Publication Date:
1997-07-04
Description:
Bovine spongiform encephalopathy (BSE) has become a public health issue because a recently evolved BSE agent has infected people, yielding an unusual form of Creutzfeld-Jakob disease (CJD). A new CJD agent that provokes similar amyloid plaques and cerebellar pathology was serially propagated. First-passage rats showed obvious clinical signs and activated microglia but had negligible PrP-res (the more protease-resistant form of host PrP) or cerebellar lesions. Microglia and astrocytes may participate in strain selection because the agent evolved, stabilized, and reproducibly provoked BSE-like disease in subsequent passages. Early vacuolar change involving activated microglia and astrocytes preceded significant PrP-res accumulation by more than 50 days. These studies reveal several inflammatory host reactions to an exogenous agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Manuelidis, L -- Fritch, W -- Xi, Y G -- NS12674/NS/NINDS NIH HHS/ -- NS34569/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1997 Jul 4;277(5322):94-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Neuropathology, Yale Medical School, 310 Cedar Street, New Haven, CT 06510, USA. laura.manuelidis@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9204907" target="_blank"〉PubMed〈/a〉
Keywords:
Amyloid beta-Protein Precursor/analysis
;
Animals
;
Astrocytes/chemistry/*ultrastructure
;
Brain/*pathology
;
Brain Chemistry
;
Cerebellum/chemistry/pathology
;
Clusterin
;
Creutzfeldt-Jakob Syndrome/metabolism/*pathology
;
Cricetinae
;
Cricetulus
;
Encephalopathy, Bovine Spongiform/metabolism/*pathology
;
Glial Fibrillary Acidic Protein/genetics/metabolism
;
Glycoproteins/analysis
;
Inflammation
;
Macrophages/chemistry/ultrastructure
;
Mice
;
Mice, Inbred Strains
;
Microglia/chemistry/*ultrastructure
;
Microscopy, Electron
;
*Molecular Chaperones
;
PrPSc Proteins/*analysis/pathogenicity
;
RNA/metabolism
;
Rats
;
Rats, Sprague-Dawley
;
Time Factors
;
Ubiquitins/analysis
;
Vacuoles/ultrastructure
;
Virulence
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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