Publication Date:
2004-11-30
Description:
Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow-derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Houghton, Jeanmarie -- Stoicov, Calin -- Nomura, Sachiyo -- Rogers, Arlin B -- Carlson, Jane -- Li, Hanchen -- Cai, Xun -- Fox, James G -- Goldenring, James R -- Wang, Timothy C -- CA95103/CA/NCI NIH HHS/ -- K22 CA90518/CA/NCI NIH HHS/ -- R01 CA87958/CA/NCI NIH HHS/ -- R01 DK58/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2004 Nov 26;306(5701):1568-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. jeanmarie.houghton@umassmed.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15567866" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Apoptosis
;
Bone Marrow Cells/*cytology
;
Bone Marrow Transplantation
;
Carcinoma in Situ/pathology
;
Cell Differentiation
;
Cell Fusion
;
Disease Progression
;
Female
;
Gastric Mucosa/chemistry/pathology
;
Gastritis/*pathology
;
Helicobacter Infections/*pathology
;
*Helicobacter felis
;
Keratins/analysis
;
Male
;
Mesenchymal Stromal Cells/physiology
;
Metaplasia
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Mucins/analysis
;
Muscle Proteins/analysis
;
Parietal Cells, Gastric/physiology
;
Peptides/analysis
;
Phenotype
;
Stem Cells/*physiology
;
Stomach Neoplasms/*pathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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