Publication Date:
2006-03-25
Description:
Targeted biological therapies hold tremendous potential for treatment of cancer, yet their use has been limited by constraints on delivery and effective tumor targeting. We combined an immune effector cell population [cytokine-induced killer (CIK) cells] with an oncolytic viral therapy to achieve directed delivery to, and regression of, tumors in both immunodeficient and immunocompetent mouse models. Preinfection of CIK cells with modified vaccinia virus resulted in a prolonged eclipse phase with the virus remaining hidden until interaction with the tumor. Whole-body imaging revealed that the cells retained their ability to traffic to and to infiltrate the tumor effectively before releasing the virus. These results illustrate the potential of combining biotherapeutics for synergistic effects that more effectively treat cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thorne, Steve H -- Negrin, Robert S -- Contag, Christopher H -- P01 CA49605/CA/NCI NIH HHS/ -- P50 CA114747/CA/NCI NIH HHS/ -- R24 CA 92862/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2006 Mar 24;311(5768):1780-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Pediatrics, Radiology, Microbiology, and Immunology Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16556847" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Line, Tumor
;
Female
;
Histocompatibility Antigens Class I/analysis
;
Humans
;
*Killer Cells, Natural/immunology/virology
;
Mammary Neoplasms, Experimental/therapy
;
Mice
;
Mice, Inbred BALB C
;
Neoplasm Transplantation
;
Neoplasms, Experimental/*therapy
;
*Oncolytic Virotherapy
;
Oncolytic Viruses/*physiology
;
Ovarian Neoplasms/therapy
;
Transplantation, Heterologous
;
Vaccinia virus/genetics/*physiology
;
Virus Replication
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink