from the upper ocean into the deep sea, due in part to processes known as the biological carbon pump. Once carbon moves below roughly 1000 meters depth in the ocean, it can remain out of the atmosphere for centuries to millennia. Without the benefits of the biological carbon pump, the atmospheric CO 2 concentration would increase by approximately 200 ppm 1 which would significantly amplify the negative effects of climate change that the world is currently trying to curtail and reverse. Unfortunately, existing scientific knowledge about this vast zone of the ocean, such as how chemical elements flow through its living systems and the physical environment, is extremely limited, jeopardizing the efforts to improve climate predictions and to inform fisheries management and ocean policy development.
    Description: Funding is: The Audacious Project housed at TED
    Keywords: Climate ; Mesopelagic ; Twilight Zone ; Fisheries ; Carbon Dioxide Removal ; Ocean ; Biological Carbon Pump ; Solubility Pump ; Carbon ; Marine Snow
    Repository Name: Woods Hole Open Access Server
    Type: Other
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  • 6
    Publication Date: 2022-10-26
    Description: © The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Kourantidou, M., Hoagland, P., Dale, A., & Bailey, M. Equitable allocations in northern fisheries: bridging the divide for Labrador Inuit. Frontiers in Marine Science, 8, (2021): 590213, https://doi.org/10.3389/fmars.2021.590213.
    Description: Canada has undertaken commitments to recognize the rights of Indigenous Peoples in fisheries through policies and agreements, including Integrated Fishery Management Plans, the Reconciliation Strategy, and Land Claim Agreements (LCAs). In addition to recognizing rights, these commitments were intended to respect geographic adjacency principles, to enhance the economic viability of Indigenous communities, and to be reflective of community dependence on marine resources. We examined the determinants of quota allocations in commercial fisheries involving Nunatsiavut, Northern Labrador, the first self-governing region for the Inuit peoples in Canada. It has been argued that current fishery allocations for Nunatsiavut Inuit have not satisfied federal commitments to recognize Indigenous rights. Indicators that measure equity in commercial allocations for the turbot or Greenland halibut (Reinhardtius hippoglossoides) and northern shrimp (Pandalus borealis) fisheries were identified and assessed. In these two cases, historical allocations continue to predominate for allocations based upon equity or other social or economic considerations. We illustrate equity-enhancing changes in the quota distribution under scenarios of different levels of inequality aversion, and we make qualitative assessments of the effects of these allocations to Nunatsiavut for socioeconomic welfare. This approach could benefit fisheries governance in Northern Labrador, where federal commitments to equity objectives continue to be endorsed but have not yet been integrated fully into quota allocations.
    Description: This research was undertaken with funding from the Canada First Research Excellence Fund through the Ocean Frontier Institute (MK and MB) and the Johnson Endowment of the Woods Hole Oceanographic Institution’s (WHOI) Marine Policy Center (PH).
    Keywords: Fisheries ; Allocations ; Equity ; Indigenous rights ; Access
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 7
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    In:  aqdchief@seafdec.org.ph | http://aquaticcommons.org/id/eprint/18569 | 2002 | 2015-11-15 16:06:30 | 18569 | Southeast Asian Fisheries Development Center, Aquaculture Department
    Publication Date: 2022-08-02
    Description: This paper summarizes the results of the experiments on the induced breeding and larval rearing of milkfish (Chanos chanos) during the 1979 season. Milkfish larvae could be reared successfully without the use of trochophore larvae of oysters as feed during the first few days. In order to induce the ovulation of wild adult milkfish a higher dose of human chorionic gonadotropin hormone is required.
    Keywords: Fisheries ; Chanos chanos ; ISEW ; Philippines ; marine environment ; Brood stocks ; Fish culture ; Fish larvae ; Food organisms ; Induced breeding ; Larval development ; Sex hormones
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
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    Format: 1-3
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  • 8
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    In:  library@seafdec.org.ph | http://aquaticcommons.org/id/eprint/20100 | 17342 | 2016-02-24 22:18:26 | 20100 | Southeast Asian Fisheries Development Center, Aquaculture Department
    Publication Date: 2022-08-02
    Description: An outline is given of aquaculture and fisheries in Asia, providing information of use to students whose work can influence laws, rules, policy and regulations on aquaculture and fisheries, with the view in mind to sustainable aquaculture. In this issue, the following countries are examined: China, Indonesia, and Bangladesh.
    Keywords: Aquaculture ; Fisheries ; Fishery management ; Aquaculture development ; Aquaculture regulations ; Marine aquaculture ; Freshwater aquaculture ; Fishery industry ; Asia ; Bangladesh ; China
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: 7-8
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  • 9
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    In:  library@seafdec.org.ph | http://aquaticcommons.org/id/eprint/20067 | 2002 | 2016-03-04 15:16:24 | 20067 | Southeast Asian Fisheries Development Center, Aquaculture Department
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Aquaculture ; Vietnam ; Sri Lanka ; Sri Lanka ; Vietnam ; brackishwater environment ; freshwater environment ; marine environment ; Aquaculture ; Aquaculture techniques ; Brackishwater aquaculture ; Feed ; Fish culture ; Fish diseases ; Fisheries ; Fishery data ; Food organisms ; Freshwater aquaculture ; Marine aquaculture ; Marine fisheries ; Mollusc culture ; Pond culture ; Seaweed culture ; Shrimp culture
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: pp.9-10, 27
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  • 10
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    In:  library@seafdec.org.ph | http://aquaticcommons.org/id/eprint/20055 | 2002 | 2016-03-03 11:33:32 | 20055 | Southeast Asian Fisheries Development Center, Aquaculture Department
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Aquaculture ; Asia ; Cambodia ; India ; Asia ; Cambodia ; India ; Myanmar ; Myanmar ; brackishwater environment ; freshwater environment ; marine environment ; Aquaculture ; Aquaculture development ; Aquaculture economics ; Aquaculture techniques ; Brackishwater aquaculture ; Catching methods ; Culture effects ; Environmental impact ; Fish culture ; Fisheries ; Fishery development ; Fishery resources ; Fishery statistics ; Freshwater aquaculture ; Marine aquaculture ; Shrimp culture ; Sustainability ; Trade
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: pp.9-10, 29
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  • 11
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26291 | 23782 | 2019-04-08 09:42:05 | 26291 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Pollution ; Indonesia ; Heavy metals ; Chemical pollution ; Pollution monitoring
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 10-19
    Format: 10
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  • 12
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26293 | 23782 | 2019-03-22 03:49:21 | 26293 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Myanmar ; Heavy metals ; Cadmium ; Lead ; Mercury ; Biological sampling ; Fish ; Fishery products ; Seafood
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 38-46
    Format: 9
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  • 13
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    Secretariat, Southeast Asian Fisheries Development Center | Bangkok, Thailand
    In:  http://aquaticcommons.org/id/eprint/26259 | 2002 | 2019-03-01 05:56:06 | 26259 | Southeast Asian Fisheries Development Center, Secretariat
    Publication Date: 2022-08-02
    Description: Round scad exploration by purse seine in the waters of western Philippines was conducted from April 22 to May 7, 1998 for a period of five (5) fishing days with a total catch of 7.3 tons and an average of 1.5 tons per setting. Dominant species caught were Decapterus spp. having 70.09% of the total catch, followed by Selar spp. at 12.66% and Rastrelliger spp. 10.70%. Among the Decapterus spp. caught, D. macrosoma attained the highest total catch composition by species having 68.81% followed by D. kurroides and D.russelli with 0.31% and 1.14% respectively. The round scad fishery stock was composed mainly of juvenile fish (less than 13 cm) and Age group II (13 cm to 14 cm). Few large round scad at Age group IV and V (20 cm to 28 cm) stayed at the fishery. Other fishes caught were: Auxis rochei (0.85%), A. thazard (0.12%), Caranx spp. (0.45%), Emmilichthys nitidus (0.58%), Euthynnus affinis (0.42%), Leiognathus ruconius (0.58%), Loligo sp. (0.31%), Megalaspis cordyla (0.09%), Rastrelliger spp. (10.70%), Sardinella longiceps (0.03%), Scomberoides lysan (0.24%), Selar spp. (12.66%), Sphyraena spp. (0.90%), Thunnus albacares (0.96%) and others (1.02%). Tuna and tuna like fishes such as yellowfin tuna, eastern little tuna, bullet tuna, frigate tuna and oceanic squid are distributed in the upper latitudes of the survey area. On the other hand, round scads, big-eyed scads and Indian mackerels are dominantly present in the lower latitudes of the survey area.
    Keywords: Fisheries ; Exploratory fishing ; Purse seining ; Age composition ; Catch composition ; Fishery surveys ; Carangid fisheries ; South China Sea ; Philippines ; Rastrelliger ; Decapterus
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  • 14
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    Training Department, Southeast Asian Fisheries Development Center | Samut Prakarn, Thailand
    In:  http://aquaticcommons.org/id/eprint/26215 | 17342 | 2019-02-08 06:25:54 | 26215 | Southeast Asian Fisheries Development Center, Training Department
    Publication Date: 2022-08-02
    Description: Presented in this paper is the status of the fishery industry in Brunei Darussalam. Specifically, it discussed the following topics: fishery management strategies, zonation scheme, licencing, the use of poisons and explosives, the minimum cod-end mesh size for trawlers, closed areas, enhancement of fishing grounds, and the enforcement activities.
    Keywords: Fisheries ; Fishery resources ; Fishery management ; Fisheries ; Ecological zonation ; Licensing ; Fish poisoning ; Catching methods ; Illegal fishing ; Explosive fishing ; Fishing gear ; Season regulations ; Fishing grounds
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  • 15
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26295 | 23782 | 2019-03-22 08:39:12 | 26295 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Thailand ; Cadmium ; Lead ; Mercury ; Biological sampling ; Fish ; Fishery products ; Seafood
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
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  • 16
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26292 | 23782 | 2019-03-22 03:43:09 | 26292 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Malaysia ; Cadmium ; Lead ; Mercury ; Biological sampling ; Fish ; Fishery products ; Seafood
    Repository Name: AquaDocs
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    Format: application/pdf
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    Format: 20-37
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  • 17
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    Secretariat, Southeast Asian Fisheries Development Center | Bangkok, Thailand
    In:  http://aquaticcommons.org/id/eprint/26258 | 2002 | 2019-03-01 06:00:19 | 26258 | Southeast Asian Fisheries Development Center, Secretariat
    Publication Date: 2022-08-02
    Description: An exploratory tuna longline fishing survey was conducted using the research and training vessels of the Southeast Asian Fisheries Development Center, the 1,178 GT MV SEAFDEC and the Bureau of Fisheries and Aquatic Resources, the 165 GT MV MAYA-MAYA in the South China Sea Waters, West of the Philippines from April to May, 1998. A total of 3,796 hooks was set in sixteen (16) fishing stations. There were no tuna caught during the entire survey but only minor and irrelevant species like the Pacific lancetfish, sharks and an opah species, Lampris guttatus. The important fishing and oceanographic factors during the survey and other research results on longline are described and analyzed. Additional longline studies within and near the Philippines territorial waters are also presented to substantiate the research results of the joint SEAFDEC/BFAR resource exploratory.
    Keywords: Fisheries ; Exploratory fishing ; Catch composition ; Fishery surveys ; Longlining ; Tuna fisheries ; South China Sea ; Philippines
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  • 18
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26299 | 23782 | 2019-03-27 06:00:01 | 26299 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Keywords: Chemistry ; Fisheries ; Malaysia ; Pesticides ; Biological sampling ; Fish ; Fishery products ; Biochemical analysis ; Lethal limits
    Repository Name: AquaDocs
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  • 19
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26300 | 23782 | 2019-03-27 05:58:36 | 26300 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Keywords: Aquaculture ; Chemistry ; Fisheries ; Myanmar ; Pesticides ; Biological sampling ; Fish ; Fishery products ; Lethal limits
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 75-83
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26307 | 23782 | 2019-03-27 03:35:56 | 26307 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Indonesia ; Histamines ; Biological sampling ; Fish ; Fishery products ; Quality control
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 116-123
    Format: 8
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26303 | 23782 | 2019-03-27 05:51:15 | 26303 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Keywords: Chemistry ; Fisheries ; Thailand ; Pesticides ; Biological sampling ; Fish ; Fishery products ; Dried products ; Lethal limits
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 100-105
    Format: 6
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26309 | 23782 | 2019-03-27 03:49:31 | 26309 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Myanmar ; Histamines ; Biological sampling ; Biochemical analysis ; Fish ; Fishery products
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 129-133
    Format: 5
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26826 | 23782 | 2019-11-21 00:56:12 | 26826 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Description: Presented in the paper is the standard procedure in the determination of K value which is an index to measure the enzymatic freshness of fish and squid. Specifically, reagents, apparatus and the analytical procedures needed and the calculations are presented.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Fishery products ; Fish inspection ; Fishery industry ; Food technology ; Standards ; Specifications
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: B-6.1-B-6.7
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26825 | 23782 | 2019-11-21 00:52:35 | 26825 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Description: Presented in the paper is the standard procedure in measuring K value in fish meat by means of the freshness testing paper technique.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Fishery products ; Fish inspection ; Fishery industry ; Food technology ; Standards ; Specifications
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: B-7.1-B-7.2
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26802 | 23782 | 2019-11-12 05:28:20 | 26802 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Description: Presented in the paper is the standard procedure in the measurement of pH in the fresh fish meat. Specifically, the procedures in sampling and sample preparation, apparatus and reagents required, and the analytical procedures are presented.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Microbiological analysis ; Fishery products ; Processed fishery products ; Fish inspection ; Fishery industry ; Food additives ; Food technology ; Standards ; Specifications ; pH
    Repository Name: AquaDocs
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    Format: application/pdf
    Format: application/pdf
    Format: A-3.1-A-3.2
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26842 | 23782 | 2019-11-15 07:54:48 | 26842 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Description: Starch is commonly used in the production of fish jelly products as an extender and as binding agent. The paper provides the methodology in the determination of starch in fish jelly products. Instructions for sample preparation and the reagents needed are presented. Detailed procedures in the determination of the starch in a sample are provided.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Fishery products ; Fishery industry ; Food technology ; Standards ; Specifications ; Starch ; Additives ; Food additives
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: D-4.1-D-4.4
    Format: 4
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26881 | 23782 | 2019-11-05 02:46:02 | 26881 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Description: Monitoring and investigative work undertaken in the Philippines regarding dinoflagellate blooms are described. Chronological observations of the occurrence of red tides, aerial surveys, spatial distribution of the dinoflagellate and the physical environment are discussed. Fishing and the examination of gut content of fish and mussels and bioassay tests are detailed. Incidents of paralytic shellfish poisoning in the Philippines are considered briefly.
    Keywords: Fisheries ; Health ; Environmental monitoring ; Red tides ; Public health ; Medicine ; Dangerous organisms ; Philippines
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 52-79
    Format: 28
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26885 | 23782 | 2019-11-05 02:23:34 | 26885 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Description: A report is made of the first incidence occurring of paralytic shellfish poisoning in Thailand in May 1983, following an extensive bloom of Trichodesmium erythraeum. Investigations undertaken regarding the source of the toxicity are outlined.
    Keywords: Fisheries ; Health ; Biological poisons ; Public health ; Red tides ; Shellfish ; Dangerous organisms ; Thailand
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 90-91
    Format: 2
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26879 | 23782 | 2019-11-05 02:54:38 | 26879 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Description: A brief account is given of recent cases of paralytic shellfish poisoning in Sabah, Malaysia, and toxicological studies undertaken. Hydrography surveys, underwater observations after the occurrence of the red tides and plankton studies and monitoring of red tides are discussed.
    Keywords: Fisheries ; Health ; Shellfish ; Toxicity tests ; Red tides ; Public health ; Dangerous organisms ; Malaysia
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 35-42
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26852 | 23782 | 2019-11-15 07:36:44 | 26852 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Description: Cholera is an acute specific infection caused by the organism, Vibrio cholera. Diagnosis may be confirmed by the presence of large numbers of the comma-shaped bacilli on direct microscopic examination of a fecal or vomitus smear, and by the isolation of the organism on culture. Fish and shellfish have been identified as vehicles of cholera. Large numbers of V. cholera must usually be ingested to cause cholera. Thus problems often occur when poor handling and inadequate refrigeration have allowed the organism to multiply. Presented in the paper is the methodology of determining the presence of Vibrio cholera in fish and fishery products.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Fishery products ; Fishery industry ; Food technology ; Standards ; Specifications ; Aerobic bacteria ; Microbiological analysis ; Microorganisms ; Pathogenic bacteria ; Pathogens ; Health and safety ; Public health ; Microbial contamination ; Vibrio cholerae
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    Format: application/pdf
    Format: E-7.1-E-7.5
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    Secretariat, Southeast Asian Fisheries Development Center | Bangkok, Thailand
    In:  http://aquaticcommons.org/id/eprint/26890 | 23782 | 2019-11-14 01:01:29 | 26890 | Southeast Asian Fisheries Development Center, Secretariat
    Publication Date: 2022-08-02
    Description: Fishery statistics in Brunei Darussalam have been collected by the Department of Fisheries since the 1940s. In the early 1980s, a number of statistics were collected, such as catch and effort data of artisanal fishermen, aquaculture statistics, processing statistics as well as data from major wet markets focusing on the amount, prices of marketed fish either from the local fishermen or imported. In 1984, the collection of statistics on commercial fishing was started. The statistics have been used in the formulation of fishery management and development policies as well as for sectoral development. Following a brief account of the responsibility and statistic collections of the Department of Fisheries, an examination is made of employment in the fishery sector, fisheries production, fish marketed and the GDP for the fishery industry. Fisheries in Brunei Darussalam is a very healthy industry, where production is well below the maximum allowable harvestable limit of 20,000 tons at 30%. The Department is embarking to increase production from the capture fishery to reduce the country's dependence on imported fish; the same applies for aquaculture, in order to complement production from the capture fisheries. The processing sector is also increasing in importance, especially with the increase in the number of capture fishery licenses, and the demand for quality and value-added products.
    Keywords: Fisheries ; Marine fisheries ; Fishery statistics ; Aquaculture development ; Aquaculture statistics ; Fish catch statistics ; Marine aquaculture ; Freshwater aquaculture ; Fishery development ; Marine ; Brackish ; Freshwater
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    Format: application/pdf
    Format: application/pdf
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26843 | 23782 | 2019-11-15 07:52:55 | 26843 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Description: Sodium chloride is an important additive for the production of fish jelly products. It extracts the salt soluble protein to give the gel strength of the final product. The paper provides the methodology in the determination of the amount of sodium chloride in fish jelly products. Instructions for sample preparation and the reagents needed are presented. Detailed procedures in the determination of the salt in a sample are provided.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Fishery products ; Fishery industry ; Food technology ; Standards ; Specifications ; Additives ; Food additives ; Salts ; Sodium chloride
    Repository Name: AquaDocs
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    Format: application/pdf
    Format: D-5.1-D-5.2
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    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26851 | 23782 | 2019-11-14 01:29:31 | 26851 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Publication Date: 2022-08-02
    Description: Food poisoning due to Vibrio parahaemolyticus is a food-borne infection resulting from the ingestion of a large number of this organism (about 106-109 viable cells). The major symptoms are diarrhea and abdominal pain with headache, fever, and vomiting also occurring. The organisms are excreted during the acute stage of the illness after which they decrease rapidly. The differentiation of V. parahaemolyticus from other pathogenic species of Vibrio is based mainly on salt tolerance, Voges-Proskauer reaction, fermentation of sucrose, and growth at 43°C. Presented in the paper is the methodology of determining the presence of Vibrio cholera in fish and fishery products.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Fishery products ; Fishery industry ; Food technology ; Standards ; Specifications ; Aerobic bacteria ; Microbiological analysis ; Microorganisms ; Pathogenic bacteria ; Pathogens ; Health and safety ; Public health ; Microbial contamination ; Vibrio parahaemolyticus ; Vibrio cholerae
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  • 34
    Publication Date: 2004-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beckman, Mary -- New York, N.Y. -- Science. 2004 Jun 25;304(5679):1888-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15218114" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Bedding and Linens ; *Behavior, Animal ; Female ; Male ; *Maternal Deprivation ; Mice ; *Mothers ; Mutation ; *Object Attachment ; Odors ; Receptors, Opioid, mu/genetics/*physiology ; Vocalization, Animal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2004 Nov 26;306(5701):1455-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15567822" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Cells/*cytology ; Bone Marrow Transplantation ; Cell Differentiation ; Cell Fusion ; Disease Progression ; Female ; Gastric Mucosa/chemistry/pathology ; Gastritis/microbiology/*pathology ; Helicobacter Infections/*pathology ; *Helicobacter felis ; Male ; Mice ; Mice, Inbred C57BL ; Stem Cells/*cytology ; Stomach Neoplasms/*pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 36
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-08-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bedalov, Antonio -- Simon, Julian A -- New York, N.Y. -- Science. 2004 Aug 13;305(5686):954-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Clinical Research Division and J. A. Simon is in the Clinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. abedalov@fhcrc.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15310883" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*physiology ; Cell Nucleus/metabolism ; Cell Survival ; Cells, Cultured ; Ganglia, Spinal/cytology ; Mice ; Mutation ; NAD/biosynthesis/*metabolism ; Nerve Tissue Proteins/genetics/*metabolism ; Neurodegenerative Diseases/drug therapy/physiopathology ; Neuroprotective Agents/therapeutic use ; Nicotinamide-Nucleotide Adenylyltransferase/metabolism ; RNA, Small Interfering ; Sirtuin 1 ; Sirtuins/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Wallerian Degeneration/metabolism/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 37
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-11-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2004 Nov 5;306(5698):966-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15528423" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cyclooxygenase 2 ; Humans ; Inflammation/*complications/immunology ; Isoenzymes/metabolism ; Macrophage Colony-Stimulating Factor/physiology ; Macrophages/immunology ; Membrane Proteins ; Mice ; NF-kappa B/physiology ; Neoplasms/*etiology/immunology ; Prostaglandin-Endoperoxide Synthases/metabolism ; Risk Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 38
    Publication Date: 2004-10-02
    Description: The Golgi enzyme beta1,6 N-acetylglucosaminyltransferase V (Mgat5) is up-regulated in carcinomas and promotes the substitution of N-glycan with poly N-acetyllactosamine, the preferred ligand for galectin-3 (Gal-3). Here, we report that expression of Mgat5 sensitized mouse cells to multiple cytokines. Gal-3 cross-linked Mgat5-modified N-glycans on epidermal growth factor and transforming growth factor-beta receptors at the cell surface and delayed their removal by constitutive endocytosis. Mgat5 expression in mammary carcinoma was rate limiting for cytokine signaling and consequently for epithelial-mesenchymal transition, cell motility, and tumor metastasis. Mgat5 also promoted cytokine-mediated leukocyte signaling, phagocytosis, and extravasation in vivo. Thus, conditional regulation of N-glycan processing drives synchronous modification of cytokine receptors, which balances their surface retention against loss via endocytosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Partridge, Emily A -- Le Roy, Christine -- Di Guglielmo, Gianni M -- Pawling, Judy -- Cheung, Pam -- Granovsky, Maria -- Nabi, Ivan R -- Wrana, Jeffrey L -- Dennis, James W -- New York, N.Y. -- Science. 2004 Oct 1;306(5693):120-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15459394" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line, Tumor ; Cell Membrane/metabolism ; Cell Movement ; Cell Transformation, Neoplastic ; *Endocytosis ; Galectin 3/metabolism ; Genetic Vectors ; Glycosylation ; Golgi Apparatus/enzymology ; Growth Substances/metabolism/pharmacology ; Macrophages, Peritoneal/physiology ; Mammary Neoplasms, Animal/metabolism/pathology ; Mice ; Mice, Transgenic ; N-Acetylglucosaminyltransferases/genetics/*metabolism ; Neoplasm Metastasis ; Phagocytosis ; Polysaccharides/*metabolism ; Receptor, Epidermal Growth Factor/*metabolism ; Receptors, Cytokine/*metabolism ; Receptors, Transforming Growth Factor beta/*metabolism ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 39
    Publication Date: 2004-05-08
    Description: There are 481 segments longer than 200 base pairs (bp) that are absolutely conserved (100% identity with no insertions or deletions) between orthologous regions of the human, rat, and mouse genomes. Nearly all of these segments are also conserved in the chicken and dog genomes, with an average of 95 and 99% identity, respectively. Many are also significantly conserved in fish. These ultraconserved elements of the human genome are most often located either overlapping exons in genes involved in RNA processing or in introns or nearby genes involved in the regulation of transcription and development. Along with more than 5000 sequences of over 100 bp that are absolutely conserved among the three sequenced mammals, these represent a class of genetic elements whose functions and evolutionary origins are yet to be determined, but which are more highly conserved between these species than are proteins and appear to be essential for the ontogeny of mammals and other vertebrates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bejerano, Gill -- Pheasant, Michael -- Makunin, Igor -- Stephen, Stuart -- Kent, W James -- Mattick, John S -- Haussler, David -- 1P41HG02371/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2004 May 28;304(5675):1321-5. Epub 2004 May 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA. jill@soe.ucsc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15131266" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing ; Animals ; Base Sequence ; Chickens/genetics ; Computational Biology ; *Conserved Sequence ; DNA, Intergenic ; Dogs/genetics ; Evolution, Molecular ; Exons ; Gene Expression Regulation ; Genes ; Genome ; *Genome, Human ; Humans ; Introns ; Mice/genetics ; Molecular Sequence Data ; Mutation ; Nucleic Acid Conformation ; RNA/chemistry/genetics/metabolism ; Rats/genetics ; Takifugu/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 40
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2004 Jul 16;305(5682):326-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15256650" target="_blank"〉PubMed〈/a〉
    Keywords: Analgesics ; Animals ; Brain/physiology ; Cell Death ; Chronic Disease ; Dinoprostone/metabolism ; Gene Expression Profiling ; Humans ; Inflammation/physiopathology ; Ion Channels/*physiology ; Neuralgia/physiopathology ; Neurons/*physiology ; Neurons, Afferent/physiology ; Pain/drug therapy/genetics/*physiopathology ; Receptors, Drug/genetics/*physiology ; Receptors, Glutamate/*physiology ; Signal Transduction ; Sodium Channels/physiology ; Spinal Cord/cytology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 41
    Publication Date: 2004-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beja-Pereira, Albano -- England, Phillip R -- Ferrand, Nuno -- Jordan, Steve -- Bakhiet, Amel O -- Abdalla, Mohammed A -- Mashkour, Marjan -- Jordana, Jordi -- Taberlet, Pierre -- Luikart, Gordon -- New York, N.Y. -- Science. 2004 Jun 18;304(5678):1781.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lab. d'Ecologie Alpine, UMR CNRS-UJF 5553, 38041 Grenoble, France. albano.beja-pereira@ujf-grenoble.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15205528" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Animal Husbandry ; Animals ; *Animals, Domestic/classification/genetics ; Animals, Wild/genetics ; Archaeology ; Asia ; Cytochromes b/genetics ; DNA, Mitochondrial/genetics ; Equidae/classification/*genetics ; Haplotypes ; Molecular Sequence Data ; *Phylogeny ; Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 42
    Publication Date: 2004-10-02
    Description: Over the past 50 million years, successive clades of large carnivorous mammals diversified and then declined to extinction. In most instances, the cause of the decline remains a puzzle. Here we argue that energetic constraints and pervasive selection for larger size (Cope's rule) in carnivores lead to dietary specialization (hypercarnivory) and increased vulnerability to extinction. In two major clades of extinct North American canids, the evolution of large size was associated with a dietary shift to hypercarnivory and a decline in species durations. Thus, selection for attributes that promoted individual success resulted in progressive evolutionary failure of their clades.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Valkenburgh, Blaire -- Wang, Xiaoming -- Damuth, John -- New York, N.Y. -- Science. 2004 Oct 1;306(5693):101-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, University of California at Los Angeles, Los Angeles, CA 90095-1606, USA. bvanval@ucla.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15459388" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Body Constitution ; Body Weight ; *Carnivora/anatomy & histology/classification/physiology ; Cuspid/anatomy & histology ; *Diet ; *Fossils ; Incisor/anatomy & histology ; Jaw/anatomy & histology ; Molar/anatomy & histology ; North America ; Paleodontology ; Population Density ; Population Dynamics ; Predatory Behavior ; Principal Component Analysis ; Selection, Genetic
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  • 43
    Publication Date: 2004-01-06
    Description: MDM2 binds the p53 tumor suppressor protein with high affinity and negatively modulates its transcriptional activity and stability. Overexpression of MDM2, found in many human tumors, effectively impairs p53 function. Inhibition of MDM2-p53 interaction can stabilize p53 and may offer a novel strategy for cancer therapy. Here, we identify potent and selective small-molecule antagonists of MDM2 and confirm their mode of action through the crystal structures of complexes. These compounds bind MDM2 in the p53-binding pocket and activate the p53 pathway in cancer cells, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts in nude mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vassilev, Lyubomir T -- Vu, Binh T -- Graves, Bradford -- Carvajal, Daisy -- Podlaski, Frank -- Filipovic, Zoran -- Kong, Norman -- Kammlott, Ursula -- Lukacs, Christine -- Klein, Christian -- Fotouhi, Nader -- Liu, Emily A -- New York, N.Y. -- Science. 2004 Feb 6;303(5659):844-8. Epub 2004 Jan 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Discovery Oncology, Roche Research Center, Hoffmann-La Roche, Inc., Nutley, NJ 07110, USA. lyubomir.vassilev@roche.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14704432" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis/*drug effects ; Binding Sites ; Cell Cycle/drug effects ; Cell Division/*drug effects ; Cell Line ; Cell Line, Tumor ; Cell Survival/drug effects ; Crystallization ; Crystallography, X-Ray ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclins/metabolism ; Dose-Response Relationship, Drug ; Gene Expression ; Genes, p53 ; Humans ; Hydrophobic and Hydrophilic Interactions ; Imidazoles/chemistry/metabolism/*pharmacology ; Mice ; Mice, Nude ; Models, Molecular ; Molecular Weight ; NIH 3T3 Cells ; Neoplasm Transplantation ; Neoplasms, Experimental/drug therapy/metabolism/*pathology ; *Nuclear Proteins ; Phosphorylation ; Piperazines/chemistry/metabolism/*pharmacology ; Protein Conformation ; Proto-Oncogene Proteins/*antagonists & inhibitors/chemistry/metabolism ; Proto-Oncogene Proteins c-mdm2 ; Stereoisomerism ; Transplantation, Heterologous ; Tumor Suppressor Protein p53/*metabolism
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  • 44
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krajick, Kevin -- New York, N.Y. -- Science. 2004 Mar 12;303(5664):1600-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15016975" target="_blank"〉PubMed〈/a〉
    Keywords: *Altitude ; Animals ; Biodiversity ; *Climate ; *Ecosystem ; Environment ; Environmental Pollutants/analysis ; Fishes/physiology ; Geography ; Lagomorpha/physiology ; *Plant Development ; Population Dynamics ; Temperature ; Trees/*growth & development
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  • 45
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-03-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krajick, Kevin -- New York, N.Y. -- Science. 2004 Mar 5;303(5663):1457.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15001752" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; Animals ; Desert Climate ; *Ecology ; *Ecosystem ; Financial Support ; Genome ; *Genomics ; *International Cooperation ; Israel ; Jordan ; Sequence Analysis, DNA ; United States ; Universities
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  • 46
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-09-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fouts, William R -- New York, N.Y. -- Science. 2004 Sep 24;305(5692):1909-10; author reply 1909-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15448251" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Lizards/*anatomy & histology ; Predatory Behavior ; *Selection, Genetic
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  • 47
    Publication Date: 2004-10-02
    Description: To identify previously unknown small molecules that inhibit cell cycle machinery, we performed a chemical genetic screen in Xenopus extracts. One class of inhibitors, termed ubistatins, blocked cell cycle progression by inhibiting cyclin B proteolysis and inhibited degradation of ubiquitinated Sic1 by purified proteasomes. Ubistatins blocked the binding of ubiquitinated substrates to the proteasome by targeting the ubiquitin-ubiquitin interface of Lys(48)-linked chains. The same interface is recognized by ubiquitin-chain receptors of the proteasome, indicating that ubistatins act by disrupting a critical protein-protein interaction in the ubiquitin-proteasome system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Verma, Rati -- Peters, Noel R -- D'Onofrio, Mariapina -- Tochtrop, Gregory P -- Sakamoto, Kathleen M -- Varadan, Ranjani -- Zhang, Mingsheng -- Coffino, Philip -- Fushman, David -- Deshaies, Raymond J -- King, Randall W -- CA78048/CA/NCI NIH HHS/ -- GM068276/GM/NIGMS NIH HHS/ -- GM65334/GM/NIGMS NIH HHS/ -- GM66492/GM/NIGMS NIH HHS/ -- P50 CA92131/CA/NCI NIH HHS/ -- R01 GM-45335/GM/NIGMS NIH HHS/ -- R21CA108545/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2004 Oct 1;306(5693):117-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Howard Hughes Medical Institute (HHMI), California Institute of Technology, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15459393" target="_blank"〉PubMed〈/a〉
    Keywords: Anaphase-Promoting Complex-Cyclosome ; Animals ; Cell Extracts ; Cyclin B/metabolism ; Cyclin-Dependent Kinase Inhibitor Proteins ; Cysteine Endopeptidases/metabolism ; *Drug Evaluation, Preclinical ; Interphase ; Mitosis ; Molecular Structure ; Multienzyme Complexes/*antagonists & inhibitors/metabolism ; Ornithine Decarboxylase/metabolism ; Proteasome Endopeptidase Complex ; Protein Binding ; Proteins/*metabolism ; Quinolines/*metabolism/pharmacology ; Recombinant Fusion Proteins ; Saccharomyces cerevisiae Proteins/metabolism ; Sulfanilic Acids/*metabolism/pharmacology ; Ubiquitin/*metabolism ; Ubiquitin-Protein Ligase Complexes/metabolism ; Xenopus laevis
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  • 48
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-12-14
    Description: The current understanding of how birds fly must be revised, because birds use their hand-wings in an unconventional way to generate lift and drag. Physical models of a common swift wing in gliding posture with a 60 degrees sweep of the sharp hand-wing leading edge were tested in a water tunnel. Interactions with the flow were measured quantitatively with digital particle image velocimetry at Reynolds numbers realistic for the gliding flight of a swift between 3750 and 37,500. The results show that gliding swifts can generate stable leading-edge vortices at small (5 degrees to 10 degrees) angles of attack. We suggest that the flow around the arm-wings of most birds can remain conventionally attached, whereas the swept-back hand-wings generate lift with leading-edge vortices.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Videler, J J -- Stamhuis, E J -- Povel, G D E -- New York, N.Y. -- Science. 2004 Dec 10;306(5703):1960-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Marine Biology (Experimental Marine Zoology Group), Groningen University, Post Office Box 14, 9750 AA, Haren, Netherlands. j.j.videler@biol.rug.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15591209" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomechanical Phenomena ; Birds/anatomy & histology/*physiology ; *Flight, Animal ; Models, Anatomic ; Wings, Animal/anatomy & histology/*physiology
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  • 49
    Publication Date: 2004-05-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coleman, C Norman -- Stone, Helen B -- Moulder, John E -- Pellmar, Terry C -- New York, N.Y. -- Science. 2004 Apr 30;304(5671):693-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Radiation Research Program, Division of Cancer Treatment & Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15118152" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytokines/therapeutic use ; Disease Models, Animal ; Free Radical Scavengers/therapeutic use ; Humans ; Isoflavones/therapeutic use ; Radiation Injuries/*drug therapy/prevention & control ; Radiation Injuries, Experimental/drug therapy ; Radiation-Protective Agents/administration & dosage/*therapeutic use ; Radiotherapy/adverse effects ; Whole-Body Irradiation/adverse effects
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  • 50
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-04-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vigne, J-D -- Guilaine, J -- Debue, K -- Haye, L -- Gerard, P -- New York, N.Y. -- Science. 2004 Apr 9;304(5668):259.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CNRS-Museum national d'Histoire naturelle, Department of Ecology and Biodiversity Management, UMR 5197, C.P. 56, F-75231 Paris Cedex 5, France. vigne@mnhn.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15073370" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Domestic/anatomy & histology ; *Archaeology ; *Burial ; *Cats/anatomy & histology ; Cyprus ; Humans ; Skeleton ; Time
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  • 51
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2172.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15618495" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Breeding ; Dogs/*anatomy & histology/*genetics/growth & development ; Genetic Variation ; Hindlimb ; Neoplasm Proteins/genetics ; Nose/anatomy & histology ; Phenotype ; Selection, Genetic ; Skull/anatomy & histology ; *Tandem Repeat Sequences ; Toes/anatomy & histology ; Transcription Factors/genetics
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  • 52
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-12-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2004 Dec 10;306(5703):1884-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15591181" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arizona ; *Conservation of Natural Resources ; *Ecosystem ; Environment ; *Fishes ; *Geologic Sediments ; *Rivers ; *Snails ; Water Movements
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  • 53
    Publication Date: 2004-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- New York, N.Y. -- Science. 2004 Sep 10;305(5690):1558-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15361602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apolipoprotein A-I/metabolism ; Biomarkers/analysis ; Cardiovascular Diseases/*diagnosis ; Cholesterol/metabolism ; Humans ; Lipoproteins, HDL/*metabolism ; Magnetic Resonance Imaging ; Oxidation-Reduction ; Peroxidase/*metabolism ; Risk Factors ; Tyrosine/*analogs & derivatives/metabolism
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  • 54
    Publication Date: 2004-10-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2004 Oct 29;306(5697):796-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15514125" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Brain/cytology ; Circadian Rhythm ; *Eye ; Gene Duplication ; Genome ; Homeodomain Proteins/*analysis ; Humans ; Light ; Photoreceptor Cells, Invertebrate/chemistry/*cytology ; Photoreceptor Cells, Vertebrate/chemistry/cytology ; Polychaeta/chemistry/*cytology/*genetics ; Retinal Ganglion Cells/cytology ; Rod Opsins/analysis/*chemistry/*genetics
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  • 55
    Publication Date: 2004-01-24
    Description: What are the components that control the assembly of subcellular organelles in eukaryotic cells? Although membranes can clearly be distorted by cytosolic factors, very little is known about the intrinsic mechanisms that control the biogenesis, shape, and organization of organellar membranes. Here, we found that the unconventional phospholipid lysobisphosphatidic acid (LBPA) could induce the formation of multivesicular liposomes that resembled the multivesicular endosomes that exist where this lipid is found in vivo. This process depended on the same pH gradient that exists across endosome membranes in vivo and was selectively controlled by Alix. In turn, Alix regulated the organization of LBPA-containing endosomes in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsuo, Hirotami -- Chevallier, Julien -- Mayran, Nathalie -- Le Blanc, Isabelle -- Ferguson, Charles -- Faure, Julien -- Blanc, Nathalie Sartori -- Matile, Stefan -- Dubochet, Jacques -- Sadoul, Remy -- Parton, Robert G -- Vilbois, Francis -- Gruenberg, Jean -- New York, N.Y. -- Science. 2004 Jan 23;303(5657):531-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva 4, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14739459" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Annexin A2/metabolism ; Arylsulfonates/metabolism ; Calcium-Binding Proteins/genetics/*metabolism ; Carrier Proteins/genetics/*metabolism ; Cell Cycle Proteins ; Cell Line ; Coloring Agents/metabolism ; Cytosol/metabolism ; Endocytosis ; Endosomal Sorting Complexes Required for Transport ; Endosomes/*metabolism/ultrastructure ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Lipid Bilayers ; Liposomes/*metabolism ; Lysophospholipids/chemistry/*metabolism ; Membrane Glycoproteins/metabolism ; Molecular Structure ; Monoglycerides ; RNA Interference ; RNA, Small Interfering/metabolism ; Vesicular stomatitis Indiana virus/physiology ; Viral Envelope Proteins/metabolism
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  • 56
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vinogradov, Alexander E -- New York, N.Y. -- Science. 2004 Apr 16;304(5669):389-90; author reply 389-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15087529" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Biological ; Animals ; Body Constitution ; DNA Transposable Elements ; *Evolution, Molecular ; Gene Duplication ; *Genome ; Mammals/*genetics ; Models, Biological ; Population Density
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  • 57
    Publication Date: 2004-01-24
    Description: Many birds perform visual signals during their learned songs, but little is known about the interrelationship between visual and vocal displays. We show here that male brown-headed cowbirds (Molothrus ater) synchronize the most elaborate wing movements of their display with atypically long silent periods in their song, potentially avoiding adverse biomechanical effects on sound production. Furthermore, expiratory effort for song is significantly reduced when cowbirds perform their wing display. These results show a close integration between vocal and visual displays and suggest that constraints and synergistic interactions between the motor patterns of multimodal signals influence the evolution of birdsong.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cooper, Brenton G -- Goller, Franz -- DC04390/DC/NIDCD NIH HHS/ -- DC05722/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 2004 Jan 23;303(5657):544-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Utah, Salt Lake City, UT 84112, USA. cooper@biology.utah.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14739462" target="_blank"〉PubMed〈/a〉
    Keywords: Abdominal Muscles/physiology ; Air Sacs/physiology ; Animals ; Electromyography ; Male ; *Motor Activity ; Movement ; Posture ; Pressure ; Pulmonary Ventilation ; *Respiration ; Respiratory Muscles/physiology ; Songbirds/*physiology ; Video Recording ; *Vocalization, Animal ; Wings, Animal/*physiology
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  • 58
    Publication Date: 2004-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coplan, Paul M -- Mitchnick, Mark -- Rosenberg, Zeda F -- New York, N.Y. -- Science. 2004 Jun 25;304(5679):1911-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉International Partnership for Microbicides, Silver Spring, MD 20910, USA. PCoplan@ipm-microbicides.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15218130" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Intravaginal ; Administration, Rectal ; Advisory Committees ; Animals ; Anti-HIV Agents/*administration & dosage/pharmacology/therapeutic use ; Clinical Trials, Phase III as Topic ; Condoms ; *Drug Approval ; Drug Evaluation, Preclinical ; Drug Therapy, Combination ; Female ; Financial Support ; *Government Regulation ; HIV/drug effects ; HIV Infections/*prevention & control/*transmission ; Humans ; Patient Selection ; Placebos ; Randomized Controlled Trials as Topic
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  • 59
    Publication Date: 2004-09-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2004 Sep 3;305(5689):1396-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15353775" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Skull/anatomy & histology ; *Tooth ; Urodela/*anatomy & histology/*classification/genetics
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  • 60
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-05-08
    Description: I report on tiny skeletons of stem-group hummingbirds from the early Oligocene of Germany that are of essentially modern appearance and exhibit morphological specializations toward nectarivory and hovering flight. These are the oldest fossils of modern-type hummingbirds, which had not previously been reported from the Old World. The findings demonstrate that early hummingbird evolution was not restricted to the New World. They further suggest that bird-flower coevolution dates back to the early Oligocene and open another view on the origin of ornithophily in Old World plants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mayr, Gerald -- New York, N.Y. -- Science. 2004 May 7;304(5672):861-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Forschungsinstitut Senckenberg, Division of Ornithology, Senckenberganlage 25, D-60325 Frankfurt a.M., Germany. Gerald.Mayr@senckenberg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15131303" target="_blank"〉PubMed〈/a〉
    Keywords: Americas ; Animals ; *Biological Evolution ; *Birds/anatomy & histology/classification ; Bone and Bones/anatomy & histology ; Europe ; Flight, Animal ; Flowers ; *Fossils ; Germany
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beutler, Ernest -- New York, N.Y. -- Science. 2004 Dec 17;306(5704):2051-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA. beutler@scripps.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15604397" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antimicrobial Cationic Peptides/*metabolism ; Biological Transport ; Cation Transport Proteins/genetics/*metabolism ; Enterocytes/metabolism ; Erythropoiesis ; Erythropoietin/genetics/metabolism ; Gene Expression Regulation ; Hemochromatosis/genetics ; Hepatocytes/metabolism ; Hepcidins ; Histocompatibility Antigens Class I/genetics ; Homeostasis ; Iron/*metabolism ; Iron Regulatory Protein 1/*metabolism ; Iron Regulatory Protein 2/*metabolism ; Membrane Proteins/genetics ; Mice ; Models, Biological ; Mutation ; Nitric Oxide/metabolism ; Oxygen/physiology ; Response Elements ; Signal Transduction ; Transcription, Genetic
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2004 Jul 2;305(5680):37.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15232086" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Awards and Prizes ; Berlin ; *Biological Evolution ; Biology/history ; Birds ; History, 20th Century ; History, 21st Century ; Museums/*history ; United States
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  • 63
    Publication Date: 2004-11-06
    Description: Phosphorylation of the human histone variant H2A.X and H2Av, its homolog in Drosophila melanogaster, occurs rapidly at sites of DNA double-strand breaks. Little is known about the function of this phosphorylation or its removal during DNA repair. Here, we demonstrate that the Drosophila Tip60 (dTip60) chromatin-remodeling complex acetylates nucleosomal phospho-H2Av and exchanges it with an unmodified H2Av. Both the histone acetyltransferase dTip60 as well as the adenosine triphosphatase Domino/p400 catalyze the exchange of phospho-H2Av. Thus, these data reveal a previously unknown mechanism for selective histone exchange that uses the concerted action of two distinct chromatin-remodeling enzymes within the same multiprotein complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kusch, Thomas -- Florens, Laurence -- Macdonald, W Hayes -- Swanson, Selene K -- Glaser, Robert L -- Yates, John R 3rd -- Abmayr, Susan M -- Washburn, Michael P -- Workman, Jerry L -- New York, N.Y. -- Science. 2004 Dec 17;306(5704):2084-7. Epub 2004 Nov 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. tnk@stowers-institute.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15528408" target="_blank"〉PubMed〈/a〉
    Keywords: Acetyl Coenzyme A/metabolism ; Acetylation ; Acetyltransferases/genetics/*metabolism ; Adenosine Triphosphatases/metabolism ; Animals ; Cell Line ; *DNA Damage ; DNA Repair ; Dimerization ; Drosophila Proteins/genetics/metabolism ; Drosophila melanogaster/embryology/genetics/*metabolism ; Embryo, Nonmammalian/metabolism ; Histone Acetyltransferases ; Histones/*metabolism ; Multiprotein Complexes/*metabolism ; Nucleosomes/*metabolism ; Phosphorylation ; RNA Interference ; Recombinant Proteins/metabolism ; Transcription Factors/metabolism
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  • 64
    Publication Date: 2004-03-06
    Description: Attention modulates our subjective perception of time. The less we attend to an event's duration, the shorter it seems to last. Attention to time or color stimulus attributes was modulated parametrically in an event-related functional magnetic resonance imaging study. Linear increases in task performance were accompanied by corresponding increases in brain activity. Increasing attention to time selectively increased activity in a corticostriatal network, including pre-supplementary motor area and right frontal operculum. Increasing attention to color selectively increased activity in area V4. By identifying areas whose activity was specifically modulated by attention to time, we have defined the core neuroanatomical substrates of timing behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coull, Jennifer T -- Vidal, Franck -- Nazarian, Bruno -- Macar, Francoise -- New York, N.Y. -- Science. 2004 Mar 5;303(5663):1506-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique (CNRS), 31 Chemin Joseph-Aiguier, 13402 Marseille Cedex 20, France. jcoull@lnf.cnrs-mrs.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15001776" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; *Attention ; Brain Mapping ; Cerebral Cortex/*physiology ; Color Perception ; Cues ; Frontal Lobe/physiology ; Humans ; Magnetic Resonance Imaging ; Motor Cortex/physiology ; Occipital Lobe/physiology ; Photic Stimulation ; Task Performance and Analysis ; *Time Perception
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-10-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2004 Oct 8;306(5694):217-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15472054" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/organization & administration ; Animals ; Europe ; *Genetic Research ; International Cooperation ; Italy ; Mice/*genetics ; Research Personnel
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  • 66
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2004 Jun 18;304(5678):1736.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15205506" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Biological ; Alleles ; Animals ; *Biological Evolution ; Breeding ; Crosses, Genetic ; Environment ; Extremities/growth & development ; Fresh Water ; Gene Expression Regulation ; Genes ; Genome ; Homeodomain Proteins/*genetics/metabolism ; Mutation ; Paired Box Transcription Factors ; Seawater ; Selection, Genetic ; Smegmamorpha/*anatomy & histology/*genetics ; Transcription Factors/*genetics/metabolism
    Print ISSN: 0036-8075
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  • 67
    Publication Date: 2004-02-07
    Description: The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gamblin, S J -- Haire, L F -- Russell, R J -- Stevens, D J -- Xiao, B -- Ha, Y -- Vasisht, N -- Steinhauer, D A -- Daniels, R S -- Elliot, A -- Wiley, D C -- Skehel, J J -- AI-13654/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council (MRC) National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14764886" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Binding Sites ; Birds ; Crystallography, X-Ray ; Hemagglutinin Glycoproteins, Influenza Virus/*chemistry/*metabolism ; History, 20th Century ; Humans ; Hydrogen Bonding ; Influenza A virus/*immunology/metabolism/pathogenicity ; Influenza, Human/epidemiology/history/*virology ; Membrane Glycoproteins/chemistry/metabolism ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Protein Structure, Tertiary ; Receptors, Virus/*metabolism ; Sequence Alignment ; Sialic Acids/metabolism ; Species Specificity ; Swine
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  • 68
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2004 Jun 11;304(5677):1590.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15192195" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; *Genome ; *Genome, Human ; Humans ; Pan troglodytes/*genetics ; *Polymorphism, Single Nucleotide ; *Recombination, Genetic
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  • 69
    Publication Date: 2004-09-11
    Description: The turnover of Jun proteins, like that of other transcription factors, is regulated through ubiquitin-dependent proteolysis. Usually, such processes are regulated by extracellular stimuli through phosphorylation of the target protein, which allows recognition by F box-containing E3 ubiquitin ligases. In the case of c-Jun and JunB, we found that extracellular stimuli also modulate protein turnover by regulating the activity of an E3 ligase by means of its phosphorylation. Activation of the Jun amino-terminal kinase (JNK) mitogen-activated protein kinase cascade after T cell stimulation accelerated degradation of c-Jun and JunB through phosphorylation-dependent activation of the E3 ligase Itch. This pathway modulates cytokine production by effector T cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gao, Min -- Labuda, Tord -- Xia, Ying -- Gallagher, Ewen -- Fang, Deyu -- Liu, Yun-Cai -- Karin, Michael -- AI43477/AI/NIAID NIH HHS/ -- ES04151/ES/NIEHS NIH HHS/ -- ES06376/ES/NIEHS NIH HHS/ -- R21AI48542/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Oct 8;306(5694):271-5. Epub 2004 Sep 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0723, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15358865" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD28/immunology ; CD4-Positive T-Lymphocytes/immunology/*metabolism ; Interferon-gamma/metabolism ; Interleukins/metabolism ; Lymphocyte Activation ; *MAP Kinase Kinase Kinase 1 ; MAP Kinase Kinase Kinases/genetics/metabolism ; Mice ; Mitogen-Activated Protein Kinase 8 ; Mitogen-Activated Protein Kinase 9 ; Mitogen-Activated Protein Kinases/*metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-jun/genetics/*metabolism ; RNA, Messenger/genetics/metabolism ; Receptors, Antigen, T-Cell/immunology ; Recombinant Fusion Proteins/metabolism ; T-Lymphocytes/immunology/*metabolism ; Th2 Cells/cytology/immunology/metabolism ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/*metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2004 May 28;304(5675):1227.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15166337" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Genome ; Mammals/*genetics ; Regulatory Sequences, Nucleic Acid ; *Sequence Analysis, DNA ; Sequence Homology, Nucleic Acid
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  • 71
    Publication Date: 2004-12-14
    Description: Mammalian oocytes are held in prophase arrest by an unknown signal from the surrounding somatic cells. Here we show that the orphan Gs-linked receptor GPR3, which is localized in the oocyte, maintains this arrest. Oocytes from Gpr3 knockout mice resume meiosis within antral follicles, independently of an increase in luteinizing hormone, and this phenotype can be reversed by injection of Gpr3 RNA into the oocytes. Thus, the GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle and is crucial for the regulation of meiosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mehlmann, Lisa M -- Saeki, Yoshinaga -- Tanaka, Shigeru -- Brennan, Thomas J -- Evsikov, Alexei V -- Pendola, Frank L -- Knowles, Barbara B -- Eppig, John J -- Jaffe, Laurinda A -- New York, N.Y. -- Science. 2004 Dec 10;306(5703):1947-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, University of Connecticut Health Center (UCHC), Farmington, CT 06032, USA. lmehlmann@neuron.uchc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15591206" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Animals ; Chondroitin Sulfate Proteoglycans/genetics/metabolism ; Expressed Sequence Tags ; Female ; Granulosa Cells/physiology ; Heterotrimeric GTP-Binding Proteins/*metabolism ; In Situ Hybridization ; Lectins, C-Type ; Ligands ; Luteinizing Hormone/metabolism ; *Meiosis ; Metaphase ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitosis ; Oocytes/*physiology ; Ovarian Follicle/*physiology ; RNA/genetics/metabolism ; Receptors, G-Protein-Coupled/genetics/*physiology ; Versicans
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  • 72
    Publication Date: 2004-11-30
    Description: The widespread extinctions of large mammals at the end of the Pleistocene epoch have often been attributed to the depredations of humans; here we present genetic evidence that questions this assumption. We used ancient DNA and Bayesian techniques to reconstruct a detailed genetic history of bison throughout the late Pleistocene and Holocene epochs. Our analyses depict a large diverse population living throughout Beringia until around 37,000 years before the present, when the population's genetic diversity began to decline dramatically. The timing of this decline correlates with environmental changes associated with the onset of the last glacial cycle, whereas archaeological evidence does not support the presence of large populations of humans in Eastern Beringia until more than 15,000 years later.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shapiro, Beth -- Drummond, Alexei J -- Rambaut, Andrew -- Wilson, Michael C -- Matheus, Paul E -- Sher, Andrei V -- Pybus, Oliver G -- Gilbert, M Thomas P -- Barnes, Ian -- Binladen, Jonas -- Willerslev, Eske -- Hansen, Anders J -- Baryshnikov, Gennady F -- Burns, James A -- Davydov, Sergei -- Driver, Jonathan C -- Froese, Duane G -- Harington, C Richard -- Keddie, Grant -- Kosintsev, Pavel -- Kunz, Michael L -- Martin, Larry D -- Stephenson, Robert O -- Storer, John -- Tedford, Richard -- Zimov, Sergei -- Cooper, Alan -- New York, N.Y. -- Science. 2004 Nov 26;306(5701):1561-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Henry Wellcome Ancient Biomolecules Centre, Oxford University, South Parks Road, Oxford OX13PS, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15567864" target="_blank"〉PubMed〈/a〉
    Keywords: Alaska ; Animals ; Bayes Theorem ; *Bison/classification/genetics ; Canada ; China ; *Climate ; DNA, Mitochondrial/genetics ; Environment ; *Fossils ; Genetic Variation ; Genetics, Population ; Human Activities ; Humans ; North America ; Phylogeny ; Population Dynamics ; Sequence Analysis, DNA ; Time
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  • 73
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-08-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2004 Aug 13;305(5686):929.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15310869" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blast Crisis/*pathology ; Cell Differentiation ; Cell Division ; Cells, Cultured ; Cytoskeletal Proteins/metabolism ; Granulocytes/cytology ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/blood/*pathology ; Macrophages/cytology ; Mice ; Myeloid Progenitor Cells/pathology/*physiology ; Stem Cells/physiology ; Trans-Activators/metabolism ; beta Catenin
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  • 74
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-11-06
    Description: One of the important roles of microRNA (miRNA) is to direct the cleavage of messenger RNA (mRNA). However, the mechanisms of decay of the cleaved mRNA products is not well understood. We show that miRNA-directed cleavage products in organisms as diverse as Arabidopsis, mouse, and Epstein-Barr virus have at their 3' ends a stretch (1 to 24 nucleotides) of oligouridine posttranscriptionally added downstream of the cleavage site. This 3' uridine addition, as shown for Arabidopsis, is correlated with decapping and 5' shortening of the cleaved products, suggesting a mechanistic step in the miRNA-directed mRNA decay mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, Binzhang -- Goodman, Howard M -- New York, N.Y. -- Science. 2004 Nov 5;306(5698):997.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15528436" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arabidopsis ; Cells, Cultured ; Cloning, Molecular ; Herpesvirus 4, Human/metabolism ; Humans ; Mice ; MicroRNAs/*metabolism ; Poly U/metabolism ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Uridine/*metabolism
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  • 75
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2004 Apr 23;304(5670):501-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15105467" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; *Embryonic and Fetal Development ; Female ; Gene Expression Regulation, Developmental ; *Genomic Imprinting ; Insulin-Like Growth Factor II/genetics/physiology ; Japan ; Mice ; Mutation ; Oocytes/*physiology ; *Parthenogenesis ; RNA, Long Noncoding ; RNA, Untranslated/genetics/physiology
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  • 76
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2004 Apr 2;304(5667):27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15060291" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Conservation of Natural Resources ; Ecosystem ; Environment ; Food Chain ; *Invertebrates ; United States
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  • 77
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2004 Jul 30;305(5684):589.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15286333" target="_blank"〉PubMed〈/a〉
    Keywords: Amyloid/chemistry/metabolism ; Animals ; Brain Chemistry ; Escherichia coli/genetics/metabolism ; Mice ; Mice, Transgenic ; Prion Diseases/*etiology ; Prions/administration & dosage/biosynthesis/chemistry/*pathogenicity ; Protein Folding ; Recombinant Proteins/administration & dosage/chemistry ; Time Factors
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  • 78
    Publication Date: 2004-11-06
    Description: In RNA interference (RNAi), double-stranded RNA (dsRNA) triggers degradation of homologous messenger RNA. In many organisms, RNA-dependent RNA polymerase (RdRp) is required to initiate or amplify RNAi, but the substrate for dsRNA synthesis in vivo is not known. Here, we show that RdRp-dependent transgene silencing in Arabidopsis was caused by mutation of XRN4, which is a ribonuclease (RNase) implicated in mRNA turnover by means of decapping and 5'-3' exonucleolysis. When both XRN4 and the RdRp were mutated, the plants accumulated decapped transgene mRNA. We propose that mRNAs lacking a cap structure become exposed to RdRp to initiate or maintain RNAi.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gazzani, S -- Lawrenson, T -- Woodward, C -- Headon, D -- Sablowski, R -- BBS/E/J/00000594/Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2004 Nov 5;306(5698):1046-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15528448" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arabidopsis/*genetics ; Arabidopsis Proteins/genetics ; Exoribonucleases/genetics ; Gene Silencing ; Homeodomain Proteins/genetics ; Mutation ; Plant Proteins/genetics ; Plants, Genetically Modified ; RNA Caps ; *RNA Interference ; RNA Replicase/metabolism ; RNA, Messenger/*metabolism ; RNA, Plant/*metabolism ; Rats ; Recombinant Fusion Proteins/genetics
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  • 79
    Publication Date: 2004-06-26
    Description: A honey bee colony is characterized by high genetic diversity among its workers, generated by high levels of multiple mating by its queen. Few clear benefits of this genetic diversity are known. Here we show that brood nest temperatures in genetically diverse colonies (i.e., those sired by several males) tend to be more stable than in genetically uniform ones (i.e., those sired by one male). One reason this increased stability arises is because genetically determined diversity in workers' temperature response thresholds modulates the hive-ventilating behavior of individual workers, preventing excessive colony-level responses to temperature fluctuations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, Julia C -- Myerscough, Mary R -- Graham, Sonia -- Oldroyd, Benjamin P -- New York, N.Y. -- Science. 2004 Jul 16;305(5682):402-4. Epub 2004 Jun 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biological Sciences, Macleay Building A12, University of Sydney, NSW 2006, Australia. jjones@bio.usyd.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15218093" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bees/genetics/*physiology ; Behavior, Animal ; Biological Evolution ; Body Temperature Regulation ; Female ; *Genetic Variation ; Homeostasis ; Male ; Selection, Genetic ; Sexual Behavior, Animal ; Temperature
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  • 80
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-11-06
    Description: Autophagy, the process by which cells recycle cytoplasm and dispose of excess or defective organelles, has entered the research spotlight largely owing to the discovery of the protein components that drive this process. Identifying the autophagy genes in yeast and finding orthologs in other organisms reveals the conservation of the mechanism of autophagy in eukaryotes and allows the use of molecular genetics and biology in different model systems to study this process. By mostly morphological studies, autophagy has been linked to disease processes. Whether autophagy protects from or causes disease is unclear. Here, we summarize current knowledge about the role of autophagy in disease and health.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1705980/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1705980/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shintani, Takahiro -- Klionsky, Daniel J -- GM53396/GM/NIGMS NIH HHS/ -- R01 GM053396/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 Nov 5;306(5698):990-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Michigan, Life Sciences Institute, Ann Arbor, MI 48109-2216, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15528435" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Autophagy/*physiology ; Humans ; Infection/physiopathology ; Muscular Diseases/physiopathology ; Neoplasms/physiopathology ; Neurodegenerative Diseases/physiopathology ; Phagosomes/physiology
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  • 81
    Publication Date: 2004-03-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bidoia, C -- Misgeld, T -- Weinzierl, E -- Buffelli, M -- Feng, G -- Cangiano, A -- Lichtman, J W -- Sanes, J R -- New York, N.Y. -- Science. 2004 Mar 26;303(5666):1977; author reply 1977.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dipartimento di Scienze Neurologiche e della Visione, Universita' di Verona, Strada Le Grazie 8, Verona, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15044788" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/physiology/ultrastructure ; Cell Adhesion Molecules, Neuronal/genetics/*physiology ; Crosses, Genetic ; Diaphragm/innervation ; Extracellular Matrix Proteins/genetics/*physiology ; Mice ; Mice, Neurologic Mutants ; Mice, Transgenic ; Motor Endplate/ultrastructure ; Muscle, Skeletal/innervation ; Mutation ; Nerve Tissue Proteins ; Neuromuscular Junction/*growth & development/physiology/ultrastructure ; Phenotype ; Serine Endopeptidases ; Synapses/*physiology/ultrastructure
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  • 82
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2004 Aug 6;305(5685):772-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15297645" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antirheumatic Agents/therapeutic use ; Arthritis, Juvenile/drug therapy/genetics/immunology ; Autoimmunity ; Cell Movement ; Child ; Dendritic Cells/*immunology/physiology ; Humans ; *Immune Tolerance ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-1/genetics/physiology ; Lymph Nodes/immunology ; Mice ; Sialoglycoproteins/therapeutic use ; T-Lymphocytes/immunology ; Up-Regulation
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 83
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-04-10
    Description: Intracellular parasites use various strategies to invade cells and to subvert cellular signaling pathways and, thus, to gain a foothold against host defenses. Efficient cell entry, ability to exploit intracellular niches, and persistence make these parasites treacherous pathogens. Most intracellular parasites gain entry via host-mediated processes, but apicomplexans use a system of adhesion-based motility called "gliding" to actively penetrate host cells. Actin polymerization-dependent motility facilitates parasite migration across cellular barriers, enables dissemination within tissues, and powers invasion of host cells. Efficient invasion has brought widespread success to this group, which includes Toxoplasma, Plasmodium, and Cryptosporidium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sibley, L D -- New York, N.Y. -- Science. 2004 Apr 9;304(5668):248-53.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Microbiology, Center for Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA. sibley@borcim.wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15073368" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/physiology ; Animals ; Apicomplexa/*pathogenicity/*physiology ; Cell Adhesion ; Cell Membrane/parasitology ; Cells/*parasitology ; Cryptosporidium/pathogenicity/physiology ; Models, Biological ; Molecular Motor Proteins/physiology ; Movement ; Plasmodium/pathogenicity/physiology ; Protozoan Proteins/metabolism ; Toxoplasma/pathogenicity/physiology ; Vacuoles/parasitology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 84
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-01-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2004 Jan 23;303(5657):455-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14739433" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Experimentation ; Animals ; Biological Specimen Banks ; Cloning, Organism ; Databases, Nucleic Acid ; *Disease Models, Animal ; Embryo, Mammalian ; Evolution, Molecular ; *Genome ; Genome, Human ; Humans ; Mice/genetics ; Models, Animal ; Mutagenesis ; *Rats/genetics ; Recombination, Genetic ; Sequence Analysis, DNA
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-09-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gascon, Claude -- Smith, Michael Leonard -- New York, N.Y. -- Science. 2004 Sep 24;305(5692):1922-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Conservation International, Washington, DC 20036, USA. c.gascon@conservation.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15448259" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Electric Fish/*physiology ; Rivers ; South America
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  • 86
    Publication Date: 2004-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2004 Aug 6;305(5685):772.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15297644" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoimmune Diseases/immunology ; B-Lymphocytes/immunology ; Humans ; *Immune Tolerance ; Receptors, Interleukin-2/analysis ; T-Lymphocytes/*immunology ; T-Lymphocytes, Regulatory/*immunology
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  • 87
    Publication Date: 2004-02-21
    Description: Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor. We identified a primary receptor for FIV as CD134 (OX40), a T cell activation antigen and costimulatory molecule. CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Infection is CXCR4-dependent, analogous to infection with X4 strains of HIV. Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimojima, Masayuki -- Miyazawa, Takayuki -- Ikeda, Yasuhiro -- McMonagle, Elizabeth L -- Haining, Hayley -- Akashi, Hiroomi -- Takeuchi, Yasuhiro -- Hosie, Margaret J -- Willett, Brian J -- R01 AI49765-01A1/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Feb 20;303(5661):1192-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14976315" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; CD4-Positive T-Lymphocytes/immunology/metabolism/virology ; Cats ; Cell Line ; Cell Line, Tumor ; DNA, Complementary ; Gene Library ; HIV/metabolism ; HeLa Cells ; Heterocyclic Compounds/pharmacology ; Humans ; Immunodeficiency Virus, Feline/*metabolism/pathogenicity ; Mice ; Molecular Sequence Data ; NIH 3T3 Cells ; Receptors, CXCR4/antagonists & inhibitors/metabolism ; Receptors, OX40 ; Receptors, Tumor Necrosis Factor/chemistry/genetics/immunology/*metabolism ; Receptors, Virus/chemistry/genetics/immunology/*metabolism ; Species Specificity ; Transduction, Genetic ; Transfection
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  • 88
    Publication Date: 2004-02-07
    Description: Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth factor-beta (TGF-beta) signaling in such epithelial-mesenchymal interactions was determined by conditional inactivation of the TGF-beta type II receptor gene in mouse fibroblasts (Tgfbr2fspKO). The loss of TGF-beta responsiveness in fibroblasts resulted in intraepithelial neoplasia in prostate and invasive squamous cell carcinoma of the forestomach, both associated with an increased abundance of stromal cells. Activation of paracrine hepatocyte growth factor (HGF) signaling was identified as one possible mechanism for stimulation of epithelial proliferation. Thus, TGF-beta signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhowmick, Neil A -- Chytil, Anna -- Plieth, David -- Gorska, Agnieszka E -- Dumont, Nancy -- Shappell, Scott -- Washington, M Kay -- Neilson, Eric G -- Moses, Harold L -- AR41943/AR/NIAMS NIH HHS/ -- CA102162/CA/NCI NIH HHS/ -- CA68485/CA/NCI NIH HHS/ -- CA85492/CA/NCI NIH HHS/ -- DK46282/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2004 Feb 6;303(5659):848-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14764882" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinoma, Squamous Cell/etiology/metabolism/pathology ; Cell Division ; *Cell Transformation, Neoplastic ; Cells, Cultured ; Epithelial Cells/*physiology ; Female ; Fibroblasts/*physiology ; Hepatocyte Growth Factor/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Neoplasms, Glandular and Epithelial/*etiology/metabolism/pathology ; Prostate/cytology/metabolism/pathology ; Prostatic Intraepithelial Neoplasia/etiology/metabolism/pathology ; Protein-Serine-Threonine Kinases ; Proto-Oncogene Proteins c-met/metabolism ; Receptors, Transforming Growth Factor beta/genetics/metabolism ; Recombination, Genetic ; *Signal Transduction ; Stomach/cytology/metabolism/pathology ; Stomach Neoplasms/etiology/metabolism/pathology ; Stromal Cells/*physiology ; Transforming Growth Factor beta/*physiology
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2004 Feb 6;303(5659):744.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14764840" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing ; Animals ; Cell Adhesion Molecules ; Drosophila/cytology/*genetics/growth & development ; Drosophila Proteins/*genetics/physiology ; Gene Expression Profiling ; *Gene Expression Regulation, Developmental ; Genes, Insect ; Neurons/*physiology ; Oligonucleotide Array Sequence Analysis ; Proteins/*genetics/physiology
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  • 90
    Publication Date: 2004-02-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2004 Feb 13;303(5660):950.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14963304" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Crustacea ; Feeding Behavior ; Fishes ; Ligaments/chemistry/physiology ; *Mastication ; Predatory Behavior ; Sharks/*anatomy & histology/physiology ; Tooth/*anatomy & histology/physiology
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  • 91
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kafatos, Fotis C -- New York, N.Y. -- Science. 2004 Nov 26;306(5701):1475.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15567837" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; Animals ; Europe ; *Genetic Research ; International Cooperation ; Italy ; Mice/*genetics ; Research Personnel
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  • 92
    Publication Date: 2004-10-30
    Description: The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Birnbaum, S G -- Yuan, P X -- Wang, M -- Vijayraghavan, S -- Bloom, A K -- Davis, D J -- Gobeske, K T -- Sweatt, J D -- Manji, H K -- Arnsten, A F T -- AG06036/AG/NIA NIH HHS/ -- P50 MH068789/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2004 Oct 29;306(5697):882-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, CT 06520-8001, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15514161" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic alpha-Agonists/pharmacology ; Alkaloids ; Animals ; Benzophenanthridines ; Carbolines/pharmacology ; Electrophysiology ; Enzyme Activation ; Female ; Imidazoles/pharmacology ; Lithium Carbonate/pharmacology ; Macaca mulatta ; Male ; Memory/drug effects/*physiology ; Neurons/drug effects/physiology ; Phenanthridines/pharmacology ; Prefrontal Cortex/enzymology/*physiology ; Protein Kinase C/antagonists & inhibitors/*metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Adrenergic, alpha-1/physiology ; Signal Transduction ; Stress, Physiological/physiopathology ; Tetradecanoylphorbol Acetate/pharmacology ; Valproic Acid/pharmacology
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  • 93
    Publication Date: 2004-05-01
    Description: The functional and anatomical rearrangements of cortical sensory maps accompanying changes in experience are not well understood. We examined in vivo and in vitro how the sensory map and underlying synaptic connectivity of the developing rat barrel cortex are altered when the sensory input to the cortex is partially deprived. In the nondeprived cortex, both the sensory responses and synaptic connectivity between columns were strengthened through an increase in the synaptic connection probability between L2/3 pyramids in adjacent columns. This was accompanied by a selective growth of L2/3pyramid axonal arbors between spared columns. In contrast, deprived and nondeprived cortical columns became weakly connected in their L2/3 pyramid connections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petersen, Carl C H -- Brecht, Michael -- Hahn, Thomas T G -- Sakmann, Bert -- New York, N.Y. -- Science. 2004 Apr 30;304(5671):739-42.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Physiology, Max-Planck-Institute for Medical Research, Jahnstrasse 29, Heidelberg D-69120, Germany. carl.petersen@epfl.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15118164" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain Mapping ; Electric Stimulation ; Excitatory Postsynaptic Potentials ; Image Processing, Computer-Assisted ; In Vitro Techniques ; Nerve Net/physiology ; *Neuronal Plasticity ; Patch-Clamp Techniques ; Pyramidal Cells/*physiology/ultrastructure ; Rats ; Rats, Wistar ; Somatosensory Cortex/cytology/growth & development/*physiology ; Synapses/*physiology ; Synaptic Transmission ; Vibrissae/*physiology
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  • 94
    Publication Date: 2004-05-15
    Description: In higher metazoans, phagocytosis is essential in host defense against microbial pathogens and in clearance of apoptotic cells. Both microbial and apoptotic cells are delivered on a common route from phagosomes to lysosomes for degradation. Here, we found that activation of the Toll-like receptor (TLR) signaling pathway by bacteria, but not apoptotic cells, regulated phagocytosis at multiple steps including internalization and phagosome maturation. Phagocytosis of bacteria was impaired in the absence of TLR signaling. Two modes of phagosome maturation were observed, constitutive and inducible; their differential engagement depended on the ability of the cargo to trigger TLR signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blander, J Magarian -- Medzhitov, Ruslan -- AI46688/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 May 14;304(5673):1014-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15143282" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing ; Animals ; Antigens, Differentiation/metabolism ; Apoptosis ; Bacteria/*immunology/metabolism ; Enzyme Activation ; Enzyme Inhibitors/pharmacology ; Escherichia coli/immunology/physiology ; Lysosomes/ultrastructure ; Macrophages/*immunology/metabolism/microbiology/ultrastructure ; Membrane Glycoproteins/genetics/*metabolism ; Mice ; Microscopy, Immunoelectron ; Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism ; Myeloid Differentiation Factor 88 ; *Phagocytosis ; Phagosomes/microbiology/*physiology/ultrastructure ; Receptors, Cell Surface/genetics/*metabolism ; Receptors, Immunologic/metabolism ; Recombinant Proteins/metabolism ; Salmonella typhimurium/immunology/physiology ; *Signal Transduction ; Staphylococcus aureus/immunology/physiology ; Toll-Like Receptors ; p38 Mitogen-Activated Protein Kinases
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  • 95
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bliss, Tim -- Schoepfer, Ralf -- New York, N.Y. -- Science. 2004 May 14;304(5673):973-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. tbliss@nimr.mrc.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15143268" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Calcium/metabolism ; Hippocampus/cytology/physiology ; *Long-Term Potentiation ; *Long-Term Synaptic Depression ; Pyramidal Cells/*physiology ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*metabolism ; Synapses/*physiology ; Synaptic Transmission
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  • 96
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-04-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- Vogel, Gretchen -- New York, N.Y. -- Science. 2004 Apr 9;304(5668):192-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15073347" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arrhythmias, Cardiac ; *Bone Marrow Transplantation/adverse effects ; Cardiac Output, Low/therapy ; Clinical Trials as Topic ; Europe ; Granulocyte Colony-Stimulating Factor/adverse effects ; *Heart/physiology ; Heart Diseases/pathology/physiopathology/*therapy ; Humans ; Myoblasts/*transplantation ; Myocardial Infarction/therapy ; Myocardium/pathology ; Myocytes, Cardiac/physiology ; *Stem Cell Transplantation/adverse effects ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kafatos, Fotis C -- Eisner, Thomas -- New York, N.Y. -- Science. 2004 Feb 27;303(5662):1257.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14988521" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior ; Biological Evolution ; *Biological Science Disciplines ; Ecology ; Genetics ; Humans ; *Interdisciplinary Communication ; Molecular Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-10-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2004 Oct 29;306(5697):789.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15514120" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Body Height ; Bone and Bones/anatomy & histology ; Female ; *Fossils ; Hominidae/*anatomy & histology ; Humans ; Indonesia ; Skeleton ; Skull/*anatomy & histology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickrell, John -- New York, N.Y. -- Science. 2004 Jul 16;305(5682):332-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15256653" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthozoa/growth & development ; Diving ; Ecosystem ; France ; History, 20th Century ; History, 21st Century ; *Marine Biology/history ; Organizations, Nonprofit ; Societies, Scientific/*organization & administration ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
    Publication Date: 2004-07-17
    Description: For seasonally breeding vertebrates, reproductive cycling is often coupled with changes in vocalizations that function in courtship and territoriality. Less is known about changes in auditory sensitivity to those vocalizations. Here, we show that nonreproductive female midshipman fish treated with either testosterone or 17beta-estradiol exhibit an increase in the degree of temporal encoding of the frequency content of male vocalizations by the inner ear that mimics the reproductive female's auditory phenotype. This sensory plasticity provides an adaptable mechanism that enhances coupling between sender and receiver in vocal communication.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sisneros, Joseph A -- Forlano, Paul M -- Deitcher, David L -- Bass, Andrew H -- 1F32DC00445/DC/NIDCD NIH HHS/ -- 5T32MH15793/MH/NIMH NIH HHS/ -- DC00092/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 2004 Jul 16;305(5682):404-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA. sisneros@u.washington.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15256672" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Adaptation, Physiological ; Animals ; Auditory Threshold ; Batrachoidiformes/*physiology ; Estradiol/blood/*pharmacology ; Estrogen Receptor alpha ; Female ; Hair Cells, Auditory/physiology ; Hearing/*physiology ; Male ; Neurons, Afferent/drug effects/*physiology ; Phenotype ; Random Allocation ; Receptors, Estrogen/genetics/metabolism ; Reproduction ; Saccule and Utricle/drug effects/*innervation/physiology ; Seasons ; Sexual Behavior, Animal ; Testosterone/blood/*pharmacology ; Vestibulocochlear Nerve/physiology ; *Vocalization, Animal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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