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  • United States  (1,318)
  • Female  (874)
  • Male  (822)
  • American Association for the Advancement of Science (AAAS)  (2,295)
  • American Association of Petroleum Geologists (AAPG)
  • 2000-2004  (2,295)
Collection
Keywords
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  • American Association for the Advancement of Science (AAAS)  (2,295)
  • American Association of Petroleum Geologists (AAPG)
  • Springer  (5)
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Year
  • 101
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    Research and the Bayh-Dole Act (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reczek, Peter R -- New York, N.Y. -- Science. 2004 Jan 2;303(5654):40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14704412" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; *Industry ; Patents as Topic/*legislation & jurisprudence ; *Research ; Technology Transfer ; United States ; *Universities
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 102
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    A cluster of metabolic defects caused by mutation in a mitochondrial tRNA (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-23
    Description: Hypertension and dyslipidemia are risk factors for atherosclerosis and occur together more often than expected by chance. Although this clustering suggests shared causation, unifying factors remain unknown. We describe a large kindred with a syndrome including hypertension, hypercholesterolemia, and hypomagnesemia. Each phenotype is transmitted on the maternal lineage with a pattern indicating mitochondrial inheritance. Analysis of the mitochondrial genome of the maternal lineage identified a homoplasmic mutation substituting cytidine for uridine immediately 5' to the mitochondrial transfer RNA(Ile) anticodon. Uridine at this position is nearly invariate among transfer RNAs because of its role in stabilizing the anticodon loop. Given the known loss of mitochondrial function with aging, these findings may have implications for the common clustering of these metabolic disorders.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033655/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033655/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, Frederick H -- Hariri, Ali -- Farhi, Anita -- Zhao, Hongyu -- Petersen, Kitt Falk -- Toka, Hakan R -- Nelson-Williams, Carol -- Raja, Khalid M -- Kashgarian, Michael -- Shulman, Gerald I -- Scheinman, Steven J -- Lifton, Richard P -- MO1 RR-00125/RR/NCRR NIH HHS/ -- P50 HL-55007/HL/NHLBI NIH HHS/ -- R01 AG023686/AG/NIA NIH HHS/ -- R01 AG023686-01A1/AG/NIA NIH HHS/ -- R01 AG023686-02/AG/NIA NIH HHS/ -- R01 AG023686-03/AG/NIA NIH HHS/ -- R01 AG023686-04/AG/NIA NIH HHS/ -- R01 DK-49230/DK/NIDDK NIH HHS/ -- R01 DK049230/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2004 Nov 12;306(5699):1190-4. Epub 2004 Oct 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15498972" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aging ; Anticodon ; Body Mass Index ; Cluster Analysis ; Cytidine ; *Extrachromosomal Inheritance ; Female ; Humans ; Hypercholesterolemia/*genetics/physiopathology ; Hypertension/*genetics/physiopathology ; Magnesium/*blood/urine ; Male ; Metabolic Syndrome X/genetics ; Middle Aged ; Mitochondria/*genetics/metabolism ; Mitochondria, Muscle/metabolism/pathology ; Muscle Fibers, Skeletal/pathology ; *Mutation ; Pedigree ; Phenotype ; RNA/genetics ; RNA, Transfer, Ile/*genetics ; Syndrome ; Thymidine ; Uridine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 103
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    Genetics. Genomic research and human subject privacy (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Zhen -- Owen, Art B -- Altman, Russ B -- LM007033/LM/NLM NIH HHS/ -- U01-GM61374/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 Jul 9;305(5681):183.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Stanford University School of Medicine, CA 94305-5120, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15247459" target="_blank"〉PubMed〈/a〉
    Keywords: *Databases, Genetic/legislation & jurisprudence ; *Genetic Privacy/legislation & jurisprudence ; *Genetic Research/legislation & jurisprudence ; *Genomics/legislation & jurisprudence ; Genotype ; Humans ; Informed Consent ; Pharmacogenetics ; Phenotype ; *Polymorphism, Single Nucleotide ; Public Policy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 104
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    2004 presidential forum: Bush and Kerry offer their views on science (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2004 Oct 1;306(5693):46-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15459366" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Evolution ; Cloning, Organism ; Embryo Research ; Energy-Generating Resources ; Environment ; Greenhouse Effect ; *Politics ; Public Health ; Research/economics ; *Science/education ; Security Measures ; Space Flight ; Stem Cells ; Travel ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 105
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    The candidates speak (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2004 Oct 1;306(5693):19.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15459348" target="_blank"〉PubMed〈/a〉
    Keywords: *Politics ; Research ; *Science ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 106
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    Asian brains: U.S. v. Europe (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Djerassi, Carl -- New York, N.Y. -- Science. 2004 Jul 30;305(5684):609.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15286347" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Asia ; *Authorship ; Drosophila/genetics ; Europe ; *Internationality ; Publishing ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 107
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    2004 annual meeting. Oceans policy is in for an overhaul (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Withgott, Jay -- New York, N.Y. -- Science. 2004 Feb 20;303(5661):1123.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14976289" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Conservation of Natural Resources ; Ecosystem ; *Environment ; Fishes ; Oceans and Seas ; *Public Policy ; Research Support as Topic ; *Seawater ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 108
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    Conservation policy in coffee landscapes (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dietsch, Thomas V -- Philpott, Stacy M -- Rice, Robert A -- Greenberg, Russell -- Bichier, Peter -- New York, N.Y. -- Science. 2004 Jan 30;303(5658):625-6; author reply 625-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14752143" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Animals ; Coffea/*growth & development ; *Coffee/economics ; Commerce ; *Conservation of Natural Resources ; *Crops, Agricultural/economics ; *Ecosystem ; *Public Policy ; Trees ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 109
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    RAD51C is required for Holliday junction processing in mammalian cells (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-13
    Description: During genetic recombination and the recombinational repair of chromosome breaks, DNA molecules become linked at points of strand exchange. Branch migration and resolution of these crossovers, or Holliday junctions (HJs), complete the recombination process. Here, we show that extracts from cells carrying mutations in the recombination/repair genes RAD51C or XRCC3 have reduced levels of HJ resolvase activity. Moreover, depletion of RAD51C from fractionated human extracts caused a loss of branch migration and resolution activity, but these functions were restored by complementation with a variety of RAD51 paralog complexes containing RAD51C. We conclude that the RAD51 paralogs are involved in HJ processing in human cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Yilun -- Masson, Jean-Yves -- Shah, Rajvee -- O'Regan, Paul -- West, Stephen C -- New York, N.Y. -- Science. 2004 Jan 9;303(5655):243-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14716019" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Animals ; CHO Cells ; Cell Line ; Cricetinae ; DNA Repair ; DNA, Cruciform/chemistry/*metabolism ; DNA-Binding Proteins/chemistry/genetics/isolation & purification/*metabolism ; Electrophoresis, Polyacrylamide Gel ; Female ; HeLa Cells ; Holliday Junction Resolvases/*metabolism ; Humans ; Mutation ; Protein Structure, Tertiary ; Recombinant Proteins/metabolism ; Recombination, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 110
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    Environmental chemistry. Tracking the dirty byproducts of a world trying to stay clean (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Renner, Rebecca -- New York, N.Y. -- Science. 2004 Dec 10;306(5703):1887.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15591183" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arctic Regions ; Canada ; Caprylates/analysis/chemistry ; Drug Combinations ; Environmental Pollutants/*analysis/toxicity ; Fluorocarbons/*analysis/chemistry/toxicity ; Humans ; Surface-Active Agents/*analysis/chemistry/toxicity ; Trichloroethanes/analysis/chemistry ; United States ; United States Environmental Protection Agency ; Volatilization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 111
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    Comment on "Managing soil carbon" (II) (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Renwick, W H -- Smith, S V -- Sleezer, R O -- Buddemeier, Robert W -- New York, N.Y. -- Science. 2004 Sep 10;305(5690):1567; author reply 1567.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geography, Miami University, Oxford, OH 45056, USA. renwicwh@muohio.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15361609" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Atmosphere ; Carbon/*analysis ; Carbon Dioxide/analysis ; Oxidation-Reduction ; Soil/*analysis ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 112
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    Extracellular replication of Listeria monocytogenes in the murine gall bladder (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-07
    Description: The bacterium Listeria monocytogenes can cause a life-threatening systemic illness in humans. Despite decades of progress in animal models of listeriosis, much remains unknown about the processes of infection and colonization. Here, we report that L. monocytogenes can replicate in the murine gall bladder and provide evidence that its replication there is extracellular and intraluminal. In vivo bioluminescence imaging was employed to determine the location of the infection over time in live animals, revealing strong signals from the gall bladder over a period of several days, in diseased as well as asymptomatic animals. The data suggest that L. monocytogenes may be carried in the human gall bladder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hardy, Jonathan -- Francis, Kevin P -- DeBoer, Monica -- Chu, Pauline -- Gibbs, Karine -- Contag, Christopher H -- R01HD37543/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2004 Feb 6;303(5659):851-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14764883" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Colony Count, Microbial ; Female ; Gallbladder/*microbiology ; Gallbladder Diseases/*microbiology ; Listeria monocytogenes/genetics/*growth & development/isolation & ; purification/pathogenicity ; Listeriosis/*microbiology ; Liver/microbiology ; Luminescence ; Mice ; Mice, Inbred BALB C ; Mutation ; Spleen/microbiology ; Time Factors ; Virulence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 113
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    Drug discovery (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2004 Mar 19;303(5665):1729.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15031461" target="_blank"〉PubMed〈/a〉
    Keywords: *Chemistry, Pharmaceutical ; Combinatorial Chemistry Techniques ; Drug Costs ; *Drug Design ; Drug Evaluation, Preclinical ; *Drug Industry/economics ; Economics, Pharmaceutical ; Financing, Government ; *Pharmaceutical Preparations ; *Research Support as Topic ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 114
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    Science, law, and the IBM case (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2004 Jul 16;305(5682):309.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15256641" target="_blank"〉PubMed〈/a〉
    Keywords: Computers ; *Epidemiologic Studies ; Humans ; Industry/*legislation & jurisprudence ; *Jurisprudence ; Neoplasms/*mortality ; Occupational Exposure/*adverse effects ; *Publishing ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 115
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    Cancer risk and salmon intake (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lund, Eiliv -- Engeset, Dagrun -- Alsaker, Elin -- Skeie, Gun -- Hjartaker, Anette -- Lundebye, Anne-Katrine -- Niebor, Evert -- New York, N.Y. -- Science. 2004 Jul 23;305(5683):477-8; author reply 477-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15273378" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cardiovascular Diseases/prevention & control ; *Diet ; Environmental Pollutants/analysis/toxicity ; Female ; *Fisheries ; *Food Contamination ; Humans ; Neoplasms/chemically induced/*epidemiology ; Norway ; Risk Assessment ; *Salmon
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 116
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    A welcome retreat at Treasury (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-04-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2004 Apr 9;304(5668):171.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15073338" target="_blank"〉PubMed〈/a〉
    Keywords: Commerce/*legislation & jurisprudence ; Cuba ; International Cooperation/*legislation & jurisprudence ; Peer Review, Research/*legislation & jurisprudence ; Publishing/*legislation & jurisprudence ; Travel/legislation & jurisprudence ; United States ; *United States Government Agencies
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 117
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    GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-08
    Description: Prostaglandin E2 (PGE2) is a crucial mediator of inflammatory pain sensitization. Here, we demonstrate that inhibition of a specific glycine receptor subtype (GlyR alpha3) by PGE2-induced receptor phosphorylation underlies central inflammatory pain sensitization. We show that GlyR alpha3 is distinctly expressed in superficial layers of the spinal cord dorsal horn. Mice deficient in GlyR alpha3 not only lack the inhibition of glycinergic neurotransmission by PGE2 seen in wild-type mice but also show a reduction in pain sensitization induced by spinal PGE2 injection or peripheral inflammation. Thus, GlyR alpha3 may provide a previously unrecognized molecular target in pain therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, Robert J -- Depner, Ulrike B -- Wassle, Heinz -- Ahmadi, Seifollah -- Heindl, Cornelia -- Reinold, Heiko -- Smart, Trevor G -- Harvey, Kirsten -- Schutz, Burkhard -- Abo-Salem, Osama M -- Zimmer, Andreas -- Poisbeau, Pierrick -- Welzl, Hans -- Wolfer, David P -- Betz, Heinrich -- Zeilhofer, Hanns Ulrich -- Muller, Ulrike -- New York, N.Y. -- Science. 2004 May 7;304(5672):884-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, The School of Pharmacy, London WC1N 1AX, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15131310" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cell Line ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Dinoprostone/administration & dosage/*metabolism/pharmacology ; Female ; Freund's Adjuvant ; Glycine/metabolism ; Humans ; Inflammation/metabolism/*physiopathology ; Male ; Mice ; Mice, Knockout ; Molecular Sequence Data ; Neurons/metabolism ; Pain/*physiopathology ; Patch-Clamp Techniques ; Phosphorylation ; Posterior Horn Cells/*metabolism ; Receptors, Glycine/chemistry/genetics/*metabolism ; Signal Transduction ; Spinal Cord/*metabolism ; Synaptic Transmission ; Transfection ; Zymosan
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 118
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    Biotechnology. Monsanto pulls the plug on genetically modified wheat (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2004 May 21;304(5674):1088-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15155915" target="_blank"〉PubMed〈/a〉
    Keywords: *Biotechnology ; Commerce ; Crops, Agricultural/*genetics ; Glycine/*analogs & derivatives/toxicity ; Herbicides/toxicity ; Marketing ; Nutritive Value ; *Plants, Genetically Modified ; Triticum/*genetics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Managing your own lab (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cech, Thomas R -- Bond, Enriqueta -- New York, N.Y. -- Science. 2004 Jun 18;304(5678):1717.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15205494" target="_blank"〉PubMed〈/a〉
    Keywords: *Education, Continuing ; *Faculty ; Laboratories/*organization & administration ; National Institutes of Health (U.S.) ; Personnel Management ; Research Personnel/*education ; Societies, Scientific ; United States ; Universities
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    Intersubject synchronization of cortical activity during natural vision (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-16
    Description: To what extent do all brains work alike during natural conditions? We explored this question by letting five subjects freely view half an hour of a popular movie while undergoing functional brain imaging. Applying an unbiased analysis in which spatiotemporal activity patterns in one brain were used to "model" activity in another brain, we found a striking level of voxel-by-voxel synchronization between individuals, not only in primary and secondary visual and auditory areas but also in association cortices. The results reveal a surprising tendency of individual brains to "tick collectively" during natural vision. The intersubject synchronization consisted of a widespread cortical activation pattern correlated with emotionally arousing scenes and regionally selective components. The characteristics of these activations were revealed with the use of an open-ended "reverse-correlation" approach, which inverts the conventional analysis by letting the brain signals themselves "pick up" the optimal stimuli for each specialized cortical area.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hasson, Uri -- Nir, Yuval -- Levy, Ifat -- Fuhrmann, Galit -- Malach, Rafael -- New York, N.Y. -- Science. 2004 Mar 12;303(5664):1634-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15016991" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Attention ; Auditory Cortex/physiology ; Brain Mapping ; Cerebral Cortex/*physiology ; Emotions ; Face ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; *Motion Pictures as Topic ; Occipital Lobe/physiology ; Photic Stimulation ; Temporal Lobe/physiology ; Vision, Ocular ; Visual Cortex/*physiology ; *Visual Perception
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    Drug safety. IOM recommends action on dietary supplements (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-04-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2004 Apr 9;304(5668):188.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15073343" target="_blank"〉PubMed〈/a〉
    Keywords: *Dietary Supplements/adverse effects/standards ; *Institute of Medicine (U.S.) ; Legislation, Drug ; Legislation, Food ; United States ; United States Food and Drug Administration/*legislation & jurisprudence
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    Periodical cicadas as resource pulses in North American forests (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-30
    Description: Resource pulses are occasional events of ephemeral resource superabundance that occur in many ecosystems. Aboveground consumers in diverse communities often respond strongly to resource pulses, but few studies have investigated the belowground consequences of resource pulses in natural ecosystems. This study shows that resource pulses of 17-year periodical cicadas (Magicicada spp.) directly increase microbial biomass and nitrogen availability in forest soils, with indirect effects on growth and reproduction in forest plants. These findings suggest that pulses of periodical cicadas create "bottom-up cascades," resulting in strong and reciprocal links between the aboveground and belowground components of a North American forest ecosystem.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, Louie H -- New York, N.Y. -- Science. 2004 Nov 26;306(5701):1565-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Population Biology, Section of Evolution and Ecology, University of California, One Shields Avenue, Davis, CA 95616, USA. lhyang@ucdavis.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15567865" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria/growth & development ; Biomass ; Campanulaceae/chemistry/*growth & development ; *Ecosystem ; Fatty Acids/analysis ; Fungi/growth & development ; Hemiptera/growth & development/*physiology ; Life Cycle Stages ; Nitrates/analysis ; Nitrogen Isotopes/analysis ; Quaternary Ammonium Compounds/analysis ; Seeds/growth & development ; Soil/analysis ; Soil Microbiology ; Time Factors ; *Trees/growth & development ; United States
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    Genetically modified organisms. Experts recommend a cautious approach (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2004 Jan 23;303(5657):449.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14739429" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Animals ; *Animals, Genetically Modified ; Arthropods/*genetics ; Crops, Agricultural/*genetics ; Genetics, Population ; Government Regulation ; National Academy of Sciences (U.S.) ; *Plants, Genetically Modified ; United States
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    Anterior cingulate conflict monitoring and adjustments in control (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-14
    Description: Conflict monitoring by the anterior cingulate cortex (ACC) has been posited to signal a need for greater cognitive control, producing neural and behavioral adjustments. However, the very occurrence of behavioral adjustments after conflict has been questioned, along with suggestions that there is no direct evidence of ACC conflict-related activity predicting subsequent neural or behavioral adjustments in control. Using the Stroop color-naming task and controlling for repetition effects, we demonstrate that ACC conflict-related activity predicts both greater prefrontal cortex activity and adjustments in behavior, supporting a role of ACC conflict monitoring in the engagement of cognitive control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerns, John G -- Cohen, Jonathan D -- MacDonald, Angus W 3rd -- Cho, Raymond Y -- Stenger, V Andrew -- Carter, Cameron S -- New York, N.Y. -- Science. 2004 Feb 13;303(5660):1023-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychological Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14963333" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Mapping ; *Cognition ; *Conflict (Psychology) ; Cues ; Female ; Frontal Lobe/*physiology ; Gyrus Cinguli/*physiology ; Humans ; Magnetic Resonance Imaging ; Male ; Neuropsychological Tests ; Prefrontal Cortex/*physiology ; Reaction Time
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    Gene targeting in stem cells from individuals with osteogenesis imperfecta (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-21
    Description: Adult stem cells offer the potential to treat many diseases through a combination of ex vivo genetic manipulation and autologous transplantation. Mesenchymal stem cells (MSCs, also referred to as marrow stromal cells) are adult stem cells that can be isolated as proliferating, adherent cells from bones. MSCs can differentiate into multiple cell types present in several tissues, including bone, fat, cartilage, and muscle, making them ideal candidates for a variety of cell-based therapies. Here, we have used adeno-associated virus vectors to disrupt dominant-negative mutant COL1A1 collagen genes in MSCs from individuals with the brittle bone disorder osteogenesis imperfecta, demonstrating successful gene targeting in adult human stem cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chamberlain, Joel R -- Schwarze, Ulrike -- Wang, Pei-Rong -- Hirata, Roli K -- Hankenson, Kurt D -- Pace, James M -- Underwood, Robert A -- Song, Kit M -- Sussman, Michael -- Byers, Peter H -- Russell, David W -- New York, N.Y. -- Science. 2004 Feb 20;303(5661):1198-201.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Washington, Seattle, WA 98195-7720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14976317" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Bone Marrow Cells/physiology ; Cell Differentiation ; Cells, Cultured ; Collagen Type I/chemistry/*genetics/metabolism ; Dependovirus/genetics ; *Gene Targeting ; Genetic Therapy ; Genetic Vectors ; Humans ; Kanamycin Kinase/genetics ; Male ; Mesenchymal Stromal Cells/*physiology ; Mice ; Osteogenesis ; Osteogenesis Imperfecta/*genetics/*therapy ; Point Mutation ; Recombination, Genetic ; Stem Cell Transplantation
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    Environment. Uncertain science underlies new mercury standards (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2004 Jan 2;303(5654):34.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14704409" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants/analysis/toxicity ; Animals ; Birds ; Fishes ; Food Chain ; Government Regulation ; Humans ; Maximum Allowable Concentration ; *Mercury/analysis/metabolism/toxicity ; Power Plants/*standards ; United States ; *United States Environmental Protection Agency
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    Neuronal activity related to reward value and motivation in primate frontal cortex (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-04-10
    Description: In several areas of the macaque brain, neurons fire during delayed-response tasks at a rate determined by the value of the reward expected at the end of the trial. The activity of these neurons might be related to the value of the expected reward or to the degree of motivation induced by expectation of the reward. We describe results indicating that the nature of reward-dependent activity varies across areas. Neuronal activity in orbitofrontal cortex represents the value of the expected reward, whereas neuronal activity in premotor cortex reflects the degree of motivation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roesch, Matthew R -- Olson, Carl R -- EY08098/EY/NEI NIH HHS/ -- EY11831/EY/NEI NIH HHS/ -- MH45156/MH/NIMH NIH HHS/ -- P41RR03631/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2004 Apr 9;304(5668):307-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for the Neural Basis of Cognition, Mellon Institute, Room 115, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA. roesch@cnbc.cmu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15073380" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cues ; Electrodes ; Frontal Lobe/*physiology ; Macaca mulatta ; Magnetic Resonance Imaging ; Male ; *Motivation ; Motor Cortex/physiology ; Neurons/*physiology ; Psychomotor Performance ; *Reward ; Saccades
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    Archaeology. Putting the stone in Stonehenge (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2004 Jun 25;304(5679):1889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15218116" target="_blank"〉PubMed〈/a〉
    Keywords: *Archaeology ; Dental Enamel/chemistry ; England ; Humans ; Male ; Oxygen Isotopes/analysis ; *Paleodontology ; Strontium/analysis ; Wales
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    Scientific exchanges. A wary pas de deux (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-09-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2004 Sep 17;305(5691):1696-703.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15375241" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Animals ; Biomedical Research ; *Biotechnology ; Cloning, Organism ; Humans ; *International Cooperation ; Korea ; Public Health ; *Research ; *Science ; United States ; Universities ; World Health Organization
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    Aging in rhesus monkeys: relevance to human health interventions (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-09-09
    Description: Progress in gerontological research has been promoted through the use of numerous animal models, which have helped identify possible mechanisms of aging and age-related chronic diseases and evaluate possible interventions with potential relevance to human aging and disease. Further development of nonhuman primate models, particularly rhesus monkeys, could accelerate this progress, because their closer genetic relationship to humans produces a highly similar aging phenotype. Because the relatively long lives of primates increase the administrative and economic demands on research involving them, new emphasis has emerged on increasing the efficient use of these valuable resources through cooperative, interdisciplinary research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roth, George S -- Mattison, Julie A -- Ottinger, Mary Ann -- Chachich, Mark E -- Lane, Mark A -- Ingram, Donald K -- New York, N.Y. -- Science. 2004 Sep 3;305(5689):1423-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Experimental Gerontology, Intramural Research Program, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15353793" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Biomarkers ; Caloric Restriction ; Chronic Disease ; Cross-Sectional Studies ; Disease Models, Animal ; Female ; Heart Diseases/physiopathology/therapy ; Humans ; Longitudinal Studies ; Macaca mulatta/*physiology ; Male ; *Models, Animal ; Neoplasms/physiopathology/therapy
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    International cooperation. Priorities for rebuilding civilian Iraqi science (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2004 May 14;304(5673):943-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15143250" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research ; Biotechnology ; *International Cooperation ; Iraq ; *Science ; United Arab Emirates ; United States
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    That's my hand! Activity in premotor cortex reflects feeling of ownership of a limb (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-03
    Description: When we look at our hands, we immediately know that they are part of our own body. This feeling of ownership of our limbs is a fundamental aspect of self-consciousness. We have studied the neuronal counterparts of this experience. A perceptual illusion was used to manipulate feelings of ownership of a rubber hand presented in front of healthy subjects while brain activity was measured by functional magnetic resonance imaging. The neural activity in the premotor cortex reflected the feeling of ownership of the hand. This suggests that multisensory integration in the premotor cortex provides a mechanism for bodily self-attribution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ehrsson, H Henrik -- Spence, Charles -- Passingham, Richard E -- New York, N.Y. -- Science. 2004 Aug 6;305(5685):875-7. Epub 2004 Jul 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK. h.ehrsson@fil.ion.ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15232072" target="_blank"〉PubMed〈/a〉
    Keywords: *Body Image ; Brain/physiology ; Brain Mapping ; Cerebellum/physiology ; Female ; Hand ; Humans ; Magnetic Resonance Imaging ; Male ; Motor Cortex/*physiology ; Neurons/*physiology ; Parietal Lobe/physiology ; Proprioception ; Time Factors ; Touch ; Vision, Ocular
    Print ISSN: 0036-8075
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    Neglect of women in science (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rubin, Vera -- New York, N.Y. -- Science. 2004 Dec 10;306(5703):1891.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15591185" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; Female ; Humans ; Male ; Men ; *Prejudice ; *Science ; *Women
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    Research ethics. South Korean cloning team denies improprieties (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, Dennis -- New York, N.Y. -- Science. 2004 May 14;304(5673):945.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15143251" target="_blank"〉PubMed〈/a〉
    Keywords: Authorship ; Cell Line ; Cloning, Organism/*ethics/legislation & jurisprudence ; *Embryo Research ; Embryo, Mammalian/*cytology ; Ethics Committees, Research ; *Ethics, Research ; Female ; Humans ; Korea ; Research Support as Topic ; *Stem Cells ; Tissue Donors
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    Neural systems underlying the suppression of unwanted memories (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-13
    Description: Over a century ago, Freud proposed that unwanted memories can be excluded from awareness, a process called repression. It is unknown, however, how repression occurs in the brain. We used functional magnetic resonance imaging to identify the neural systems involved in keeping unwanted memories out of awareness. Controlling unwanted memories was associated with increased dorsolateral prefrontal activation, reduced hippocampal activation, and impaired retention of those memories. Both prefrontal cortical and right hippocampal activations predicted the magnitude of forgetting. These results confirm the existence of an active forgetting process and establish a neurobiological model for guiding inquiry into motivated forgetting.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, Michael C -- Ochsner, Kevin N -- Kuhl, Brice -- Cooper, Jeffrey -- Robertson, Elaine -- Gabrieli, Susan W -- Glover, Gary H -- Gabrieli, John D E -- MH59940/MH/NIMH NIH HHS/ -- MH62126/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2004 Jan 9;303(5655):232-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Oregon, Eugene, OR 97403, USA. mcanders@darkwing.uoregon.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14716015" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Mapping ; Cues ; Female ; Gyrus Cinguli/physiology ; Hippocampus/*physiology ; Humans ; Magnetic Resonance Imaging ; *Memory ; Mental Recall ; Prefrontal Cortex/*physiology ; *Repression, Psychology ; Retention (Psychology) ; Temporal Lobe/physiology
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    Extensive gene traffic on the mammalian X chromosome (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-24
    Description: Mammalian sex chromosomes have undergone profound changes since evolving from ancestral autosomes. By examining retroposed genes in the human and mouse genomes, we demonstrate that, during evolution, the mammalian X chromosome has generated and recruited a disproportionately high number of functional retroposed genes, whereas the autosomes experienced lower gene turnover. Most autosomal copies originating from X-linked genes exhibited testis-biased expression. Such export is incompatible with mutational bias and is likely driven by natural selection to attain male germline function. However, the excess recruitment is consistent with a combination of both natural selection and mutational bias.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Emerson, J J -- Kaessmann, Henrik -- Betran, Esther -- Long, Manyuan -- GM-065429-01A1/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 Jan 23;303(5657):537-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14739461" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Chromosomes, Human/genetics ; Chromosomes, Human, X/*genetics ; Chromosomes, Mammalian/genetics ; Computational Biology ; Dosage Compensation, Genetic ; Female ; Gene Expression Profiling ; Genes, Duplicate ; Genetic Linkage ; Genome ; Genome, Human ; Humans ; Introns ; Male ; Mice ; Monte Carlo Method ; Mutation ; Oligonucleotide Array Sequence Analysis ; Ovary/metabolism ; Pseudogenes/*genetics ; *Recombination, Genetic ; Retroelements/*genetics ; Selection, Genetic ; Sex Characteristics ; Testis/metabolism ; X Chromosome/*genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Bioterrorism. Biosecurity goes global (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-09-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2004 Sep 17;305(5691):1706-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15375245" target="_blank"〉PubMed〈/a〉
    Keywords: Bioterrorism/*prevention & control ; *International Cooperation ; *Security Measures ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 138
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    Population-level HIV declines and behavioral risk avoidance in Uganda (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-01
    Description: Uganda provides the clearest example that human immunodeficiency virus (HIV) is preventable if populations are mobilized to avoid risk. Despite limited resources, Uganda has shown a 70% decline in HIV prevalence since the early 1990s, linked to a 60% reduction in casual sex. The response in Uganda appears to be distinctively associated with communication about acquired immunodeficiency syndrome (AIDS) through social networks. Despite substantial condom use and promotion of biomedical approaches, other African countries have shown neither similar behavioral responses nor HIV prevalence declines of the same scale. The Ugandan success is equivalent to a vaccine of 80% effectiveness. Its replication will require changes in global HIV/AIDS intervention policies and their evaluation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stoneburner, Rand L -- Low-Beer, Daniel -- New York, N.Y. -- Science. 2004 Apr 30;304(5671):714-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Population Health Evaluation Unit, Cambridge University, Cambridge, UK. randstoneburner@netzero.net〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15118157" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Distribution ; Condoms ; Disease Outbreaks ; Female ; HIV Infections/*epidemiology/*prevention & control ; Health Education ; Health Knowledge, Attitudes, Practice ; Humans ; Incidence ; Information Dissemination ; Male ; Middle Aged ; Pregnancy ; Pregnancy Complications, Infectious/*epidemiology/*prevention & control ; Prevalence ; *Risk Reduction Behavior ; Sexual Abstinence ; *Sexual Behavior ; Social Support ; Uganda/epidemiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 139
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    The importance of educating girls (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-09-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herz, Barbara -- New York, N.Y. -- Science. 2004 Sep 24;305(5692):1910-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15448252" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Developing Countries ; *Education ; Family ; Female ; Humans ; Male ; Population Growth ; *Women
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 140
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    Data security. Report upholds public access to genetic codes (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-09-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2004 Sep 17;305(5691):1692.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15375236" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; *Bioterrorism ; *Databases, Nucleic Acid ; *Genome, Bacterial ; *Genome, Viral ; Information Dissemination ; National Academy of Sciences (U.S.) ; Public Sector ; Security Measures ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 141
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    Physiology. Heeding the hormonal call (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zakon, Harold -- New York, N.Y. -- Science. 2004 Jul 16;305(5682):349-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Neurobiology, University of Texas, Austin, TX 78712, USA. h.zakon@mail.utexas.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15256660" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Batrachoidiformes/*physiology ; Biological Evolution ; Ear, Inner/drug effects/*innervation/physiology ; Electric Fish/physiology ; Estrogens/*pharmacology/physiology ; Female ; Hair Cells, Auditory/physiology ; Hearing/*physiology ; Male ; Neurons, Afferent/*physiology ; Receptors, Estrogen/physiology ; Reproduction ; Sensory Receptor Cells/physiology ; Sexual Behavior, Animal ; Testosterone/pharmacology/physiology ; Vestibulocochlear Nerve/physiology ; *Vocalization, Animal
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 142
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    Influenza. WHO adds more "1918" to pandemic predictions (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2004 Dec 17;306(5704):2025.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15604380" target="_blank"〉PubMed〈/a〉
    Keywords: Centers for Disease Control and Prevention (U.S.) ; Disease Outbreaks/*statistics & numerical data ; Forecasting ; *Global Health ; Humans ; Influenza Vaccines ; Influenza, Human/*mortality/transmission/virology ; Orthomyxoviridae/pathogenicity ; United States ; Virulence ; *World Health Organization
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Global workforce bolsters U.S. science (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zerhouni, Elias A -- New York, N.Y. -- Science. 2004 May 28;304(5675):1211.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15166330" target="_blank"〉PubMed〈/a〉
    Keywords: Career Choice ; *Engineering/education ; *Foreign Professional Personnel ; *Internationality ; Policy Making ; *Science/education ; Security Measures ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Oceanography. Other marine labs also paddle hard to stay afloat (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2004 Jul 9;305(5681):167.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15247449" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/*economics ; *Marine Biology ; *Oceanography ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 145
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    Influenza. Crisis underscores fragility of vaccine production system (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2004 Oct 15;306(5695):385.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15486259" target="_blank"〉PubMed〈/a〉
    Keywords: *Drug Contamination ; *Drug Industry ; Great Britain ; Humans ; Immunization Programs ; Influenza Vaccines/*supply & distribution ; Influenza, Human/prevention & control ; Licensure ; Serratia marcescens ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 146
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    Biomedicine. Do airborne particles induce heritable mutations? (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samet, Jonathan M -- DeMarini, David M -- Malling, Heinrich V -- New York, N.Y. -- Science. 2004 May 14;304(5673):971-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA. jsamet@jhsph.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15143266" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/*toxicity ; Air Pollution/*adverse effects ; Animals ; DNA Damage ; Female ; Filtration/instrumentation ; *Germ-Line Mutation ; Humans ; Industry ; Male ; Mice ; Mutagens/*toxicity ; Ontario ; Particle Size ; Polycyclic Hydrocarbons, Aromatic/toxicity ; Pregnancy ; Spermatogonia/drug effects/physiology ; Stem Cells/drug effects/physiology ; Tandem Repeat Sequences
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 147
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    Information access. NIH public access policy (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-14
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808281/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808281/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zerhouni, Elias A -- New York, N.Y. -- Science. 2004 Dec 10;306(5703):1895.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15591188" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; Copyright ; Cost-Benefit Analysis ; Financing, Government ; *Information Dissemination ; Internet ; *National Institutes of Health (U.S.)/economics ; National Library of Medicine (U.S.) ; Peer Review, Research ; Periodicals as Topic ; *Public Policy ; *Publishing ; *Research Support as Topic ; United States
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  • 148
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    Ecology. A head start for some redstarts (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hill, Geoffrey E -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2201-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Science, Auburn University, Auburn, AL 36849, USA. ghill@acesag.auburn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15619587" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Migration ; Animals ; Carotenoids/*analysis ; Feathers/*chemistry/growth & development ; Female ; Hydrogen/*analysis ; Isotopes ; Life Cycle Stages ; Male ; *Molting ; Pigmentation ; *Reproduction ; Seasons ; Songbirds/growth & development/*physiology ; Time Factors
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  • 149
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    Cognitive imitation in rhesus macaques (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-17
    Description: Experiments on imitation typically evaluate a student's ability to copy some feature of an expert's motor behavior. Here, we describe a type of observational learning in which a student copies a cognitive rule rather than a specific motor action. Two rhesus macaques were trained to respond, in a prescribed order, to different sets of photographs that were displayed on a touch-sensitive monitor. Because the position of the photographs varied randomly from trial to trial, sequences could not be learned by motor imitation. Both monkeys learned new sequences more rapidly after observing an expert execute those sequences than when they had to learn new sequences entirely by trial and error.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Subiaul, Francys -- Cantlon, Jessica F -- Holloway, Ralph L -- Terrace, Herbert S -- R01 MH40462/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2004 Jul 16;305(5682):407-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anthropology, Columbia University, New York, NY 10027, USA. subiaul@aol.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15256673" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cognition ; *Imitative Behavior ; *Learning ; Macaca mulatta/*physiology/psychology ; Male
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    Survivable development (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arledge, Bill -- New York, N.Y. -- Science. 2004 Jun 25;304(5679):1904.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15218126" target="_blank"〉PubMed〈/a〉
    Keywords: *Conservation of Natural Resources ; *Military Personnel ; Public Policy ; United States
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  • 151
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    Matching behavior and the representation of value in the parietal cortex (2004)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2004-06-19
    Description: Psychologists and economists have long appreciated the contribution of reward history and expectation to decision-making. Yet we know little about how specific histories of choice and reward lead to an internal representation of the "value" of possible actions. We approached this problem through an integrated application of behavioral, computational, and physiological techniques. Monkeys were placed in a dynamic foraging environment in which they had to track the changing values of alternative choices through time. In this context, the monkeys' foraging behavior provided a window into their subjective valuation. We found that a simple model based on reward history can duplicate this behavior and that neurons in the parietal cortex represent the relative value of competing actions predicted by this model.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sugrue, Leo P -- Corrado, Greg S -- Newsome, William T -- New York, N.Y. -- Science. 2004 Jun 18;304(5678):1782-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA. leo@monkeybiz.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15205529" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; *Choice Behavior ; Computer Simulation ; Cues ; Decision Making ; Macaca mulatta ; Male ; Mathematics ; Models, Psychological ; Neurons/physiology ; Parietal Lobe/*physiology ; Probability ; Regression Analysis ; Reward ; Saccades
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    Infectious diseases. Second lab accident fuels fears about SARS (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, Dennis -- New York, N.Y. -- Science. 2004 Jan 2;303(5654):26.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14704402" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Containment of Biohazards ; Guidelines as Topic ; Humans ; Laboratory Infection/prevention & control/*transmission ; Male ; *Medical Laboratory Personnel ; *SARS Virus ; Severe Acute Respiratory Syndrome/prevention & control/*transmission ; Taiwan ; World Health Organization
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  • 153
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    Extremist tendencies (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Ya-Ping -- He, Shigang -- New York, N.Y. -- Science. 2004 Dec 10;306(5703):1861.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15591167" target="_blank"〉PubMed〈/a〉
    Keywords: China ; *International Cooperation ; *Research ; *Research Personnel ; *Travel ; United States
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  • 154
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    A foot in each country (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cho, Adrian -- New York, N.Y. -- Science. 2004 May 28;304(5675):1286.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15166367" target="_blank"〉PubMed〈/a〉
    Keywords: Career Choice ; *Foreign Professional Personnel ; *Internationality ; *Research Personnel ; United States
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  • 155
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    NIOSH's work on firefighting (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schaitberger, Harold A -- New York, N.Y. -- Science. 2004 Jul 30;305(5684):607.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15286344" target="_blank"〉PubMed〈/a〉
    Keywords: *Fires ; Humans ; *National Institute for Occupational Safety and Health (U.S.)/organization & ; administration ; Occupational Health ; United States
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  • 156
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    Profile: Xavier Delannay (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2004 May 28;304(5675):1279.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15166359" target="_blank"〉PubMed〈/a〉
    Keywords: Belgium ; Biotechnology ; Career Choice ; Emigration and Immigration ; History, 20th Century ; History, 21st Century ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 157
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    Dissociable roles of ventral and dorsal striatum in instrumental conditioning (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-04-17
    Description: Instrumental conditioning studies how animals and humans choose actions appropriate to the affective structure of an environment. According to recent reinforcement learning models, two distinct components are involved: a "critic," which learns to predict future reward, and an "actor," which maintains information about the rewarding outcomes of actions to enable better ones to be chosen more frequently. We scanned human participants with functional magnetic resonance imaging while they engaged in instrumental conditioning. Our results suggest partly dissociable contributions of the ventral and dorsal striatum, with the former corresponding to the critic and the latter corresponding to the actor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Doherty, John -- Dayan, Peter -- Schultz, Johannes -- Deichmann, Ralf -- Friston, Karl -- Dolan, Raymond J -- New York, N.Y. -- Science. 2004 Apr 16;304(5669):452-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK. j.odoherty@fil.ion.ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15087550" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Basal Ganglia/*physiology ; Caudate Nucleus/*physiology ; Conditioning, Classical ; *Conditioning, Operant ; Female ; Humans ; Learning ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nucleus Accumbens/*physiology ; Probability ; Putamen/*physiology ; Reinforcement (Psychology) ; Reward
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 158
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    Biosecurity. Researchers urge U.S. to keep SARS off select agent list (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2004 Jun 18;304(5678):1726.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15205496" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *Biomedical Research ; *SARS Virus ; *Security Measures ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 159
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    Biodefense research. Accidental anthrax shipment spurs debate over safety (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- Kaiser, Jocelyn -- New York, N.Y. -- Science. 2004 Jun 18;304(5678):1726-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15205495" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthrax ; Anthrax Vaccines ; *Bacillus anthracis ; *Containment of Biohazards ; Humans ; Laboratory Infection ; Mice ; *Safety Management ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 160
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    Visual pattern recognition in Drosophila is invariant for retinal position (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-18
    Description: Vision relies on constancy mechanisms. Yet, these are little understood, because they are difficult to investigate in freely moving organisms. One such mechanism, translation invariance, enables organisms to recognize visual patterns independent of the region of their visual field where they had originally seen them. Tethered flies (Drosophila melanogaster) in a flight simulator can recognize visual patterns. Because their eyes are fixed in space and patterns can be displayed in defined parts of their visual field, they can be tested for translation invariance. Here, we show that flies recognize patterns at retinal positions where the patterns had not been presented before.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tang, Shiming -- Wolf, Reinhard -- Xu, Shuping -- Heisenberg, Martin -- New York, N.Y. -- Science. 2004 Aug 13;305(5686):1020-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Biophysics Academia Sinica, 15 Datun Road, Chaoyang, Beijing 100101, P.R. China. tang-shm@sohu.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15310908" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Color Perception ; Conditioning (Psychology) ; Cues ; Drosophila melanogaster/*physiology ; Female ; Flight, Animal ; Learning ; Orientation ; *Pattern Recognition, Visual ; Retina/physiology ; Size Perception
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 161
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    Emerging infectious diseases. A global fire brigade responds to disease outbreaks (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, Martin -- New York, N.Y. -- Science. 2004 Mar 12;303(5664):1605.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15016977" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Centers for Disease Control and Prevention (U.S.) ; Communicable Disease Control ; Communicable Diseases, Emerging/*epidemiology/prevention & control ; *Disease Outbreaks/prevention & control ; Humans ; Population Surveillance ; United States ; *World Health Organization/organization & administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 162
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    Marine conservation. U.S. asked to act immediately to protect deep-sea corals (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2004 Apr 2;304(5667):31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15060295" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthozoa ; *Conservation of Natural Resources ; *Ecosystem ; Environment ; *Porifera ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 163
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    NIOSH and the CDC reorganization (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Key, Marcus M -- Robbins, Anthony -- Millar, J Donald J -- Rosenstock, Linda -- New York, N.Y. -- Science. 2004 Jul 30;305(5684):607.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15286343" target="_blank"〉PubMed〈/a〉
    Keywords: Centers for Disease Control and Prevention (U.S.)/*organization & administration ; Government Regulation ; National Institute for Occupational Safety and Health (U.S.)/*organization & ; administration ; Research ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 164
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    Intellectual property. Most academics eschewing patents? (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2004 Mar 19;303(5665):1757.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15031475" target="_blank"〉PubMed〈/a〉
    Keywords: Intellectual Property ; *Patents as Topic ; *Research Personnel ; United States ; *Universities
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 165
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    Individual factors in suicide terrorism (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tobena, Adolf -- New York, N.Y. -- Science. 2004 Apr 2;304(5667):47-9; author reply 47-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15060306" target="_blank"〉PubMed〈/a〉
    Keywords: *Behavior ; Female ; Humans ; Islam ; Male ; *Personality ; Religion ; *Suicide ; Temperament ; *Terrorism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 166
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    Intellectual property. NIH roils academe with advice on licensing DNA patents (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2004 Mar 19;303(5665):1757-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15031474" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology/*legislation & jurisprudence ; *Dna ; Genes ; Guidelines as Topic ; *National Institutes of Health (U.S.) ; *Patents as Topic ; Technology Transfer ; United States ; Universities/*legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 167
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    Reversible immunocontraception in male monkeys immunized with eppin (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-13
    Description: Various forms of birth control have been developed for women; however, there are currently few options for men. The development of male contraceptives that are effective, safe, and reversible is desired for family planning throughout the world. We now report contraception of male nonhuman primates (Macaca radiata) immunized with Eppin, a testis/epididymis-specific protein. Seven out of nine males (78%) developed high titers to Eppin, and all of these high-titer monkeys were infertile. Five out of seven (71%) high-anti-Eppin titer males recovered fertility when immunization was stopped. This study demonstrates that effective and reversible male immunocontraception is an attainable goal. This method of immunocontraception may be extended to humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'rand, M G -- Widgren, E E -- Sivashanmugam, P -- Richardson, R T -- Hall, S H -- French, F S -- VandeVoort, C A -- Ramachandra, S G -- Ramesh, V -- Jagannadha Rao, A -- New York, N.Y. -- Science. 2004 Nov 12;306(5699):1189-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratories for Reproductive Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. morand@unc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15539605" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/analysis/blood ; *Contraception, Immunologic ; Female ; Fertility ; Freund's Adjuvant ; Immunization, Secondary ; Macaca mulatta ; Macaca radiata ; Male ; Proteinase Inhibitory Proteins, Secretory ; Proteins/*immunology ; Recombinant Proteins/immunology ; Semen/immunology ; Time Factors ; Vaccination ; *Vaccines, Contraceptive
    Print ISSN: 0036-8075
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  • 168
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    Brood parasitic cowbird nestlings use host young to procure resources (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-07
    Description: Young brood parasites that tolerate the company of host offspring challenge the existing evolutionary view of family life. In theory, all parasitic nestlings should be ruthlessly self-interested and should kill host offspring soon after hatching. Yet many species allow host young to live, even though they are rivals for host resources. Here we show that the tolerance of host nestlings by the parasitic brown-headed cowbird Molothrus ater is adaptive. Host young procure the cowbird a higher provisioning rate, so it grows more rapidly. The cowbird's unexpected altruism toward host offspring simply promotes its selfish interests in exploiting host parents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kilner, Rebecca M -- Madden, Joah R -- Hauber, Mark E -- New York, N.Y. -- Science. 2004 Aug 6;305(5685):877-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK. rmk1002@hermes.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15297677" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; Feeding Behavior ; Female ; Male ; *Nesting Behavior ; Regression Analysis ; Social Behavior ; Songbirds/growth & development/*physiology
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  • 169
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    An everlasting gender gap? (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2004 Jul 30;305(5684):639-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15286362" target="_blank"〉PubMed〈/a〉
    Keywords: Anaerobic Threshold ; Body Constitution ; Doping in Sports ; Female ; Heart/physiology ; Humans ; Male ; Muscle, Skeletal/anatomy & histology/physiology ; Oxygen Consumption ; Physical Endurance ; Pulmonary Ventilation ; *Running ; *Sex Characteristics ; Testosterone/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 170
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    Peering under the hood of Africa's runners (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2004 Jul 30;305(5684):637-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15286361" target="_blank"〉PubMed〈/a〉
    Keywords: Africa, Eastern ; Africa, Western ; *African Continental Ancestry Group/genetics ; Body Composition ; Body Constitution ; Energy Metabolism ; Female ; Humans ; Kenya ; Lactates/metabolism ; Leg/anatomy & histology ; Male ; Muscle Fibers, Fast-Twitch/physiology ; Muscle Fibers, Slow-Twitch/physiology ; Muscle, Skeletal/anatomy & histology/enzymology/*physiology ; Oxygen Consumption ; Physical Endurance ; Physical Fitness ; *Running/physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 171
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    Behavioral science. NIMH takes a new tack, upsetting behavioral researchers (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2004 Oct 22;306(5696):602.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15498989" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal ; *Behavioral Research ; *Biomedical Research ; Humans ; *Mental Disorders ; Mental Processes ; National Institute of Mental Health (U.S.)/*organization & administration ; Psychology, Social ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
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  • 172
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    Genetics. Ethical aspects of ES cell-derived gametes (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-09-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Testa, Giuseppe -- Harris, John -- New York, N.Y. -- Science. 2004 Sep 17;305(5691):1719.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genomics, BIOTEC, Dresden University of Technology, Dresden, Germany. testa@mpi-cbg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15375251" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bioethical Issues ; Cloning, Organism/*ethics ; Embryo Research/ethics ; Embryo, Mammalian/*cytology ; Female ; Fertilization in Vitro ; Genomic Imprinting ; *Germ Cells ; Humans ; Infertility ; Male ; Mice ; Parents ; Reproductive Techniques, Assisted/*ethics ; *Stem Cells
    Print ISSN: 0036-8075
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  • 173
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    Evolution of behavior. Seeking the key to music (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, Michael -- New York, N.Y. -- Science. 2004 Nov 12;306(5699):1120-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15539578" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Biological ; Animals ; *Biological Evolution ; Cooperative Behavior ; *Cultural Evolution ; Emotions ; Endorphins/physiology ; Female ; Humans ; Language ; Male ; Maternal Behavior ; *Music ; Nonverbal Communication ; Object Attachment ; Selection, Genetic ; Sexual Behavior ; *Social Behavior
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 174
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    Neuroscience. Imaging studies show how brain thinks about pain (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2004 Feb 20;303(5661):1121.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14976285" target="_blank"〉PubMed〈/a〉
    Keywords: *Analgesia ; Animals ; Brain/*physiology ; Brain Mapping ; Cerebral Cortex/physiology ; *Empathy ; Female ; Humans ; Limbic System/physiology ; Magnetic Resonance Imaging ; Male ; *Pain ; *Placebo Effect
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 175
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    What can progeroid syndromes tell us about human aging? (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-09-09
    Description: Human genetic diseases that resemble accelerated aging provide useful models for gerontologists. They combine known single-gene mutations with deficits in selected tissues that are reminiscent of changes seen during normal aging. Here, we describe recent progress toward linking molecular and cellular changes with the phenotype seen in two of these disorders. One in particular, Werner syndrome, provides evidence to support the hypothesis that the senescence of somatic cells may be a causal agent of normal aging.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kipling, David -- Davis, Terence -- Ostler, Elizabeth L -- Faragher, Richard G A -- New York, N.Y. -- Science. 2004 Sep 3;305(5689):1426-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15353794" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cell Aging ; Cell Division ; DNA Helicases/genetics/physiology ; Exodeoxyribonucleases ; Female ; Gene Expression ; Humans ; Male ; Mice ; Models, Animal ; Mutation ; Phenotype ; RecQ Helicases ; Telomere/metabolism ; *Werner Syndrome/genetics/pathology/physiopathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 176
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    White House. Researchers blast U.S. bioethics panel shuffle (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2004 Mar 5;303(5663):1447.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15001745" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; *Bioethics ; Biotechnology ; *Ethics Committees ; *Ethics, Research ; Politics ; Stem Cells ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Creationism. Georgia backs off a bit, but in other states battles heat up (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 2004 Feb 27;303(5662):1268.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14988522" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Evolution ; Biological Science Disciplines/education ; *Curriculum ; Georgia ; Natural Science Disciplines/education ; *Religion and Science ; Textbooks as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Education. Bonus pay for research faculty (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mallon, William T -- Korn, David -- New York, N.Y. -- Science. 2004 Jan 23;303(5657):476-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Association of American Medical Colleges, Washington, DC 20037, USA. wmallon@aamc.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14739444" target="_blank"〉PubMed〈/a〉
    Keywords: *Employee Incentive Plans ; *Faculty, Medical ; *Research Personnel ; Research Support as Topic ; *Salaries and Fringe Benefits ; *Schools, Medical ; Teaching ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Regulation of bone mass in mice by the lipoxygenase gene Alox15 (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-13
    Description: The development of osteoporosis involves the interaction of multiple environmental and genetic factors. Through combined genetic and genomic approaches, we identified the lipoxygenase gene Alox15 as a negative regulator of peak bone mineral density in mice. Crossbreeding experiments with Alox15 knockout mice confirmed that 12/15-lipoxygenase plays a role in skeletal development. Pharmacologic inhibitors of this enzyme improved bone density and strength in two rodent models of osteoporosis. These results suggest that drugs targeting the 12/15-lipoxygenase pathway merit investigation as a therapy for osteoporosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klein, Robert F -- Allard, John -- Avnur, Zafrira -- Nikolcheva, Tania -- Rotstein, David -- Carlos, Amy S -- Shea, Marie -- Waters, Ruth V -- Belknap, John K -- Peltz, Gary -- Orwoll, Eric S -- AR44659/AR/NIAMS NIH HHS/ -- HG02322/HG/NHGRI NIH HHS/ -- R01 AR044659/AR/NIAMS NIH HHS/ -- R01 AR044659-08/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2004 Jan 9;303(5655):229-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bone and Mineral Research Unit, Department of Medicine, School of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA. kleinro@ohsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14716014" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonate 12-Lipoxygenase/*genetics/*metabolism ; Arachidonate 15-Lipoxygenase/*genetics/*metabolism ; Bone Density/drug effects/*genetics ; Bone Marrow Cells/metabolism ; Cell Differentiation ; Cells, Cultured ; Crosses, Genetic ; Enzyme Inhibitors/pharmacology ; Female ; Fluorenes/pharmacology ; Gene Expression Profiling ; Genetic Linkage ; Kidney/metabolism ; Lipoxygenase Inhibitors ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Mice, Knockout ; Mice, Transgenic ; Oligonucleotide Array Sequence Analysis ; Osteoblasts/cytology/metabolism/physiology ; Osteogenesis ; Osteoporosis/enzymology ; Polymorphism, Genetic ; Quantitative Trait Loci ; Rats ; Receptors, Cytoplasmic and Nuclear/metabolism ; Stromal Cells/metabolism ; Transcription Factors/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 180
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    Transgenic RNAi reveals essential function for CTCF in H19 gene imprinting (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-13
    Description: The imprinted regulation of H19 and Insulin-like growth factor 2 expression involves binding of the vertebrate insulator protein, CCCTC binding factor (CTCF), to the maternally hypomethylated differentially methylated domain (DMD). How this hypomethylated state is maintained during oogenesis and the role of CTCF, if any, in this process are not understood. With the use of a transgenic RNA interference (RNAi)-based approach to generate oocytes with reduced amounts of CTCF protein, we found increased methylation of the H19 DMD and decreased developmental competence of CTCF-deficient oocytes. Our results suggest that CTCF protects the H19 DMD from de novo methylation during oocyte growth and is required for normal preimplantation development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fedoriw, Andrew M -- Stein, Paula -- Svoboda, Petr -- Schultz, Richard M -- Bartolomei, Marisa S -- HD-42026/HD/NICHD NIH HHS/ -- T32 HD-07516/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2004 Jan 9;303(5655):238-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14716017" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/genetics ; Animals ; DNA Methylation ; DNA-Binding Proteins/genetics/*metabolism ; Embryonic and Fetal Development ; Female ; Fertilization in Vitro ; Gene Targeting ; *Genomic Imprinting ; Litter Size ; Mice ; Mice, Transgenic ; Nuclear Proteins/genetics ; Oocytes/*metabolism ; *RNA Interference ; RNA, Long Noncoding ; RNA, Messenger/genetics/metabolism ; RNA, Untranslated/*genetics ; Repressor Proteins/genetics/*metabolism ; Zygote/physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Clinical trials or exploitation? (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marino, Ignazio R -- Cirillo, Claudia -- New York, N.Y. -- Science. 2004 Oct 1;306(5693):54-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15459369" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials as Topic/*ethics/standards ; Guidelines as Topic ; Humans ; *Internationality ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Gastric cancer originating from bone marrow-derived cells (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-30
    Description: Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow-derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Houghton, Jeanmarie -- Stoicov, Calin -- Nomura, Sachiyo -- Rogers, Arlin B -- Carlson, Jane -- Li, Hanchen -- Cai, Xun -- Fox, James G -- Goldenring, James R -- Wang, Timothy C -- CA95103/CA/NCI NIH HHS/ -- K22 CA90518/CA/NCI NIH HHS/ -- R01 CA87958/CA/NCI NIH HHS/ -- R01 DK58/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2004 Nov 26;306(5701):1568-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. jeanmarie.houghton@umassmed.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15567866" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Bone Marrow Cells/*cytology ; Bone Marrow Transplantation ; Carcinoma in Situ/pathology ; Cell Differentiation ; Cell Fusion ; Disease Progression ; Female ; Gastric Mucosa/chemistry/pathology ; Gastritis/*pathology ; Helicobacter Infections/*pathology ; *Helicobacter felis ; Keratins/analysis ; Male ; Mesenchymal Stromal Cells/physiology ; Metaplasia ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mucins/analysis ; Muscle Proteins/analysis ; Parietal Cells, Gastric/physiology ; Peptides/analysis ; Phenotype ; Stem Cells/*physiology ; Stomach Neoplasms/*pathology
    Print ISSN: 0036-8075
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    Hormone therapy: physiological complexity belies therapeutic simplicity (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-29
    Description: The results of the Women's Health Initiative, a study anticipated to provide definitive answers about health benefits and risks of postmenopausal hormone therapy, have generated debate and confusion among clinicians, researchers, and the lay public. The ovarian hormones estrogen and progesterone, which decline at menopause, normally elicit complex tissue-specific responses throughout the body. Major advances are providing a detailed molecular definition of how that differential action is achieved. Here we review estrogen and progestin actions, discuss how effectively knowledge of steroid hormone endocrinology has been incorporated into clinical studies, and consider the impact on modern hormone therapy protocols and pharmaceutical development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Turgeon, Judith L -- McDonnell, Donald P -- Martin, Kathryn A -- Wise, Phyllis M -- AG02224/AG/NIA NIH HHS/ -- AG17164/AG/NIA NIH HHS/ -- DK48807/DK/NIDDK NIH HHS/ -- DK50495/DK/NIDDK NIH HHS/ -- DK66606/DK/NIDDK NIH HHS/ -- HD12137/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2004 May 28;304(5675):1269-73.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, University of California-Davis, Davis, CA 95616, USA. jlturgeon@ucdavis.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15166356" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Animals ; Cardiovascular Physiological Phenomena/drug effects ; *Estrogen Replacement Therapy/adverse effects ; Estrogens/administration & dosage/pharmacology/*physiology ; Female ; Humans ; Lipid Metabolism ; Medroxyprogesterone Acetate/administration & dosage/metabolism/pharmacology ; Middle Aged ; Neuroprotective Agents ; Progesterone/metabolism/pharmacology/*physiology ; Randomized Controlled Trials as Topic ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Signal Transduction ; Stroke/prevention & control
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Genetics. Patient advocate named co-inventor on patent for the PXE disease gene (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-08-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2004 Aug 27;305(5688):1226.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15333813" target="_blank"〉PubMed〈/a〉
    Keywords: Genetic Testing ; Humans ; Molecular Diagnostic Techniques ; Multidrug Resistance-Associated Proteins/*genetics ; Mutation ; *Patents as Topic ; *Patient Advocacy ; Pseudoxanthoma Elasticum/diagnosis/*genetics ; United States
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    Medicine. Microbicide shuts the door on HIV (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2004 Oct 15;306(5695):387.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15486260" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Intravaginal ; Animals ; Anti-HIV Agents/administration & dosage/*therapeutic use ; Anti-Infective Agents, Local/administration & dosage/*therapeutic use ; *CCR5 Receptor Antagonists ; Chemokine CCL5/administration & dosage/*analogs & derivatives/*therapeutic use ; Female ; HIV/drug effects ; HIV Infections/*prevention & control/transmission ; Haplorhini ; Humans ; Male ; Receptors, CCR5/metabolism ; Simian Acquired Immunodeficiency Syndrome/*prevention & control/transmission ; Simian Immunodeficiency Virus/drug effects ; Vagina/virology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Social psychology. Why ordinary people torture enemy prisoners (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fiske, Susan T -- Harris, Lasana T -- Cuddy, Amy J C -- New York, N.Y. -- Science. 2004 Nov 26;306(5701):1482-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Princeton University, Princeton NJ 08544-1010, USA. sfiske@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15567841" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression ; Emotions ; Group Processes ; Human Rights Abuses ; Humans ; Interpersonal Relations ; Iraq ; Meta-Analysis as Topic ; Military Personnel/*psychology ; Peer Group ; Prejudice ; *Prisoners ; *Psychology, Social ; Social Conformity ; Stress, Physiological ; Torture/*psychology ; United States ; Warfare
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    AIDS treatment. Drugmakers test restrictions on generics in U.S. programs (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2004 Oct 8;306(5694):213.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15472049" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-HIV Agents/administration & dosage/*therapeutic use ; *Developing Countries ; *Drug Approval ; Drugs, Generic/administration & dosage/*therapeutic use ; HIV Infections/*drug therapy ; Humans ; Therapeutic Equivalency ; United States ; *United States Food and Drug Administration ; World Health Organization
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 188
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    Computational constraints on syntactic processing in a nonhuman primate (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-17
    Description: The capacity to generate a limitless range of meaningful expressions from a finite set of elements differentiates human language from other animal communication systems. Rule systems capable of generating an infinite set of outputs ("grammars") vary in generative power. The weakest possess only local organizational principles, with regularities limited to neighboring units. We used a familiarization/discrimination paradigm to demonstrate that monkeys can spontaneously master such grammars. However, human language entails more sophisticated grammars, incorporating hierarchical structure. Monkeys tested with the same methods, syllables, and sequence lengths were unable to master a grammar at this higher, "phrase structure grammar" level.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fitch, W Tecumseh -- Hauser, Marc D -- New York, N.Y. -- Science. 2004 Jan 16;303(5656):377-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Psychology, University of St. Andrews, St. Andrews, Fife, KY16 9AJ, Scotland. wtsf@st-andrews.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14726592" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Cues ; Female ; Humans ; Intelligence ; *Language ; *Learning ; *Linguistics ; Male ; Memory ; *Saguinus ; Speech
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  • 189
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    Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-14
    Description: Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition. In this study, we report the derivation of a pluripotent embryonic stem (ES) cell line (SCNT-hES-1) from a cloned human blastocyst. The SCNT-hES-1 cells displayed typical ES cell morphology and cell surface markers and were capable of differentiating into embryoid bodies in vitro and of forming teratomas in vivo containing cell derivatives from all three embryonic germ layers in severe combined immunodeficient mice. After continuous proliferation for more than 70 passages, SCNT-hES-1 cells maintained normal karyotypes and were genetically identical to the somatic nuclear donor cells. Although we cannot completely exclude the possibility that the cells had a parthenogenetic origin, imprinting analyses support a SCNT origin of the derived human ES cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hwang, Woo Suk -- Ryu, Young June -- Park, Jong Hyuk -- Park, Eul Soon -- Lee, Eu Gene -- Koo, Ja Min -- Jeon, Hyun Yong -- Lee, Byeong Chun -- Kang, Sung Keun -- Kim, Sun Jong -- Ahn, Curie -- Hwang, Jung Hye -- Park, Ky Young -- Cibelli, Jose B -- Moon, Shin Yong -- New York, N.Y. -- Science. 2004 Mar 12;303(5664):1669-74. Epub 2004 Feb 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. hwangws@snu.ac.kr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14963337" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomarkers/analysis ; Blastocyst/*cytology ; Cell Differentiation ; *Cell Line ; *Cloning, Organism ; Culture Media ; Culture Techniques ; DNA Fingerprinting ; Embryo, Mammalian/*cytology ; Female ; Genomic Imprinting ; Humans ; Karyotyping ; Male ; Mice ; Mice, SCID ; Nuclear Transfer Techniques ; Oocyte Donation ; Ovarian Follicle/cytology ; Parthenogenesis ; Pluripotent Stem Cells/chemistry/*cytology ; Reverse Transcriptase Polymerase Chain Reaction ; Tandem Repeat Sequences ; Teratoma/etiology/pathology ; Testicular Neoplasms/etiology/pathology
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    Medicine. Visfatin: a new adipokine (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hug, Christopher -- Lodish, Harvey F -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):366-7. Epub 2004 Dec 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15604359" target="_blank"〉PubMed〈/a〉
    Keywords: Adipocytes/metabolism ; Adipose Tissue/*metabolism ; Animals ; Blood Glucose/analysis ; Cytokines/blood/genetics/*metabolism ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Female ; Gene Targeting ; Glucose/metabolism ; Hepatocytes/metabolism ; Humans ; Insulin/blood/metabolism ; Mice ; Mice, Obese ; Molecular Mimicry ; Muscle Cells/metabolism ; Nicotinamide Phosphoribosyltransferase ; Receptor, Insulin/metabolism ; Recombinant Proteins/metabolism ; Subcutaneous Tissue ; Viscera
    Print ISSN: 0036-8075
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    Medicine. Metabolic defects tied to mitochondrial gene (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2004 Oct 22;306(5696):592-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15498983" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Mitochondrial/genetics ; Female ; Humans ; Hypercholesterolemia/*genetics ; Hypertension/*genetics ; Magnesium/*blood ; Metabolic Syndrome X/genetics ; Mitochondria/*genetics/metabolism ; *Point Mutation ; RNA, Transfer/chemistry/*genetics/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Asia and Africa: on different trajectories? (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2004 Jun 25;304(5679):1932-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15218138" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/epidemiology/prevention & control/transmission ; Africa/epidemiology ; Asia/epidemiology ; Computer Simulation ; Condoms ; *Disease Outbreaks ; Female ; HIV Infections/*epidemiology/prevention & control/transmission ; Harm Reduction ; Health Education ; Homosexuality, Male ; Humans ; Male ; Models, Statistical ; Needle-Exchange Programs ; Prevalence ; Prostitution ; Risk Factors ; Sexual Behavior ; Substance Abuse, Intravenous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 193
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    HIV/AIDS in India. Sonagachi sex workers stymie HIV (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2004 Apr 23;304(5670):506.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15105470" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/epidemiology/*prevention & ; control/transmission ; Community Health Workers ; Community-Institutional Relations ; Condoms ; Female ; HIV Infections/epidemiology/*prevention & control/transmission ; Humans ; India/epidemiology ; Prevalence ; *Prostitution
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 194
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    HIV/AIDS in India. HIV/AIDS: India's many epidemics (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2004 Apr 23;304(5670):504-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15105469" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; Acquired Immunodeficiency Syndrome/drug therapy/*epidemiology/transmission ; Ambulatory Care Facilities ; Anti-HIV Agents/therapeutic use ; Delivery of Health Care ; *Disease Outbreaks ; Drug Utilization ; Female ; Government Programs ; HIV Infections/drug therapy/*epidemiology/transmission ; Health Services Accessibility ; Hospitals ; Humans ; India/epidemiology ; Male ; Prevalence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 195
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    Recombination of human mitochondrial DNA (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kraytsberg, Yevgenya -- Schwartz, Marianne -- Brown, Timothy A -- Ebralidse, Konstantin -- Kunz, Wolfram S -- Clayton, David A -- Vissing, John -- Khrapko, Konstantin -- AG18388/AG/NIA NIH HHS/ -- AG19787/AG/NIA NIH HHS/ -- ES11343/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2004 May 14;304(5673):981.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15143273" target="_blank"〉PubMed〈/a〉
    Keywords: DNA Replication ; DNA, Mitochondrial/*genetics ; Fathers ; Female ; Humans ; Male ; Mitochondria, Muscle/genetics ; Mothers ; Polymerase Chain Reaction ; *Recombination, Genetic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 196
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    What's on the label? (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krebs, John -- New York, N.Y. -- Science. 2004 Nov 12;306(5699):1101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15539567" target="_blank"〉PubMed〈/a〉
    Keywords: Europe ; Food Industry ; *Food Labeling ; Food, Genetically Modified ; Humans ; *Nutrition Policy ; *Nutritional Physiological Phenomena ; Obesity ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 197
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    By carrot or by stick: cognitive reinforcement learning in parkinsonism (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-06
    Description: To what extent do we learn from the positive versus negative outcomes of our decisions? The neuromodulator dopamine plays a key role in these reinforcement learning processes. Patients with Parkinson's disease, who have depleted dopamine in the basal ganglia, are impaired in tasks that require learning from trial and error. Here, we show, using two cognitive procedural learning tasks, that Parkinson's patients off medication are better at learning to avoid choices that lead to negative outcomes than they are at learning from positive outcomes. Dopamine medication reverses this bias, making patients more sensitive to positive than negative outcomes. This pattern was predicted by our biologically based computational model of basal ganglia-dopamine interactions in cognition, which has separate pathways for "Go" and "NoGo" responses that are differentially modulated by positive and negative reinforcement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frank, Michael J -- Seeberger, Lauren C -- O'reilly, Randall C -- MH069597-01/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2004 Dec 10;306(5703):1940-3. Epub 2004 Nov 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309-0345, USA. frankmj@psych.colorado.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15528409" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Antiparkinson Agents/therapeutic use ; Basal Ganglia/*physiopathology ; *Cognition ; Computer Simulation ; Dopamine/*physiology ; Feedback, Psychological ; Female ; Frontal Lobe/physiopathology ; Humans ; *Learning ; Male ; Matched-Pair Analysis ; Middle Aged ; Models, Neurological ; Parkinson Disease/drug therapy/*physiopathology/*psychology ; Probability ; *Reinforcement (Psychology)
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 198
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    Medicine. Magic bullet gone astray: medications and the Internet (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Veronin, Michael A -- Youan, Bi-Botti C -- New York, N.Y. -- Science. 2004 Jul 23;305(5683):481.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA. michael.veronin@ttuhsc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15273381" target="_blank"〉PubMed〈/a〉
    Keywords: Commerce ; Drug Contamination ; *Drug Prescriptions/standards ; *Internet ; Legislation, Pharmacy ; Patient Education as Topic ; *Pharmacies ; Public Policy ; Simvastatin/chemistry/standards ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 199
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    The problems of bonus pay (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berg, Jeremy M -- New York, N.Y. -- Science. 2004 May 7;304(5672):824.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15131290" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Employee Incentive Plans ; *Faculty, Medical ; *Research Personnel ; Research Support as Topic ; *Salaries and Fringe Benefits ; Schools, Medical ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 200
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    Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-10-09
    Description: We report that Id knockout mouse embryos display multiple cardiac defects, but mid-gestation lethality is rescued by the injection of 15 wild-type embryonic stem (ES) cells into mutant blastocysts. Myocardial markers altered in Id mutant cells are restored to normal throughout the chimeric myocardium. Intraperitoneal injection of ES cells into female mice before conception also partially rescues the cardiac phenotype with no incorporation of ES cells. Insulin-like growth factor 1, a long-range secreted factor, in combination with WNT5a, a locally secreted factor, likely account for complete reversion of the cardiac phenotype. Thus, ES cells have the potential to reverse congenital defects through Id-dependent local and long-range effects in a mammalian embryo.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351017/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351017/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fraidenraich, Diego -- Stillwell, Elizabeth -- Romero, Elizabeth -- Wilkes, David -- Manova, Katia -- Basson, Craig T -- Benezra, Robert -- K01 HL076568/HL/NHLBI NIH HHS/ -- KO1HL076568/HL/NHLBI NIH HHS/ -- R01 CA107429/CA/NCI NIH HHS/ -- R01CA107429/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2004 Oct 8;306(5694):247-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Biology and Genetics Program, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15472070" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst ; Cell Division ; Cells, Cultured ; DNA-Binding Proteins/genetics ; Embryo Loss ; Embryo, Mammalian/*cytology ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Heart/*embryology ; Heart Defects, Congenital/embryology/*therapy ; Inhibitor of Differentiation Protein 1 ; Inhibitor of Differentiation Protein 2 ; Insulin-Like Growth Factor I/genetics/physiology ; Maternal-Fetal Exchange ; Mice ; Mice, Knockout ; Myocardium/cytology/metabolism ; Myocytes, Cardiac/cytology ; Oligonucleotide Array Sequence Analysis ; Pericardium/embryology/metabolism ; Pregnancy ; Proto-Oncogene Proteins/genetics/physiology ; Repressor Proteins/genetics ; *Stem Cell Transplantation ; Stem Cells/*physiology ; Transcription Factors/genetics ; Wnt Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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