ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    The climatological relationship between tropical cyclones in the southwest pacific and the Madden–Julian Oscillation (2014)
    Wiley
    Details
    Publication Date: 2014-04-16
    Description: ABSTRACT The focus of this study is the climatological relationship between southwest Pacific Tropical Cyclone (TC) activity and the Madden–Julian Oscillation (MJO) on the interannual time-scale. It investigates TC seasonal characteristics (e.g. cyclogenesis, track morphology, ex-tropical transition, and intensity) as modulated by the phase and intensity of the MJO. The approach is novel as in addition to the focus on the intraseasonal variability of TCs there is also a focus on the interannual variability of TCs even though the MJO is an intraseasonal phenomenon. Links between the MJO, the Southern Annular Mode (SAM) and TC variability are also investigated. Using the MJO phases defined by Wheeler and Hendon ( ), southwest Pacific TC frequency exhibited a statistically significant decrease during MJO phases 2 and 3, and an increase during phases 6 and 7; and during the positive phase of the SAM, an increased frequency of TCs undergoing extratropical transition was observed. In summary, the results show a clear intraseasonal climatological relationship between specific phases of the MJO with respect to a decreased (increased) frequency of TCs during the paired MJO phases 2–3 (6–7); as well as the existence of a statistically significant relationship between the MJO and SAM with respect to the extratropical transition (ETT) of TCs. During positive phases of the SAM, coincident with weak interannual MJO phases 4–5 and 6–7, there are statistically significant greater frequency percentages of TCs undergoing ETT.
    Print ISSN: 0899-8418
    Electronic ISSN: 1097-0088
    Topics: Geosciences , Physics
    Published by Wiley
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    The climatological relationship between tropical cyclones in the southwest Pacific and the southern annular mode (2014)
    Wiley
    Details
    Publication Date: 2014-04-08
    Description: ABSTRACT In this study, we focus on possible climatological relationships between southwest Pacific tropical cyclone (TC) activity and the Southern Annular Mode (SAM) and ENSO, at both interannual and synoptic time-scales. The investigation focuses on TC seasonal characteristics (e.g. cyclogenesis, track characteristics, extratropical transition, and intensity) as modulated according to the polarity of the SAM and ENSO. At synoptic time-scales, we also look at possible triggers of TC cyclogenesis in the SAM signal up to 20 days in advance. The physical basis for this relationship is assessed using a number of different gridded data fields. During seasons characterized by positive phases of SAM and both positive and negative Southern Oscillation Index (SOI) values, there is an increased frequency of TCs undergoing extratropical transition near New Zealand. At synoptic time-scales, we found an interesting yet inconclusive relationship between the SAM and tropical cyclogenesis during SOI positive seasons. While statistically significant, there is no clear physical mechanism linking the mid-latitude SAM phenomenon to the genesis of TCs. In summary, the results show a clear interannual climatological relationship between an increased frequency of TCs undergoing extratropical transition near New Zealand and the positive phase of SAM.
    Print ISSN: 0899-8418
    Electronic ISSN: 1097-0088
    Topics: Geosciences , Physics
    Published by Wiley
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Human antibodies that neutralize dengue virus [Microbiology] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-05-09
    Description: Dengue is a mosquito-borne flavivirus that is spreading at an unprecedented rate and has developed into a major health and economic burden in over 50 countries. Even though infected individuals develop potent and long-lasting serotype-specific neutralizing antibodies (Abs), the epitopes engaged by human neutralizing Abs have not been identified. Here, we demonstrate that the dengue virus (DENV)-specific serum Ab response in humans consists of a large fraction of cross-reactive, poorly neutralizing Abs and a small fraction of serotype-specific, potently inhibitory Abs. Although many mouse-generated, strongly neutralizing monoclonal antibodies (mAbs) recognize epitopes that are present on recombinant DENV envelope (E) proteins, unexpectedly, the majority of neutralizing Abs in human immune sera bound to intact virions but not to the ectodomain of purified soluble E proteins. These conclusions with polyclonal Abs were confirmed with newly generated human mAbs derived from DENV-immune individuals. Two of three strongly neutralizing human mAbs bound to E protein epitopes that were preserved on the virion but not on recombinant E (rE) protein. We propose that humans produce Abs that neutralize DENV infection by binding a complex, quaternary structure epitope that is expressed only when E proteins are assembled on a virus particle. Mapping studies indicate that this epitope has a footprint that spans adjacent E protein dimers and includes residues at the hinge between domains I and II of E protein. These results have significant implications for the DENV Ab and vaccine field.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones (2013)
    Oxford University Press
    Details
    Publication Date: 2013-12-11
    Description: TDP-43 aggregation in the cytoplasm or nucleus is a key feature of the pathology of amyotrophic lateral sclerosis and frontotemporal dementia and is observed in numerous other neurodegenerative diseases, including Alzheimer's disease. Despite this fact, the inciting events leading to TDP-43 aggregation remain unclear. We observed that endogenous TDP-43 undergoes reversible aggregation in the nucleus after the heat shock and that this behavior is mediated by the C-terminal prion domain. Substitution of the prion domain from TIA-1 or an authentic yeast prion domain from RNQ1 into TDP-43 can completely recapitulate heat shock-induced aggregation. TDP-43 is constitutively bound to members of the Hsp40/Hsp70 family, and we found that heat shock-induced TDP-43 aggregation is mediated by the availability of these chaperones interacting with the inherently disordered C-terminal prion domain. Finally, we observed that the aggregation of TDP-43 during heat shock led to decreased binding to hnRNPA1, and a change in TDP-43 RNA-binding partners suggesting that TDP-43 aggregation alters its function in response to misfolded protein stress. These findings indicate that TDP-43 shares properties with physiologic prions from yeast, in that self-aggregation is mediated by a Q/N-rich disordered domain, is modulated by chaperone proteins and leads to altered function of the protein. Furthermore, they indicate that TDP-43 aggregation is regulated by chaperone availability, explaining the recurrent observation of TDP-43 aggregates in degenerative diseases of both the brain and muscle where protein homeostasis is disrupted.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    On the state of the knowledge of rainfall extremes in the western and northern Pacific basin (2014)
    Wiley
    Details
    Publication Date: 2014-03-26
    Description: ABSTRACT The relevant literature on extreme rainfall events in the Pacific remains relatively sparse compared to other regions (e.g. the coterminous United States, Europe, etc.). Moreover, several recent reports on climate in the Pacific mention the paucity of extremes information and often list ‘trends in historical climate’ as a necessary next step. This scientific assessment meets this need by examining historical trends in and drivers of extreme rainfall events across the entire Pacific Basin, inclusive from Alaska southward to Australia, and longitudinally from the Philippines eastward to North America, with an emphasis on island and coastal locations (within 200 km of the coastline). There is evidence of a general decrease in the frequency of annual extreme rainfall events, yet the amount of extreme precipitation contributing to annual and seasonal totals appears to be on the rise. Region-wide, the number of consecutive dry days is increasing for those locations that are already dry, while the number of consecutive wet days is increasing for the already wet locales. The data for extreme rainfall statistics are considered to be relatively high quality for trend detection, while the level of understanding of the physical causes behind extreme rainfall is positively high. Since the ability to analyze the changes in historical rainfall extremes with some confidence is relatively recent, understanding is expected to improve in the future with the advancement of new datasets and ‘climate reanalysis’ projects.
    Print ISSN: 0899-8418
    Electronic ISSN: 1097-0088
    Topics: Geosciences , Physics
    Published by Wiley
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Aspirin-dependent cyclooxygenase acetylation [Medical Sciences] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-11-26
    Description: The cardiovascular safety of nonsteroidal antiinflammatory drugs (NSAIDs) may be influenced by interactions with antiplatelet doses of aspirin. We sought to quantitate precisely the propensity of commonly consumed NSAIDs—ibuprofen, naproxen, and celecoxib—to cause a drug–drug interaction with aspirin in vivo by measuring the target engagement of aspirin directly by MS....
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Development of an enhanced tropical cyclone tracks database for the southwest Pacific from 1840 to 2010 (2011)
    Wiley
    Details
    Publication Date: 2011-08-03
    Description: The ecosystems and economies of small island nation states and territories of the tropical southwest Pacific region are widely agreed to be among the most vulnerable to climate variability and weather extremes anywhere in the world. Tropical Cyclones (TCs) are capable of exacerbating existing hazards and those made more severe by climate change (e.g. local sea level rise). In order to properly understand TC impacts in this region, a comprehensive database of TC tracks is required. This work has collated TC best track data from forecast centres around the globe with the aim of producing a unified global best TC track dataset for the historical period. Data from the International Best Tracks for Climate Stewardship (IBTrACS) project information for the southwest Pacific (135°E–120°W, 5°–25°S) is built upon and included in this effort. We document the construction of an enhanced TC database for the southwest Pacific, the quality controls needed to construct the database, and discuss how it has enhanced the chronology of region-wide historical TC activity in light of newly discovered data. We suggest this enhanced dataset can be used in forthcoming climate and weather studies to better characterize the climatology and behaviour of TCs in the southwest Pacific. Copyright © 2011 Royal Meteorological Society
    Print ISSN: 0899-8418
    Electronic ISSN: 1097-0088
    Topics: Geosciences , Physics
    Published by Wiley
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Archaeology. Blitzkrieg against the moas (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, J -- New York, N.Y. -- Science. 2000 Mar 24;287(5461):2170-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, UCLA Medical School, Los Angeles, CA 90095-1751, USA. jdiamond@mednet.ucla.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10744538" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Archaeology ; *Birds/physiology ; Humans ; New Zealand ; Population Dynamics ; Reproduction ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Ecology. Dammed experiments! (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, J -- New York, N.Y. -- Science. 2001 Nov 30;294(5548):1847-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, UCLA School of Medicine, Los Angeles, CA 90095, USA. jdiamond@mednet.ucla.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11729294" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brazil ; *Ecosystem ; *Environment ; *Food Chain ; Fresh Water ; *Geography ; Models, Biological ; Panama ; Population Density ; Power Plants ; Trees/physiology ; Venezuela
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Palaeontology: The last giant kangaroo (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-08-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, Jared -- England -- Nature. 2008 Aug 14;454(7206):835-6. doi: 10.1038/454835a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18704074" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Archaeology ; *Extinction, Biological ; Fossils ; Humans ; Macropodidae/*physiology ; Tasmania ; Time
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...