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  • 1
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    The Carboniferous Timescale (2020)
    London : The Geological Society
    Details
    Keywords: Carboniferous; Pangaea; ice age; biochronology; biostratigraphy; magnetostratigraphy; radioisotopic age
    Description / Table of Contents: 10 December 2020 --- Proposed chronostratigraphic units for the Carboniferous and Early Permian of the southwestern Gondwana margin / Carlos R. González and Pamela Díaz Saravia / Geological Society, London, Special Publications, 512, https://doi.org/10.1144/SP512-2020-48 --- 7 December 2020 --- A geomagnetic polarity timescale for the Carboniferous / Mark W. Hounslow / Geological Society, London, Special Publications, 512, https://doi.org/10.1144/SP512-2020-102 --- 1 December 2020 --- Carboniferous Smaller Foraminifera: Convergences and Divergences / Daniel Vachard and François Le Coze / Geological Society, London, Special Publications, 512, https://doi.org/10.1144/SP512-2020-42 --- 30 November 2020 --- Carboniferous Crinoids / William I. Ausich, Thomas W. Kammer and Georgy V. Mirantsev / Geological Society, London, Special Publications, 512, https://doi.org/10.1144/SP512-2020-71 --- 27 November 2020 --- Carboniferous macrofloral biostratigraphy – an overview / Stanislav Opluštil, Christopher J. Cleal, Jun Wang and Mingli Wan / Geological Society, London, Special Publications, 512, https://doi.org/10.1144/SP512-2020-97 --- 26 November 2020 --- The biostratigraphy of Carboniferous chondrichthyans / Michał Ginter / Geological Society, London, Special Publications, 512, https://doi.org/10.1144/SP512-2020-91 --- 25 November 2020 --- Carboniferous isotope stratigraphy / Jitao Chen, Bo Chen and Isabel P. Montañez / Geological Society, London, Special Publications, 512, https://doi.org/10.1144/SP512-2020-72 --- 24 November 2020 --- Carboniferous conodont biostratigraphy / James E. Barrick, Alexander S. Alekseev, Silvia Blanco-Ferrera, Natalia V. Goreva, Keyi Hu, Lance L. Lambert, Tamara I. Nemyrovska, Yuping Qi, Scott M. Ritter and Javier Sanz-López / Geological Society, London, Special Publications, 512, https://doi.org/10.1144/SP512-2020-38
    Pages: Illustrationen, Diagramme, Karten
    Edition: online first
    URL: https://sp.lyellcollection.org/online-first/512
    Language: English
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  • 2
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    Function analysis of ARF18 in rapeseed [Agricultural Sciences] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-09-16
    Description: Seed weight (SW), which is one of the three major factors influencing grain yield, has been widely accepted as a complex trait that is controlled by polygenes, particularly in polyploid crops. Brassica napus L., which is the second leading crop source for vegetable oil around the world, is a tetraploid...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    DICER-dependent biogenesis of let-7 miRNAs affects human cell response to DNA damage via targeting p21/p27 (2015)
    Oxford University Press
    Details
    Publication Date: 2015-02-18
    Description: Recently, it was reported that knockdown of DICER reduced the ATM-dependent DNA damage response and homologous recombination repair (HRR) via decreasing DICER-generated small RNAs at the damage sites. However, we found that knockdown of DICER dramatically increased cell resistance to camptothecin that induced damage required ATM to facilitate HRR. This phenotype is due to a prolonged G1/S transition via decreasing DICER-dependent biogenesis of miRNA let-7 , which increased the p21 Waf1/Cip1 /p27 Kip1 levels and resulted in decreasing the HRR efficiency. These results uncover a novel function of DICER in regulating the cell cycle through miRNA biogenesis, thus affecting cell response to DNA damage.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 4
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    Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations (2018)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2018
    Description: 〈p〉Cerebral cavernous malformation (CCM) is a common cerebrovascular disease that can occur sporadically or be inherited. They are major causes of stroke, cerebral hemorrhage, and neurological deficits in the younger population. Loss-of-function mutations in three genes, 〈i〉CCM1〈/i〉, 〈i〉CCM2〈/i〉, and 〈i〉CCM3〈/i〉, have been identified as the cause of human CCMs. Currently, no drug is available to treat CCM disease. Hyperactive mitogen-activated protein kinase kinase Kinase 3 (MEKK3) kinase signaling as a consequence of loss of 〈i〉CCM〈/i〉 genes is an underlying cause of CCM lesion development. Using a U.S. Food and Drug Administration–approved kinase inhibitor library combined with virtual modeling and biochemical and cellular assays, we have identified a clinically approved small compound, ponatinib, that is capable of inhibiting MEKK3 activity and normalizing expression of downstream kruppel-like factor (KLF) target genes. Treatment with this compound in neonatal mouse models of CCM can prevent the formation of new CCM lesions and reduce the growth of already formed lesions. At the ultracellular level, ponatinib can normalize the flattening and disorganization of the endothelium caused by 〈i〉CCM〈/i〉 deficiency. Collectively, our study demonstrates ponatinib as a novel compound that may prevent CCM initiation and progression in mouse models through inhibition of MEKK3-KLF signaling.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations (2018)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2018-11-08
    Description: Cerebral cavernous malformation (CCM) is a common cerebrovascular disease that can occur sporadically or be inherited. They are major causes of stroke, cerebral hemorrhage, and neurological deficits in the younger population. Loss-of-function mutations in three genes, CCM1 , CCM2 , and CCM3 , have been identified as the cause of human CCMs. Currently, no drug is available to treat CCM disease. Hyperactive mitogen-activated protein kinase kinase Kinase 3 (MEKK3) kinase signaling as a consequence of loss of CCM genes is an underlying cause of CCM lesion development. Using a U.S. Food and Drug Administration–approved kinase inhibitor library combined with virtual modeling and biochemical and cellular assays, we have identified a clinically approved small compound, ponatinib, that is capable of inhibiting MEKK3 activity and normalizing expression of downstream kruppel-like factor (KLF) target genes. Treatment with this compound in neonatal mouse models of CCM can prevent the formation of new CCM lesions and reduce the growth of already formed lesions. At the ultracellular level, ponatinib can normalize the flattening and disorganization of the endothelium caused by CCM deficiency. Collectively, our study demonstrates ponatinib as a novel compound that may prevent CCM initiation and progression in mouse models through inhibition of MEKK3-KLF signaling.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Identification of QTLs for 14 Agronomically Important Traits in Setaria italica Based on SNPs Generated from High-Throughput Sequencing (2017)
    Genetics Society of America (GSA)
    Details
    Publication Date: 2017-05-06
    Description: Foxtail millet ( Setaria italica ) is an important crop possessing C4 photosynthesis capability. The S. italica genome was de novo sequenced in 2012, but the sequence lacked high-density genetic maps with agronomic and yield trait linkages. In the present study, we resequenced a foxtail millet population of 439 recombinant inbred lines (RILs) and developed high-resolution bin map and high-density SNP markers, which could provide an effective approach for gene identification. A total of 59 QTL for 14 agronomic traits in plants grown under long- and short-day photoperiods were identified. The phenotypic variation explained ranged from 4.9 to 43.94%. In addition, we suggested that there may be segregation distortion on chromosome 6 that is significantly distorted toward Zhang gu. The newly identified QTL will provide a platform for sequence-based research on the S. italica genome, and for molecular marker-assisted breeding.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Published by Genetics Society of America (GSA)
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  • 7
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    Energy consumption quota management of Wanda commercial buildings in China (2016)
    Institute of Physics (IOP)
    Details
    Publication Date: 2016-09-27
    Description: There is limited research of commercial buildings’ energy use data conducted based on practical analysis in China nowadays. Some energy consumption quota tools like Energy Star in U.S or VDI 3807 in Germany have limitation in China's building sector. This study introduces an innovative methodology of applying energy use quota model and empirical management to commercial buildings, which was in accordance of more than one hundred opened shopping centers of a real estate group in China. On the basis of statistical benchmarking, a new concept of “Modified coefficient”, which considers weather, occupancy, business layout, operation schedule and HVAC efficiency, is originally introduced in this paper. Our study shows that the average energy use quota increases from north to south. The average energy use quota of sample buildings is 159 kWh/(m2.a) of severe cold climate zone, 179 kWh/(m2.a) of cold zone, 188 kWh/(m2.a) of hot summer and cold winter zone, and 200 kWh/(m2.a) of hot summ...
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
    Published by Institute of Physics (IOP)
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  • 8
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    In vitro culture of cynomolgus monkey embryos beyond early gastrulation (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉Gastrulation is a key event in embryonic development when the germ layers are specified and the basic animal body plan is established. The complexities of primate gastrulation remain a mystery because of the difficulties in accessing primate embryos at this stage. Here, we report the establishment of an in vitro culture (IVC) system that supports the continuous development of cynomolgus monkey blastocysts beyond early gastrulation up to 20 days after fertilization. The IVC embryos highly recapitulated the key events of in vivo early postimplantation development, including segregation of the epiblast and hypoblast, formation of the amniotic and yolk sac cavities, appearance of the primordial germ cells, and establishment of the anterior-posterior axis. Single-cell RNA-sequencing analyses of the IVC embryos provide information about lineage specification during primate early postimplantation development. This system provides a platform with which to explore the characteristics and mechanisms of early postimplantation embryogenesis in primates with possible conservation of cell movements and lineages in human embryogenesis.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Template-free synthesis of Nd0.1Bi0.9FeO3 nanotubes with large inner diameter and wasp-waisted hysteresis loop (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-08-12
    Description: One-dimensional (1D) nanotubes of Nd 0.1 Bi 0.9 FeO 3 (NBFO) with an inner diameter of ∼50 nm were synthesized via sol-gel based electrospinning without template assistant. The phases, morphologies, crystalline structures, and magnetic properties of these 1D nanostructures were characterized by means of X-ray diffraction, scanning electron microscopy, transmission electron microscopy and SQUID, respectively. It was found that the calcination condition plays a crucial role in determining the morphologies and the magnetic properties. Interestingly, these 1D NBFO nanotubes exhibit wasp-waisted magnetic hysteresis with a lower coercivity and larger saturation magnetization, which were prevalent in natural rocks and artificial composite materials. The origin of these wasp-waisted hysteresis loops was discussed.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 10
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    Late Permian rugose corals from Gyanyima of Drhada, Tibet (Xizang), Southwest China (2019)
    Paleontological Society
    Details
    Publication Date: 2019
    Description: 〈span〉〈div〉Abstract〈/div〉The rugose corals described in this study were collected from the Gyanyima section in the Ngari region of southwestern Tibet (Xizang) and are assigned to three genera and 11 species, including a new genus and seven new species: 〈span〉Waagenophyllum〈/span〉 (〈span〉Waagenophyllum〈/span〉) 〈span〉ngariense〈/span〉 He, 1990; 〈span〉W〈/span〉. (〈span〉W〈/span〉.) 〈span〉elegantulum〈/span〉 He in Luo et al., 1989; 〈span〉W〈/span〉. (〈span〉W〈/span〉.) 〈span〉minutum〈/span〉 Zhao, 1981; 〈span〉W〈/span〉. (〈span〉W〈/span〉.) 〈span〉tachtabulasicum〈/span〉 Ilyina, 1997; 〈span〉W〈/span〉. (〈span〉W〈/span〉.) 〈span〉gyanyimaense〈/span〉 n. sp., 〈span〉W〈/span〉. (〈span〉W〈/span〉.) 〈span〉intermedium〈/span〉 n. sp., 〈span〉Waagenophyllum〈/span〉 (〈span〉Liangshanophyllum〈/span〉) 〈span〉clisicolumellum〈/span〉 n. sp., 〈span〉Ipciphyllum naoticum〈/span〉 n. sp., 〈span〉I. floricolumellum〈/span〉 n. sp., 〈span〉I. zandaense〈/span〉 n. sp., and 〈span〉Gyanyimaphyllum crassiseptatum〈/span〉 n. gen. n. sp. Ontogeny and intraspecific variation are given special attention when describing and discussing these taxa. Coral reefs, with 〈span〉Waagenophyllum〈/span〉 as the major skeletal reef builder, occur in several horizons in the uppermost part of the section. The accompanying foraminifers indicate the rugose coral fauna is a late Permian Changhsingian age. Therefore, this is possibly one of the latest Permian rugose coral reefs in the world known up to now.UUID: http://zoobank.org/b9e621cb-197d-4208-8267-14d62f382a1b〈/span〉
    Print ISSN: 0022-3360
    Electronic ISSN: 1937-2337
    Topics: Geosciences
    Published by Paleontological Society
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