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  • 1
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    Biomedicine. Do airborne particles induce heritable mutations? (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samet, Jonathan M -- DeMarini, David M -- Malling, Heinrich V -- New York, N.Y. -- Science. 2004 May 14;304(5673):971-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA. jsamet@jhsph.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15143266" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/*toxicity ; Air Pollution/*adverse effects ; Animals ; DNA Damage ; Female ; Filtration/instrumentation ; *Germ-Line Mutation ; Humans ; Industry ; Male ; Mice ; Mutagens/*toxicity ; Ontario ; Particle Size ; Polycyclic Hydrocarbons, Aromatic/toxicity ; Pregnancy ; Spermatogonia/drug effects/physiology ; Stem Cells/drug effects/physiology ; Tandem Repeat Sequences
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Genotoxicity biomarkers associated with exposure to traffic and near-road atmospheres: a review (2013)
    Oxford University Press
    Details
    Publication Date: 2013-08-14
    Print ISSN: 0267-8357
    Electronic ISSN: 1464-3804
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 3
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    Ionizing radiation-induced mutagenesis: radiation studies in Neurospora predictive for results in mammalian cells (1999)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: Ionizing radiation was the first mutagen discovered and was used to develop the first mutagenicity assay. In the ensuing 70+ years, ionizing radiation became a fundamental tool in understanding mutagenesis and is still a subject of intensive research. Frederick de Serres et al. developed and used the Neurospora crassa ad-3 system initially to explore the mutagenic effects of ionizing radiation. Using this system, de Serres et al. demonstrated the dependence of the frequency and spectra of mutations induced by ionizing radiation on the dose, dose rate, radiation quality, repair capabilities of the cells, and the target gene employed. This work in Neurospora predicted the subsequent observations of the mutagenic effects of ionizing radiation in mammalian cells. Modeled originally on the mouse specific-locus system developed by William L. Russell, the N. crassa ad-3 system developed by de Serres has itself served as a model for interpreting the results in subsequent systems in mammalian cells. This review describes the primary findings on the nature of ionizing radiation-induced mutagenesis in the N. crassa ad-3 system and the parallel observations made years later in mammalian cells.
    Keywords: Life Sciences (General)
    Type: Mutation research (ISSN 0027-5107); Volume 437; 2; 135-50
    Format: text
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    NASA TECHNICAL REPORTS
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