Publication Date:
2004-10-30
Description:
The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Birnbaum, S G -- Yuan, P X -- Wang, M -- Vijayraghavan, S -- Bloom, A K -- Davis, D J -- Gobeske, K T -- Sweatt, J D -- Manji, H K -- Arnsten, A F T -- AG06036/AG/NIA NIH HHS/ -- P50 MH068789/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2004 Oct 29;306(5697):882-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, CT 06520-8001, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15514161" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenergic alpha-Agonists/pharmacology
;
Alkaloids
;
Animals
;
Benzophenanthridines
;
Carbolines/pharmacology
;
Electrophysiology
;
Enzyme Activation
;
Female
;
Imidazoles/pharmacology
;
Lithium Carbonate/pharmacology
;
Macaca mulatta
;
Male
;
Memory/drug effects/*physiology
;
Neurons/drug effects/physiology
;
Phenanthridines/pharmacology
;
Prefrontal Cortex/enzymology/*physiology
;
Protein Kinase C/antagonists & inhibitors/*metabolism
;
Rats
;
Rats, Sprague-Dawley
;
Receptors, Adrenergic, alpha-1/physiology
;
Signal Transduction
;
Stress, Physiological/physiopathology
;
Tetradecanoylphorbol Acetate/pharmacology
;
Valproic Acid/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
