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  • 1
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    Yeast life-span extension by calorie restriction is independent of NAD fluctuation (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-11-08
    Description: Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD+-dependent deacetylase. We report that CR reduces nuclear NAD+ levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, Rozalyn M -- Latorre-Esteves, Magda -- Neves, Ana Rute -- Lavu, Siva -- Medvedik, Oliver -- Taylor, Christopher -- Howitz, Konrad T -- Santos, Helena -- Sinclair, David A -- P01 AG027916/AG/NIA NIH HHS/ -- R01 AG019719/AG/NIA NIH HHS/ -- R01 AG019972/AG/NIA NIH HHS/ -- R01 AG028730/AG/NIA NIH HHS/ -- R01 GM068072/GM/NIGMS NIH HHS/ -- R37 AG028730/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2003 Dec 19;302(5653):2124-6. Epub 2003 Nov 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14605207" target="_blank"〉PubMed〈/a〉
    Keywords: Acetaldehyde/metabolism ; Aerobiosis ; *Bacterial Proteins ; CCAAT-Binding Factor/genetics/metabolism ; Caloric Restriction ; Culture Media ; DNA-Binding Proteins ; Genes, Fungal ; Genes, Reporter ; Histidine/metabolism ; Histone Deacetylases/*metabolism ; Hydro-Lyases/genetics/metabolism ; Longevity ; Magnetic Resonance Spectroscopy ; NAD/*metabolism ; Recombinant Fusion Proteins/metabolism ; Repressor Proteins/genetics/metabolism ; Saccharomyces cerevisiae/genetics/growth & development/*physiology ; Saccharomyces cerevisiae Proteins/genetics/metabolism ; Silent Information Regulator Proteins, Saccharomyces cerevisiae/*metabolism ; Sirtuin 1 ; Sirtuin 2 ; Sirtuins/*metabolism ; Transcription Factors/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    The foot-and-mouth epidemic in Great Britain: pattern of spread and impact of interventions (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-04-17
    Description: We present an analysis of the current foot-and-mouth disease epidemic in Great Britain over the first 2 months of the spread of the virus. The net transmission potential of the pathogen and the increasing impact of control measures are estimated over the course of the epidemic to date. These results are used to parameterize a mathematical model of disease transmission that captures the differing spatial contact patterns between farms before and after the imposition of movement restrictions. The model is used to make predictions of future incidence and to simulate the impact of additional control strategies. Hastening the slaughter of animals with suspected infection is predicted to slow the epidemic, but more drastic action, such as "ring" culling or vaccination around infection foci, is necessary for more rapid control. Culling is predicted to be more effective than vaccination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferguson, N M -- Donnelly, C A -- Anderson, R M -- New York, N.Y. -- Science. 2001 May 11;292(5519):1155-60. Epub 2001 Apr 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Infectious Disease Epidemiology, Imperial College School of Medicine, St. Mary's Campus, Norfolk Place, London W2 1PG, UK. Neil.Ferguson@ic.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11303090" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Domestic/virology ; Aphthovirus/physiology ; Cattle ; Commerce ; Disease Reservoirs ; Foot-and-Mouth Disease/economics/epidemiology/*prevention & control/*transmission ; Great Britain/epidemiology ; Incidence ; Models, Biological ; Quarantine ; Sheep/virology ; Swine/virology ; Time Factors ; Vaccination/economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Badgers and bovine TB: conflicts between conservation and health (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krebs, J R -- Anderson, R M -- Clutton-Brock, T -- Donnelly, C A -- Frost, S -- Morrison, W I -- Woodroffe, R -- Young, D -- New York, N.Y. -- Science. 1998 Feb 6;279(5352):817-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Natural Environment Research Council, Swindon, Wilts, SN2 1EU, UK. hqpo@wpo.nerc.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9480550" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Husbandry ; Animals ; Carnivora/*microbiology ; Cattle ; Disease Reservoirs/*veterinary ; Great Britain/epidemiology ; Incidence ; *Pest Control ; Research ; Tuberculosis/transmission/*veterinary ; Tuberculosis, Bovine/epidemiology/*prevention & control/*transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-03-26
    Description: Recent studies indicate that mammals, including humans, maintain some capacity to renew cardiomyocytes throughout postnatal life. Yet, there is little or no significant cardiac muscle regeneration after an injury such as acute myocardial infarction. By contrast, zebrafish efficiently regenerate lost cardiac muscle, providing a model for understanding how natural heart regeneration may be blocked or enhanced. In the absence of lineage-tracing technology applicable to adult zebrafish, the cellular origins of newly regenerated cardiac muscle have remained unclear. Using new genetic fate-mapping approaches, here we identify a population of cardiomyocytes that become activated after resection of the ventricular apex and contribute prominently to cardiac muscle regeneration. Through the use of a transgenic reporter strain, we found that cardiomyocytes throughout the subepicardial ventricular layer trigger expression of the embryonic cardiogenesis gene gata4 within a week of trauma, before expression localizes to proliferating cardiomyocytes surrounding and within the injury site. Cre-recombinase-based lineage-tracing of cells expressing gata4 before evident regeneration, or of cells expressing the contractile gene cmlc2 before injury, each labelled most cardiac muscle in the ensuing regenerate. By optical voltage mapping of surface myocardium in whole ventricles, we found that electrical conduction is re-established between existing and regenerated cardiomyocytes between 2 and 4 weeks post-injury. After injury and prolonged fibroblast growth factor receptor inhibition to arrest cardiac regeneration and enable scar formation, experimental release of the signalling block led to gata4 expression and morphological improvement of the injured ventricular wall without loss of scar tissue. Our results indicate that electrically coupled cardiac muscle regenerates after resection injury, primarily through activation and expansion of cardiomyocyte populations. These findings have implications for promoting regeneration of the injured human heart.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040215/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040215/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kikuchi, Kazu -- Holdway, Jennifer E -- Werdich, Andreas A -- Anderson, Ryan M -- Fang, Yi -- Egnaczyk, Gregory F -- Evans, Todd -- Macrae, Calum A -- Stainier, Didier Y R -- Poss, Kenneth D -- GM075846/GM/NIGMS NIH HHS/ -- HL007101/HL/NHLBI NIH HHS/ -- HL007208/HL/NHLBI NIH HHS/ -- HL054737/HL/NHLBI NIH HHS/ -- HL064282/HL/NHLBI NIH HHS/ -- HL081674/HL/NHLBI NIH HHS/ -- K08 HL068711/HL/NHLBI NIH HHS/ -- R01 HL081674/HL/NHLBI NIH HHS/ -- R01 HL081674-05/HL/NHLBI NIH HHS/ -- R01 HL081674-06/HL/NHLBI NIH HHS/ -- R01 HL109264/HL/NHLBI NIH HHS/ -- R21 GM075946/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Mar 25;464(7288):601-5. doi: 10.1038/nature08804.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20336144" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Cell Proliferation ; Electric Conductivity ; GATA Transcription Factors/*genetics/*metabolism ; Gene Expression Regulation ; Heart/*physiology ; Myocytes, Cardiac/*cytology/*metabolism ; Regeneration/genetics/*physiology ; Zebrafish/genetics/metabolism/*physiology ; Zebrafish Proteins/*genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Antigenic diversity thresholds and the development of AIDS (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-11-15
    Description: Longitudinal studies of patients infected with HIV-1 reveal a long and variable incubation period between infection and the development of AIDS. Data from a small number of infected patients show temporal changes in the number of genetically distinct strains of the virus throughout the incubation period, with a slow but steady rise in diversity during the progression to disease. A mathematical model of the dynamic interaction between viral diversity and the human immune system suggests the existence of an antigen diversity threshold, below which the immune system is able to regulate viral population growth but above which the virus population induces the collapse of the CD4+ lymphocyte population. The model suggests that antigenic diversity is the cause, not a consequence, of immunodeficiency disease. The model is compared with available data, and is used to assess how the timing of the application of chemotherapy or immunotherapy influences the rate of progress to disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nowak, M A -- Anderson, R M -- McLean, A R -- Wolfs, T F -- Goudsmit, J -- May, R M -- New York, N.Y. -- Science. 1991 Nov 15;254(5034):963-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Oxford, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1683006" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*immunology/prevention & control/therapy ; Base Sequence ; CD4-Positive T-Lymphocytes ; Computer Simulation ; DNA, Viral/genetics ; HIV Antigens/genetics ; HIV Core Protein p24/metabolism ; HIV-1/genetics/*immunology ; Humans ; Immunotherapy ; Leukocyte Count ; Molecular Sequence Data ; Mutation ; Oligonucleotides/chemistry ; Time Factors ; Vaccination
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    HIV decline associated with behavior change in eastern Zimbabwe (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-02-04
    Description: Few sub-Saharan African countries have witnessed declines in HIV prevalence, and only Uganda has compelling evidence for a decline founded on sexual behavior change. We report a decline in HIV prevalence in eastern Zimbabwe between 1998 and 2003 associated with sexual behavior change in four distinct socioeconomic strata. HIV prevalence fell most steeply at young ages-by 23 and 49%, respectively, among men aged 17 to 29 years and women aged 15 to 24 years-and in more educated groups. Sexually experienced men and women reported reductions in casual sex of 49 and 22%, respectively, whereas recent cohorts reported delayed sexual debut. Selective AIDS-induced mortality contributed to the decline in HIV prevalence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gregson, Simon -- Garnett, Geoffrey P -- Nyamukapa, Constance A -- Hallett, Timothy B -- Lewis, James J C -- Mason, Peter R -- Chandiwana, Stephen K -- Anderson, Roy M -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2006 Feb 3;311(5761):664-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Infectious Disease Epidemiology, Imperial College London, UK. Sajgregson@aol.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16456081" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Cohort Studies ; Condoms ; *Disease Outbreaks/prevention & control ; Emigration and Immigration ; Female ; HIV Infections/*epidemiology/mortality/prevention & control/transmission ; Humans ; Incidence ; Longitudinal Studies ; Male ; Prevalence ; Risk-Taking ; *Sexual Behavior ; Socioeconomic Factors ; Zimbabwe/epidemiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Caloric restriction delays disease onset and mortality in rhesus monkeys (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-07-11
    Description: Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812811/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812811/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Colman, Ricki J -- Anderson, Rozalyn M -- Johnson, Sterling C -- Kastman, Erik K -- Kosmatka, Kristopher J -- Beasley, T Mark -- Allison, David B -- Cruzen, Christina -- Simmons, Heather A -- Kemnitz, Joseph W -- Weindruch, Richard -- P01 AG-11915/AG/NIA NIH HHS/ -- P01 AG011915/AG/NIA NIH HHS/ -- P01 AG011915-11A29002/AG/NIA NIH HHS/ -- P51 RR000167/RR/NCRR NIH HHS/ -- RR020141-01/RR/NCRR NIH HHS/ -- RR15459-01/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2009 Jul 10;325(5937):201-4. doi: 10.1126/science.1173635.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA. rcolman@primate.wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19590001" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Atrophy/epidemiology/prevention & control ; Body Weight ; Brain/*pathology ; *Caloric Restriction ; Cardiovascular Diseases/epidemiology/*prevention & control ; Diabetes Mellitus/epidemiology/*prevention & control ; Female ; Glucose/metabolism ; Incidence ; *Longevity ; Macaca mulatta ; Male ; Neoplasms/epidemiology/*prevention & control
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 8
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    Public health. Public health risk from the avian H5N1 influenza epidemic (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferguson, Neil M -- Fraser, Christophe -- Donnelly, Christl A -- Ghani, Azra C -- Anderson, Roy M -- New York, N.Y. -- Science. 2004 May 14;304(5673):968-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St. Mary's campus, Norfolk Place, London W2 1PG, UK. neil.ferguson@imperial.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15143265" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Domestic ; Birds ; Cluster Analysis ; *Disease Outbreaks/veterinary ; Global Health ; Humans ; Influenza A Virus, H5N1 Subtype/genetics/*pathogenicity ; Influenza in Birds/epidemiology/prevention & control/transmission/virology ; Influenza, Human/*epidemiology/*transmission/virology ; Mathematics ; *Population Surveillance ; *Public Health ; Reassortant Viruses/genetics/pathogenicity ; Recombination, Genetic ; Risk Assessment ; Zoonoses
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-05-27
    Description: We present an analysis of the first 10 weeks of the severe acute respiratory syndrome (SARS) epidemic in Hong Kong. The epidemic to date has been characterized by two large clusters-initiated by two separate "super-spread" events (SSEs)-and by ongoing community transmission. By fitting a stochastic model to data on 1512 cases, including these clusters, we show that the etiological agent of SARS is moderately transmissible. Excluding SSEs, we estimate that 2.7 secondary infections were generated per case on average at the start of the epidemic, with a substantial contribution from hospital transmission. Transmission rates fell during the epidemic, primarily as a result of reductions in population contact rates and improved hospital infection control, but also because of more rapid hospital attendance by symptomatic individuals. As a result, the epidemic is now in decline, although continued vigilance is necessary for this to be maintained. Restrictions on longer range population movement are shown to be a potentially useful additional control measure in some contexts. We estimate that most currently infected persons are now hospitalized, which highlights the importance of control of nosocomial transmission.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riley, Steven -- Fraser, Christophe -- Donnelly, Christl A -- Ghani, Azra C -- Abu-Raddad, Laith J -- Hedley, Anthony J -- Leung, Gabriel M -- Ho, Lai-Ming -- Lam, Tai-Hing -- Thach, Thuan Q -- Chau, Patsy -- Chan, King-Pan -- Lo, Su-Vui -- Leung, Pak-Yin -- Tsang, Thomas -- Ho, William -- Lee, Koon-Hung -- Lau, Edith M C -- Ferguson, Neil M -- Anderson, Roy M -- New York, N.Y. -- Science. 2003 Jun 20;300(5627):1961-6. Epub 2003 May 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK. s.riley@imperial.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12766206" target="_blank"〉PubMed〈/a〉
    Keywords: Cluster Analysis ; Contact Tracing ; Cross Infection/epidemiology/prevention & control/transmission ; *Disease Outbreaks/prevention & control/statistics & numerical data ; *Epidemiologic Methods ; Global Health ; Hong Kong/epidemiology ; Hospitalization ; Humans ; Infection Control ; Mathematics ; *Models, Statistical ; Patient Isolation ; Probability ; *Public Health Practice ; Quarantine ; SARS Virus/physiology ; Severe Acute Respiratory Syndrome/*epidemiology/prevention & ; control/*transmission/virology ; Stochastic Processes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Mathematical studies of parasitic infection and immunity (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-06-24
    Description: The techniques that underpin modern molecular biology have been rapidly adopted by those interested in the major parasitic infections of humans. The parasitological literature is full of reports of genes and their amino acid sequences, of molecules, of cell membrane receptors and channels, and of the fine details of the immunological responses mounted by the host to combat infection. Much less enthusiasm has been shown for the mathematical techniques that facilitate the analysis and interpretation of dynamical processes such as transmission, evolution, and the interplay between parasite population growth and immunological responses within the host. Molecular techniques provide enormous opportunities for description, but ultimately, understanding biological systems with the precision that physicists and engineers aspire to in their own fields will require quantitative description of the many rate processes that dictate both an observed pattern and the dynamics of its change.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, R M -- New York, N.Y. -- Science. 1994 Jun 24;264(5167):1884-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Oxford, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8009218" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antigenic Variation ; Host-Parasite Interactions ; Humans ; Mathematics ; *Models, Biological ; Parasites/immunology/physiology ; *Parasitic Diseases/epidemiology/immunology/parasitology/transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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