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  • Time Factors  (357)
  • American Association for the Advancement of Science (AAAS)  (357)
  • International Union of Crystallography (IUCr)
  • National Academy of Sciences
  • 2000-2004  (230)
  • 1980-1984  (127)
  • 1930-1934
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  • American Association for the Advancement of Science (AAAS)  (357)
  • International Union of Crystallography (IUCr)
  • National Academy of Sciences
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  • 1
    Publication Date: 2003-05-31
    Description: Patients with cerebellar damage are known to exhibit deficits in the temporal control of movements. We report that these deficits are restricted to discontinuous movements. Cerebellar patients exhibited no deficit in temporal variability when producing continuous, rhythmic movements. We hypothesize that the temporal properties of continuous movements are emergent and reflect the operation of other control parameters not associated with the cerebellum. In contrast, discontinuous movements require an explicit representation of the temporal goal, a function of the cerebellum. The requirement for explicit temporal representation provides a parsimonious account of cerebellar involvement in a range of tasks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spencer, Rebecca M C -- Zelaznik, Howard N -- Diedrichsen, Jorn -- Ivry, Richard B -- NS17778/NS/NINDS NIH HHS/ -- NS30256/NS/NINDS NIH HHS/ -- NS40813/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2003 May 30;300(5624):1437-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of California, Berkeley, 3210 Tolman Hall #1650, Berkeley, CA 94720, USA. rspencer@socrates.berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12775842" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Aged, 80 and over ; Cerebellar Diseases/*physiopathology ; Cerebellum/physiology/*physiopathology ; Female ; Humans ; Male ; Middle Aged ; *Motor Activity ; Movement ; *Psychomotor Performance ; Spinocerebellar Degenerations/*physiopathology ; Time Factors
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-07-06
    Description: Fishery management plans ignore the potential for evolutionary change in harvestable biomass. We subjected populations of an exploited fish (Menidia menidia) to large, small, or random size-selective harvest of adults over four generations. Harvested biomass evolved rapidly in directions counter to the size-dependent force of fishing mortality. Large-harvested populations initially produced the highest catch but quickly evolved a lower yield than controls. Small-harvested populations did the reverse. These shifts were caused by selection of genotypes with slower or faster rates of growth. Management tools that preserve natural genetic variation are necessary for long-term sustainable yield.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Conover, David O -- Munch, Stephan B -- New York, N.Y. -- Science. 2002 Jul 5;297(5578):94-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marine Sciences Research Center, State University of New York, Stony Brook, NY 11794-5000, USA. dconover@notes.cc.sunysb.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12098697" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Biomass ; Body Constitution ; Body Weight ; Conservation of Natural Resources ; *Fisheries ; Fishes/anatomy & histology/*genetics/*growth & development ; Genetic Variation ; Population Dynamics ; Regression Analysis ; *Selection, Genetic ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2002 Apr 19;296(5567):451-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11964452" target="_blank"〉PubMed〈/a〉
    Keywords: Canada/epidemiology ; Cluster Analysis ; Environmental Exposure/adverse effects ; *Famous Persons ; Female ; History, 21st Century ; Humans ; Male ; Parkinson Disease/*epidemiology/etiology ; *Television ; Time Factors ; Virus Diseases/complications/epidemiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2002-09-21
    Description: Conversion of new memories into a lasting form may involve the gradual refinement and linking together of neural representations stored widely throughout neocortex. This consolidation process may require coordinated reactivation of distributed components of memory traces while the cortex is "offline," i.e., not engaged in processing external stimuli. Simultaneous neural ensemble recordings from four sites in the macaque neocortex revealed such coordinated reactivation. In motor, somatosensory, and parietal cortex (but not prefrontal cortex), the behaviorally induced correlation structure and temporal patterning of neural ensembles within and between regions were preserved, confirming a major tenet of the trace-reactivation theory of memory consolidation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoffman, K L -- McNaughton, B L -- MH01565/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2002 Sep 20;297(5589):2070-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, AZ 85724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12242447" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain Mapping ; Cues ; Electrodes, Implanted ; Macaca mulatta ; Male ; Memory/*physiology ; Mental Recall/*physiology ; Motor Cortex/physiology ; Neocortex/*physiology ; Neurons/*physiology ; Parietal Lobe/physiology ; Prefrontal Cortex/physiology ; Somatosensory Cortex/physiology ; Time Factors
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lubick, Naomi -- New York, N.Y. -- Science. 2003 Jul 25;301(5632):451.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12881542" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; Conservation of Natural Resources ; DNA, Mitochondrial/genetics ; *Ecosystem ; Female ; Genetic Variation ; Genetics, Population ; Male ; Mutation ; Population Density ; Population Dynamics ; Time Factors ; *Whales/genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-07-26
    Description: It is well known that hunting dramatically reduced all baleen whale populations, yet reliable estimates of former whale abundances are elusive. Based on coalescent models for mitochondrial DNA sequence variation, the genetic diversity of North Atlantic whales suggests population sizes of approximately 240,000 humpback, 360,000 fin, and 265,000 minke whales. Estimates for fin and humpback whales are far greater than those previously calculated for prewhaling populations and 6 to 20 times higher than present-day population estimates. Such discrepancies suggest the need for a quantitative reevaluation of historical whale populations and a fundamental revision in our conception of the natural state of the oceans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roman, Joe -- Palumbi, Stephen R -- New York, N.Y. -- Science. 2003 Jul 25;301(5632):508-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12881568" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; Base Sequence ; Conservation of Natural Resources ; DNA, Mitochondrial/genetics ; *Ecosystem ; Female ; Genetic Variation ; Genetics, Population ; Male ; Molecular Sequence Data ; Population Density ; Population Dynamics ; Time Factors ; *Whales/classification/genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2003-09-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, Richard A -- New York, N.Y. -- Science. 2003 Sep 26;301(5641):1834.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14512597" target="_blank"〉PubMed〈/a〉
    Keywords: Extraterrestrial Environment ; *Mars ; Space Flight ; *Spacecraft ; Time Factors
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  • 8
    Publication Date: 2003-09-23
    Description: Dietary restriction (DR) increases life-span in organisms from yeast to mammals, presumably by slowing the accumulation of aging-related damage. Here we show that in Drosophila, DR extends life-span entirely by reducing the short-term risk of death. Two days after the application of DR at any age for the first time, previously fully fed flies are no more likely to die than flies of the same age that have been subjected to long-term DR. DR of mammals may also reduce short-term risk of death, and hence DR instigated at any age could generate a full reversal of mortality.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mair, William -- Goymer, Patrick -- Pletcher, Scott D -- Partridge, Linda -- New York, N.Y. -- Science. 2003 Sep 19;301(5640):1731-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14500985" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; *Caloric Restriction ; Demography ; *Diet ; Drosophila/*physiology ; Female ; *Longevity ; Male ; Mortality ; Reproduction ; Risk ; Temperature ; Time Factors
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  • 9
    Publication Date: 2003-01-11
    Description: In the Pacific Ocean, air and ocean temperatures, atmospheric carbon dioxide, landings of anchovies and sardines, and the productivity of coastal and open ocean ecosystems have varied over periods of about 50 years. In the mid-1970s, the Pacific changed from a cool "anchovy regime" to a warm "sardine regime." A shift back to an anchovy regime occurred in the middle to late 1990s. These large-scale, naturally occurring variations must be taken into account when considering human-induced climate change and the management of ocean living resources.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chavez, Francisco P -- Ryan, John -- Lluch-Cota, Salvador E -- Niquen C, Miguel -- New York, N.Y. -- Science. 2003 Jan 10;299(5604):217-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Monterey Bay Aquarium Research Institute, 7700 Sandholdt Road, Moss Landing, CA 95039, USA. chfr@mbari.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12522241" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atmosphere ; Birds ; Carbon Dioxide ; *Climate ; *Ecosystem ; *Fishes ; Pacific Ocean ; *Seawater ; Temperature ; Time Factors
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  • 10
    Publication Date: 2000-03-17
    Description: Chronic blockade of dopamine D2 receptors, a common mechanism of action for antipsychotic drugs, down-regulates D1 receptors in the prefrontal cortex and, as shown here, produces severe impairments in working memory. These deficits were reversed in monkeys by short-term coadministration of a D1 agonist, ABT 431, and this improvement was sustained for more than a year after cessation of D1 treatment. These findings indicate that pharmacological modulation of the D1 signaling pathway can produce long-lasting changes in functional circuits underlying working memory. Resetting this pathway by brief exposure to the agonist may provide a valuable strategy for therapeutic intervention in schizophrenia and other dopamine dysfunctional states.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Castner, S A -- Williams, G V -- Goldman-Rakic, P S -- P01DA10160/DA/NIDA NIH HHS/ -- P50MH44866/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2000 Mar 17;287(5460):2020-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10720329" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antipsychotic Agents/*pharmacology ; Cyclic AMP/metabolism ; Dopamine/metabolism ; Dopamine Agonists/*pharmacology ; Dopamine Antagonists/pharmacology ; Down-Regulation ; Female ; Haloperidol/*pharmacology ; Haplorhini ; Memory/*drug effects ; Prefrontal Cortex/drug effects/metabolism ; Psychomotor Performance/drug effects ; Pyridines/*pharmacology ; Receptors, Dopamine D1/agonists/*metabolism ; Signal Transduction ; Tetrahydronaphthalenes/*pharmacology ; Time Factors
    Print ISSN: 0036-8075
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2000-02-26
    Description: Repetition priming has been characterized neurophysiologically as a decreased response following stimulus repetition. The present study used event-related functional magnetic resonance imaging to investigate whether this repetition-related response is sensitive to stimulus familiarity. A right fusiform region exhibited an attenuated response to the repetition of familiar stimuli, both faces and symbols, but exhibited an enhanced response to the repetition of unfamiliar stimuli. Moreover, both repetition effects were modulated by lag between successive presentations. Further experiments replicated the interactions between repetition, familiarity, and lag and demonstrated the persistence of these effects over multiple repetitions. Priming-related responses are therefore not unitary but depend on the presence or absence of preexisting stimulus representations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Henson, R -- Shallice, T -- Dolan, R -- New York, N.Y. -- Science. 2000 Feb 18;287(5456):1269-72.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Department of Cognitive Neurology, Institute of Neurology, Institute of Cognitive Neuroscience and Department of Psychology, University College London, London WC1E 6BT, UK. r.henson@ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10678834" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Mapping ; Face ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Memory/*physiology ; *Pattern Recognition, Visual ; Regression Analysis ; Temporal Lobe/*physiology ; Time Factors
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  • 12
    Publication Date: 2000-11-25
    Description: We generated a mutant of the red fluorescent protein drFP583. The mutant (E5) changes its fluorescence from green to red over time. The rate of color conversion is independent of protein concentration and therefore can be used to trace time-dependent expression. We used in vivo labeling with E5 to measure expression from the heat shock-dependent promoter in Caenorhabditis elegans and from the Otx-2 promoter in developing Xenopus embryos. Thus, E5 is a "fluorescent timer" that can be used to monitor both activation and down-regulation of target promoters on the whole-organism scale.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Terskikh, A -- Fradkov, A -- Ermakova, G -- Zaraisky, A -- Tan, P -- Kajava, A V -- Zhao, X -- Lukyanov, S -- Matz, M -- Kim, S -- Weissman, I -- Siebert, P -- 1 RO3 TW01362-01/TW/FIC NIH HHS/ -- New York, N.Y. -- Science. 2000 Nov 24;290(5496):1585-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Medicine, Stanford University, Stanford, CA 94305, USA. Alexey.Terskikh@Stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11090358" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/embryology/metabolism ; Caenorhabditis elegans/embryology/genetics ; Cell Line ; Color ; Fluorescence ; Gene Expression Profiling/*methods ; *Gene Expression Regulation ; Gene Expression Regulation, Developmental ; Heat-Shock Proteins/genetics ; *Homeodomain Proteins ; Humans ; Luminescent Proteins/*chemistry/*genetics/metabolism ; Mutation ; Nerve Tissue Proteins/genetics ; Otx Transcription Factors ; *Promoter Regions, Genetic ; Temperature ; Time Factors ; Trans-Activators/genetics ; Xenopus laevis/embryology
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  • 13
    Publication Date: 2000-02-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, R D -- Meltzer, D -- Duan, N -- New York, N.Y. -- Science. 2000 Jan 14;287(5451):237-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Illinois at Chicago, Chicago, IL 60612, USA. rdgib@uic.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10660422" target="_blank"〉PubMed〈/a〉
    Keywords: *Government Regulation ; Health Policy ; Humans ; Institute of Medicine (U.S.) ; *Liver Transplantation/mortality ; *Organ Transplantation/mortality ; *Patient Selection ; *Resource Allocation ; Time Factors ; *Tissue and Organ Procurement/legislation & jurisprudence/standards ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
    Publication Date: 2001-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Streets, D G -- Jiang, K -- Hu, X -- Sinton, J E -- Zhang, X Q -- Xu, D -- Jacobson, M Z -- Hansen, J E -- New York, N.Y. -- Science. 2001 Nov 30;294(5548):1835-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Decision and Information Sciences Division, Argonne National Laboratory, Argonne, IL 60439, USA. dstreets@anl.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11729288" target="_blank"〉PubMed〈/a〉
    Keywords: Bioelectric Energy Sources/economics ; Carbon Dioxide/*metabolism ; China ; Coal/economics ; *Conservation of Energy Resources/economics ; Electricity ; *Energy-Generating Resources/economics ; *Greenhouse Effect ; Methane/metabolism ; Time Factors ; Wood
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  • 15
    Publication Date: 2001-11-27
    Description: Adhesions between fibroblastic cells and extracellular matrix have been studied extensively in vitro, but little is known about their in vivo counterparts. Here, we characterized the composition and function of adhesions in three-dimensional (3D) matrices derived from tissues or cell culture. "3D-matrix adhesions" differ from focal and fibrillar adhesions characterized on 2D substrates in their content of alpha5beta1 and alphavbeta3 integrins, paxillin, other cytoskeletal components, and tyrosine phosphorylation of focal adhesion kinase (FAK). Relative to 2D substrates, 3D-matrix interactions also display enhanced cell biological activities and narrowed integrin usage. These distinctive in vivo 3D-matrix adhesions differ in structure, localization, and function from classically described in vitro adhesions, and as such they may be more biologically relevant to living organisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cukierman, E -- Pankov, R -- Stevens, D R -- Yamada, K M -- New York, N.Y. -- Science. 2001 Nov 23;294(5547):1708-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11721053" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Animals ; *Cell Adhesion/drug effects ; Cell Culture Techniques/methods ; Cell Division ; Cell Movement ; Cell Size ; Cells, Cultured ; Culture Techniques/methods ; Cycloheximide/pharmacology ; Cytoskeletal Proteins/metabolism ; Extracellular Matrix/chemistry/metabolism ; Fibroblasts/chemistry/*cytology/*metabolism ; Fibronectins/metabolism ; Fluorescent Antibody Technique, Indirect ; Focal Adhesion Kinase 1 ; Focal Adhesion Protein-Tyrosine Kinases ; Focal Adhesions/chemistry/metabolism ; Glutaral/metabolism ; Humans ; Imaging, Three-Dimensional/*methods ; Integrins/metabolism ; Mice ; Mitogen-Activated Protein Kinases/metabolism ; Molecular Conformation ; Phosphorylation ; Protein-Tyrosine Kinases/metabolism ; Time Factors
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  • 16
    Publication Date: 2001-04-17
    Description: In mammals, the central circadian pacemaker resides in the hypothalamic suprachiasmatic nucleus (SCN), but circadian oscillators also exist in peripheral tissues. Here, using wild-type and cryptochrome (mCry)-deficient cell lines derived from mCry mutant mice, we show that the peripheral oscillator in cultured fibroblasts is identical to the oscillator in the SCN in (i) temporal expression profiles of all known clock genes, (ii) the phase of the various mRNA rhythms (i.e., antiphase oscillation of Bmal1 and mPer genes), (iii) the delay between maximum mRNA levels and appearance of nuclear mPER1 and mPER2 protein, (iv) the inability to produce oscillations in the absence of functional mCry genes, and (v) the control of period length by mCRY proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yagita, K -- Tamanini, F -- van Der Horst, G T -- Okamura, H -- New York, N.Y. -- Science. 2001 Apr 13;292(5515):278-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, Chuo-ku, Kobe 650-0017, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11303101" target="_blank"〉PubMed〈/a〉
    Keywords: ARNTL Transcription Factors ; Animals ; Basic Helix-Loop-Helix Transcription Factors ; Biological Clocks/*genetics ; CLOCK Proteins ; Cell Cycle Proteins ; Cell Line ; Cell Nucleus/metabolism ; Circadian Rhythm/*genetics ; Cryptochromes ; *DNA-Binding Proteins ; *Drosophila Proteins ; Endothelin-1/pharmacology ; *Eye Proteins ; Fibroblasts/*physiology ; Flavoproteins/genetics/metabolism ; Gene Expression Profiling ; *Gene Expression Regulation ; Nuclear Proteins/genetics/metabolism ; Period Circadian Proteins ; *Photoreceptor Cells, Invertebrate ; RNA, Messenger/genetics/metabolism ; Rats ; Receptors, G-Protein-Coupled ; Suprachiasmatic Nucleus/metabolism ; Time Factors ; Trans-Activators/genetics/metabolism ; Transcription Factors/genetics/metabolism
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-10-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daniels, S R -- New York, N.Y. -- Science. 2001 Sep 28;293(5539):2392-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11579936" target="_blank"〉PubMed〈/a〉
    Keywords: Antihypertensive Agents/*therapeutic use ; *Controlled Clinical Trials as Topic ; Follow-Up Studies ; Humans ; Hypertension/*drug therapy ; Meta-Analysis as Topic ; *Placebos/adverse effects ; Time Factors
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  • 18
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beckman, M -- New York, N.Y. -- Science. 2001 Nov 30;294(5548):1803.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11729272" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Nucleus/*virology ; Cytoplasm/*virology ; Dependovirus/*physiology ; Fluorescence ; Genetic Vectors/physiology ; Host-Parasite Interactions/physiology ; Humans ; Microscopy, Fluorescence/methods ; Spectrometry, Fluorescence/*methods ; Time Factors
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 2001 Jul 27;293(5530):624-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11474094" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Animals ; Databases, Factual ; *Ecology ; *Ecosystem ; Government Agencies ; International Cooperation ; Internet ; Plants ; Research Support as Topic ; Software ; Time Factors ; Trees ; Weather
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berendsen, H J -- New York, N.Y. -- Science. 2001 Dec 14;294(5550):2304-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Nijenborgh 4, 9747 AG Groningen, Netherlands. berendsen@chem.rug.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11743188" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Aquaporin 1 ; Aquaporins/chemistry/*metabolism ; Bacterial Outer Membrane Proteins/chemistry/*metabolism ; Cell Membrane Permeability ; *Computational Biology ; *Computer Simulation ; *Escherichia coli Proteins ; Hydrogen Bonding ; Kinetics ; Lipid Bilayers ; *Models, Biological ; Permeability ; Static Electricity ; Time Factors ; Water/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 2001 Jul 27;293(5530):626.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11474096" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Dioxide ; Disasters ; Ecology ; *Ecosystem ; Financing, Government ; Government Agencies ; Massachusetts ; Research Support as Topic ; Time Factors ; *Trees
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  • 22
    Publication Date: 2001-12-01
    Description: We describe a method, based on single-molecule imaging, that allows the real-time visualization of the infection pathway of single viruses in living cells, each labeled with only one fluorescent dye molecule. The tracking of single viruses removes ensemble averaging. Diffusion trajectories with high spatial and time resolution show various modes of motion of adeno-associated viruses (AAV) during their infection pathway into living HeLa cells: (i) consecutive virus touching at the cell surface and fast endocytosis; (ii) free and anomalous diffusion of the endosome and the virus in the cytoplasm and the nucleus; and (iii) directed motion by motor proteins in the cytoplasm and in nuclear tubular structures. The real-time visualization of the infection pathway of single AAVs shows a much faster infection than was generally observed so far.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seisenberger, G -- Ried, M U -- Endress, T -- Buning, H -- Hallek, M -- Brauchle, C -- New York, N.Y. -- Science. 2001 Nov 30;294(5548):1929-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department Chemie, Ludwig-Maximilians-Universitat Munchen, Butenandtstrasse 11, D-81377 Munchen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11729319" target="_blank"〉PubMed〈/a〉
    Keywords: Adsorption ; Biological Transport ; Cell Nucleus/*virology ; Cell Survival ; Cytoplasm/*virology ; Dependovirus/*physiology ; Diffusion ; Endocytosis ; Endosomes/virology ; Fluorescence ; Fluorescent Dyes/metabolism ; Genetic Vectors/physiology ; HeLa Cells ; Host-Parasite Interactions/physiology ; Humans ; Microscopy, Fluorescence/*methods ; Molecular Motor Proteins/metabolism ; Movement ; Nocodazole/pharmacology ; Spectrometry, Fluorescence/*methods ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, A -- New York, N.Y. -- Science. 2001 May 11;292(5519):1044-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11352044" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Computer Graphics ; *Computer Simulation ; Computers ; Fractals ; Image Processing, Computer-Assisted/*methods ; Internet ; Microscopy, Video ; Motion Pictures as Topic ; Publishing ; Reproducibility of Results ; Software ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 24
    Publication Date: 2001-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tynan, C T -- DeMaster, D P -- Peterson, W T -- New York, N.Y. -- Science. 2001 Nov 30;294(5548):1894.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Northwest Fisheries Science Center (NWFSC), National Oceanic and Atmospheric Administration (NOAA), Seattle, WA 98112, USA. Cynthia.Tynan@noaa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11729308" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Migration ; Animals ; *Ecosystem ; *Environment ; Food Chain ; *Geography ; Pacific Ocean ; Seawater ; Survival Rate ; Temperature ; Time Factors ; Whales/*physiology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickrell, J -- New York, N.Y. -- Science. 2001 Jul 27;293(5530):625.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11474095" target="_blank"〉PubMed〈/a〉
    Keywords: Ecology ; *Ecosystem ; England ; *Fertilizers ; Poaceae/*growth & development ; Time Factors
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-03-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, K -- New York, N.Y. -- Science. 2001 Mar 9;291(5510):1884-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11245184" target="_blank"〉PubMed〈/a〉
    Keywords: Angiosperms/growth & development/*physiology ; Ecosystem ; Seasons ; Seeds/growth & development/*physiology ; Time Factors
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-03-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simkin, T -- Siebert, L -- Blong, R -- New York, N.Y. -- Science. 2001 Jan 12;291(5502):255.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Museum of Natural History, Smithsonian Institution, Washington, DC 20560-0119, USA. simkin@nmnh.si.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11253213" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Mortality ; Time Factors ; Volcanic Eruptions/*statistics & numerical data
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  • 28
    Publication Date: 2001-06-26
    Description: The location and mechanisms responsible for the carbon sink in northern mid-latitude lands are uncertain. Here, we used an improved estimation method of forest biomass and a 50-year national forest resource inventory in China to estimate changes in the storage of living biomass between 1949 and 1998. Our results suggest that Chinese forests released about 0.68 petagram of carbon between 1949 and 1980, for an annual emission rate of 0.022 petagram of carbon. Carbon storage increased significantly after the late 1970s from 4.38 to 4.75 petagram of carbon by 1998, for a mean accumulation rate of 0.021 petagram of carbon per year, mainly due to forest expansion and regrowth. Since the mid-1970s, planted forests (afforestation and reforestation) have sequestered 0.45 petagram of carbon, and their average carbon density increased from 15.3 to 31.1 megagrams per hectare, while natural forests have lost an additional 0.14 petagram of carbon, suggesting that carbon sequestration through forest management practices addressed in the Kyoto Protocol could help offset industrial carbon dioxide emissions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fang, J -- Chen, A -- Peng, C -- Zhao, S -- Ci, L -- New York, N.Y. -- Science. 2001 Jun 22;292(5525):2320-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Urban and Environmental Science, and Key Laboratory for Earth Surface Processes of the Ministry of Education, Peking University, Beijing 100871, China. jyfang@urban.pku.edu.cn〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11423660" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomass ; *Carbon ; Carbon Dioxide ; China ; Conservation of Natural Resources ; Forestry ; Time Factors ; *Trees
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-11-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferber, D -- New York, N.Y. -- Science. 2001 Nov 23;294(5547):1638-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11721029" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biolistics ; Blood Pressure ; Clinical Trials as Topic ; Coronary Artery Disease/genetics/therapy ; DNA/administration & dosage/genetics ; Electroporation ; Gene Expression ; Gene Transfer Techniques/*trends ; Genetic Therapy/*methods/trends ; Genetic Vectors/*administration & dosage/*adverse effects/genetics ; Hemophilia A/genetics/therapy ; Humans ; Injections, Intra-Arterial ; Melanoma/genetics/therapy ; Microinjections ; Muscular Dystrophies/genetics/therapy ; Organ Specificity ; Plasmids/administration & dosage/genetics ; RNA/administration & dosage/genetics ; Time Factors ; Transfection ; Transgenes/genetics ; Viruses/genetics/pathogenicity
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adkins, J -- New York, N.Y. -- Science. 2001 Nov 30;294(5548):1844-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉California Institute of Technology, Pasadena, CA 91125, USA. jess@gps.caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11729292" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; *Atmosphere ; Calibration ; Carbon/metabolism ; Carbon Dioxide/metabolism ; Carbon Radioisotopes/metabolism ; Cold Climate ; Cosmic Radiation ; Geologic Sediments/*analysis/chemistry/parasitology ; Greenland ; Half-Life ; Ice ; Plankton/metabolism ; *Seawater ; Temperature ; Time Factors ; Volcanic Eruptions
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  • 31
    Publication Date: 2001-12-01
    Description: Marine reserves have been widely promoted as conservation and fishery management tools. There are robust demonstrations of conservation benefits, but fishery benefits remain controversial. We show that marine reserves in Florida (United States) and St. Lucia have enhanced adjacent fisheries. Within 5 years of creation, a network of five small reserves in St. Lucia increased adjacent catches of artisanal fishers by between 46 and 90%, depending on the type of gear the fishers used. In Florida, reserve zones in the Merritt Island National Wildlife Refuge have supplied increasing numbers of world record-sized fish to adjacent recreational fisheries since the 1970s. Our study confirms theoretical predictions that marine reserves can play a key role in supporting fisheries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, C M -- Bohnsack, J A -- Gell, F -- Hawkins, J P -- Goodridge, R -- New York, N.Y. -- Science. 2001 Nov 30;294(5548):1920-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA. cr10@york.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11729316" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Biomass ; Cnidaria/physiology ; Conservation of Natural Resources/*methods ; *Ecosystem ; Fisheries/*methods/statistics & numerical data ; *Fishes/physiology ; Florida ; Humans ; Middle Aged ; Saint Lucia ; Time Factors
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  • 32
    Publication Date: 2001-04-17
    Description: We present an analysis of the current foot-and-mouth disease epidemic in Great Britain over the first 2 months of the spread of the virus. The net transmission potential of the pathogen and the increasing impact of control measures are estimated over the course of the epidemic to date. These results are used to parameterize a mathematical model of disease transmission that captures the differing spatial contact patterns between farms before and after the imposition of movement restrictions. The model is used to make predictions of future incidence and to simulate the impact of additional control strategies. Hastening the slaughter of animals with suspected infection is predicted to slow the epidemic, but more drastic action, such as "ring" culling or vaccination around infection foci, is necessary for more rapid control. Culling is predicted to be more effective than vaccination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferguson, N M -- Donnelly, C A -- Anderson, R M -- New York, N.Y. -- Science. 2001 May 11;292(5519):1155-60. Epub 2001 Apr 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Infectious Disease Epidemiology, Imperial College School of Medicine, St. Mary's Campus, Norfolk Place, London W2 1PG, UK. Neil.Ferguson@ic.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11303090" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Domestic/virology ; Aphthovirus/physiology ; Cattle ; Commerce ; Disease Reservoirs ; Foot-and-Mouth Disease/economics/epidemiology/*prevention & control/*transmission ; Great Britain/epidemiology ; Incidence ; Models, Biological ; Quarantine ; Sheep/virology ; Swine/virology ; Time Factors ; Vaccination/economics
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  • 33
    Publication Date: 2001-06-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Al-Khatib, S M -- Califf, R M -- Hasselblad, V -- Alexander, J H -- McCrory, D C -- Sugarman, J -- New York, N.Y. -- Science. 2001 Jun 15;292(5524):2013-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Duke Clinical Research Institute, Durham, NC 27710, USA. alkha001@mc.duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11408643" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Antihypertensive Agents/*therapeutic use ; Bayes Theorem ; *Control Groups ; Ethics, Medical ; Humans ; Hypertension/*drug therapy ; Patient Selection ; *Placebos/adverse effects ; *Randomized Controlled Trials as Topic ; Risk Factors ; Time Factors
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-11-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, D -- New York, N.Y. -- Science. 2001 Nov 23;294(5547):1634.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11721025" target="_blank"〉PubMed〈/a〉
    Keywords: Age Determination by Skeleton ; Archaeology/*methods/*standards ; *Fossils ; Humans ; Japan ; Publishing/legislation & jurisprudence ; Reproducibility of Results ; Research Personnel/psychology/standards ; Suicide ; Time Factors
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-12-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rollin, B E -- Loew, F M -- New York, N.Y. -- Science. 2001 Nov 30;294(5548):1831-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11732546" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Care Committees ; Animal Experimentation ; Animal Rights ; Animal Welfare/*standards ; Animals ; Decision Making ; Ethical Review/*standards ; *Models, Animal ; Peer Review, Research/methods/*standards ; Reproducibility of Results ; Research Design/*standards ; Time Factors
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉States, D J -- New York, N.Y. -- Science. 2001 May 11;292(5519):1066-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11352052" target="_blank"〉PubMed〈/a〉
    Keywords: Authorship ; Base Sequence ; Databases as Topic ; *Human Genome Project/economics ; Humans ; National Institutes of Health (U.S.) ; *Public Sector/economics ; *Publishing ; Time Factors ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-07-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koenig, R -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11441159" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Climate ; Cnidaria/physiology ; Conservation of Natural Resources ; Greenhouse Effect ; Humans ; Ice ; International Cooperation ; Oceans and Seas ; Specimen Handling/*methods ; Temperature ; Time Factors ; Trees/growth & development/physiology
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  • 38
    Publication Date: 2001-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alverson, K -- Bradley, R -- Briffa, K -- Cole, J -- Hughes, M -- Larocque, I -- Pedersen, T -- Thompson, L -- Tudhope, S -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):47-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11444288" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Dioxide/metabolism ; *Climate ; Cnidaria/physiology ; Conservation of Natural Resources ; Greenhouse Effect ; Humans ; Ice ; Oceans and Seas ; Rain ; Seawater/analysis/chemistry ; Specimen Handling/*methods ; Temperature ; Time Factors ; Trees/growth & development/physiology
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  • 39
    Publication Date: 2001-02-07
    Description: Mitral cells (MCs) in the olfactory bulb (OB) respond to odors with slow temporal firing patterns. The representation of each odor by activity patterns across the MC population thus changes continuously throughout a stimulus, in an odor-specific manner. In the zebrafish OB, we found that this distributed temporal patterning progressively reduced the similarity between ensemble representations of related odors, thereby making each odor's representation more specific over time. The tuning of individual MCs was not sharpened during this process. Hence, the individual responses of MCs did not become more specific, but the odor-coding MC assemblies changed such that their overlap decreased. This optimization of ensemble representations did not occur among olfactory afferents but resulted from OB circuit dynamics. Time can therefore gradually optimize stimulus representations in a sensory network.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friedrich, R W -- Laurent, G -- New York, N.Y. -- Science. 2001 Feb 2;291(5505):889-94.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉California Institute of Technology, Division of Biology, MC 139-74, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11157170" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids ; Animals ; Dendrites/physiology ; In Vitro Techniques ; Interneurons/physiology ; Membrane Potentials ; Neural Conduction ; Neural Inhibition ; Neurons/physiology ; *Odors ; Olfactory Bulb/*cytology/*physiology ; Olfactory Pathways/physiology ; Olfactory Receptor Neurons/physiology ; Patch-Clamp Techniques ; Receptors, Odorant/physiology ; Smell/*physiology ; Time Factors ; Zebrafish
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  • 40
    Publication Date: 2002-03-30
    Description: Television viewing and aggressive behavior were assessed over a 17-year interval in a community sample of 707 individuals. There was a significant association between the amount of time spent watching television during adolescence and early adulthood and the likelihood of subsequent aggressive acts against others. This association remained significant after previous aggressive behavior, childhood neglect, family income, neighborhood violence, parental education, and psychiatric disorders were controlled statistically.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, Jeffrey G -- Cohen, Patricia -- Smailes, Elizabeth M -- Kasen, Stephanie -- Brook, Judith S -- DA-03188/DA/NIDA NIH HHS/ -- MH-36971/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2002 Mar 29;295(5564):2468-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Columbia University and the New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA. jjohnso@pi.cpmc.columbia.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11923542" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Aggression ; Child Abuse ; Educational Status ; Female ; Humans ; Income ; Interviews as Topic ; Longitudinal Studies ; Male ; Mental Disorders ; Sex Characteristics ; Socioeconomic Factors ; Surveys and Questionnaires ; *Television ; Theft ; Time Factors ; *Violence
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  • 41
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zimmer, Carl -- New York, N.Y. -- Science. 2002 May 10;296(5570):999-1000.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004092" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Cell Division ; Chromosomes/physiology ; Embryo, Nonmammalian/physiology ; Female ; Fertilization ; Male ; Motion Pictures as Topic ; Nuclear Envelope/physiology ; Reproduction ; Sex Determination Processes ; Sex Ratio ; Time Factors ; Wasps/embryology/*microbiology/*physiology ; Wolbachia/*physiology ; Zygote/*physiology
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  • 42
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2002 Mar 22;295(5563):2197.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11910085" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antarctic Regions ; Birds/blood/*genetics ; Bone and Bones/metabolism ; DNA, Mitochondrial/*genetics/isolation & purification ; Emigration and Immigration ; *Evolution, Molecular ; *Fossils ; Genetic Variation/genetics ; *Ice ; Mutagenesis/genetics ; Phylogeny ; Siberia ; Time Factors ; Ursidae/*genetics
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  • 43
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brookmeyer, Ron -- Blades, Natalie -- New York, N.Y. -- Science. 2002 Mar 8;295(5561):1861.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. rbrook@jhsph.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11884746" target="_blank"〉PubMed〈/a〉
    Keywords: Anthrax/epidemiology/*prevention & control ; *Antibiotic Prophylaxis ; Bacillus anthracis ; *Bioterrorism ; Disease Outbreaks/*prevention & control ; Humans ; Likelihood Functions ; Models, Statistical ; Population Surveillance ; Probability ; Respiratory Tract Infections/epidemiology/*prevention & control ; Risk Assessment ; Spores, Bacterial ; Time Factors ; United States/epidemiology
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  • 44
    Publication Date: 2002-11-09
    Description: In young animals, monocular deprivation leads to an ocular dominance shift, whereas in adults after the critical period there is no such shift. Chondroitin sulphate proteoglycans (CSPGs) are components of the extracellular matrix (ECM) inhibitory for axonal sprouting. We tested whether the developmental maturation of the ECM is inhibitory for experience-dependent plasticity in the visual cortex. The organization of CSPGs into perineuronal nets coincided with the end of the critical period and was delayed by dark rearing. After CSPG degradation with chondroitinase-ABC in adult rats, monocular deprivation caused an ocular dominance shift toward the nondeprived eye. The mature ECM is thus inhibitory for experience-dependent plasticity, and degradation of CSPGs reactivates cortical plasticity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pizzorusso, Tommaso -- Medini, Paolo -- Berardi, Nicoletta -- Chierzi, Sabrina -- Fawcett, James W -- Maffei, Lamberto -- New York, N.Y. -- Science. 2002 Nov 8;298(5596):1248-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Scuola Normale Superiore, 56100 Pisa, Italy. tommaso@in.pi.cnr.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12424383" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/physiology ; Chondroitin ABC Lyase/*metabolism ; Chondroitin Sulfate Proteoglycans/*metabolism ; Darkness ; *Dominance, Ocular ; Extracellular Matrix/*metabolism ; Extracellular Matrix Proteins/metabolism ; Glycosaminoglycans/metabolism ; Lectins, C-Type ; Light ; Nerve Tissue Proteins/metabolism ; *Neuronal Plasticity ; Neurons/physiology ; Rats ; Synapses/physiology ; Time Factors ; Visual Acuity ; Visual Cortex/*physiology
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  • 45
    Publication Date: 2002-04-06
    Description: We experimentally show that in blue tits (Parus caeruleus) egg-laying date is causally linked to experience in the previous year. Females that received additional food in the nestling period in one year laid eggs later in the next year compared with the control birds, whatever the degree of synchronization with the natural food abundance in the previous year. As a result, they raised their brood much later than the peak period of nestling food availability in the next year. The response to experience is adaptive for blue tits, which live in heterogeneous habitats where the peak period of food varies, but once settled will breed at the same location for life.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grieco, Fabrizio -- van Noordwijk, Arie J -- Visser, Marcel E -- New York, N.Y. -- Science. 2002 Apr 5;296(5565):136-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Netherlands Institute of Ecology, Center for Terrestrial Ecology, Post Office Box 40, 6666 ZG Heteren, Netherlands. grieco@cto.nioo.knaw.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11935025" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; *Behavior, Animal ; Cues ; Environment ; Female ; *Food ; *Learning ; Male ; *Oviposition ; *Reproduction ; Songbirds/*physiology ; Time Factors
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  • 46
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-03-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, Craig A -- Bushman, Brad J -- New York, N.Y. -- Science. 2002 Mar 29;295(5564):2377-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Iowa State University, Ames, IA 50011-3180, USA. caa@iastate.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11923513" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Aggression ; Humans ; Longitudinal Studies ; *Social Problems ; *Television ; Time Factors ; *Violence
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  • 47
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2000-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, J -- New York, N.Y. -- Science. 2000 Mar 24;287(5461):2170-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, UCLA Medical School, Los Angeles, CA 90095-1751, USA. jdiamond@mednet.ucla.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10744538" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Archaeology ; *Birds/physiology ; Humans ; New Zealand ; Population Dynamics ; Reproduction ; Time Factors
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  • 48
    Publication Date: 2000-12-23
    Description: Quantifying the moisture history of the Amazon Basin is essential for understanding the cause of rain forest diversity and its potential as a methane source. We reconstructed the Amazon River outflow history for the past 14,000 years to provide a moisture budget for the river drainage basin. The oxygen isotopic composition of planktonic foraminifera recovered from a marine sediment core in a region of Amazon River discharge shows that the Amazon Basin was extremely dry during the Younger Dryas, with the discharge reduced by at least 40% as compared with that of today. After the Younger Dryas, a meltwater-driven discharge event was followed by a steady increase in the Amazon Basin effective moisture throughout the Holocene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maslin, M A -- Burns, S J -- New York, N.Y. -- Science. 2000 Dec 22;290(5500):2285-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Environmental Change Research Centre, Department of Geography, University College London, 26 Bedford Way, London, WC1H 0AP, UK. mmaslin@geog.ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11125137" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; Brazil ; *Climate ; Eukaryota/*chemistry ; *Fresh Water ; *Geologic Sediments ; Methane ; Oxygen Isotopes/*analysis ; Seawater ; Temperature ; Time Factors ; Zooplankton/*chemistry
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  • 49
    Publication Date: 2000-11-10
    Description: The hippocampal CA1 region is crucial for converting new memories into long-term memories, a process believed to continue for week(s) after initial learning. By developing an inducible, reversible, and CA1-specific knockout technique, we could switch N-methyl-D-aspartate (NMDA) receptor function off or on in CA1 during the consolidation period. Our data indicate that memory consolidation depends on the reactivation of the NMDA receptor, possibly to reinforce site-specific synaptic modifications to consolidate memory traces. Such a synaptic reinforcement process may also serve as a cellular means by which the new memory is transferred from the hippocampus to the cortex for permanent storage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimizu, E -- Tang, Y P -- Rampon, C -- Tsien, J Z -- New York, N.Y. -- Science. 2000 Nov 10;290(5494):1170-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11073458" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning (Psychology) ; Doxycycline/pharmacology ; Excitatory Postsynaptic Potentials ; Fear ; Green Fluorescent Proteins ; Hippocampus/*physiology ; Long-Term Potentiation ; Luminescent Proteins/biosynthesis ; Maze Learning ; Memory/*physiology ; Mice ; Mice, Knockout ; Mice, Transgenic ; Receptors, AMPA/physiology ; Receptors, N-Methyl-D-Aspartate/genetics/*physiology ; Retention (Psychology) ; Synapses/*physiology ; Synaptic Transmission ; Time Factors
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  • 50
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2000-07-06
    Description: Establishing the date when immunodeficiency viruses were transmitted from nonhuman primates to humans should provide a clue to the origin of the AIDS pandemic. In his Perspective, Hillis discusses an important analysis of the molecular divergence of SIV and HIV genes (Korber et al.). This analysis establishes 1931 as the date of origin of the HIV-1 M-group viruses (the principal cause of the AIDS pandemic). Hillis discusses three possible hypotheses of immunodeficiency virus transmission that are consistent with this date.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hillis, D M -- New York, N.Y. -- Science. 2000 Jun 9;288(5472):1757-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Integrative Biology and the Institute for Cellular and Molecular Biology, School of Biological Sciences, University of Texas, Austin, TX 78712, USA. dhillis@mail.utexas.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10877695" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/epidemiology/*transmission/*virology ; Africa/epidemiology ; Animals ; Confidence Intervals ; Disease Outbreaks ; *Evolution, Molecular ; Genes, env ; Genes, gag ; HIV-1/classification/*genetics ; Humans ; Pan troglodytes ; Phylogeny ; Simian Acquired Immunodeficiency Syndrome/transmission/virology ; Simian Immunodeficiency Virus/classification/*genetics ; Time Factors ; Zoonoses
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2000-12-02
    Description: Natural enemy-victim interactions are of major applied importance and of fundamental interest to ecologists. A key question is what stabilizes these interactions, allowing the long-term coexistence of the two species. Three main theoretical explanations have been proposed: behavioral responses, time-dependent factors such as delayed density dependence, and spatial heterogeneity. Here, using the powerful moment-closure technique, we show a fundamental equivalence between these three elements. Limited movement by organisms is a ubiquitous feature of ecological systems, allowing spatial structure to develop; we show that the effects of this can be naturally described in terms of time lags or within-generation functional responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keeling, M J -- Wilson, H B -- Pacala, S W -- New York, N.Y. -- Science. 2000 Dec 1;290(5497):1758-61.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. matt@zoo.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11099413" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Computer Simulation ; *Ecosystem ; *Host-Parasite Interactions ; Mathematics ; *Models, Biological ; Models, Statistical ; Movement ; Population Dynamics ; Reproduction ; Stochastic Processes ; Time Factors
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  • 52
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2000-08-19
    Description: Most researchers have believed that the days were long gone when water splashed on the surface of Mars or even near it. Now continuing analyses of martian meteorites and stunning images from the Mars Global Surveyor (MGS), which has been in orbit since 1997, are breathing new life into the Red Planet. Last month's announcement that the camera aboard MGS had spied signs of geologically recent--possibly even ongoing--water seeps has caught everyone's attention. Other, perhaps more persuasive, signs also suggest that water may even now flow on or beneath the frigid surface.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, R A -- New York, N.Y. -- Science. 2000 Aug 4;289(5480):714-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10950711" target="_blank"〉PubMed〈/a〉
    Keywords: Exobiology ; *Extraterrestrial Environment ; Hot Temperature ; *Mars ; Meteoroids ; Time Factors ; Volcanic Eruptions ; *Water
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  • 53
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Patel, S S -- Ogmen, H -- Bedell, H E -- Sampath, V -- R01-EY05068/EY/NEI NIH HHS/ -- R01-MH49892/MH/NIMH NIH HHS/ -- T30-EY07551/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2000 Nov 10;290(5494):1051.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Electrical & Computer Engineering, College of Engineering, University of Houston, Houston, TX 77204, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11184992" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Models, Neurological ; *Motion Perception ; *Optical Illusions ; Time Factors ; *Visual Perception
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  • 54
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2000-02-05
    Description: The Redfield ratio [carbon:nitrogen:phosphorus (C:N:P)] of particle flux to the deep ocean is a key factor in marine biogeochemical cycling. Changes in oceanic carbon sequestration have been linked to variations in the Redfield ratio on geological time scales, but this ratio generally is assumed to be constant with time in the modern ocean. However, deep-water Redfield ratios in the northern hemisphere show evidence for temporal trends over the past five decades. The North Atlantic Ocean exhibits a rising N:P ratio, which may be related to increased deposition of atmospheric nitrous oxides from anthropogenic N emissions. In the North Pacific Ocean, increasing C:N and C:P ratios are accompanied by rising remineralization rates, which suggests intensified export production. Stronger export of carbon in this region may be due to enhanced bioavailability of aeolian iron. These findings imply that the biological part of the marine carbon cycle currently is not in steady state.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pahlow, M -- Riebesell, U -- New York, N.Y. -- Science. 2000 Feb 4;287(5454):831-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Alfred Wegener Institute for Polar and Marine Research, Post Office Box 120161, D-27515 Bremerhaven, Germany. mpahlow@awi-bremerhaven.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10657291" target="_blank"〉PubMed〈/a〉
    Keywords: Atlantic Ocean ; Carbon/*analysis ; Nitrogen/*analysis ; Pacific Ocean ; Phosphorus/*analysis ; Seawater/*chemistry ; Time Factors
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  • 55
    Publication Date: 2001-07-28
    Description: Ecological extinction caused by overfishing precedes all other pervasive human disturbance to coastal ecosystems, including pollution, degradation of water quality, and anthropogenic climate change. Historical abundances of large consumer species were fantastically large in comparison with recent observations. Paleoecological, archaeological, and historical data show that time lags of decades to centuries occurred between the onset of overfishing and consequent changes in ecological communities, because unfished species of similar trophic level assumed the ecological roles of overfished species until they too were overfished or died of epidemic diseases related to overcrowding. Retrospective data not only help to clarify underlying causes and rates of ecological change, but they also demonstrate achievable goals for restoration and management of coastal ecosystems that could not even be contemplated based on the limited perspective of recent observations alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jackson, J B -- Kirby, M X -- Berger, W H -- Bjorndal, K A -- Botsford, L W -- Bourque, B J -- Bradbury, R H -- Cooke, R -- Erlandson, J -- Estes, J A -- Hughes, T P -- Kidwell, S -- Lange, C B -- Lenihan, H S -- Pandolfi, J M -- Peterson, C H -- Steneck, R S -- Tegner, M J -- Warner, R R -- New York, N.Y. -- Science. 2001 Jul 27;293(5530):629-37.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0244, USA. jbcj@ucsd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11474098" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Archaeology ; Bacteria ; Cnidaria ; Conservation of Natural Resources ; *Ecosystem ; Eutrophication ; *Fishes ; Geologic Sediments ; Humans ; *Marine Biology ; Seaweed ; Shellfish ; Time Factors
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-09-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bancroft, C -- Bowler, T -- Bloom, B -- Clelland, C T -- New York, N.Y. -- Science. 2001 Sep 7;293(5536):1763-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11556362" target="_blank"〉PubMed〈/a〉
    Keywords: Archaeology ; DNA/*chemistry/*genetics/metabolism ; Fossils ; Information Storage and Retrieval/*methods ; Literature ; Oligonucleotide Array Sequence Analysis/methods ; Sensitivity and Specificity ; Time Factors
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  • 57
    Publication Date: 2001-07-07
    Description: The brain frequently needs to store information for short periods. In vision, this means that the perceptual correlate of a stimulus has to be maintained temporally once the stimulus has been removed from the visual scene. However, it is not known how the visual system transfers sensory information into a memory component. Here, we identify a neural correlate of working memory in the monkey primary visual cortex (V1). We propose that this component may link sensory activity with memory activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Super, H -- Spekreijse, H -- Lamme, V A -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):120-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Graduate School Neurosciences Amsterdam, Department of Visual System Analysis, Academic Medical Center, University of Amsterdam, Post Office Box 12011, 1100 AA Amsterdam, Netherlands. h.super@ioi.knaw.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11441187" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Computers ; Cues ; Electrodes ; Fixation, Ocular/physiology ; Macaca mulatta/*physiology ; Memory/*physiology ; Motion ; Neurons/*physiology ; Photic Stimulation ; Saccades/physiology ; Time Factors ; Visual Cortex/*physiology
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  • 58
    Publication Date: 2001-11-17
    Description: We document the decimation and recovery of the commonest lizard species, Anolis sagrei, on 66 islands in the Bahamas that were directly hit by Hurricane Floyd in September 1999. Before the hurricane, an island's area was a better predictor of the occurrence of A. sagrei than was its altitude. Immediately after, altitude was a better predictor: Apparently all lizards on islands lower than about 3 meters maximum elevation perished in the storm surge. After about 1 year, area again became the better predictor. By 19 months after the hurricane, A. sagrei populations occurred on 88% of the islands they formerly occupied. Recovery occurred via overwater colonization and propagation from eggs that survived inundation, mechanisms that were enhanced by larger island area. Thus, natural processes first destroyed and then quickly restored a highly regular species-area distribution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schoener, T W -- Spiller, D A -- Losos, J B -- New York, N.Y. -- Science. 2001 Nov 16;294(5546):1525-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Evolution and Ecology, University of California, Davis, CA 95616, USA. twschoener@ucdavis.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11711674" target="_blank"〉PubMed〈/a〉
    Keywords: Altitude ; Animals ; Bahamas ; Conservation of Natural Resources ; *Disasters ; *Ecosystem ; Geography ; *Lizards/physiology ; Ovum/physiology ; Population Density ; Population Dynamics ; Reproduction ; Time Factors
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  • 59
    Publication Date: 2001-07-28
    Description: Both biotic interactions and abiotic random forcing are crucial influences on population dynamics. This frequently leads to roughly equal importance of deterministic and stochastic forces. The resulting tension between noise and determinism makes ecological dynamics unique, with conceptual and methodological challenges distinctive from those in other dynamical systems. The theory for stochastic, nonlinear ecological dynamics has been developed alongside methods to test models. A range of dynamical components has been considered-density dependence, environmental and demographic stochasticity, and climatic forcing-as well as their often complex interactions. We discuss recent advances in understanding ecological dynamics and testing theory using long-term data and review how dynamical forces interact to generate some central field and laboratory time series.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bjornstad, O N -- Grenfell, B T -- New York, N.Y. -- Science. 2001 Jul 27;293(5530):638-43.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology, 501 ASI Building, Penn State University, University Park, PA 16802, USA. onb1@psu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11474099" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Wild/physiology ; Climate ; *Ecosystem ; Environment ; Models, Biological ; Models, Statistical ; Nonlinear Dynamics ; Population Dynamics ; Population Growth ; Stochastic Processes ; Time Factors
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  • 60
    Publication Date: 2001-11-17
    Description: In the modern ocean, a significant amount of nitrogen fixation is attributed to filamentous, nonheterocystous cyanobacteria of the genus Trichodesmium. In these organisms, nitrogen fixation is confined to the photoperiod and occurs simultaneously with oxygenic photosynthesis. Nitrogenase, the enzyme responsible for biological N2 fixation, is irreversibly inhibited by oxygen in vitro. How nitrogenase is protected from damage by photosynthetically produced O2 was once an enigma. Using fast repetition rate fluorometry and fluorescence kinetic microscopy, we show that there is both temporal and spatial segregation of N2 fixation and photosynthesis within the photoperiod. Linear photosynthetic electron transport protects nitrogenase by reducing photosynthetically evolved O2 in photosystem I (PSI). We postulate that in the early evolutionary phase of oxygenic photosynthesis, nitrogenase served as an electron acceptor for anaerobic heterotrophic metabolism and that PSI was favored by selection because it provided a micro-anaerobic environment for N2 fixation in cyanobacteria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berman-Frank, I -- Lundgren, P -- Chen, Y B -- Kupper, H -- Kolber, Z -- Bergman, B -- Falkowski, P -- New York, N.Y. -- Science. 2001 Nov 16;294(5546):1534-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Environmental Biophysics and Molecular Ecology Program, Institute of Marine and Coastal Sciences, Rutgers University, 71 Dudley Road, New Brunswick, NJ 08901, USA. irfrank@imcs.rutgers.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11711677" target="_blank"〉PubMed〈/a〉
    Keywords: Aerobiosis ; Anaerobiosis ; Biological Evolution ; Circadian Rhythm ; Cyanobacteria/enzymology/*metabolism ; Dibromothymoquinone/pharmacology ; Diuron/pharmacology ; Electron Transport ; Fluorometry ; Light ; Microscopy, Fluorescence ; *Nitrogen Fixation ; Nitrogenase/metabolism ; Oxidation-Reduction ; Oxygen/*metabolism ; Oxygen Consumption ; Photoperiod ; *Photosynthesis ; Photosynthetic Reaction Center Complex Proteins/metabolism ; *Photosystem II Protein Complex ; Quinones/metabolism ; Time Factors
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  • 61
    Publication Date: 2001-11-27
    Description: The "intermediate disturbance hypothesis," which postulates maximum diversity at intermediate regimes of disturbance, has never been clearly proved to apply to species-rich tropical forest tree communities and to local-scale canopy disturbances that modify light environments. This hypothesis was tested on a sample of 17,000 trees in a Guianan forest, 10 years after a silvicultural experiment that added to natural treefall gaps a wide range of disturbance intensities. Species richness, standardized to eliminate density effects, peaked at intermediate disturbance levels, particularly when disturbance intensity was estimated through the percentage of stems of strongly light-dependent species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Molino, J F -- Sabatier, D -- New York, N.Y. -- Science. 2001 Nov 23;294(5547):1702-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Recherche pour le Developpement, c/o Cirad-foret, Campus International de Baillarguet, TA10/D, 34398 Montpellier Cedex 5, France. molino@mpl.ird.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11721052" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Ecosystem ; French Guiana ; Germination ; *Models, Biological ; Reproducibility of Results ; Seasons ; Seeds/physiology ; Soil ; Sunlight ; Time Factors ; Trees/growth & development/*physiology ; *Tropical Climate
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  • 62
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-07-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helmuth, L -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):27-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11441155" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/physiology ; Animals ; Cues ; Fixation, Ocular/physiology ; Frontal Lobe/physiology ; Haplorhini/*physiology ; Memory/*physiology ; Motion ; Neurons/*physiology ; Photic Stimulation ; Saccades/physiology ; Time Factors ; Visual Cortex/*physiology
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  • 63
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, M -- New York, N.Y. -- Science. 2001 Nov 9;294(5545):1266-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11701907" target="_blank"〉PubMed〈/a〉
    Keywords: Anthrax/*diagnosis ; Bacillus anthracis/growth & development/immunology/*isolation & purification ; *Bacteriological Techniques ; *Bioterrorism ; Centers for Disease Control and Prevention (U.S.) ; Colony Count, Microbial ; *Environmental Microbiology ; Humans ; Immunologic Tests ; Oligonucleotide Array Sequence Analysis ; Polymerase Chain Reaction ; Sensitivity and Specificity ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Spores, Bacterial/isolation & purification ; Time Factors ; United States
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  • 64
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helmuth, L -- New York, N.Y. -- Science. 2001 Jun 22;292(5525):2233.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11423630" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; In Vitro Techniques ; Interneurons/*physiology ; Neocortex/cytology/*physiology ; Nerve Net/*physiology ; Pyramidal Cells/*physiology ; Rats ; Synapses/physiology ; Synaptic Transmission ; Time Factors ; gamma-Aminobutyric Acid/metabolism
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  • 65
    Publication Date: 2001-08-11
    Description: The temporal resolution of neuronal integration depends on the time window within which excitatory inputs summate to reach the threshold for spike generation. Here, we show that in rat hippocampal pyramidal cells this window is very narrow (less than 2 milliseconds). This narrowness results from the short delay with which disynaptic feed-forward inhibition follows monosynaptic excitation. Simultaneous somatic and dendritic recordings indicate that feed-forward inhibition is much stronger in the soma than in the dendrites, resulting in a broader integration window in the latter compartment. Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pouille, F -- Scanziani, M -- New York, N.Y. -- Science. 2001 Aug 10;293(5532):1159-63.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11498596" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Axons/physiology ; Bicuculline/pharmacology ; Dendrites/physiology ; Electric Stimulation ; Evoked Potentials ; *Excitatory Postsynaptic Potentials ; GABA Antagonists/pharmacology ; GABA-A Receptor Antagonists ; Hippocampus/cytology/*physiology ; In Vitro Techniques ; Interneurons/physiology ; *Neural Inhibition ; Patch-Clamp Techniques ; Pyramidal Cells/*physiology ; Pyridazines/pharmacology ; Rats ; Rats, Wistar ; Receptors, GABA-A/metabolism ; *Synaptic Transmission ; Time Factors
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  • 66
    Publication Date: 2001-07-28
    Description: By integrating a wide range of experimental, comparative, and theoretical approaches, ecologists are starting to gain a detailed understanding of the long-term dynamics of vegetation. We explore how patterns of variation in demographic traits among species have provided insight into the processes that structure plant communities. We find a common set of mechanisms, derived from ecological and evolutionary principles, that underlie the main forces shaping systems as diverse as annual plant communities and tropical forests. Trait variation between species maintains diversity and has important implications for ecosystem processes. Hence, greater understanding of how Earth's vegetation functions will likely require integration of ecosystem science with ideas from plant evolutionary, population, and community ecology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rees, M -- Condit, R -- Crawley, M -- Pacala, S -- Tilman, D -- New York, N.Y. -- Science. 2001 Jul 27;293(5530):650-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Imperial College and NERC Centre for Population Biology, Silwood Park, Ascot, Berks SL5 7PY, UK. mrees@ic.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11474101" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Climate ; *Ecosystem ; Environment ; Plant Development ; *Plants ; Poaceae/growth & development ; Population Density ; Population Dynamics ; Seeds ; Time Factors ; Trees ; Tropical Climate
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  • 67
    Publication Date: 2001-05-19
    Description: Force microscopy has been used to quantitatively measure the infinitesimal forces that characterize interactions between Shewanella oneidensis (a dissimilatory metal-reducing bacterium) and goethite (alpha-FeOOH), both commonly found in Earth near-surface environments. Force measurements with subnanonewton resolution were made in real time with living cells under aerobic and anaerobic solutions as a function of the distance, in nanometers, between a cell and the mineral surface. Energy values [in attojoules (10(-18) joules)] derived from these measurements show that the affinity between S. oneidensis and goethite rapidly increases by two to five times under anaerobic conditions in which electron transfer from bacterium to mineral is expected. Specific signatures in the force curves suggest that a 150-kilodalton putative iron reductase is mobilized within the outer membrane of S. oneidensis and specifically interacts with the goethite surface to facilitate the electron transfer process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lower, S K -- Hochella, M F Jr -- Beveridge, T J -- New York, N.Y. -- Science. 2001 May 18;292(5520):1360-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NanoGeoscience and Technology Laboratory, Department of Geological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. slower@vt.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11359008" target="_blank"〉PubMed〈/a〉
    Keywords: Aerobiosis ; Anaerobiosis ; *Bacterial Adhesion ; Electron Transport ; *FMN Reductase ; Geologic Sediments/chemistry/*microbiology ; Iron Compounds/chemistry/*metabolism ; *Microscopy, Atomic Force ; Minerals ; NADH, NADPH Oxidoreductases/metabolism ; Shewanella/enzymology/*metabolism ; Time Factors
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  • 68
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-07-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, D C -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):56-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Graduate School of Oceanography, University of Rhode Island, Narragansett, RI 02881-1197, USA. dcsmith@gso.uri.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11441169" target="_blank"〉PubMed〈/a〉
    Keywords: Archaea/chemistry/*physiology ; Atlantic Ocean ; *Biological Evolution ; Carbon/metabolism ; Carbon Dioxide/metabolism ; *Fossils ; Geologic Sediments/chemistry/microbiology ; Membrane Lipids/analysis ; Oxygen/metabolism ; Temperature ; Time Factors
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  • 69
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-03-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackay, C R -- von Andrian, U H -- New York, N.Y. -- Science. 2001 Mar 23;291(5512):2323-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Arthritis and Asthma Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia. c.mackay@garvan.unsw.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11269302" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens/*immunology ; Antigens, Thy-1/immunology ; Antigens, Viral/immunology ; CD4-Positive T-Lymphocytes/*immunology ; CD8-Positive T-Lymphocytes/*immunology ; Cell Movement ; Humans ; *Immunologic Memory ; Lymphocyte Activation ; Lymphoid Tissue/*immunology ; Mice ; Receptors, CCR7 ; Receptors, Chemokine/metabolism ; Rhabdoviridae Infections/immunology ; T-Lymphocyte Subsets/*immunology ; Time Factors ; Vesicular stomatitis Indiana virus/immunology
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  • 70
    Publication Date: 2001-06-26
    Description: The temporal pattern and relative timing of action potentials among neocortical neurons may carry important information. However, how cortical circuits detect or generate coherent activity remains unclear. Using paired recordings in rat neocortical slices, we found that the firing of fast-spiking cells can reflect the spiking pattern of single-axon pyramidal inputs. Moreover, this property allowed groups of fast-spiking cells interconnected by electrical and gamma-aminobutyric acid (GABA)-releasing (GABAergic) synapses to detect the relative timing of their excitatory inputs. These results indicate that networks of fast-spiking cells may play a role in the detection and promotion of synchronous activity within the neocortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galarreta, M -- Hestrin, S -- EY09120/EY/NEI NIH HHS/ -- EY12114/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2001 Jun 22;292(5525):2295-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Comparative Medicine, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. galarreta@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11423653" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Axons/physiology ; Excitatory Postsynaptic Potentials ; Female ; In Vitro Techniques ; Interneurons/*physiology ; Kinetics ; Male ; Neocortex/cytology/*physiology ; Nerve Net/*physiology ; Pyramidal Cells/*physiology ; Rats ; Rats, Sprague-Dawley ; Synapses/physiology ; *Synaptic Transmission ; Time Factors ; gamma-Aminobutyric Acid/*metabolism
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  • 71
    Publication Date: 2002-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Neill, Brian C -- Oppenheimer, Michael -- New York, N.Y. -- Science. 2002 Jun 14;296(5575):1971-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Watson Institute for International Studies and the Center for Environmental Studies, Brown University, Providence, RI 02912 USA. bconeill@brown.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12065820" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atmosphere ; Carbon Dioxide ; *Climate ; *Cnidaria ; Developed Countries ; *Ecosystem ; *Greenhouse Effect ; Ice ; *International Cooperation ; Oceans and Seas ; Policy Making ; Probability ; Time Factors ; United Nations
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  • 72
    Publication Date: 2002-11-02
    Description: Spatially extended population models predict complex spatiotemporal patterns, such as spiral waves and spatial chaos, as a result of the reaction-diffusion dynamics that arise from trophic interactions. However, examples of such patterns in ecological systems are scarce. We develop a quantitative technique to demonstrate the existence of waves in Central European larch budmoth (Zeiraphera diniana Gn.) outbreaks. We show that these waves travel toward the northeast-east at 210 kilometers per year. A theoretical model involving a moth-enemy interaction predicts directional waves, but only if dispersal is directionally biased or habitat productivity varies across the landscape. Our study confirms that nonlinear ecological interactions can lead to complex spatial dynamics at a regional scale.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bjornstad, Ottar N -- Peltonen, Mikko -- Liebhold, Andrew M -- Baltensweiler, Werner -- New York, N.Y. -- Science. 2002 Nov 1;298(5595):1020-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Entomology and Biology, 501 ASI Building, Pennsylvania State University, University Park, PA 16802, USA. onb1@psu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12411704" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Ecology ; Ecosystem ; Emigration and Immigration ; Environment ; Europe ; Flight, Animal ; Host-Parasite Interactions ; *Larix ; Mathematics ; Models, Statistical ; *Moths/parasitology/physiology ; Nonlinear Dynamics ; Parasites/physiology ; Population Density ; Population Dynamics ; Statistics, Nonparametric ; Time Factors ; Trees
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  • 73
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-27
    Description: Evolution can be predicted in the short term from a knowledge of selection and inheritance. However, in the long term evolution is unpredictable because environments, which determine the directions and magnitudes of selection coefficients, fluctuate unpredictably. These two features of evolution, the predictable and unpredictable, are demonstrated in a study of two populations of Darwin's finches on the Galapagos island of Daphne Major. From 1972 to 2001, Geospiza fortis (medium ground finch) and Geospiza scandens (cactus finch) changed several times in body size and two beak traits. Natural selection occurred frequently in both species and varied from unidirectional to oscillating, episodic to gradual. Hybridization occurred repeatedly though rarely, resulting in elevated phenotypic variances in G. scandens and a change in beak shape. The phenotypic states of both species at the end of the 30-year study could not have been predicted at the beginning. Continuous, long-term studies are needed to detect and interpret rare but important events and nonuniform evolutionary change.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grant, Peter R -- Grant, B Rosemary -- New York, N.Y. -- Science. 2002 Apr 26;296(5568):707-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Princeton University, Washington Road, Princeton, NJ 08544-1003, USA. prgrantprinceton.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11976447" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Beak/*anatomy & histology ; *Biological Evolution ; Body Constitution ; Climate ; Ecosystem ; Ecuador ; Female ; Food ; Genetic Variation ; Genetics, Population ; Hybridization, Genetic ; Male ; Phenotype ; Sampling Studies ; Seeds ; *Selection, Genetic ; Sex Ratio ; *Songbirds/anatomy & histology/genetics/physiology ; Time Factors
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  • 74
    Publication Date: 2002-01-19
    Description: To explore neuronal mechanisms underlying long-term consequences of stress, we studied stress-induced changes in the neuritic translocation of acetylcholinesterase (AChE) splice variants. Under normal conditions, we found the synaptic AChE-S mRNA and protein in neurites. Corticosterone, anticholinesterases, and forced swim, each facilitated a rapid (minutes), yet long-lasting (weeks), shift from AChE-S to the normally rare AChE-R mRNA, promoted AChE-R mRNA translocation into neurites, and induced enzyme secretion. Weeks after stress, electrophysiological measurements in hippocampus slices displayed apparently normal evoked synaptic responses but extreme hypersensitivity to both anticholinesterases and atropine. Our findings suggest that neuronal hypersensitivity under stress involves neuritic replacement of AChE-S with AChE-R.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meshorer, Eran -- Erb, Christina -- Gazit, Roi -- Pavlovsky, Lev -- Kaufer, Daniela -- Friedman, Alon -- Glick, David -- Ben-Arie, Nissim -- Soreq, Hermona -- New York, N.Y. -- Science. 2002 Jan 18;295(5554):508-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry, The Institute of Life Sciences and The Eric Roland Center for Neurodegenerative Diseases, The Hebrew University of Jerusalem, Israel 91904.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11799248" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Acetylcholinesterase/*genetics/*metabolism ; Action Potentials ; *Alternative Splicing ; Animals ; Atropine/pharmacology ; Cells, Cultured ; Cerebellum/cytology ; Cholinesterase Inhibitors/pharmacology ; Corticosterone/pharmacology ; Hippocampus/cytology/metabolism/physiology ; In Situ Hybridization, Fluorescence ; In Vitro Techniques ; Mice ; Mice, Transgenic ; Neurites/*metabolism ; Neurons/*metabolism ; Oligonucleotides, Antisense/pharmacology ; PC12 Cells ; Physostigmine/pharmacology ; RNA, Messenger/genetics/*metabolism ; Rats ; Stress, Physiological/genetics/*physiopathology ; Time Factors
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  • 75
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helmuth, Laura -- New York, N.Y. -- Science. 2002 Aug 2;297(5582):752-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12161622" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*diagnosis/*metabolism/pathology/physiopathology ; Amyloid beta-Peptides/*analysis ; Brain/metabolism/pathology/physiopathology ; Cataract/metabolism/pathology ; Humans ; Lens, Crystalline/metabolism/pathology ; Molecular Probes/*metabolism ; Plaque, Amyloid/chemistry/metabolism/pathology ; Time Factors ; Tomography, Emission-Computed/*methods
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  • 76
    Publication Date: 2000-06-10
    Description: HIV-1 sequences were analyzed to estimate the timing of the ancestral sequence of the main group of HIV-1, the strains responsible for the AIDS pandemic. Using parallel supercomputers and assuming a constant rate of evolution, we applied maximum-likelihood phylogenetic methods to unprecedented amounts of data for this calculation. We validated our approach by correctly estimating the timing of two historically documented points. Using a comprehensive full-length envelope sequence alignment, we estimated the date of the last common ancestor of the main group of HIV-1 to be 1931 (1915-41). Analysis of a gag gene alignment, subregions of envelope including additional sequences, and a method that relaxed the assumption of a strict molecular clock also supported these results.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Korber, B -- Muldoon, M -- Theiler, J -- Gao, F -- Gupta, R -- Lapedes, A -- Hahn, B H -- Wolinsky, S -- Bhattacharya, T -- N01 AI 85338/AI/NIAID NIH HHS/ -- R01 AI 44596/AI/NIAID NIH HHS/ -- R01-HD37356/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 2000 Jun 9;288(5472):1789-96.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Los Alamos National Laboratory, Los Alamos, NM 87545, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10846155" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*epidemiology/transmission/*virology ; Africa/epidemiology ; Animals ; Confidence Intervals ; Consensus Sequence ; Disease Outbreaks ; Europe/epidemiology ; *Evolution, Molecular ; Genes, env ; HIV Envelope Protein gp160/genetics ; HIV-1/classification/*genetics ; Haiti/epidemiology ; Humans ; Likelihood Functions ; Pan troglodytes ; Phylogeny ; Simian Acquired Immunodeficiency Syndrome/transmission/virology ; Simian Immunodeficiency Virus/genetics ; Time Factors ; United States/epidemiology ; Zoonoses
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  • 77
    Publication Date: 2000-04-15
    Description: The mechanisms by which hepatitis C virus (HCV) induces chronic infection in the vast majority of infected individuals are unknown. Sequences within the HCV E1 and E2 envelope genes were analyzed during the acute phase of hepatitis C in 12 patients with different clinical outcomes. Acute resolving hepatitis was associated with relative evolutionary stasis of the heterogeneous viral population (quasispecies), whereas progressing hepatitis correlated with genetic evolution of HCV. Consistent with the hypothesis of selective pressure by the host immune system, the sequence changes occurred almost exclusively within the hypervariable region 1 of the E2 gene and were temporally correlated with antibody seroconversion. These data indicate that the evolutionary dynamics of the HCV quasispecies during the acute phase of hepatitis C predict whether the infection will resolve or become chronic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Farci, P -- Shimoda, A -- Coiana, A -- Diaz, G -- Peddis, G -- Melpolder, J C -- Strazzera, A -- Chien, D Y -- Munoz, S J -- Balestrieri, A -- Purcell, R H -- Alter, H J -- New York, N.Y. -- Science. 2000 Apr 14;288(5464):339-44.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Sciences, University of Cagliari, Via San Giorgio 12, 09124 Cagliari, Italy. farcip@pacs.unica.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10764648" target="_blank"〉PubMed〈/a〉
    Keywords: Acute Disease ; Adult ; Aged ; Antibodies, Viral ; Disease Progression ; *Evolution, Molecular ; Female ; Genes, Viral ; Genetic Variation ; Hepacivirus/*genetics/immunology/physiology ; Hepatitis C/immunology/*virology ; Hepatitis C Antibodies/biosynthesis ; Hepatitis C, Chronic/immunology/*virology ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; Phylogeny ; Prospective Studies ; Selection, Genetic ; Time Factors ; Viral Envelope Proteins/*genetics/immunology ; Virus Replication
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  • 78
    Publication Date: 2000-01-15
    Description: The introduction and rapid spread of Drosophila subobscura in the New World two decades ago provide an opportunity to determine the predictability and rate of evolution of a geographic cline. In ancestral Old World populations, wing length increases clinally with latitude. In North American populations, no wing length cline was detected one decade after the introduction. After two decades, however, a cline has evolved and largely converged on the ancestral cline. The rate of morphological evolution on a continental scale is very fast, relative even to rates measured within local populations. Nevertheless, different wing sections dominate the New versus Old World clines. Thus, the evolution of geographic variation in wing length has been predictable, but the means by which the cline is achieved is contingent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huey, R B -- Gilchrist, G W -- Carlson, M L -- Berrigan, D -- Serra, L -- New York, N.Y. -- Science. 2000 Jan 14;287(5451):308-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Washington, Box 351800, Seattle, WA 98195-1800, USA. hueyrb@u.washington.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10634786" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Drosophila/*anatomy & histology/*genetics ; Europe ; Female ; Geography ; Male ; North America ; Sex Characteristics ; Time Factors ; Wings, Animal/*anatomy & histology
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  • 79
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2000-09-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, A -- New York, N.Y. -- Science. 2000 Sep 1;289(5484):1472-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10991732" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Archaeology ; *Birds ; Humans ; New Zealand ; Time Factors
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  • 80
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2000-11-10
    Description: Gene duplication has generally been viewed as a necessary source of material for the origin of evolutionary novelties, but it is unclear how often gene duplicates arise and how frequently they evolve new functions. Observations from the genomic databases for several eukaryotic species suggest that duplicate genes arise at a very high rate, on average 0.01 per gene per million years. Most duplicated genes experience a brief period of relaxed selection early in their history, with a moderate fraction of them evolving in an effectively neutral manner during this period. However, the vast majority of gene duplicates are silenced within a few million years, with the few survivors subsequently experiencing strong purifying selection. Although duplicate genes may only rarely evolve new functions, the stochastic silencing of such genes may play a significant role in the passive origin of new species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lynch, M -- Conery, J S -- R01-GM36827/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2000 Nov 10;290(5494):1151-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Oregon, Eugene, OR 97403, USA. mlynch@oregon.uoregon.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11073452" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Substitution ; Animals ; Arabidopsis/genetics ; Base Sequence ; Caenorhabditis elegans/genetics ; Chickens/genetics ; Databases, Factual ; Drosophila melanogaster/genetics ; *Evolution, Molecular ; Gene Duplication ; Gene Silencing ; *Genes, Duplicate ; *Genome ; Humans ; Mice ; Models, Genetic ; Mutation ; Oryza/genetics ; Probability ; Proteins/chemistry/genetics ; Saccharomyces cerevisiae/genetics ; Selection, Genetic ; Stochastic Processes ; Time Factors
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  • 81
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2000-04-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Manuelidis, L -- New York, N.Y. -- Science. 2000 Apr 14;288(5464):273-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10777407" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Indoles/pharmacokinetics/*pharmacology/therapeutic use ; Macrophages/*drug effects ; PrPSc Proteins/*drug effects ; Prions/*drug effects ; Scrapie/*drug therapy ; Time Factors
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  • 82
    Publication Date: 2001-07-07
    Description: Biogeochemical and stable carbon isotopic analysis of black-shale sequences deposited during an Albian oceanic anoxic event (approximately 112 million years ago) indicate that up to 80 weight percent of sedimentary organic carbon is derived from marine, nonthermophilic archaea. The carbon-13 content of archaeal molecular fossils indicates that these archaea were living chemoautotrophically. Their massive expansion may have been a response to the strong stratification of the ocean during this anoxic event. Indeed, the sedimentary record of archaeal membrane lipids suggests that this anoxic event marks a time in Earth history at which certain hyperthermophilic archaea adapted to low-temperature environments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuypers, M M -- Blokker, P -- Erbacher, J -- Kinkel, H -- Pancost, R D -- Schouten, S -- Sinninghe Damste, J S -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):92-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Marine Biogeochemistry and Toxicology, Netherlands Institute for Sea Research (NIOZ), Post Office Box 59, 1790 AB Den Burg, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11441180" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Archaea/chemistry/*physiology ; Atlantic Ocean ; *Biological Evolution ; Carbon/metabolism ; Carbon Isotopes ; Cyanobacteria/chemistry/metabolism ; Eukaryota/chemistry/metabolism ; *Fossils ; Geologic Sediments/analysis/chemistry/microbiology ; Membrane Lipids/analysis ; Oxygen/*metabolism ; Plankton/metabolism ; Plants/chemistry/metabolism ; Temperature ; Time Factors
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  • 83
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-02-24
    Description: Interactions between enemies and their victims are found in all ecological communities. But what has puzzled ecologists is how victims and enemies coexist together for long periods of time without all of the victims being killed off. In a Perspective, Hastings explains a new model (Keeling et al.), which shows that variation in the distribution of victim and enemy species acts as a stabilizing factor in interactions between them.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hastings, A -- New York, N.Y. -- Science. 2000 Dec 1;290(5497):1712-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental Science and Policy, University of California, Davis, CA 95616, USA. amhastings@ucdavis.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11186394" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Computer Simulation ; *Ecosystem ; *Host-Parasite Interactions ; Insects/*parasitology/*physiology ; *Models, Biological ; Models, Statistical ; Population Dynamics ; Stochastic Processes ; Time Factors
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  • 84
    Publication Date: 2001-06-26
    Description: For the period 1980-89, we estimate a carbon sink in the coterminous United States between 0.30 and 0.58 petagrams of carbon per year (petagrams of carbon = 10(15) grams of carbon). The net carbon flux from the atmosphere to the land was higher, 0.37 to 0.71 petagrams of carbon per year, because a net flux of 0.07 to 0.13 petagrams of carbon per year was exported by rivers and commerce and returned to the atmosphere elsewhere. These land-based estimates are larger than those from previous studies (0.08 to 0.35 petagrams of carbon per year) because of the inclusion of additional processes and revised estimates of some component fluxes. Although component estimates are uncertain, about one-half of the total is outside the forest sector. We also estimated the sink using atmospheric models and the atmospheric concentration of carbon dioxide (the tracer-transport inversion method). The range of results from the atmosphere-based inversions contains the land-based estimates. Atmosphere- and land-based estimates are thus consistent, within the large ranges of uncertainty for both methods. Atmosphere-based results for 1980-89 are similar to those for 1985-89 and 1990-94, indicating a relatively stable U.S. sink throughout the period.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pacala, S W -- Hurtt, G C -- Baker, D -- Peylin, P -- Houghton, R A -- Birdsey, R A -- Heath, L -- Sundquist, E T -- Stallard, R F -- Ciais, P -- Moorcroft, P -- Caspersen, J P -- Shevliakova, E -- Moore, B -- Kohlmaier, G -- Holland, E -- Gloor, M -- Harmon, M E -- Fan, S M -- Sarmiento, J L -- Goodale, C L -- Schimel, D -- Field, C B -- New York, N.Y. -- Science. 2001 Jun 22;292(5525):2316-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Atmospheric and Oceanic Sciences Program, Princeton University, Princeton, NJ 08544, USA. Pacala@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11423659" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; *Atmosphere ; *Carbon/metabolism ; Carbon Dioxide ; Conservation of Natural Resources ; Ecosystem ; Fires ; Forestry ; Soil ; Time Factors ; *Trees/metabolism ; United States ; Wood
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  • 85
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-09-08
    Description: In addition to altering global ecology, technology and human population growth also affect evolutionary trajectories, dramatically accelerating evolutionary change in other species, especially in commercially important, pest, and disease organisms. Such changes are apparent in antibiotic and human immunodeficiency virus (HIV) resistance to drugs, plant and insect resistance to pesticides, rapid changes in invasive species, life-history change in commercial fisheries, and pest adaptation to biological engineering products. This accelerated evolution costs at least $33 billion to $50 billion a year in the United States. Slowing and controlling arms races in disease and pest management have been successful in diverse ecological and economic systems, illustrating how applied evolutionary principles can help reduce the impact of humankind on evolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palumbi, S R -- New York, N.Y. -- Science. 2001 Sep 7;293(5536):1786-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. spalumbi@oeb.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11546863" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological/genetics/physiology ; Animals ; *Biological Evolution ; *Biotechnology/economics ; *Drug Resistance/genetics/physiology ; Drug Resistance, Microbial/genetics/physiology ; *Ecosystem ; Humans ; Selection, Genetic ; Time Factors
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  • 86
    Publication Date: 2001-11-27
    Description: Net uptake of carbon dioxide (CO2) measured by eddy covariance in a 60- to 80-year-old forest averaged 2.0 +/- 0.4 megagrams of carbon per hectare per year during 1993 to 2000, with interannual variations exceeding 50%. Biometry indicated storage of 1.6 +/- 0.4 megagrams of carbon per hectare per year over 8 years, 60% in live biomass and the balance in coarse woody debris and soils, confirming eddy-covariance results. Weather and seasonal climate (e.g., variations in growing-season length or cloudiness) regulated seasonal and interannual fluctuations of carbon uptake. Legacies of prior disturbance and management, especially stand age and composition, controlled carbon uptake on the decadal time scale, implying that eastern forests could be managed for sequestration of carbon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barford, C C -- Wofsy, S C -- Goulden, M L -- Munger, J W -- Pyle, E H -- Urbanski, S P -- Hutyra, L -- Saleska, S R -- Fitzjarrald, D -- Moore, K -- New York, N.Y. -- Science. 2001 Nov 23;294(5547):1688-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Engineering and Applied Science and Department of Earth and Planetary Science, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11721047" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; *Atmosphere/analysis ; Biomass ; Biometry ; Carbon/metabolism ; Carbon Dioxide/*metabolism ; Climate ; *Ecosystem ; New England ; Nitrogen/analysis ; Probability ; Seasons ; Soil/analysis ; Time Factors ; Trees/growth & development/*metabolism
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  • 87
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sugden, A -- Stone, R -- New York, N.Y. -- Science. 2001 Jul 27;293(5530):623.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11474093" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Ecology ; *Ecosystem ; Time Factors
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  • 88
    Publication Date: 2001-11-27
    Description: Killed or inactivated vaccines targeting intracellular bacterial and protozoal pathogens are notoriously ineffective at generating protective immunity. For example, vaccination with heat-killed Listeria monocytogenes (HKLM) is not protective, although infection with live L. monocytogenes induces long-lived, CD8 T cell-mediated immunity. We demonstrate that HKLM immunization primes memory CD8 T lymphocyte populations that, although substantial in size, are ineffective at providing protection from subsequent L. monocytogenes infection. In contrast to live infection, which elicits large numbers of effector CD8 T cells, HKLM immunization primes T lymphocytes that do not acquire effector functions. Our studies show that it is possible to dissociate T cell-dependent protective immunity from memory T cell expansion, and that generation of effector T cells may be necessary for long-term protective immunity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lauvau, G -- Vijh, S -- Kong, P -- Horng, T -- Kerksiek, K -- Serbina, N -- Tuma, R A -- Pamer, E G -- AI 39031/AI/NIAID NIH HHS/ -- AI42135/AI/NIAID NIH HHS/ -- F32 AI09629-02/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2001 Nov 23;294(5547):1735-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Infectious Disease Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Immunology Program, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10021, USA. pamere@mskcc.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11721060" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Vaccines/*immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/cytology/*immunology ; Cell Division ; *Cytotoxicity, Immunologic ; Immunologic Memory/*immunology ; Listeria monocytogenes/*immunology/physiology ; Listeriosis/*immunology/microbiology/prevention & control ; Lymphocyte Activation ; Mice ; Substrate Specificity ; Time Factors ; Vaccination ; Vaccines, Attenuated/immunology
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoshihara, Y -- Nagao, H -- Mori, K -- New York, N.Y. -- Science. 2001 Feb 2;291(5505):835-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Neurobiology of the Synapse, RIKEN Brain Science Institute, Saitama 351-0198, Japan. yoshihara@brain.riken.go.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11225631" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dendrites/*physiology ; Interneurons/physiology ; Neural Conduction ; Neural Inhibition ; Odors ; Olfactory Bulb/*cytology/*physiology ; Olfactory Pathways/*physiology ; Olfactory Receptor Neurons/physiology ; Receptors, Odorant/*physiology ; Smell/*physiology ; Synapses ; Time Factors ; Zebrafish
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  • 90
    Publication Date: 2001-04-03
    Description: Song imitation in birds provides good material for studying the basic biology of vocal learning. Techniques were developed for inducing the rapid onset of song imitation in young zebra finches and for tracking trajectories of vocal change over a 7-week period until a match to a model song was achieved. Exposure to a model song induced the prompt generation of repeated structured sounds (prototypes) followed by a slow transition from repetitive to serial delivery of syllables. Tracking this transition revealed two phenomena: (i) Imitations of dissimilar sounds can emerge from successive renditions of the same prototype, and (ii) developmental trajectories for some sounds followed paths of increasing acoustic mismatch until an abrupt correction occurred by period doubling. These dynamics are likely to reflect underlying neural and articulatory constraints on the production and imitation of sounds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tchernichovski, O -- Mitra, P P -- Lints, T -- Nottebohm, F -- DC04722-01/DC/NIDCD NIH HHS/ -- MH18343/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2001 Mar 30;291(5513):2564-9. Epub 2001 Mar 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Field Research Center, The Rockefeller University, Millbrook, NY 12545, USA. tcherno@mail.rockefeller.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11283361" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Animals ; Imitative Behavior/*physiology ; Learning/*physiology ; Male ; Music ; Neurons/physiology ; Pitch Perception ; Songbirds/*physiology ; Time Factors ; Vocalization, Animal/*physiology
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  • 91
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zimmer, C -- New York, N.Y. -- Science. 2001 Jul 27;293(5530):627-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11474097" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cnidaria ; *Ecosystem ; Eutrophication ; Fisheries ; International Cooperation ; Israel ; Jordan ; Marine Biology ; Oceans and Seas ; Time Factors ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 92
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-11-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Medley, G F -- New York, N.Y. -- Science. 2001 Nov 23;294(5547):1663-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ecology and Epidemiology Group, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK. graham.medley@warwick.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11721038" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/epidemiology ; Age Distribution ; Age Factors ; Age of Onset ; Animals ; Cattle ; Creutzfeldt-Jakob Syndrome/diagnosis/*epidemiology/genetics/transmission ; Disease Susceptibility/epidemiology ; Encephalopathy, Bovine Spongiform/epidemiology ; Genetic Predisposition to Disease ; Great Britain/epidemiology ; HIV Infections/epidemiology ; Humans ; Incidence ; Prevalence ; Probability ; Risk ; Sheep ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
    Publication Date: 2001-09-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Layne, S P -- Beugelsdijk, T J -- Patel, C K -- Taubenberger, J K -- Cox, N J -- Gust, I D -- Hay, A J -- Tashiro, M -- Lavanchy, D -- New York, N.Y. -- Science. 2001 Sep 7;293(5536):1729.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11546841" target="_blank"〉PubMed〈/a〉
    Keywords: Environmental Monitoring/economics/methods ; Epidemiological Monitoring ; Humans ; Influenza, Human/diagnosis/economics/*epidemiology ; *International Cooperation ; Internet ; Population Surveillance/*methods ; Time Factors ; World Health Organization
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
    Publication Date: 2001-07-07
    Description: Marine mammals often forage in dark or turbid waters. Whereas dolphins use echolocation under such conditions, pinnipeds apparently lack this sensory ability. For seals hunting in the dark, one source of sensory information may consist of fish-generated water movements, which seals can detect with their highly sensitive whiskers. Water movements in the wake of fishes persist for several minutes. Here we show that blindfolded seals can use their whiskers to detect and accurately follow hydrodynamic trails generated by a miniature submarine. This shows that hydrodynamic information can be used for long-distance prey location.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dehnhardt, G -- Mauck, B -- Hanke, W -- Bleckmann, H -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):102-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut fur Zoologie, Universitat Bonn, Poppelsdorfer Schloss, D-53115 Bonn, Germany. dehnhardt@neurobiologie.ruhr-uni-bochum.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11441183" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustics ; Animals ; Cues ; Fishes/physiology ; Probability ; Seals, Earless/*physiology ; Swimming ; Time Factors ; Vibrissae/*physiology ; Video Recording ; *Water Movements
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  • 95
    Publication Date: 2001-11-27
    Description: The size of the variant Creutzfeldt-Jakob Disease (vCJD) epidemic in the United Kingdom is a major public health concern and a subject of speculation. The cases are young (mean age = 28). Assuming that the risk of developing the disease in susceptible exposed subjects decreases exponentially with age after age 15, that all infections occurred between 1980 and 1989, and that the distribution of the incubation period is lognormal, we estimate that the mean duration of the incubation period is 16.7 years [95% confidence interval (CI): 12.4 to 23.2] and that the total number of cases will be 205 (upper limit of the 95% CI: 403).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valleron, A J -- Boelle, P Y -- Will, R -- Cesbron, J Y -- New York, N.Y. -- Science. 2001 Nov 23;294(5547):1726-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Epidemiology and Information Sciences, INSERM U444, CHU Saint-Antoine, Universite Pierre et Marie Curie et Assistance Publique-Hopitaux de Paris, 27 rue Chaligny, 75012 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11721058" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Distribution ; Age Factors ; Age of Onset ; Animals ; Cattle ; Child ; Child, Preschool ; Creutzfeldt-Jakob Syndrome/*epidemiology/mortality/transmission ; Disease Susceptibility/epidemiology ; Great Britain/epidemiology ; Humans ; Incidence ; Infant ; Models, Biological ; Prevalence ; Probability ; Risk ; Time Factors
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  • 96
    Publication Date: 2001-12-01
    Description: Sea surface reservoir ages must be known to establish a common chronological framework for marine, continental, and cryospheric paleoproxies, and are crucial for understanding ocean-continent climatic relationships and the paleoventilation of the ocean. Radiocarbon dates of planktonic foraminifera and tephra contemporaneously deposited over Mediterranean marine and terrestrial regions reveal that the reservoir ages were similar to the modern one (approximately 400 years) during most of the past 18,000 carbon-14 years. However, reservoir ages increased by a factor of 2 at the beginning of the last deglaciation. This is attributed to changes of the North Atlantic thermohaline circulation during the massive ice discharge event Heinrich 1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Siani, G -- Paterne, M -- Michel, E -- Sulpizio, R -- Sbrana, A -- Arnold, M -- Haddad, G -- New York, N.Y. -- Science. 2001 Nov 30;294(5548):1917-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratoire des Sciences du Climat et de l'Environnement (LSCE), Unite Mixte de Service, CNRS, Avenue de la Terrasse, F-91118 Gif-sur-Yvette, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11729315" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; Atmosphere ; Calibration ; Carbon/metabolism ; Carbon Dioxide/metabolism ; Carbon Radioisotopes/metabolism ; *Cold Climate ; Fresh Water ; Geologic Sediments/parasitology ; Greenland ; *Ice ; Mediterranean Sea ; Plankton/*metabolism ; Seawater ; Temperature ; Time Factors ; Volcanic Eruptions
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  • 97
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morel, C M -- New York, N.Y. -- Science. 2001 Jan 19;291(5503):435-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11228137" target="_blank"〉PubMed〈/a〉
    Keywords: *Genomics ; Humans ; Malaria/*prevention & control ; *Research ; Time Factors ; United Nations ; World Health Organization
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  • 98
    Publication Date: 2001-05-08
    Description: Most of the oceanic reservoir of dissolved organic matter (DOM) is of marine origin and is resistant to microbial oxidation, but little is known about the mechanisms of its formation. In a laboratory study, natural assemblages of marine bacteria rapidly (in 〈48 hours) utilized labile compounds (glucose, glutamate) and produced refractory DOM that persisted for more than a year. Only 10 to 15% of the bacterially derived DOM was identified as hydrolyzable amino acids and sugars, a feature consistent with marine DOM. These results suggest that microbial processes alter the molecular structure of DOM, making it resistant to further degradation and thereby preserving fixed carbon in the ocean.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ogawa, H -- Amagai, Y -- Koike, I -- Kaiser, K -- Benner, R -- New York, N.Y. -- Science. 2001 May 4;292(5518):917-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ocean Research Institute, The University of Tokyo, 1-15-1 Minamidai, Nakano, Tokyo 164-8639, Japan. hogawa@ori.u-tokyo.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11340202" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/*metabolism ; Amino Sugars/metabolism ; Bacteria/*metabolism ; Biodegradation, Environmental ; *Carbohydrate Metabolism ; Carbon/*metabolism ; Culture Media ; Glucose/metabolism ; Glutamic Acid/metabolism ; Muramic Acids/metabolism ; Organic Chemicals/*metabolism ; Peptidoglycan/metabolism ; Quaternary Ammonium Compounds/metabolism ; Seawater/*microbiology ; Time Factors
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  • 99
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-11-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 2001 Nov 2;294(5544):985.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11691969" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Viral/blood/*immunology ; *Bioterrorism ; Disease Outbreaks ; Humans ; Immunologic Memory ; Smallpox/epidemiology/immunology/*prevention & control ; Smallpox Vaccine/*immunology ; T-Lymphocytes/*immunology ; Time Factors ; Vaccination ; Vaccinia virus/immunology ; Variola virus/*immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
    Publication Date: 2002-10-12
    Description: We have identified the xenobiotic receptor CAR (constitutive androstane receptor) as a key regulator of acetaminophen metabolism and hepatotoxicity. Known CAR activators as well as high doses of acetaminophen induced expression of three acetaminophen-metabolizing enzymes in wild-type but not in CAR null mice, and the CAR null mice were resistant to acetaminophen toxicity. Inhibition of CAR activity by administration of the inverse agonist ligand androstanol 1 hour after acetaminophen treatment blocked hepatotoxicity in wild type but not in CAR null mice. These results suggest an innovative therapeutic approach for treating the adverse effects of acetaminophen and potentially other hepatotoxic agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Jun -- Huang, Wendong -- Chua, Steven S -- Wei, Ping -- Moore, David D -- R01 DK46546/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2002 Oct 11;298(5592):422-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12376703" target="_blank"〉PubMed〈/a〉
    Keywords: Acetaminophen/metabolism/*toxicity ; Acetylcysteine/pharmacology ; Alanine Transaminase/blood ; Analgesics, Non-Narcotic/metabolism/toxicity ; Androstanols/pharmacology ; Animals ; Aryl Hydrocarbon Hydroxylases/genetics/metabolism ; Benzoquinones/metabolism ; Cytochrome P-450 CYP1A2/genetics/metabolism ; Cytochrome P-450 CYP2E1/genetics/metabolism ; Cytochrome P-450 CYP3A ; Cytochrome P-450 Enzyme System/genetics/metabolism ; Glutathione/metabolism ; Glutathione S-Transferase pi ; Glutathione Transferase/genetics/metabolism ; Humans ; Imines/metabolism ; Isoenzymes/genetics/metabolism ; Liver/*drug effects/*metabolism/pathology ; Mice ; Mice, Knockout ; Mice, Transgenic ; Oxidoreductases, N-Demethylating/genetics/metabolism ; Phenobarbital/pharmacology ; Pyridines/pharmacology ; RNA, Messenger/genetics/metabolism ; Receptors, Cytoplasmic and Nuclear/agonists/antagonists & ; inhibitors/genetics/*metabolism ; Time Factors ; Transcription Factors/agonists/antagonists & inhibitors/genetics/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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