Publication Date:
2004-12-14
Description:
Mammalian oocytes are held in prophase arrest by an unknown signal from the surrounding somatic cells. Here we show that the orphan Gs-linked receptor GPR3, which is localized in the oocyte, maintains this arrest. Oocytes from Gpr3 knockout mice resume meiosis within antral follicles, independently of an increase in luteinizing hormone, and this phenotype can be reversed by injection of Gpr3 RNA into the oocytes. Thus, the GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle and is crucial for the regulation of meiosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mehlmann, Lisa M -- Saeki, Yoshinaga -- Tanaka, Shigeru -- Brennan, Thomas J -- Evsikov, Alexei V -- Pendola, Frank L -- Knowles, Barbara B -- Eppig, John J -- Jaffe, Laurinda A -- New York, N.Y. -- Science. 2004 Dec 10;306(5703):1947-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, University of Connecticut Health Center (UCHC), Farmington, CT 06032, USA. lmehlmann@neuron.uchc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15591206" target="_blank"〉PubMed〈/a〉
Keywords:
Adenylyl Cyclases/metabolism
;
Animals
;
Chondroitin Sulfate Proteoglycans/genetics/metabolism
;
Expressed Sequence Tags
;
Female
;
Granulosa Cells/physiology
;
Heterotrimeric GTP-Binding Proteins/*metabolism
;
In Situ Hybridization
;
Lectins, C-Type
;
Ligands
;
Luteinizing Hormone/metabolism
;
*Meiosis
;
Metaphase
;
Mice
;
Mice, Inbred C57BL
;
Mice, Knockout
;
Mitosis
;
Oocytes/*physiology
;
Ovarian Follicle/*physiology
;
RNA/genetics/metabolism
;
Receptors, G-Protein-Coupled/genetics/*physiology
;
Versicans
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
