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  • 1
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    Steroid-dependent auditory plasticity leads to adaptive coupling of sender and receiver (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-17
    Description: For seasonally breeding vertebrates, reproductive cycling is often coupled with changes in vocalizations that function in courtship and territoriality. Less is known about changes in auditory sensitivity to those vocalizations. Here, we show that nonreproductive female midshipman fish treated with either testosterone or 17beta-estradiol exhibit an increase in the degree of temporal encoding of the frequency content of male vocalizations by the inner ear that mimics the reproductive female's auditory phenotype. This sensory plasticity provides an adaptable mechanism that enhances coupling between sender and receiver in vocal communication.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sisneros, Joseph A -- Forlano, Paul M -- Deitcher, David L -- Bass, Andrew H -- 1F32DC00445/DC/NIDCD NIH HHS/ -- 5T32MH15793/MH/NIMH NIH HHS/ -- DC00092/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 2004 Jul 16;305(5682):404-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA. sisneros@u.washington.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15256672" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Adaptation, Physiological ; Animals ; Auditory Threshold ; Batrachoidiformes/*physiology ; Estradiol/blood/*pharmacology ; Estrogen Receptor alpha ; Female ; Hair Cells, Auditory/physiology ; Hearing/*physiology ; Male ; Neurons, Afferent/drug effects/*physiology ; Phenotype ; Random Allocation ; Receptors, Estrogen/genetics/metabolism ; Reproduction ; Saccule and Utricle/drug effects/*innervation/physiology ; Seasons ; Sexual Behavior, Animal ; Testosterone/blood/*pharmacology ; Vestibulocochlear Nerve/physiology ; *Vocalization, Animal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development (2016)
    Genetics Society of America (GSA)
    Details
    Publication Date: 2016-02-05
    Description: Inositol 1,4,5-trisphosphate (IP 3 ) regulates a host of biological processes from egg activation to cell death. When IP 3 -specific receptors (IP3Rs) bind to IP 3 , they release calcium from the ER into the cytoplasm, triggering a variety of cell type- and developmental stage-specific responses. Alternatively, inositol polyphosphate kinases can phosphorylate IP 3 ; this limits IP3R activation by reducing IP 3 levels, and also generates new signaling molecules altogether. These divergent pathways draw from the same IP 3 pool yet cause very different cellular responses. Therefore, controlling the relative rates of IP3R activation vs. phosphorylation of IP 3 is essential for proper cell functioning. Establishing a model system that sensitively reports the net output of IP 3 signaling is crucial for identifying the controlling genes. Here we report that mutant alleles of wavy ( wy ), a classic locus of the fruit fly Drosophila melanogaster , map to IP 3 3-kinase 2 ( IP3K2 ), a member of the inositol polyphosphate kinase gene family. Mutations in wy disrupt wing structure in a highly specific pattern. RNAi experiments using GAL4 and GAL80 ts indicated that IP3K2 function is required in the wing discs of early pupae for normal wing development. Gradations in the severity of the wy phenotype provide high-resolution readouts of IP3K2 function and of overall IP 3 signaling, giving this system strong potential as a model for further study of the IP 3 signaling network. In proof of concept, a dominant modifier screen revealed that mutations in IP3R strongly suppress the wy phenotype, suggesting that the wy phenotype results from reduced IP 4 levels, and/or excessive IP3R signaling.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Published by Genetics Society of America (GSA)
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  • 3
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    Vesicle capture produces large neuropeptide stores [Neuroscience] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-03-05
    Description: Neurons vary in their capacity to produce, store, and release neuropeptides packaged in dense-core vesicles (DCVs). Specifically, neurons used for cotransmission have terminals that contain few DCVs and many small synaptic vesicles, whereas neuroendocrine neuron terminals contain many DCVs. Although the mechanistic basis for presynaptic variation is unknown, past research...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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