ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Rats  (2,686)
  • Deutschland
  • Organic Chemistry
  • American Association for the Advancement of Science (AAAS)  (2,714)
  • Verlag Julius Klinkhardt  (16)
  • Springer Nature  (3)
  • 1
    facet.materialart.
    Unknown
    Lehrer*innenbildung und Bologna-Prozess (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: Contrary to the assumption of worldwide diffusion processes of internationally circulating reform ideas in education there are examples of regions that resist. In the present study, the phenomenon of incorporating international reform ideas into local education systems is examined using new institutionalism as a theory for its explanatory power of worldwide diffusion processes in education together with a set of cases that offer semi-lab-like conditions: Not all German federated states have adopted Bachelor’s and Master’s degrees for teacher training; some have maintained the state examination. Based on this empirical finding, the question of the dissertation is: Whether and how were the Bachelor’s and Master’s degree in German teacher training implemented on the federated statelevel in the period between 1999 and 2013? It can be shown that the federal ministers of higher education specified three core characteristics of the Bologna Process, namely the introduction of Bachelor’s and Master’s degrees, a credit point system, and modularisation. A decision of the Standing Conference of the Ministers of Education and Cultural Affairs of Germany made in 2005 further ensured that the reformed degrees were recognised nationwide for teachers as well. The educational organisations’ demands were characterised by a large number of positive and only a few negative votes concerning the implementation of the Bologna Process in German teacher education. To provide specific insights into the reform process, this study focuses on teacher training for secondary school teachers, comparing the teacher training regulations as of 1999 with all subsequent changes until 2013 to obtain the degree of change for each federated state. As a result, it can be stated that eight states introduced reformed degrees into secondary school teacher education and eight states kept the state examination. Both groups are then compared as to whether a change of the degree towards Bachelor’s and Master’s is more likely to be accompanied by further reforms. The results suggest that while changes have occurred in all states, the percentage increase of courses in education and didactics, as well as the increased study duration, correlates positively with a change of the degree structure. Therefore one can interpret that the Bologna reforms, especially those concerning the degree structure, were used to implement other curricular and structural reforms that were not related to the Bologna Process itself. In the last step, plenary debates on the federated state level regarding the introduction of these Bologna reforms are analysed to examine the justifications for the introduction of a change in the degree structure, as well as for maintaining the state examination. Justifications or strategies for preserving the state examination are particularly relevant because they act against the political and public expectations analysed earlier. In a nutshell, it can be stated that the innovative strength of the partial reforms adopted in the hybrid model and the exclusion of a fundamental criticism of Bachelor’s and Master’s degrees are used as a strategy to reject the implementation of a new degree structure without being interpreted as non-innovative. Federated states that implemented the degree reform referenced decisions made in other states or regions, as well as possible negative consequences of not implementing the degrees, to support their decision while also presenting it within the discourse as a window of opportunity for more fundamental reforms in teacher training.
    Description: Entgegen der Annahme weltweiter Diffusionsprozesse international kursierender Reformideen in der Bildungspolitik gibt es Beispiele für Regionen, die sich widersetzen. In der vorliegenden Arbeit wird dieses Phänomen mithilfe eines Sets an Fällen untersucht, die in ihrer Gesamtheit quasi-laborartige Bedingungen bieten: Im Zuge des Bologna-Prozesses haben einige Bundesländer die Abschlüsse ‚Bachelor‘ und ‚Master‘ für die Lehrer*innenbildung übernommen, während andere die Staatsprüfung beibehalten haben. Ausgehend von diesem Befund wird in der Arbeit die Frage untersucht, mit welchen Strategien die Bologna-Reformen in der Lehrer*innenbildung der einzelnen Bundesländer in den Jahren von 1999 bis 2013 politisch umgesetzt bzw. wie deren Implementation verhindert wurde. Die Analyse der Erwartungen bildungspolitischer Akteure zeigt, dass die Hochschulminister*innen im Bologna-Prozess drei Kernmerkmale für die Organisation von Studiengängen festlegten, nämlich Bachelor- und Masterabschlüsse, ein Leistungspunktesystem und die Modularisierung. Darüber hinaus wurde die Bologna-Reform durch die Kultusministerkonferenz im Jahr 2005 auch für die Lehrer*innenbildung deutschlandweit anerkannt. Der Diskurs weiterer wichtiger bildungspolitischer Akteure zeichnet sich darüber hinaus durch eine Vielzahl an positiven gegenüber nur wenigen negativen Stimmen zur Implementation des Bologna-Prozesses in der Lehrer*innenbildung aus. Um die tatsächlichen Reformen differenziert betrachten zu können, wird der Fokus der zweiten Untersuchung allein auf das gymnasiale Lehramt gelegt. Dabei wird für jedes Bundesland die Gestaltung der Studienphase im Jahr 1999 mit dem Stand im Jahr 2013 verglichen. Dabei kann festgestellt werden, dass in allen Bundesländern sowohl das Leistungspunktesystem als auch die Modularisierung eingeführt wurden. Eine Reform der Staatsprüfung hin zu einem Masterabschluss wurde im Untersuchungszeitraum jedoch nur in acht der 16 Bundesländer umgesetzt. Die Einführung der Bachelor- und Masterabschlüsse ging zudem mit einer prozentualen Erhöhung des Anteils der Berufswissenschaften, definiert als Fachdidaktiken, Bildungswissenschaften und Schulpraktika, sowie einer Verlängerung der Studienzeit einher. Dies kann dahingehend interpretiert werden, dass die Bologna- Reformen insgesamt und die Einführung der Bachelor- und Masterabschlüsse im Besonderen als window of opportunity genutzt wurden, um auch andere Reformen umzusetzen. In der dritten Untersuchung werden Plenardebatten in den Bundesländern im Rahmen der Einführung der Bologna-Reformen analysiert, um die Begründungen für eine Reform bzw. für die Beibehaltung der Staatsprüfung zu untersuchen. Insbesondere Begründungen bzw. Strategien der Nicht-Einführung sind dabei besonders relevant, weil sie gängigen theoretischen Annahmen der Diffusion von international kursierenden Reformideen widersprechen. Zusammenfassend kann festgehalten werden, dass die Innovationskraft bzw. Passfähigkeit des eigenen Gesetzentwurfs unter Ausschluss einer Fundamentalkritik an den Bachelor- und Masterabschlüssen als Strategie verwendet wurden, um die Einführung dieser Abschlüsse zu umgehen, ohne gleichzeitig als rückständig im Vergleich zu den Ländern mit einer vollständigen Implementation zu gelten. Bei einer Implementation der Abschlüsse dient neben dem diskursiv hergestellten window of opportunity auch der Verweis auf an anderen Orten getroffene Entscheidungen und den daraus resultierenden negativen Konsequenzen für das eigene Bundesland bei einer etwaigen Nicht-Implementation als legitimitätsstiftend.
    Keywords: Lehrerbildung ; Lehrerausbildung ; Bologna-Prozess ; Hochschulpolitik ; Bachelor-Studiengang ; Master-Studiengang ; Lehramtsstudiengang ; Hochschulreform ; Hochschule ; Entscheidung ; Strategie ; Studiengang ; Studienordnung ; Bildungspolitik ; Gymnasium ; Modularisierung ; Staatsprüfung ; Lehramtsprüfung ; Argumentation ; Debatte ; Politik ; Bundesland ; Nationaler Vergleich ; Baden-Württemberg ; Bayern ; Berlin ; Brandenburg ; Bremen ; Hamburg ; Hessen ; Mecklenburg-Vorpommern ; Niedersachsen ; Nordrhein-Westfalen ; Rheinland-Pfalz ; Saarland ; Sachsen ; Sachsen-Anhalt ; Schleswig-Holstein ; Thüringen ; Deutschland ; Teacher education ; Teachers' training ; Teacher training ; Higher education policy ; University policy ; Bachelor course ; Master course ; Preservice Teacher Education ; Higher education reform ; University reform ; Higher education institute ; Strategy ; Channel of academic studies ; Course of studies ; Course of study ; Study regulations ; Educational policy ; German academic secondary school ; Grammar School ; Secondary school ; Modularization ; First state examination for the teaching profession ; Politics ; Baden-Wurtemberg ; Baden-Wurttemberg ; Mecklenburg-Western Pomerania ; Lower Saxony ; North Rhine-Westphalia ; North-Rhine Westphalia ; Rhineland-Palatinate ; Saxony ; Saxony-Anhalt ; Thuringia ; Germany ; Teaching post ; Teaching profession ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education::JNMN Universities ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 2
    facet.materialart.
    Unknown
    Auf die Lernbegleitung kommt es an! (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: Within and outside Germany, practical phases in teacher education have been expanded in recent years. In contrast, empirical studies show that it is not primarily the duration of the internships but their qualitative design that is significant for the acquisition of competencies by the students. Against this background, the academic examination of concepts of learning support is gaining in importance. The authors in this volume take up this assumption and present ten context-bound learning support concepts and their empirical examination. Using qualitative and quantitative research methods, theory-based hypotheses are tested and framework conditions are included in the discussion. In this respect, the results of the studies presented promise on the one hand in-depth insights into the opportunities and challenges of learning support services in the school internship, and on the other hand they point to desiderata for further studies in this field of research.
    Description: Innerhalb und außerhalb Deutschlands wurden in den vergangenen Jahren Praxisphasen in der Lehrerbildung ausgebaut. Empirische Studien zeigen demgegenüber, dass nicht vorrangig die Dauer der Praktika, sondern ihre qualitative Ausgestaltung bedeutsam für den Kompetenzerwerb der Studierenden ist. Vor diesem Hintergrund gewinnt die wissenschaftliche Auseinandersetzung mit Konzepten der Lernbegleitung an Bedeutung. Die Autorinnen und Autoren im vorliegenden Band knüpfen an dieser Annahme an und stellen zehn kontextgebundene Lernbegleitungskonzepte und deren empirische Überprüfung vor. Mittels qualitativer und quantitativer Forschungsmethoden werden dabei theoriegeleitete Hypothesen überprüft und Rahmenbedingungen in die Diskussion einbezogen. Insofern versprechen die Ergebnisse der vorgestellten Studien einerseits vertiefende Einblicke in Chancen und Herausforderungen lernbegleitender Angebote im Schulpraktikum, andererseits zeigen sie Desiderate für weiterführende Untersuchungen in diesem Forschungsfeld auf.
    Keywords: Lehrerbildung ; Lehrerausbildung ; Lernbegleitung ; Praxissemester ; Schulpraxis ; Pädagogische Praxis ; Schulpraktikum ; Lehramtsstudent ; Kompetenzerwerb ; Pädagogische Kompetenz ; Lernkonzept ; Lehrerbildner ; Unterrichtsbeobachtung ; Unterrichtsanalyse ; Reflexion 〈Phil〉 ; Mentor ; Hochschule ; Schule ; Peer Group ; Lernwerkstatt ; Coaching ; Lehrberuf ; Hochschulbildung ; Professionalisierung ; Wohlbefinden ; Lehramtsstudiengang ; Handlungskompetenz ; Einstellung 〈Psy〉 ; Dozent ; Lehrer ; Feed-back ; Interaktion ; Gespräch ; Besprechung ; Unterricht ; Audioaufzeichnung ; Diagnostik ; Kohärenz ; Mentoring ; Mentorprogramm ; Unterrichtsentwicklung ; Übergang Studium - Beruf ; Qualifizierung ; Hochschullehre ; Hochschulforschung ; Fortbildung ; Biologieunterricht ; Entwicklungsforschung ; Beziehung ; Peer-Beziehungen ; Kompetenzentwicklung ; Kompetenz ; Selbsteinschätzung ; Tandem-Methode ; Geschlechtsspezifischer Unterschied ; Kollegiale Beratung ; Qualifikationsentwicklung ; Austausch ; Beratung ; Moderator ; Moderation ; Lernprozess ; Grundschule ; Außerschulischer Lernort ; Lernumgebung ; Primarbereich ; Ethnografie ; Beobachtung ; Forschendes Lernen ; Belastung ; Stressbewältigung ; Wirksamkeit ; Digitale Medien ; Beruflicher Stress ; Lehrer-Alltag ; Bildungsangebot ; Online-Kurs ; Auditives Medium ; Zufriedenheit ; Quantitative Forschung ; Qualitative Forschung ; Empirische Untersuchung ; Empirische Forschung ; Interview ; Leitfadeninterview ; Studie ; Fragebogenerhebung ; Explorative Studie ; Grounded Theory ; Evaluation ; Niedersachsen ; Thüringen ; Nordrhein-Westfalen ; Mecklenburg-Vorpommern ; Hessen ; Deutschland ; Teacher education ; Teachers' training ; Teacher training ; Practical semester ; Semester practical training ; Practical training in school ; Practice period at school ; Student teachers ; Teacher educators ; Observation of teaching ; Analysis of teaching process ; Teaching analysis ; Higher education institute ; School ; Peer groups ; Learning workshop ; Apprenticeship trade ; Teaching profession ; Higher education ; University level of education ; Professionalization ; Well being ; Well-being ; Preservice Teacher Education ; Competence for action ; Competence to act ; Lecturer ; Teacher ; Interaction ; Conversation ; Teaching ; Diagnostic ; Learning and teaching development ; Teaching improvement ; Qualification ; Higher education lecturing ; University lecturing ; University teaching ; Academic research ; Further education ; Further training ; Biology lessons ; Teaching of Biology ; Peer relationship ; Skill development ; Competency ; Self-rating ; Gender-specific difference ; Counselling ; Deliberation ; Guidance ; Learning process ; Elementary School ; Primary school ; Primary school lower level ; Educational Environment ; Learning environment ; Primary education ; Primary level ; Ethnography ; Observation ; Stress management ; Educational offer ; Educational offerings ; Educational opportunities ; Educational possibilities ; Educational provision ; Online courses ; Satisfaction ; Quantitative research ; Qualitative research ; Empirical study ; Empirical research ; Questionnaire survey ; Lower Saxony ; Thuringia ; North Rhine-Westphalia ; North-Rhine Westphalia ; Mecklenburg-Western Pomerania ; Germany ; Practice ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education::JNMT Teacher training ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education::JNMT Teacher training
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 3
    facet.materialart.
    Unknown
    Inklusionsorientierte Lehr-Lern- Bausteine für die Hochschullehre (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: Good inclusive teaching needs teachers who are able to plan and implement pedagogical offers in a heterogeneity-sensitive and adaptive way - however, in university teacher training there are only a few subject-didactically implementable contents for this so far. This book presents five flexibly applicable teaching-learning modules on central topics of inclusive teaching, which were developed by subject didacticians in cooperation with rehabilitation scientists and language educators for university teaching. Starting from the theoretical foundations, the structure, content and materials of the individual teaching-learning modules are presented and commented on didactically. Following on from this, the empirical results of the quantitative and qualitative accompanying evaluation of corresponding courses are analysed. In addition, the suitability of the teaching-learning modules for stabilisation in the university context as well as their possible use in the second and third phase of teacher training are discussed. This book aims to motivate lecturers to use the presented modules in their teaching. It is also aimed at students, researchers and teachers who want to develop their teaching in an inclusive way.
    Description: Guter inklusiver Unterricht braucht Lehrkräfte, die pädagogische Angebote heterogenitätssensibel und adaptiv planen und umsetzen können – in der universitären Lehrer*innenbildung existieren dafür bislang jedoch nur wenige fachdidaktisch implementierbare Inhalte. In diesem Buch werden fünf flexibel einsetzbare Lehr-Lern-Bausteine zu zentralen Themen inklusiven Unterrichtens vorgestellt, die von Fachdidaktiker*innen in Zusammenarbeit mit Rehabilitationswissenschaftler*innen und Sprachbildner*innen für die Hochschullehre entwickelt wurden. Ausgehend von den theoretischen Grundlagen werden der Aufbau, die Inhalte und die Materialien der einzelnen Lehr-Lern-Bausteine vorgestellt und didaktisch kommentiert. Daran anknüpfend werden die empirischen Ergebnisse der quantitativen und qualitativen Begleitevaluation entsprechender Lehrveranstaltungen analysiert. Außerdem werden die Eignung der Lehr-Lern-Bausteine für die Verstetigung im Hochschulkontext sowie deren Einsatzmöglichkeiten in der zweiten und dritten Phase der Lehrer*innenbildung diskutiert. Dieses Buch möchte Dozent*innen motivieren, die vorgestellten Bausteine selbst in ihrer Lehre einzusetzen. Es richtet sich außerdem an Student*innen, an Forscher*innen und an Lehrer*innen, die ihren Unterricht inklusionsorientiert weiterentwickeln möchten.
    Keywords: Inklusion ; Unterricht ; Hochschule ; Hochschullehre ; Professionalisierung ; Lehrerausbildung ; Lehr-Lern-Prozess ; Bildungskonzept ; Lehrerbildung ; Kompetenz ; Lehr-Lern-System ; Lehrevaluation ; Lehramtsstudiengang ; Heterogenität ; Sensibilität ; Lehrkompetenz ; Integrative Pädagogik ; Professionalität ; Pädagogisches Handeln ; Fachdidaktik ; Sonderpädagogik ; Klassenführung ; Adaptiver Unterricht ; Unterrichtskonzeption ; Sprachbildung ; Lehramtsstudent ; Baustein ; Reflexion 〈Phil〉 ; Selbstreflexion ; Pädagogische Diagnostik ; Diagnostik ; Begleituntersuchung ; Evaluation ; Empirische Untersuchung ; Quantitative Analyse ; Qualitative Analyse ; Forschungsprojekt ; Deutschland ; Inclusion ; Teaching ; Higher education institute ; Higher education lecturing ; University lecturing ; University teaching ; Professionalization ; Teacher education ; Teacher training ; Teaching-learning process ; Educational conception ; Teachers' training ; Competency ; Preservice Teacher Education ; Heterogeneity ; Sensibility ; Teaching Skills ; Integrative education ; Professionalism ; Professionality ; Specialized didactics ; Subject didactics ; Remedial instruction sciences ; Special education for the handicapped ; Special needs education ; Classroom techniques ; Conception of teaching ; Linguistic input ; Student teachers ; Self-reflexion ; Pedagogical diagnostics ; Diagnostic ; Empirical study ; Germany ; Pedagogical thinking ; Teaching-learning research ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy::JNFN Inclusive education / mainstreaming ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy::JNFK Educational strategies and policy: inclusion
    Language: German
    Format: image/jpeg
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 4
    facet.materialart.
    Unknown
    Forschungsinstrumente im Kontext institutioneller (schrift-)sprachlicher Bildung (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: This book presents a selection of survey and evaluation instruments for recording relevant facets of institutional (written) language education. The seven methods focus on different aspects of language education as well as language and reading promotion in day-care centres and schools and address different target groups (educational professionals, teachers, children). The instruments, which were developed within the framework of the initiative "Bildung durch Sprache und Schrift" (BiSS), are primarily for research purposes, but can also be used in the training and further education of educational specialists and teachers. An online appendix provides the instruments as well as all necessary materials.
    Description: In diesem Buch wird eine Auswahl von Erhebungs- und Auswertungsinstrumenten zur Erfassung relevanter Facetten institutioneller (schrift-)sprachlicher Bildung vorgestellt. Die sieben Verfahren fokussieren unterschiedliche Aspekte der Sprachbildung sowie Sprach- und Leseförderung in Kindertageseinrichtungen und Schulen und adressieren unterschiedliche Zielgruppen (pädagogische Fachkräfte, Lehrkräfte, Kinder). Die Instrumente, die im Rahmen der Initiative „Bildung durch Sprache und Schrift“ (BiSS) entwickelt wurden, sind primär für Forschungszwecke, aber auch in der Aus- und Weiterbildung von pädagogischen Fach- und Lehrkräften einsetzbar. Ein Online-Anhang stellt die Instrumente sowie alle notwendigen Materialien zur Verfügung.
    Keywords: Bildungsforschung ; Forschung ; Schriftsprache ; Sprachbildung ; Sprachförderung ; Leseförderung ; Diagnostik ; Förderungsmaßnahme ; Sprachentwicklung ; Schriftspracherwerb ; Förderdiagnostik ; Förderung ; Sprachstandsforschung ; Lesekompetenz ; Sprachkompetenz ; Sprachdiagnostik ; Fachdidaktik ; Sprachgebrauch ; Kompetenzmessung ; Handlungskompetenz ; Fachwissen ; Wissen ; Professionalisierung ; Profession ; Kompetenz ; Wissenstest ; Mathematikunterricht ; Deutschunterricht ; Fachunterricht ; Fachsprache ; Reflexion 〈Phil〉 ; Feed-back ; Videoaufzeichnung ; Videoanalyse ; Unterricht ; Lehrer-Schüler-Interaktion ; Schülermitarbeit ; Transfer ; Kindertagesstätte ; Schule ; Grundschule ; Primarbereich ; Pädagogische Fachkraft ; Lehrer ; Lehramtsstudent ; Erzieher ; Erzieherin ; Berufliche Kompetenz ; Psychometrie ; Kind ; Schüler ; Bewertung ; Anwendung ; Software ; Bildungspraxis ; Sprachpraktische Übung ; Spracherwerb ; Kindergarten ; Kindergartenalltag ; Kindergartenpädagogik ; Korrektur ; Pädagogisches Handeln ; Sekundarstufe I ; Aktivierung ; Erhebungsinstrument ; Auswertung ; Instrument ; Messinstrument ; Methode ; Forschungsmethode ; Vignette 〈Methode〉 ; Interview ; Leitfadeninterview ; Fragebogen ; Beobachtung ; Beobachtungsmethode ; Test ; Testvalidität ; Testverfahren ; Testkonstruktion ; Quantitative Forschung ; Qualitative Forschung ; Längsschnittuntersuchung ; Dokumentation ; Protokoll ; Empirische Forschung ; Datenerfassung ; Bayern ; Baden-Württemberg ; Nordrhein-Westfalen ; Sachsen-Anhalt ; Deutschland ; Educational research ; Research ; Linguistic input ; Promotion of reading ; Support for reading improvement ; Diagnostic ; Promotional measure ; Language development ; Reading competence ; Language skill ; Linguistic Competence ; Specialized didactics ; Subject didactics ; Language usage ; Competency measurement ; Skills measurement ; Skills measurements ; Competence for action ; Competence to act ; Specialized knowledge ; Knowledge ; Professionalization ; Competency ; Mathematics lessons ; Teaching of mathematics ; German language teaching ; Teaching of German ; Teaching of a special subject ; Language for special purposes ; Technical language ; Teaching ; Pupil Participation ; Day nursery ; School ; Elementary School ; Primary school ; Primary school lower level ; Primary education ; Primary level ; Teacher ; Student teachers ; Caregiver ; Carer ; Educational childcare staff ; Educator ; Kindergarten teacher ; Nursery school teachers ; Nursery teacher ; Pre-primary school teacher ; Female Educator ; Governess ; Psychometry ; Child ; Pupil ; Pupils ; Assessment ; Judgement ; Judgment ; Educational practices ; Language acquisition ; Nursery school ; Revision (Written Composition) ; Lower level secondary education ; Lower secondary ; Lower secondary education ; Secondary education lower level ; Mail surveys ; Data analysis ; Interpretation of literature ; Measurement instrument ; Method ; Research method ; Questionnaire ; Observation ; Test validity ; Test coaching ; Quantitative research ; Qualitative research ; Longitudinal analysis ; Longitudinal study ; Documentation ; Empirical research ; Data acquisition ; Data capture ; Baden-Wurtemberg ; Baden-Wurttemberg ; North Rhine-Westphalia ; North-Rhine Westphalia ; Saxony-Anhalt ; Germany ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy::JNFD Literacy strategies ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 5
    facet.materialart.
    Unknown
    Geflüchtete in ländlichen Regionen Deutschlands (2022)
    Springer Nature | Springer Fachmedien Wiesbaden
    Details
    Publication Date: 2022-11-19
    Description: Die Open-Access-Publikation präsentiert umfangreiche empirische Analysen zu Halte- und Bleibeorientierung Geflüchteter und richtet den Blick dabei besonders auf die Situation der ländlichen Regionen Deutschlands. Migrations- und Integrationsforschung in Deutschland war bislang überwiegend auf Großstädte ausgerichtet. Durch den vermehrten Zuzug geflüchteter Menschen seit 2014 sehen sich jedoch auch Kleinstädte und Dörfer in ländlichen Regionen verstärkt mit Aufgaben der Aufnahme und Integration von Geflüchteten konfrontiert. Ziel dieses Buches ist es, empirisch fundiert zu beantworten, unter welchen Voraussetzungen und wie humanitäres Engagement und ländliche Entwicklung erfolgreich verbunden werden können und wie dies von Politik und Zivilgesellschaft positiv beeinflusst werden kann.
    Keywords: Geflüchtete ; Migration ; Migrationspolitik ; Migrationsforschung ; Integration ; Integrationsbereitschaft ; ländliche Räume ; Deutschland ; Mobilität ; lokale Integrations- und Migrationspolitik ; Aufnahmegesellschaft ; Bleibeorientierung ; soziales Wohlbefinden ; German Politics ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPP Public administration ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPH Political structure & processes ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 6
    facet.materialart.
    Unknown
    Schulische Inklusion als widersprüchliche Herausforderung (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: nklusion steht als normatives Konzept in einem Spannungsverhältnis zum bisher selektiv verfassten Schulsystem. Lehrkräfte an sich inklusiv entwickelnden Schulen sind daher mit der Herausforderung konfrontiert, zwischen ihrer eigenen Praxis, einer inklusiven schulischen Programmatik, dem gesellschaftlichen Leistungsverständnis und der schulischen Selektionsfunktion vermitteln zu müssen. Die vorliegende Studie wirft zunächst einen systematischen Blick auf den Inklusionsdiskurs und untersucht hieran anschließend den Umgang mit diesem Spannungsverhältnis anhand von Gruppendiskussionen mit Lehrkräften an sich als inklusiv verstehenden Grundschulen. Mithilfe der Dokumentarischen Methode werden fallübergreifende Orientierungen rekonstruiert, die sich vor allem in der Verortung der Problemlösekompetenz unterscheiden. So sieht ein Teil Lehrkräfte die Verantwortung zur Lösung von Problemen, die bei der Realisierung von Inklusion entstehen, bei Externen, wie der Bildungsadministration. Andere sehen sich hingegen selbst in der Lage, die bei der Realisierung von Inklusion entstehenden Herausforderungen erfolgreich zu lösen. Bei Letzteren wird eine Parallele zu einem Teil des Inklusionsdiskurses deutlich, da Inklusion auch dort als pädagogisch lösbare Herausforderung angenommen wird. Die Arbeit zeigt diesbezüglich Anknüpfungspunkte für die weitere Entwicklung inklusiver Schulen auf. (DIPF/Orig.)
    Keywords: Inklusion ; Schule ; Grundschule ; Integrative Schule ; Lehrer ; Einstellung 〈Psy〉 ; Problemlösen ; Sonderpädagogik ; Gruppendiskussion ; Typisierung ; Dokumentarische Methode ; Deutschland ; Inclusion ; School ; Elementary School ; Primary school ; Primary school lower level ; Inclusive education ; Inclusive school ; Teacher ; Problem solving ; Remedial instruction sciences ; Special education for the handicapped ; Special needs education ; Group discussion ; Germany ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy::JNFN Inclusive education / mainstreaming ; bic Book Industry Communication::J Society & social sciences::JN Education::JNL Schools ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy::JNFK Educational strategies and policy: inclusion ; thema EDItEUR::J Society and Social Sciences::JN Education::JNL Schools and pre-schools ; thema EDItEUR::J Society and Social Sciences::JN Education::JNS Teaching of students with different educational needs
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 7
    facet.materialart.
    Unknown
    Inklusion als schulischer Transformationsprozess (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: With the development of inclusive schools comes a broad range of new challenges within the whole German education system. According to the different responsibilities in the educational governance of the German system, not only the state level but also the district level has an important role in the reorganization process towards an inclusive school system. This doctoral thesis thus aims at developing a set of educational indicators at district and individual school level that provides information about the inputs, processes and outputs of inclusive schooling, i.e. conditions and school organizational aspects such as experience in dealing with heterogeneity (special educational needs, migration, gender, etc.). Thereby it can also provide a foundation for continuous, largely data-based observation and analysis of the implementation process of school inclusion. This kind of monitoring can inform both German educational policy and the public regarding contexts, process characteristics, outcomes and benefits of inclusive schooling. The main question of the thesis thus is: What indicators can be identified to describe and reflect developments in the implementation of an inclusive school system at the district level? This is addressed by a three-step analysis, exemplified by a typical German municipality in North Rhine-Westphalia. (1) Starting with an analysis of available school statistics in the period from 2007 to 2015 (2), the results are supplemented by a quantitative school-leadership survey in 2016 (3). A synthesis of the given results marks the last step with a characterization of the transformation process at school and district level. The framework of indicators is meant to identify general problems and offer an empirical foundation for the information on inclusive schooling in German municipalities, thus providing valid governance knowledge for a holistic, coherent educational management as well as contributing to improve the quality of inclusive education at district level. (DIPF/Orig.)
    Description: Die Umsetzung des Inklusionsgedankens konfrontiert das gesamte Bildungssystem mit neuen Herausforderungen. Entsprechend der föderalen Zuständigkeiten sind dafür neben dem Land auch Kreise und Schulträger in der Pflicht, die Entwicklung mitzugestalten. Derzeit gibt es nur wenig systematisierte Informationen über den Stand der inklusiven Bildung im Schulsystem auf kommunaler Ebene. Dies hängt auch mit einer weitgehenden Unklarheit zusammen, welche Bemessungsgrundlagen für eine Einschätzung der Qualität inklusiv arbeitender Schulen zur Verfügung stehen, insbesondere vor dem Hintergrund der lokal höchst unterschiedlichen Formen der Unterrichtsorganisation sowie ungleichen Voraussetzungen im Hinblick auf Ressourcenverteilung (personell, räumlich und sächlich) und Schülerklientel (sonderpädagogischer Förderbedarf, soziale Herkunft, Migrationshintergrund, etc.). Untersucht werden am Beispiel des Flächenkreises Paderborn die Möglichkeiten und Grenzen, die Entwicklung des Gemeinsamen Lernens im Bereich Schule indikatorengestützt abzubilden und Schlussfolgerungen für inklusive Schulorganisation und -planung auf kleinräumiger Ebene abzuleiten. Die Hauptfrage der Arbeit lautet: Welche Indikatoren lassen sich auf kommunaler Ebene identifizieren, um Entwicklungen in den Dimensionen Input, Prozess und Output bei der Umsetzung eines inklusiven Schulsystems zu beschreiben? Die Beantwortung der Forschungsfrage folgt einem dreistufigen Vorgehen. In einem ersten Schritt werden auf Basis kleinräumiger und einzelschulischer Daten der amtlichen Schulstatistik indikatorengestützte Analysen im Zeitraum von 2007 bis 2015 durchgeführt. Im Anschluss werden diese datengestützten Befunde durch Ergebnisse einer quantitativen Schulleiterbefragung im Kreis Paderborn 2016 ergänzt. In einem letzten Schritt erfolgt drittens eine Charakterisierung des nachgezeichneten Transformationsprozesses auf Einzelschulebene sowie auf kommunaler Ebene. Die Synthese der gewonnenen Forschungsergebnisse bildet den Ausgangspunkt für die Ableitung von aussagekräftigen Indikatoren und Desideraten einer Dauerbeobachtung des Gemeinsamen Lernens von Schülerinnen und Schülern mit und ohne sonderpädagogischen Förderbedarf. Wenngleich bestimmte Qualitätsaspekte schulischer Inklusion mit den verfügbaren amtlichen und den ergänzenden Schulleiterdaten nur näherungsweise indikatorisiert werden können, wird sowohl kommunalen Entscheidungsträgerinnen und -trägern aus Politik und Verwaltung, als auch Akteurinnen und Akteuren in den Bildungseinrichtungen ein breites Spektrum an Operationalisierungen zur Verfügung gestellt, um Ansatzpunkte zur organisationalen und systemischen Weiterentwicklung von Inklusion im Schulbereich auszumachen. (DIPF/Orig.)
    Keywords: Inklusion ; Bildungsentwicklung ; Bildungsbeteiligung ; Bildungserfolg ; Sonderpädagogischer Förderbedarf ; Schulqualität ; Integrative Schule ; Integrative Beschulung ; Schulorganisation ; Schulplanung ; Gemeinde 〈Kommune〉 ; Schulleiter ; Schulentwicklung ; Transformation ; Sozialraum ; Indikator ; Amtliche Statistik ; Umfrage ; Statistische Analyse ; Quantitative Forschung ; Paderborn ; Nordrhein-Westfalen ; Deutschland ; Inclusion ; Development of education ; Educational development ; Participation in education ; Participation Rate ; Educational Success ; Success at school ; Success in Education ; Special Educational Needs ; Inclusive education ; Inclusive school ; School organisation ; School organization ; Headteacher ; Headteachers ; School head teacher ; School development ; Indicator ; Official statistics ; Statistical analysis ; Quantitative research ; North Rhine-Westphalia ; North-Rhine Westphalia ; Germany ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs ; thema EDItEUR::J Society and Social Sciences::JN Education::JNS Teaching of students with different educational needs
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 8
    facet.materialart.
    Unknown
    Schülerauslese, schulische Beurteilung und Schülertests 1880–1980 (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: The way schools deal with "heterogeneity" of pupils has been the subject of a heated debate for a number of years. The present volume shows how the observation of differences between pupils - such as those in aptitude, behaviour and interest - has increasingly come into focus in schools since the last third of the 19th century. Disputes about how "suitable" learning groups should be put together against this background increasingly determined the picture of educational and school-political debates. Selection mechanisms in the school system between 1880 and 1980 are reconstructed that distinguished between the normal and the non-normal, between the gifted and the less gifted, between those who adapted and those who did not. The contributions examine practices of observing, testing and assessing pupils, the procedures and tests used for this purpose, and the individual, pedagogical and political conditions and consequences associated with them.
    Description: Über den schulischen Umgang mit einer „Heterogenität“ der Schüler*innen wird seit einer Reihe von Jahren heftig debattiert. Der vorliegende Band zeigt, wie seit dem letzten Drittel des 19. Jahrhunderts die Beobachtung von Unterschieden – solchen der Begabung, des Verhaltens und des Interesses – zwischen Schüler*innen in den Schulen mehr und mehr in das Blickfeld rückte. Auseinandersetzungen darüber, wie vor diesem Hintergrund „passende“ Lerngruppen zusammengestellt werden sollten, bestimmten zunehmend das Bild der pädagogischen und schulpolitischen Debatten. Rekonstruiert werden Selektionsmechanismen im Schulsystem zwischen 1880 und 1980, mit denen zwischen Normalen und Nicht-Normalen, zwischen Begabten und Minderbegabten, zwischen solchen, die sich anpassten, und solchen, die das nicht taten, unterschieden wurde. Die Beiträge untersuchen Praktiken des Beobachtens, Prüfens und Beurteilens von Schüler*innen, die dafür eingesetzten Verfahren und Tests sowie die damit verbundenen individuellen, pädagogischen und politischen Bedingungen und Folgen. (DIPF/Orig.)
    Keywords: Schüler ; Auslese ; Ausleseverfahren ; Schülerbeurteilung ; Historische Bildungsforschung ; Bildungsgeschichte ; Schulgeschichte ; Geschichte 〈Histor〉 ; Heterogenität ; Inklusion ; Exklusion ; Hilfsschule ; Kategorisierung ; Sonderpädagogik ; Abitur ; Aufsatz ; Begabung ; Hochbegabung ; Differenzierung ; Selektion ; Übergang Primarstufe - Sekundarstufe I ; Schulische Integration ; Beobachtung ; Lernbehinderung ; Sonderpädagogische Einrichtung ; Förderklasse ; Diagnostik ; Pädagogische Diagnostik ; Leistungsmessung ; Intelligenztest ; Schulsystem ; Intelligenzschwäche ; Lernschwäche ; Sonderschulpädagogik ; Psychiatrie ; Pädagogik ; Handschrift ; Diagnose ; Gehirn ; Schrift ; Experiment ; Geistige Behinderung ; Bildungsfähigkeit ; Primarbereich ; Sonderschule ; Schuleignung ; Gutachten ; Pädagogische Psychologie ; Differenzielle Psychologie ; Reform ; Abiturprüfung ; Leistungsbeurteilung ; Prüfungswesen ; psychometrische Tests ; Lehrergutachten ; Praktiken des Beobachtens ; Soldat ; Kriegsbeschädigter ; Gehirnschädigung ; Übungsschule ; Berufspsychologie ; Berufseignung ; Berufsberatung ; Migrant ; Migrationshintergrund ; Schulpsychologie ; Maßnahme ; Vergleich ; Stern ; William Louis ; 19. Jahrhundert ; 20. Jahrhundert ; Kaiserreich ; Weimarer Republik ; Fallbeispiel ; Test ; Historische Quelle ; Deutschland ; Schweiz ; Deutschland-BRD ; Deutschland-DDR ; Preußen ; New York ; N.Y. ; USA ; bic Book Industry Communication::J Society & social sciences::JN Education::JNB History of education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNL Schools ; thema EDItEUR::J Society and Social Sciences::JN Education::JNB History of education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNL Schools and pre-schools
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 9
    facet.materialart.
    Unknown
    Im Spannungsverhältnis zwischen Selbst- und Fremdverstehen (2023)
    Springer Nature | Springer Fachmedien Wiesbaden
    Details
    Publication Date: 2024-03-29
    Description: Dieser Open-Access-Sammelband hinterfragt, wie sich internationale Kulturzusammenarbeit zwischen Ländern unterschiedlicher Kultursysteme und -traditionen erreichen lässt. In Deutschland ist Auswärtige Kulturpolitik von dem Gedanken geleitet, dass globale Herausforderungen Multilateralismus erfordern. Im chinesischen Diskurs dagegen finden andere Kernbegriffe wie z.B. „Tianxia“ Verwendung, die im nicht-chinesischen Kontext einer Interpretation bedürfen. Um der Differenz – aber auch den Gemeinsamkeiten – auf den Grund zu gehen, untersuchen Wissenschaftler*innen und Praktiker*innen aus China und Deutschland Selbst- und Fremdwahrnehmungen sowie Kooperationen in kulturellen Begegnungen. Auf diese Weise sollen Grundlagen für ein besseres gegenseitiges Verständnis sowie für kulturelle Kooperation zwischen beiden Ländern ermöglicht werden.
    Keywords: Auswärtige Kulturpolitik ; Kulturaustausch ; Forschungszusammenarbeit ; Tianxia ; Deutschland ; Globale Herausforderung ; China ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFS Globalization ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTQ Globalization
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 10
    facet.materialart.
    Unknown
    Erziehung – Körper – Entkörperung (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: The historical and theoretical relationship between education and the body is the focus of this discourse-analytical study. It is situated at the interface of systematic educational science and historical educational research and looks at both the current debate on educational theory and the pedagogical discussions at the end of the 18th century and the beginning of the 19th century. The starting point of the analyses is a theoretical phenomenon called disembodiment. This term refers to different dynamics that in their totality aim at the discursive exclusion and marginalisation of corporeality in the discourse on education. Three works from different currents of pedagogy are examined more closely for this purpose: Campe's 'Allgemeine Revision des gesammten Schul- und Erziehungswesens' (1785-1792), Niemeyer's 'Grundsätze der Erziehung und des Unterrichts' (1796-1824/5) and two writings by Schwarz, the 'Erziehungslehre' (1802-1813) and the 'Lehrbuch der Erziehung und Unterrichtslehre' (1805-1835). In addition to a presentation of the spectrum of perspectives on physical education, a reconstruction of the historical discourse of so-called physical education and case analyses of the anthropological contexts, the study is able to show that disembodiment tendencies can be traced not only in the current discourse, but already at the turn of the 19th century.
    Description: Das geschichtliche sowie theoretische Verhältnis von Erziehung und Körper steht im Zentrum dieser diskursanalytisch angelegten Studie. Diese ist an der Schnittstelle von systematischer Erziehungswissenschaft und historischer Bildungsforschung angesiedelt und betrachtet sowohl die aktuelle erziehungstheoretische Debatte als auch die pädagogischen Diskussionen am Ende des 18. und zu Beginn des 19. Jahrhunderts. Ausgangspunkt der Analysen ist ein theoretisches Phänomen, das als Entkörperung bezeichnet wird. Mit diesem Begriff sind unterschiedliche Dynamiken gemeint, die in ihrer Gesamtheit auf die diskursive Ausgrenzung und Marginalisierung von Körperlichkeit in der Rede über Erziehung zielen. Drei Werke aus unterschiedlichen Strömungen der Pädagogik sind hierfür näher untersucht: Die von Campe herausgegebene ‚Allgemeine Revision des gesammten Schul- und Erziehungswesens‘ (1785–1792), die ‚Grundsätze der Erziehung und des Unterrichts‘ (1796–1824/5) von Niemeyer und zwei Schriften von Schwarz, die ‚Erziehungslehre‘ (1802–1813) sowie das ‚Lehrbuch der Erziehung und Unterrichtslehre‘ (1805–1835). Neben einer Darstellung des Spektrums der körperpädagogischen Perspektiven, einer Rekonstruktion des historischen Diskurses der sogenannten physischen Erziehung und Fallanalysen zu den anthropologischen Kontexten, kann die Untersuchung im Ergebnis zeigen, dass nicht nur im aktuellen Diskurs, sondern bereits an der Wende zum 19. Jahrhundert Entkörperungstendenzen nachzuweisen sind. (DIPF/Orig.)
    Keywords: Historische Bildungsforschung ; Erziehungswissenschaft ; Körper 〈Biol〉 ; Körperlichkeit ; Leiblichkeit ; Menschlicher Körper ; Pädagogische Theorie ; Bildungstheorie ; Erziehung ; Geschichte 〈Histor〉 ; Diskursanalyse ; Historische Analyse ; Campe, Joachim Heinrich ; Niemeyer, August Hermann ; Schwarz, Friedrich Heinrich Christian ; 18. Jahrhundert ; 19. Jahrhundert ; Dissertationsschrift ; Deutschland ; Sciences of education ; Corporeality ; Corporealtity ; Human body ; Pedagogical theory ; Educational theory ; Theory of education ; Education ; History ; Discourse Analysis ; Historical analysis ; Doctoral Theses ; Germany ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 11
    facet.materialart.
    Unknown
    1918 in Bildung und Erziehung (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: "1918" signifies more than the end of the First World War. The reference to the year often also justifies narratives in the history of education. On the other hand, this volume explores the simultaneities of caesurae and traditions, ruptures and continuities in regional, national, European and global perspectives. It examines diverse paradoxes of supposedly old and new pedagogical cultures and practices as well as ambivalences of youth between rebellion and attachment to educational ideals. It also focuses on the questioning of schools and pedagogy, their relegitimisation and the intertwining of social democracy and socialism with educational reforms and traditions. In this way, the volume aims at the often described "clash of ideologies" in the interwar period and at the circulation of competing knowledge, so that it discusses the complex openness of 1918 in terms of educational history.
    Description: „1918“ bezeichnet mehr als das Ende des Ersten Weltkriegs. Der Jahresbezug begründet häufig auch bildungsgeschichtliche Narrative. Hingegen fragt der Band nach Gleichzeitigkeiten von Zäsuren und Tradierungen, Brüchen und Kontinuitäten in regionalen, nationalen, europäischen und globalen Perspektiven. Er untersucht vielfältige Paradoxien vermeintlich alter und neuer pädagogischer Kulturen und Praktiken ebenso wie Ambivalenzen der Jugend zwischen Aufbegehren und Anknüpfung an Bildungsideale. Auch die Infragestellung von Schule und Pädagogik, ihre Relegitimierung sowie die Verflechtung von Sozialdemokratie und Sozialismus mit Bildungsreformen und -traditionen werden fokussiert. Damit zielt der Band auf den vielfach beschriebenen «Kampf der Ideologien» in der Zwischenkriegszeit und auf die Zirkulation konkurrierender Wissen, sodass er bildungshistorisch die komplexe Offenheit von 1918 diskutiert.
    Keywords: Historische Bildungsforschung ; Bildungsgeschichte ; Geschichte 〈Histor〉 ; Schule ; Jugend ; Schülermitwirkung ; Lehrerseminar ; Mitbestimmung ; Reformpädagogik ; Jugendbewegung ; Kritik ; Schülerbewegung ; Aufstand ; Elternmitwirkung ; Nachkriegsgeschichte ; Zwischenkriegszeit ; Weltkrieg I ; Schülerorganisation ; Kollektives Gedächtnis ; Turnverein ; Körpererziehung ; Männlichkeit ; Patriotismus ; Persönlichkeitsbildung ; Körperkultur ; Leitbild ; Körperbild ; Geschlecht ; Geschlechtsspezifische Sozialisation ; Geschlechtergeschichte ; Turnen ; Jugendkultur ; Orientalistik ; Interesse ; Indienbild ; Rezeption ; Lehrerfortbildung ; Organisation ; Politische Kultur ; Volksschule ; Selbstwahrnehmung ; Bildungspolitik ; Praxeologie ; Lehrer ; Neuorientierung ; Pädagogik ; Reform ; Gesellschaft ; Positivismus ; Evolutionismus ; Experimentelle Pädagogik ; Kinderpsychologie ; Steuerung ; Schulbuch ; Analyse ; Vergleich ; Evangelischer Religionsunterricht ; Religionsunterricht ; Schulbuchforschung ; Lebenskunde ; Mittelschule ; Lehrmittel ; Erziehung ; Lehrplan ; Lehrplanvergleich ; Curriculum ; Kirche-Staat-Beziehung ; Schulsystem ; Sozialdemokrat ; Schriftsteller ; Sozialist ; Pädagoge ; Historische Persönlichkeit ; Pädagogisierung ; Biografie ; Autobiografie ; Linke 〈Pol〉 ; Bildung ; Arbeiterbildung ; Arbeiterbewegung ; Arbeiterklasse ; Sozialistische Bildung ; Außerschulischer Lernort ; Erwachsenenbildung ; Politisches Programm ; Erziehungsprogramm ; Sozialdemokratie ; Schulreform ; Bildungsreform ; Sozialismus ; Sozialgeschichte ; Kulturgeschichte ; Bildungszugang ; Schulgemeinde ; Quellenkritik ; Historische Quelle ; Tagore ; Rabindranath ; Thorndike ; Edward L. ; Dewey ; John ; Traber ; Alfred ; Glöckel ; Otto ; Bernfeld ; Siegfried ; 20. Jahrhundert ; Zürich ; Schweiz ; Deutschland ; Indien ; Deutschland 〈bis 1945〉 ; Tschechische Republik ; Tschechoslowakei ; USA ; Weimarer Republik ; Preußen ; Preußische Reform ; Deutsches Reich ; Wien ; Österreich ; History of education ; History of educational activities ; History ; School ; Adolescence ; Youth ; Pupil Participation ; Teachers' training college ; Codetermination ; Progressive Education ; Progressive education ; Reform pedagogics ; Youth movement ; Criticism ; Revolt ; Parent participation ; Post-war period ; Peace time ; World War I ; Student organizations ; Physical education ; Masculinity ; Patriotism ; Personality development ; Ideal (model) ; Body image ; Sex ; Gender-specific socialization ; Gymnastics ; Youth culture ; Reception ; Further education for teachers ; Further education of teachers ; Further training for teachers ; Organization ; Political culture ; Elementary School ; General compulsory school ; Primary school ; Self-perception ; Educational policy ; Teacher ; Pedagogics ; Sciences of education ; Society ; Positivism ; Experimental education ; Experimental pedagogics ; Experimental teaching ; Child psychology ; Children's hospital ; Text book ; Textbook ; Religious instruction ; Teaching of religion ; Textbook research ; Intermediate school ; Educational Materials ; Teaching aids ; Training aid ; Education ; State church separation ; School system ; Pedagogue ; Biographies ; Autobiographies ; Education of workers ; Workers' education ; Labor movement ; Working Class ; Adult education ; Adult training ; Political program ; Social democracy ; School reform ; Educational reform ; Socialism ; Social history ; Cultural history ; Access to Education ; School community ; Zurich ; Switzerland ; Germany ; India ; Czech Republic ; Czechoslovakia ; Weimar Republic ; Weimar Republic (Germany ; 1918-33) ; German Reich ; Vienna ; Austria ; bic Book Industry Communication::J Society & social sciences::JN Education::JNB History of education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNB History of education
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 12
    facet.materialart.
    Unknown
    Berufs- und Arbeitswelt in der politischen Bildung (2021)
    Springer Nature | Springer Fachmedien Wiesbaden
    Details
    Publication Date: 2024-03-29
    Description: Dieses open access-Buch analysiert den Zusammenhang von Berufsorientierung und politischer Bildung von Jugendlichen. Der Anspruch der Mündigkeitsbildung stellt die Ausgangsposition für die Vorstellungsforschung subjektiver Sinnbilder über die Berufs- und Arbeitswelt von Jugendlichen in der Sekundarstufe I dar. Dabei zeichnen sich Unterschiede in den Vorstellungen entlang der Trennlinien von sozioökonomischem Hintergrund, Herkunft, Geschlecht und Schulform ab. Die empirische Studie liefert wichtige Erkenntnisse zu den Vorstellungen und Handlungsmöglichkeiten von Schüler*innen und hilft zu verstehen, wovon diese abhängen und welche didaktischen Ansätze sich für die Berufsorientierung ableiten lassen.
    Keywords: Berufsorientierung ; Arbeitswelt ; Berufsvorstellungen ; Bildungsvorstellungen ; Jugendliche ; Didaktik der politischen Bildung ; Politische Bildung ; Schule ; Unterricht ; Sekundarstufe I ; Empirische Sozialforschung ; Biografie ; Gesellschaft ; Migrationshintergrund ; Deutschland ; Österreich ; German Politics ; open access ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPB Comparative politics ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government::JPQB Central government policies ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPB Comparative politics ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPQ Central / national / federal government::JPQB Central / national / federal government policies ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 13
    facet.materialart.
    Unknown
    Gemeinsamkeit herstellen, Differenz bearbeiten (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: Befürwortende ebenso wie skeptische Stimmen zum Thema Inklusion klingen häufig so, als sei ein Gelingen oder Scheitern inklusiver Prozesse kaum beeinflussbar. Entsprechend wenig ist untersucht, wie sich Gruppenprozesse in inklusiven Gruppen gestalten. Die vorliegende Studie schließt diese Lücke, indem sie die Zusammenarbeit in Kleingruppen im Kontext inklusiver Hochschulbildung untersucht. Gegenstand sind vier rekonstruktive Fallstudien aus Seminaren, an denen Studierende und behinderte Menschen – zumeist ohne Hochschulzugangsberechtigung – teilnehmen. Unter Anwendung der dokumentarischen Methode werden Arbeitsprozesse von Projektgruppen im Rahmen inklusionsorientierter Seminare analysiert. Die leitende Fragestellung besteht darin, wie die Mitglieder einer Gruppe Gemeinsamkeit herstellen, Differenz bearbeiten und Verantwortung verteilen. Somit ist die Ambivalenz von Gemeinsamkeit und Differenz und ihre ‚Herstellung’ in inklusiven Kleingruppen Gegenstand der Dissertation. Sie leistet für die Förder-/Sonder-/Rehabilitations- und Inklusionspädagogik einen Beitrag zur kritischen Auseinandersetzung mit Differenz und den damit verbundenen Zuschreibungen. Zugleich wird aber auch die Entstehung von gemeinsamen Erfahrungsräumen in Gruppenprozessen analysiert. Obwohl im Hochschulbereich angesiedelt, sind die Ergebnisse auch für außerschulische Jugendbildung und den Sekundarbereich als relevant anzusehen. (DIPF/Orig.)
    Keywords: Inklusion ; Hochschule ; Hochschulseminar ; Gruppe 〈Soz〉 ; Heterogene Lerngruppe ; Gruppendynamik ; Kleingruppe ; Gruppenpsychologie ; Heterogenität ; Sozialer Prozess ; Soziale Interaktion ; Soziale Integration ; Gemeinsamkeit ; Differenz ; Integrative Pädagogik ; Sonderpädagogik ; Dokumentarische Methode ; Fallbeispiel ; Deutschland ; Inclusion ; Higher education institute ; Group dynamics ; Small goup ; Small group ; Group psychology ; Heterogeneity ; Social process ; Social interaction ; Social integration ; Integrative education ; Remedial instruction sciences ; Special education for the handicapped ; Special needs education ; Exemplary model ; Germany ; Document ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy::JNFN Inclusive education / mainstreaming ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education::JNMN Universities ; thema EDItEUR::J Society and Social Sciences::JN Education::JNS Teaching of students with different educational needs ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy::JNFK Educational strategies and policy: inclusion ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 14
    facet.materialart.
    Unknown
    Inklusion im Spannungsfeld von Normalität und Diversität (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: Vor zehn Jahren regte die Ratifizierung der UN-Behindertenrechtskonvention und die damit einhergehende rechtliche Verankerung inklusiver Prozesse eine Vielzahl von strukturellen Veränderungen im Bildungssystem an. Daher liegt der inhaltliche Fokus auf Lehren und Lernen in inklusiven Settings. Thematisiert werden damit sowohl inklusives Lehren und Lernen im Bildungsverlauf durch Kindertagesstätten und Schulen als auch in den Hochschulen.
    Keywords: Inklusion ; Integration ; Sonderpädagogik ; Integrative Schule ; Integrative Pädagogik ; Integrative Beschulung ; Kindertagesstätte ; Grundschule ; Schule ; Hochschule ; Lehr-Lern-Prozess ; Lernforschung ; Lehrerausbildung ; Lehrerfortbildung ; Professionalisierung ; Weiterbildung ; Lehrerbildung ; Qualifizierung ; Reflexion 〈Phil〉 ; Lernwerkstatt ; Hochschulbildung ; Interview ; Interdisziplinäre Zusammenarbeit ; Kooperation ; Hochschullehre ; Differenzierung ; Einstellung 〈Psy〉 ; Heterogenität ; Lehrer ; Lehramtsstudent ; Normalisierung ; Diagnostik ; Übergang Schule - Beruf ; Schüler-Lehrer-Beziehung ; Lernprozess ; Frühförderung ; Erlebnispädagogik ; Normalität ; Vielfalt ; Unterrichtsqualität ; Schulorganisation ; Volksschule ; Lernumgebung ; Nachteilsausgleich ; Chancengleichheit ; Österreich ; Deutschland ; Inclusion ; Remedial instruction sciences ; Special education for the handicapped ; Special needs education ; Inclusive education ; Inclusive school ; Integrative education ; Day nursery ; Elementary School ; Primary school ; Primary school lower level ; School ; Higher education institute ; Teaching-learning process ; Research on learning ; Teacher education ; Teacher training ; Further education for teachers ; Further education of teachers ; Further training for teachers ; Professionalization ; Continuing education ; Further education ; Teachers' training ; Qualification ; Learning workshop ; Higher education ; University level of education ; Cooperation ; Higher education lecturing ; University lecturing ; University teaching ; Heterogeneity ; Teacher ; Student teachers ; Normalization (Disabilities) ; Diagnostic ; Pupil-teacher relation ; Pupil-teacher relationship ; Learning process ; Early remedial education ; Adventure pedagogics ; Experience pedagogics ; Teaching quality ; School organisation ; School organization ; General compulsory school ; Educational Environment ; Learning environment ; Equal opportunities ; Equal opportunity ; Austria ; Germany ; Type of school ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy::JNFN Inclusive education / mainstreaming ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy::JNFK Educational strategies and policy: inclusion ; thema EDItEUR::J Society and Social Sciences::JN Education::JNS Teaching of students with different educational needs
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 15
    facet.materialart.
    Unknown
    Inklusion von Lehrkräften nach der Flucht (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: This volume is dedicated to the professional re-entry of teachers with a refugee background into the teaching profession. The book presents the certificate course "Educational Science Basics for Teachers with a Refugee Background" at the University of Vienna and research results on it in detail. Furthermore, the teachers and participants reflect on their experiences with this measure. Challenges and synergies in connection with the implementation of such a course are discussed as well as international perspectives on the requalification of refugee teachers.
    Description: Der Band widmet sich dem beruflichen Wiedereinstieg von Lehrkräften mit Fluchthintergrund in den Schuldienst. Das Buch stellt den Zertifikatskurs "Bildungswissenschaftliche Grundlagen für Lehrkräfte mit Fluchthintergrund" an der Universität Wien und Forschungsergebnisse dazu eingehend dar. Weiterhin reflektieren die Lehrenden und die Teilnehmenden ihre Erfahrungen mit dieser Maßnahme. Herausforderungen und Synergien im Zusammenhang mit der Implementierung eines solchen Kurses werden ebenso diskutiert wie internationale Perspektiven auf die Requalifizierung geflüchteter Lehrkräfte.
    Keywords: Lehrer ; Beruflicher Wiedereinstieg ; Flüchtling ; Zertifikatskurs ; Zertifizierung ; Berufliche Integration ; Berufspädagogik ; Flucht ; Migration ; Migrationshintergrund ; Qualifizierung ; Qualifizierungsmaßnahme ; Berufliche Qualifikation ; Anerkennung ; Lehrerbildung ; Reflexion 〈Phil〉 ; Theorie-Praxis-Beziehung ; Unterrichtspraxis ; Heterogenität ; Weiterbildung ; Hochschule ; Hochschullehre ; Deutschland ; Schweden ; Österreich ; Teacher ; Re-entry ; Refugee ; Certification ; Occupational integration ; Vocational pedagogics ; Flight ; Running away ; Immigrant background ; Migration background ; Qualification ; National Vocational Qualification ; Occupational qualification ; Vocational qualification ; Teacher education ; Teachers' training ; Theory Practice Relationship ; Teaching practice ; Heterogeneity ; Continuing education ; Further education ; Higher education institute ; Higher education lecturing ; University lecturing ; University teaching ; Germany ; Sweden ; Austria ; bic Book Industry Communication::J Society & social sciences::JN Education::JNP Adult education, continuous learning ; thema EDItEUR::J Society and Social Sciences::JN Education::JNP Adult education, continuous learning
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 16
    facet.materialart.
    Unknown
    Lebenswege erzählen (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: The dissertation is located in the context of research on adolescence and transitions with a focus on special education. Disadvantaged adolescents are the target group of this study. Adolescents were interviewed at two points in time using biographical narrative interviews. In addition, parent interviews took place once, which serve as an addition or contrast, but primarily in order to stress the intergenerational contouring of the life phase of adolescence. The focus of the study is on how adolescents experience and handle the transition from school to post-school life. By using biographical case reconstructions, biographical coping strategies and vocational self-presentations were reconstructed from the narratives in order to illuminate the complexity that such transitions pose. The theoretical framework used in this dissertation understands adolescence as embedded in generational relations, which is also viewed in terms of inequality theory. As a result, the perspective on the adolescent life stage is not only focused on adolescent developmental tasks, but is characterized by an intergenerational view that forms the background for complex and dynamic readjustment processes. Thus, persistent familial significance in this phase of life is emphasized. By reconstructing biographical coping strategies, it becomes visible how young people deal with vocational orientation processes against their familial background and what efforts they partly expend to fulfill familial missions or to distance themselves from them. The research design of the study responds to a desideratum that exists with regard to qualitative or biographical long-term studies in the area of adolescence in school and vocational contexts. The life stories of the adolescents clearly point to the necessity of embedding transitions in an overall biographical context and of reacting to the associated ways of looking at the life phase of adolescence. (DIPF/Orig.)
    Description: Die vorliegende Studie beleuchtet mit Hilfe eines biographischen Forschungszugangs die Komplexität des Übergangsprozesses von benachteiligten Jugendlichen am Übergang von der Schule ins nachschulische Leben. Entgegen der gängigen Betonung der Ablösung vom Elternhaus wird im Rahmen der Arbeit die anhaltende familiale Bedeutung in der Lebensphase herausgearbeitet. Das Konzept der Entwicklungsaufgaben wird daher intergenerational konturiert und ungleichheitstheoretisch ausgeleuchtet. Die Ergebnisse zeigen, dass die Eltern und ihre (Berufs-)Biographien eine hohe Bedeutung für die eigene Übergangsgestaltung der Adoleszenten haben. Die biographischen Texte illustrieren die jeweiligen Bewältigungs- und Gestaltungsstrategien der Jugendlichen, die Konsequenzen für eine biographieorientierte Beratung am Übergang zulassen. Weiterhin lassen die Erkenntnisse Implikationen für Hochschullehre zu, indem biographieanalytische und ungleichheitstheoretische Aspekte in der Adoleszenzphase im Lehrplan verankert werden. (DIPF/Orig.)
    Keywords: Transition ; Übergang Schule - Beruf ; Benachteiligter Jugendlicher ; Familie ; Einflussfaktor ; Berufsbiografie ; Eltern ; Adoleszenz ; Sonderpädagogik ; Sozialer Raum ; Übergang ; Wahrnehmung ; Entscheidung ; Bewältigung ; Selbstdarstellung ; Handlungsfähigkeit ; Sozialpädagogik ; Entwicklungsaufgabe ; Benachteiligung ; Sonderpädagogischer Förderbedarf ; Förderschule ; Sozialer Hintergrund ; Forscher ; Soziale Herkunft ; Generationenverhältnis ; Bildungsaspiration ; Bourdieu, Pierre ; Empirische Untersuchung ; Biografische Methode ; Biografisches Interview ; Fallbeispiel ; Deutschland ; bic Book Industry Communication::J Society & social sciences::JN Education::JNC Educational psychology ; thema EDItEUR::J Society and Social Sciences::JN Education::JNC Educational psychology
    Language: German
    Format: image/jpeg
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 17
    facet.materialart.
    Unknown
    Inklusion im Spannungsfeld von Normalität und Diversität (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: Seit der Ratifizierung der UN-Behindertenrechtskonvention befindet sich Inklusion im Spannungsfeld von Normalität und Diversität. Soll sie auf mehr als die Anwesenheit von Menschen mit Behinderung in Erziehungs- und Bildungsinstitutionen verweisen, so müssen diese Institutionen und die darin befindlichen Akteur*innen und Praktiken weiterhin auf ihre Verstrickungen in die Reproduktion von Ausgrenzung und sozialer Ungleichheit hin thematisiert werden. So finden sich in diesem Band Beiträge zu folgenden Schwerpunkten: Grundfragen der Inklusion, Subjekttheoretische Perspektiven im Rahmen der Inklusion, Pädagogik und Bildung aus menschenrechtlicher und demokratischer Perspektive, Mechanismen der Exklusion und Inklusion sowie Inklusive Schulentwicklung.
    Keywords: Inklusion ; Integration ; Normalität ; Vielfalt ; Differenzierung ; Normalisierung ; Sonderpädagogik ; Erziehungsphilosophie ; Menschenrechte ; Exklusion ; Integrative Schule ; Integrative Pädagogik ; Integrative Beschulung ; Partizipation ; Benachteiligung ; Ungleichheit ; Gerechtigkeit ; Differenzierender Unterricht ; Schule ; Bildungspolitik ; Fremdheit ; Subjektorientierung ; Bildungsprozess ; Subjekt 〈Phil〉 ; Demokratische Bildung ; Lernprozess ; Schüler-Lehrer-Beziehung ; Bildungsbegriff ; Reziprozität ; Sonderpädagogischer Förderbedarf ; Verhaltensauffälligkeit ; Schulsport ; Körperkultur ; Körperbehinderung ; Geistige Behinderung ; Emotionale Entwicklung ; Soziale Entwicklung ; Autonomie ; Flüchtling ; Leistungsorientierung ; Systemtheorie ; Kindertagesstätte ; Schulreform ; Schulentwicklung ; Deutschland ; Österreich ; Thailand ; Inclusion ; Normalization (Disabilities) ; Remedial instruction sciences ; Special education for the handicapped ; Special needs education ; Philosophy of education ; Human rights ; Inclusive education ; Inclusive school ; Integrative education ; Disadvantage ; Justice ; Differentiated teaching ; School ; Educational policy ; Strangeness ; Educational process ; Learning process ; Pupil-teacher relation ; Pupil-teacher relationship ; Concept of education ; Special Educational Needs ; School sports ; Physical handicap ; Oligophrenia ; Social change ; Social development ; Autonomy ; Refugee ; Achievement orientation ; System theory ; Day nursery ; School reform ; School development ; Germany ; Austria ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy::JNFN Inclusive education / mainstreaming ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy::JNFK Educational strategies and policy: inclusion ; thema EDItEUR::J Society and Social Sciences::JN Education::JNS Teaching of students with different educational needs
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 18
    facet.materialart.
    Unknown
    Perspektiven auf Vielfalt in der frühen Kindheit (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: The impetus and aim of this publication is to shed light on different perspectives on diversity in early childhood and to explore possibilities for researching this together with children. Reference is made to bodies of knowledge and knowledge references that have developed and become established in the context of early childhood and diversity, and attention is paid to explaining different methods and concrete experiences of using them to explore perspectives on diversity. One focus is on the description and reflection of research with children. The book is aimed at students and researchers in educational science and its neighbouring disciplines. It gives them an insight into basic theoretical frameworks with regard to the thematic horizons of childhood, childhood research and diversity and presents methods of research that enable the active inclusion of children in a concentrated manner. Furthermore, it gives professionals in elementary education and heads of organisations an impression of methods (reflections) and procedures of research with children and can be a support for them in the context of decision-making processes about participation in research projects.
    Description: Unterschiedliche Perspektiven auf Vielfalt in der frühen Kindheit zu beleuchten und Möglichkeiten auszuloten, wie mit Kindern gemeinsam dazu geforscht werden kann, sind Anstoß und Ziel dieser Publikation. Es wird auf Wissensbestände und Wissensbezüge Bezug genommen, die sich im Kontext von früher Kindheit und Diversität entwickelt und etabliert haben und der Erläuterung unterschiedlicher Methoden und konkreter Erfahrungen Beachtung geschenkt, mit ihnen Perspektiven auf Diversität zu erforschen. Ein Schwerpunkt liegt dabei auf der Beschreibung und Reflexion des Forschens mit Kindern. Das Buch richtet sich zum einen an Studierende und Forschende der Erziehungswissenschaft und ihrer Nachbardisziplinen. Ihnen gibt es einen Einblick in grundlegende theoretische Rahmungen hinsichtlich der Themenhorizonte Kindheit, Kindheitsforschung und Diversität und stellt Methoden des Forschens, die den aktiven Einbezug von Kindern ermöglichen, in konzentrierter Weise vor. Darüber hinaus vermittelt es Fachkräften der Elementarpädagogik und Organsisationsleitungen einen Eindruck von Methoden(-reflexionen) und Vorgehensweisen des Forschens mit Kindern und kann ihnen Unterstützung im Rahmen von Entscheidungsprozessen über die Beteiligung an Forschungsprojekten sein. (DIPF/Orig.)
    Keywords: Empirische Forschung ; Selbstbestimmung ; Frühpädagogik ; Inklusion ; Teilnahme ; Behinderung ; Sonderpädagogik ; Heterogenität ; Frühe Kindheit ; Forschung ; Kind ; Kindheitsforschung ; Kindheit ; Elementarbereich ; Elementarpädagogik ; Forschendes Lernen ; Differenz ; Philosophie ; Pädagogisches Handeln ; Kindertagesbetreuung ; Vielfalt ; Partizipation ; Integration ; Erziehungswissenschaft ; Interviewtechnik ; Ethnologie ; Exklusion ; Lebenswelt ; Handpuppe ; Flucht ; Ethik ; Vulnerabilität ; Pflegekind ; Raumplanung ; Stadtentwicklung ; Sozialplanung ; Grenze ; Gleichheit ; Normativität ; Kleinkindalter ; Vorschulalter ; Kinderarbeit ; Kindergarten ; Kindergartenalltag ; Kindergartenalter ; Fotografieren ; Heimkind ; Datenerhebung ; Qualitative Forschung ; Teilnehmende Beobachtung ; Forschungsmethode ; Forschungsprojekt ; Methode ; Interview ; Schweiz ; Deutschland ; Argentinien ; Nepal ; Empirical research ; Self-determination ; Early childhood education ; Inclusion ; Participation ; Handicap ; Remedial instruction sciences ; Special education for the handicapped ; Special needs education ; Heterogeneity ; Early childhood ; Research ; Child ; Childhood ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy::JNFN Inclusive education / mainstreaming ; bic Book Industry Communication::J Society & social sciences::JN Education::JNL Schools::JNLA Pre-school & kindergarten ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy::JNFK Educational strategies and policy: inclusion ; thema EDItEUR::J Society and Social Sciences::JN Education::JNL Schools and pre-schools::JNLA Pre-school and kindergarten
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 19
    facet.materialart.
    Unknown
    Inklusionen und Exklusionen des Humanen (2021)
    Verlag Julius Klinkhardt
    Details
    Publication Date: 2024-03-29
    Description: In social debates about inclusion, the humane, the individual person, runs the risk of being lost from view, as the discussions are often only conducted on a systemic-structural level. However, aspects of concrete pedagogical and conceptual work and educational encounters are also affected. This volume is dedicated to the diversity of individuals in their respective contexts in the spectrum between inclusions and exclusions from different theoretical and practical perspectives. From everyday situations in German and American classrooms to school inclusion models and the Federal Participation Act to humane exclusions in the internationally networked digital age; from discourses on vulnerability, ethics and exclusion to the topos of the stranger in the educational inclusion debate, multiple perspectives open up.
    Description: In gesellschaftlichen Debatten um Inklusion läuft das Humane, der einzelne Mensch, Gefahr, aus dem Blick zu geraten, da die Diskussionen oftmals nur auf systemisch-struktureller Ebene geführt werden. Betroffen sind dabei jedoch auch Aspekte der konkreten pädagogischen und konzeptionellen Arbeit und der erzieherischen Begegnung. Dieser Band widmet sich der Vielfalt von Individuen in ihren jeweiligen Kontexten im Spektrum zwischen Inklusionen und Exklusionen aus unterschiedlichen theoretischen und praktischen Perspektiven. Von alltäglichen Situationen in deutschen und amerikanischen Klassenzimmern über schulische Inklusionsmodelle und das Bundesteilhabegesetz hin zu humanen Exklusionen im international vernetzten Digitalzeitalter; von Diskursen über Vulnerabilität, Ethik und Exklusion bis hin zum Topos des Fremden in der pädagogischen Inklusionsdebatte eröffnen sich multiperspektivische Betrachtungsweisen. (DIPF/Orig.)
    Keywords: Inklusion ; Exklusion ; Humanistische Pädagogik ; Vielfalt ; Sonderpädagogik ; Interdisziplinarität ; Schule ; Unterricht ; Internationaler Vergleich ; Integrative Schule ; Partizipation ; Diagnostik ; Gesetzgebung ; Sonderpädagogischer Förderbedarf ; Vulnerabilität ; Fremdes ; Digitalisierung ; Butler, Judith ; Deutschland ; USA ; Inclusion ; Humanistic pedagogics ; Remedial instruction sciences ; Special education for the handicapped ; Special needs education ; Interdisciplinarity ; School ; Teaching ; Cross-national comparison ; International comparison ; Inclusive education ; Inclusive school ; Diagnostic ; Special Educational Needs ; Foreign culture ; Digitalization ; Germany ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs ; thema EDItEUR::J Society and Social Sciences::JN Education::JNS Teaching of students with different educational needs
    Language: German
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 20
    facet.materialart.
    Unknown
    [Editors' Choice] Carboxylating stubborn alkyl chlorides (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-07-08
    Description: Author: Phil Szuromi
    Keywords: Organic Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 21
    facet.materialart.
    Unknown
    [This Week in Science] Olefins enlisted to attack ketones (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-07-08
    Description: Author: Jake Yeston
    Keywords: Organic Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 22
    facet.materialart.
    Unknown
    [This Week in Science] A radical route to ophiobolin rings (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-05-27
    Description: Author: Jake Yeston
    Keywords: Organic Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 23
    facet.materialart.
    Unknown
    [This Week in Science] A light approach to C-N bond formation (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-07-15
    Description: Author: Jake Yeston
    Keywords: Organic Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 24
    facet.materialart.
    Unknown
    [Editors' Choice] Iron takes alcohols to carboxylic acids (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-07-22
    Description: Author: Jake Yeston
    Keywords: Organic Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 25
    facet.materialart.
    Unknown
    [This Week in Science] Catalysis gets all tied up in knots (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-06-24
    Description: Author: Jake Yeston
    Keywords: Organic Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 26
    facet.materialart.
    Unknown
    [This Week in Science] Adding two fluorines to just one carbon (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-07-01
    Description: Author: Jake Yeston
    Keywords: Organic Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 27
    facet.materialart.
    Unknown
    [Perspective] Three catalysts for activating carbon-hydrogen bonds (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-06-10
    Description: Transition metal–catalyzed arylation of C–H bonds has been intensively studied for forming C–C bonds in complex-molecule synthesis (1). An acidic C–H bond (for example, one near a double bond or an O atom) is cleaved to form a carbon–metal bond, which then couples to arene. Many of these organometallic species can be generated catalytically. Much less research has dealt with unreactive nonacidic sp3 C–H bond functionalization (3). On page 1304 of this issue, Shaw et al. (3) report an efficient and general method that focuses on arylation of sp3 C–H bonds at carbon atoms adjacent to amines and to cyclic ethers by combining nickel, visible-light photoredox, and hydrogen-atom transfer (HAT) catalysis. Author: Corinne Fruit
    Keywords: Organic Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 28
    facet.materialart.
    Unknown
    [This Week in Science] A tip of the HAT to C-C bond formation (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-06-10
    Description: Author: Jake Yeston
    Keywords: Organic Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 29
    facet.materialart.
    Unknown
    [This Week in Science] A rhodium route from C-H to C-N bonds (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-09-09
    Description: Author: Jake Yeston
    Keywords: Organic Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 30
    facet.materialart.
    Unknown
    [This Week in Science] Copper-catalyzed radical relay (2016)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2016-09-07
    Description: Author: Jake Yeston
    Keywords: Organic Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 31
    facet.materialart.
    Unknown
    Cancer. BRCA2 enters the fray (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-09-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, John H -- Elledge, Stephen J -- New York, N.Y. -- Science. 2002 Sep 13;297(5588):1822-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12228708" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; BRCA1 Protein/metabolism ; BRCA2 Protein/*chemistry/*metabolism ; Binding Sites ; Breast Neoplasms/genetics ; Crystallography, X-Ray ; DNA/*metabolism ; DNA Damage ; *DNA Repair ; DNA, Single-Stranded/metabolism ; DNA-Binding Proteins/metabolism ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Predisposition to Disease ; Humans ; Mice ; Ovarian Neoplasms/genetics ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Rad51 Recombinase ; Rats ; Recombination, Genetic ; Replication Protein A
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 32
    facet.materialart.
    Unknown
    Control of synaptic strength by glial TNFalpha (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-03-23
    Description: Activity-dependent modulation of synaptic efficacy in the brain contributes to neural circuit development and experience-dependent plasticity. Although glia are affected by activity and ensheathe synapses, their influence on synaptic strength has largely been ignored. Here, we show that a protein produced by glia, tumor necrosis factor alpha (TNFalpha), enhances synaptic efficacy by increasing surface expression of AMPA receptors. Preventing the actions of endogenous TNFalpha has the opposite effects. Thus, the continual presence of TNFalpha is required for preservation of synaptic strength at excitatory synapses. Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beattie, Eric C -- Stellwagen, David -- Morishita, Wade -- Bresnahan, Jacqueline C -- Ha, Byeong Keun -- Von Zastrow, Mark -- Beattie, Michael S -- Malenka, Robert C -- DA00439/DA/NIDA NIH HHS/ -- MH063394/MH/NIMH NIH HHS/ -- NS 31193/NS/NINDS NIH HHS/ -- NS38079/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2002 Mar 22;295(5563):2282-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA. beattie.2@osu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11910117" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD/pharmacology ; Astrocytes/*metabolism ; Cells, Cultured ; Culture Media, Conditioned/pharmacology ; Gene Expression Regulation/drug effects ; Hippocampus/cytology/metabolism ; Neuronal Plasticity/drug effects ; Neurons/drug effects/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA/metabolism ; Receptors, Tumor Necrosis Factor ; Receptors, Tumor Necrosis Factor, Type I ; Synapses/drug effects/*metabolism ; Synaptic Transmission/drug effects ; Tumor Necrosis Factor-alpha/antagonists & inhibitors/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 33
    facet.materialart.
    Unknown
    Facilitation of spinal NMDA receptor currents by spillover of synaptically released glycine (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-06-28
    Description: In the mammalian CNS, N-methyl-D-aspartate (NMDA) receptors serve prominent roles in many physiological and pathophysiological processes including pain transmission. For full activation, NMDA receptors require the binding of glycine. It is not known whether the brain uses changes in extracellular glycine to modulate synaptic NMDA responses. Here, we show that synaptically released glycine facilitates NMDA receptor currents in the superficial dorsal horn, an area critically involved in pain processing. During high presynaptic activity, glycine released from inhibitory interneurons escapes the synaptic cleft and reaches nearby NMDA receptors by so-called spillover. In vivo, this process may contribute to the development of inflammatory hyperalgesia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahmadi, Seifollah -- Muth-Selbach, Uta -- Lauterbach, Andreas -- Lipfert, Peter -- Neuhuber, Winfried L -- Zeilhofer, Hanns Ulrich -- New York, N.Y. -- Science. 2003 Jun 27;300(5628):2094-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat Erlangen-Nurnberg, Fahrstrasse 17, D-91054 Erlangen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12829784" target="_blank"〉PubMed〈/a〉
    Keywords: Analgesics/pharmacology ; Animals ; Anterior Horn Cells/drug effects/metabolism ; Diffusion ; Electric Stimulation ; Evoked Potentials/drug effects ; Excitatory Postsynaptic Potentials/drug effects ; Glycine/*metabolism/pharmacology ; In Vitro Techniques ; Interneurons/metabolism ; Neural Inhibition/drug effects ; Opioid Peptides/pharmacology ; Pain Measurement ; Patch-Clamp Techniques ; Posterior Horn Cells/drug effects/*metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/*metabolism ; Serine/pharmacology ; Spinal Cord/drug effects/metabolism ; Synapses/*metabolism ; *Synaptic Transmission/drug effects ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 34
    facet.materialart.
    Unknown
    Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2 (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-11-01
    Description: Mutations in MeCP2, which encodes a protein that has been proposed to function as a global transcriptional repressor, are the cause of Rett syndrome (RT T), an X-linked progressive neurological disorder. Although the selective inactivation of MeCP2 in neurons is sufficient to confer a Rett-like phenotype in mice, the specific functions of MeCP2 in postmitotic neurons are not known. We find that MeCP2 binds selectively to BDNF promoter III and functions to repress expression of the BDNF gene. Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription. These studies indicate that MeCP2 plays a key role in the control of neuronal activity-dependent gene regulation and suggest that the deregulation of this process may underlie the pathology of RT T.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Wen G -- Chang, Qiang -- Lin, Yingxi -- Meissner, Alexander -- West, Anne E -- Griffith, Eric C -- Jaenisch, Rudolf -- Greenberg, Michael E -- HD 18655/HD/NICHD NIH HHS/ -- NS28829/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2003 Oct 31;302(5646):885-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14593183" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain-Derived Neurotrophic Factor/*genetics ; Calcium/*metabolism ; Cell Membrane/physiology ; Cells, Cultured ; *Chromosomal Proteins, Non-Histone ; Cloning, Molecular ; CpG Islands ; DNA Methylation ; DNA-Binding Proteins/*metabolism ; Electrophoretic Mobility Shift Assay ; *Gene Expression Regulation ; Gene Silencing ; Histones/metabolism ; Methyl-CpG-Binding Protein 2 ; Methylation ; Mice ; Mice, Knockout ; Neurons/metabolism/physiology ; Phosphorylation ; Potassium Chloride/pharmacology ; Precipitin Tests ; Promoter Regions, Genetic ; Rats ; *Repressor Proteins ; Rett Syndrome/genetics ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 35
    facet.materialart.
    Unknown
    Experience strengthening transmission by driving AMPA receptors into synapses (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-03-08
    Description: The mechanisms underlying experience-dependent plasticity in the brain may depend on the AMPA subclass of glutamate receptors (AMPA-Rs). We examined the trafficking of AMPA-Rs into synapses in the developing rat barrel cortex. In vivo gene delivery was combined with in vitro recordings to show that experience drives recombinant GluR1, an AMPA-R subunit, into synapses formed between layer 4 and layer 2/3 neurons. Moreover, expression of the GluR1 cytoplasmic tail, a construct that inhibits synaptic delivery of endogenous AMPA-Rs during long-term potentiation, blocked experience-driven synaptic potentiation. In general, synaptic incorporation of AMPA-Rs in vivo conforms to rules identified in vitro and contributes to plasticity driven by natural stimuli in the mammalian brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takahashi, Takuya -- Svoboda, Karel -- Malinow, Roberto -- NS032827/NS/NINDS NIH HHS/ -- NS038259/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2003 Mar 7;299(5612):1585-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Jones Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12624270" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Electrophysiology ; Gene Transfer Techniques ; Long-Term Potentiation ; *Neuronal Plasticity ; Neurons/*metabolism/virology ; Patch-Clamp Techniques ; Rats ; Receptors, AMPA/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; Sindbis Virus/genetics ; Somatosensory Cortex/*metabolism/virology ; Synapses/*metabolism ; *Synaptic Transmission ; Touch ; Vibrissae/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 36
    facet.materialart.
    Unknown
    Structural basis for a Ca2+-sensing function of the metabotropic glutamate receptors (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-03-28
    Description: The metabotropic glutamate receptors (mGluRs) are widely distributed in the brain and play important roles in synaptic plasticity. Here it is shown that some types of mGluRs are activated not only by glutamate but also by extracellular Ca2+ (Ca2+o). A single amino acid residue was found to determine the sensitivity of mGluRs to Ca2+o. One of the receptors, mGluR1alpha, but not its point mutant with reduced sensitivity to Ca2+o, caused morphological changes when transfected into mammalian cells. Thus, the sensing of Ca2+o by mGluRs may be important in cells under physiological condition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kubo, Y -- Miyashita, T -- Murata, Y -- New York, N.Y. -- Science. 1998 Mar 13;279(5357):1722-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurophysiology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2-6, Fuchu, Tokyo 183-8526, Japan. ykubo@tmin.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9497291" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/ultrastructure ; Amino Acid Sequence ; Animals ; Binding Sites ; Brain/metabolism ; CHO Cells ; Calcium/*metabolism/pharmacology ; Cell Size ; Cricetinae ; Cyclic AMP/metabolism ; G Protein-Coupled Inwardly-Rectifying Potassium Channels ; Glutamic Acid/metabolism/pharmacology ; Molecular Sequence Data ; Oocytes ; Point Mutation ; Potassium Channels/metabolism ; *Potassium Channels, Inwardly Rectifying ; Rats ; Receptors, Metabotropic Glutamate/chemistry/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; Second Messenger Systems ; Transfection ; Xenopus laevis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 37
    facet.materialart.
    Unknown
    Role of phosphorylation in regulation of the assembly of endocytic coat complexes (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-08-07
    Description: Clathrin-mediated endocytosis involves cycles of assembly and disassembly of clathrin coat components and their accessory proteins. Dephosphorylation of rat brain extract was shown to promote the assembly of dynamin 1, synaptojanin 1, and amphiphysin into complexes that also included clathrin and AP-2. Phosphorylation of dynamin 1 and synaptojanin 1 inhibited their binding to amphiphysin, whereas phosphorylation of amphiphysin inhibited its binding to AP-2 and clathrin. Thus, phosphorylation regulates the association and dissociation cycle of the clathrin-based endocytic machinery, and calcium-dependent dephosphorylation of endocytic proteins could prepare nerve terminals for a burst of endocytosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slepnev, V I -- Ochoa, G C -- Butler, M H -- Grabs, D -- De Camilli, P -- CA46128/CA/NCI NIH HHS/ -- NS36251/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1998 Aug 7;281(5378):821-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9694653" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Protein Complex alpha Subunits ; Adaptor Protein Complex beta Subunits ; Adaptor Proteins, Vesicular Transport ; Adenosine Triphosphate/metabolism ; Animals ; Binding Sites ; Carbazoles/pharmacology ; Chromatography, Affinity ; Clathrin/*metabolism ; Cyclosporine/pharmacology ; Dimerization ; Dynamin I ; Dynamins ; *Endocytosis ; Enzyme Inhibitors/pharmacology ; GTP Phosphohydrolases/*metabolism ; Indole Alkaloids ; Membrane Proteins/*metabolism ; Nerve Tissue Proteins/*metabolism ; Phosphoric Monoester Hydrolases/*metabolism ; Rats ; Recombinant Fusion Proteins/metabolism ; src Homology Domains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 38
    facet.materialart.
    Unknown
    Cholinergic switching within neocortical inhibitory networks (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-08-14
    Description: Differential actions of acetylcholine on the excitability of two subtypes of interneurons in layer V of the rat visual cortex were examined. Acetylcholine excited low-threshold spike (LTS) cells through nicotinic receptors, whereas it elicited hyperpolarization in fast spiking (FS) cells through muscarinic receptors. Axons of LTS cells were mainly distributed vertically to upper layers, and those of FS cells were primarily confined to layer V. Thus, cortical cholinergic activation may reduce some forms of intralaminar inhibition, promote intracolumnar inhibition, and change the direction of information flow within cortical circuits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xiang, Z -- Huguenard, J R -- Prince, D A -- NS 06477/NS/NINDS NIH HHS/ -- NS 07280/NS/NINDS NIH HHS/ -- NS 12151/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1998 Aug 14;281(5379):985-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9703513" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*physiology ; Animals ; Hexamethonium/pharmacology ; In Vitro Techniques ; Interneurons/physiology ; Membrane Potentials ; Muscarinic Antagonists/pharmacology ; Nerve Net/*physiology ; *Neural Inhibition ; Nicotinic Antagonists/pharmacology ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley ; Receptors, Nicotinic/physiology ; Scopolamine Hydrobromide/pharmacology ; Visual Cortex/cytology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 39
    facet.materialart.
    Unknown
    Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-02-21
    Description: Protein kinase B (PKB) is activated in response to phosphoinositide 3-kinases and their lipid products phosphatidylinositol 3,4, 5-trisphosphate [PtdIns(3,4,5)P3] and PtdIns(3,4)P2 in the signaling pathways used by a wide variety of growth factors, antigens, and inflammatory stimuli. PKB is a direct target of these lipids, but this regulation is complex. The lipids can bind to the pleckstrin homologous domain of PKB, causing its translocation to the membrane, and also enable upstream, Thr308-directed kinases to phosphorylate and activate PKB. Four isoforms of these PKB kinases were purified from sheep brain. They bound PtdIns(3,4,5)P3 and associated with lipid vesicles containing it. These kinases contain an NH2-terminal catalytic domain and a COOH-terminal pleckstrin homologous domain, and their heterologous expression augments receptor activation of PKB, which suggests they are the primary signal transducers that enable PtdIns(3,4,5)P3 or PtdIns- (3,4)P2 to activate PKB and hence to control signaling pathways regulating cell survival, glucose uptake, and glycogen metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stephens, L -- Anderson, K -- Stokoe, D -- Erdjument-Bromage, H -- Painter, G F -- Holmes, A B -- Gaffney, P R -- Reese, C B -- McCormick, F -- Tempst, P -- Coadwell, J -- Hawkins, P T -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1998 Jan 30;279(5351):710-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Inositide Laboratory, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9445477" target="_blank"〉PubMed〈/a〉
    Keywords: 3-Phosphoinositide-Dependent Protein Kinases ; Alternative Splicing ; Amino Acid Sequence ; Animals ; Cell Line ; Cell Membrane/enzymology ; Cloning, Molecular ; DNA, Complementary ; Drosophila ; Drosophila Proteins ; Enzyme Activation ; Humans ; Liposomes/metabolism ; Molecular Sequence Data ; Open Reading Frames ; Phosphatidylinositol Phosphates/*metabolism ; Phosphorylation ; Platelet-Derived Growth Factor/pharmacology ; Protein-Serine-Threonine Kinases/chemistry/genetics/isolation & ; purification/*metabolism ; Proto-Oncogene Proteins/*metabolism ; Proto-Oncogene Proteins c-akt ; Rats ; Recombinant Proteins/metabolism ; Sheep ; *Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 40
    facet.materialart.
    Unknown
    Transition from moderate to excessive drug intake: change in hedonic set point (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-10-09
    Description: Differential access to cocaine self-administration produced two patterns of drug intake in rats. With 1 hour of access per session, drug intake remained low and stable. In contrast, with 6 hours of access, drug intake gradually escalated over days. After escalation, drug consumption was characterized by an increased early drug loading and an upward shift in the cocaine dose-response function, suggesting an increase in hedonic set point. After 1 month of abstinence, escalation of cocaine intake was reinstated to a higher level than before. These findings may provide an animal model for studying the development of excessive drug intake and the basis of addiction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahmed, S H -- Koob, G F -- DA04398/DA/NIDA NIH HHS/ -- DA08467/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1998 Oct 9;282(5387):298-300.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Psychopharmacology, Department of Neuropharmacology, CVN-7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. aserge@sage.scripps.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9765157" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Addictive ; Cocaine/*administration & dosage ; Cocaine-Related Disorders/*etiology ; Dose-Response Relationship, Drug ; Drug Tolerance ; Male ; Rats ; Rats, Wistar ; Reinforcement (Psychology) ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 41
    facet.materialart.
    Unknown
    Target-specific expression of presynaptic mossy fiber plasticity (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-03-21
    Description: Mossy fiber synaptic transmission at hippocampal CA3 pyramidal cells and interneurons was compared in rat brain slices to determine whether mossy terminals are functionally equivalent. Tetanic stimulation of mossy fibers induced long-term potentiation in pyramidal neurons but was either without effect or it induced depression at synapses onto interneurons. Unlike transmission onto pyramidal neurons, transmission onto interneurons was not potentiated after adenosine 3',5'-monophosphate (cAMP) activation. Furthermore, metabotropic glutamate receptor depression of transmission onto interneurons did not involve cAMP-dependent pathways. Thus, synaptic terminals arising from a common afferent pathway do not function as a single compartment but are specialized, depending on their postsynaptic target.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maccaferri, G -- Toth, K -- McBain, C J -- New York, N.Y. -- Science. 1998 Feb 27;279(5355):1368-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cellular and Molecular Neurophysiology, Room 5A72, Building 49, National Institute of Child Health and Human Development, 9000 Rockville Pike, Bethesda MD 20892-4495, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9478900" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways ; Animals ; Colforsin/pharmacology ; Cyclic AMP/metabolism ; Cycloleucine/analogs & derivatives/pharmacology ; Cyclopropanes/pharmacology ; Electric Stimulation ; Excitatory Postsynaptic Potentials/drug effects ; Glycine/analogs & derivatives/pharmacology ; Hippocampus/cytology/*physiology ; In Vitro Techniques ; Interneurons/drug effects/*physiology ; *Long-Term Potentiation ; Mossy Fibers, Hippocampal/*physiology ; Pyramidal Cells/drug effects/*physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/agonists/physiology ; Synaptic Transmission/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 42
    facet.materialart.
    Unknown
    Src activation in the induction of long-term potentiation in CA1 hippocampal neurons (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-03-21
    Description: Long-term potentiation (LTP) is an activity-dependent strengthening of synaptic efficacy that is considered to be a model of learning and memory. Protein tyrosine phosphorylation is necessary to induce LTP. Here, induction of LTP in CA1 pyramidal cells of rats was prevented by blocking the tyrosine kinase Src, and Src activity was increased by stimulation producing LTP. Directly activating Src in the postsynaptic neuron enhanced excitatory synaptic responses, occluding LTP. Src-induced enhancement of alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) receptor-mediated synaptic responses required raised intracellular Ca2+ and N-methyl-D-aspartate (NMDA) receptors. Thus, Src activation is necessary and sufficient for inducing LTP and may function by up-regulating NMDA receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lu, Y M -- Roder, J C -- Davidow, J -- Salter, M W -- New York, N.Y. -- Science. 1998 Feb 27;279(5355):1363-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Department of Molecular and Medical Genetics, University of Toronto, M5S 1A8, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9478899" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Calcium/metabolism ; Electric Stimulation ; Enzyme Activation ; Excitatory Postsynaptic Potentials/drug effects ; Hippocampus/cytology/enzymology/*physiology ; In Vitro Techniques ; *Long-Term Potentiation ; Molecular Sequence Data ; Oligopeptides/pharmacology ; Patch-Clamp Techniques ; Peptide Fragments/pharmacology ; Proto-Oncogene Proteins pp60(c-src)/pharmacology ; Pyramidal Cells/enzymology/*physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA/physiology ; Receptors, N-Methyl-D-Aspartate/physiology ; Recombinant Proteins/pharmacology ; Up-Regulation ; src-Family Kinases/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 43
    facet.materialart.
    Unknown
    Neurons and silicon get intimate (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, R F -- New York, N.Y. -- Science. 1999 Apr 23;284(5414):578-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10328734" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Electric Stimulation ; Electrodes ; Electrodes, Implanted ; *Electronics ; Electrophysiology ; Humans ; Nerve Net/*physiology ; Nervous System Diseases/*therapy ; Neurons/*physiology ; Rats ; Silicon ; *Transistors, Electronic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 44
    facet.materialart.
    Unknown
    Stem cells. Rat spinal cord function partially restored (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wickelgren, I -- New York, N.Y. -- Science. 1999 Dec 3;286(5446):1826-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10610569" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/cytology ; Cell Differentiation ; Cell Survival ; Embryo, Mammalian ; Mice ; Neurons/cytology ; Oligodendroglia/cytology ; Rats ; Spinal Cord/cytology/*physiology ; Spinal Cord Injuries/*therapy ; *Stem Cell Transplantation ; Stem Cells/cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 45
    facet.materialart.
    Unknown
    Key brain receptor gets an unusual regulator (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wickelgren, I -- New York, N.Y. -- Science. 1999 Nov 12;286(5443):1265-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10610528" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/*enzymology ; Brain/*enzymology ; Cloning, Molecular ; Glutamic Acid/metabolism ; Neurons/metabolism ; Racemases and Epimerases/*genetics/metabolism ; Rats ; Receptors, N-Methyl-D-Aspartate/metabolism ; Serine/*biosynthesis/metabolism ; Stereoisomerism ; Synapses/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 46
    facet.materialart.
    Unknown
    Filling in the blanks of the GABAB receptor (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-01-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wickelgren, I -- New York, N.Y. -- Science. 1999 Jan 1;283(5398):14-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9917254" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/metabolism ; Cells, Cultured ; Dimerization ; Drug Design ; Humans ; Neurons/*metabolism ; Potassium Channels/metabolism ; Rats ; Receptors, GABA-B/*chemistry/*metabolism ; Signal Transduction ; gamma-Aminobutyric Acid/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 47
    facet.materialart.
    Unknown
    Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-12
    Description: To monitor changes in alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor distribution in living neurons, the AMPA receptor subunit GluR1 was tagged with green fluorescent protein (GFP). This protein (GluR1-GFP) was functional and was transiently expressed in hippocampal CA1 neurons. In dendrites visualized with two-photon laser scanning microscopy or electron microscopy, most of the GluR1-GFP was intracellular, mimicking endogenous GluR1 distribution. Tetanic synaptic stimulation induced a rapid delivery of tagged receptors into dendritic spines as well as clusters in dendrites. These postsynaptic trafficking events required synaptic N-methyl-D-aspartate (NMDA) receptor activation and may contribute to the enhanced AMPA receptor-mediatedtransmission observed during long-term potentiation and activity-dependent synaptic maturation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shi, S H -- Hayashi, Y -- Petralia, R S -- Zaman, S H -- Wenthold, R J -- Svoboda, K -- Malinow, R -- New York, N.Y. -- Science. 1999 Jun 11;284(5421):1811-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10364548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Dendrites/*metabolism/ultrastructure ; Electric Stimulation ; Hippocampus/cytology/physiology ; Humans ; Long-Term Potentiation ; *Neuronal Plasticity ; Neurons/*physiology ; Organ Culture Techniques ; Rats ; Receptor Aggregation ; Receptors, AMPA/*metabolism ; Receptors, N-Methyl-D-Aspartate/*physiology ; Recombinant Fusion Proteins/metabolism ; Synapses/metabolism/*physiology ; Synaptic Transmission ; Tetany
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 48
    facet.materialart.
    Unknown
    Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-05
    Description: Glutamatergic neurotransmission is controlled by presynaptic metabotropic glutamate receptors (mGluRs). A subdomain in the intracellular carboxyl-terminal tail of group III mGluRs binds calmodulin and heterotrimeric guanosine triphosphate-binding protein (G protein) betagamma subunits in a mutually exclusive manner. Mutations interfering with calmodulin binding and calmodulin antagonists inhibit G protein-mediated modulation of ionic currents by mGluR 7. Calmodulin antagonists also prevent inhibition of excitatory neurotransmission via presynaptic mGluRs. These results reveal a novel mechanism of presynaptic modulation in which Ca(2+)-calmodulin is required to release G protein betagamma subunits from the C-tail of group III mGluRs in order to mediate glutamatergic autoinhibition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Connor, V -- El Far, O -- Bofill-Cardona, E -- Nanoff, C -- Freissmuth, M -- Karschin, A -- Airas, J M -- Betz, H -- Boehm, S -- New York, N.Y. -- Science. 1999 Nov 5;286(5442):1180-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurochemistry, Max Planck Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10550060" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Calcium/metabolism ; Calmodulin/antagonists & inhibitors/*metabolism ; Cells, Cultured ; Dimerization ; G Protein-Coupled Inwardly-Rectifying Potassium Channels ; GTP-Binding Proteins/*metabolism ; Glutamic Acid/*metabolism ; Hippocampus/cytology/metabolism ; Humans ; Mice ; Molecular Sequence Data ; Neurons/metabolism ; Potassium Channels/metabolism ; *Potassium Channels, Inwardly Rectifying ; Presynaptic Terminals/metabolism ; Propionates/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/antagonists & inhibitors/*metabolism ; Recombinant Fusion Proteins/metabolism ; Sesterterpenes ; Signal Transduction ; Swine ; *Synaptic Transmission ; Terpenes/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 49
    facet.materialart.
    Unknown
    AP-2 recruitment to synaptotagmin stimulated by tyrosine-based endocytic motifs (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-24
    Description: Clathrin-mediated endocytosis is initiated by the recruitment of the clathrin adaptor protein AP-2 to the plasma membrane where the membrane protein synaptotagmin is thought to act as a docking site. AP-2 also interacts with endocytic motifs present in other cargo proteins. Peptides with a tyrosine-based endocytic motif stimulated binding of AP-2 to synaptotagmin and enhanced AP-2 recruitment to the plasma membrane of neuronal and non-neuronal cells. This suggests a mechanism by which nucleation of clathrin-coated pits is stimulated by the loading of cargo proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haucke, V -- De Camilli, P -- CA46128/CA/NCI NIH HHS/ -- NS36252/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1999 Aug 20;285(5431):1268-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology and Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10455054" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Protein Complex alpha Subunits ; Adaptor Proteins, Vesicular Transport ; Animals ; Binding Sites ; CHO Cells ; *Calcium-Binding Proteins ; Cattle ; Cell Membrane/metabolism ; Clathrin/*metabolism ; Coated Pits, Cell-Membrane/*metabolism ; Cricetinae ; *Endocytosis ; Membrane Glycoproteins/chemistry/*metabolism ; Membrane Proteins/*metabolism ; Nerve Tissue Proteins/chemistry/*metabolism ; Neurons/metabolism ; Oligopeptides/chemistry/metabolism/*pharmacology ; Phospholipase D/metabolism ; Protein Binding ; Rats ; Recombinant Fusion Proteins/metabolism ; Synaptic Membranes/*metabolism ; Synaptotagmins ; Tyrosine/chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 50
    facet.materialart.
    Unknown
    Techsigting. Neural regeneration. Some nerve! (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sikorski, R -- Peters, R -- New York, N.Y. -- Science. 1999 Apr 16;284(5413):453.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10232993" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Division ; Cell Separation ; Chick Embryo ; Neural Crest/*cytology/embryology ; Neuroglia/*cytology ; Neurons/*cytology ; Rats ; Regeneration ; Sciatic Nerve/*cytology/embryology ; Stem Cells/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 51
    facet.materialart.
    Unknown
    Role of DNA 5-methylcytosine transferase in cell transformation by fos (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-01-15
    Description: The Fos and Jun oncoproteins form dimeric complexes that stimulate transcription of genes containing activator protein-1 regulatory elements. We found, by representational difference analysis, that expression of DNA 5-methylcytosine transferase (dnmt1) in fos-transformed cells is three times the expression in normal fibroblasts and that fos-transformed cells contain about 20 percent more 5-methylcytosine than normal fibroblasts. Transfection of the gene encoding Dnmt1 induced morphological transformation, whereas inhibition of dnmt1 expression or activity resulted in reversion of fos transformation. Inhibition of histone deacetylase, which associates with methylated DNA, also caused reversion. These results suggest that fos may transform cells through alterations in DNA methylation and in histone deacetylation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bakin, A V -- Curran, T -- P30 CA21765/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1999 Jan 15;283(5400):387-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9888853" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine ; Acetylation ; Animals ; Cell Size ; *Cell Transformation, Neoplastic ; Cytosine/analogs & derivatives/metabolism ; DNA (Cytosine-5-)-Methyltransferase/genetics/*metabolism ; DNA Methylation ; Enzyme Inhibitors/pharmacology ; Gene Expression Regulation, Neoplastic ; *Genes, fos ; Histone Deacetylase Inhibitors ; Histones/metabolism ; Hydroxamic Acids/pharmacology ; Proto-Oncogene Proteins c-fos/*metabolism ; Rats ; Transcription, Genetic ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 52
    facet.materialart.
    Unknown
    Pigment epithelium-derived factor: a potent inhibitor of angiogenesis (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-10
    Description: In the absence of disease, the vasculature of the mammalian eye is quiescent, in part because of the action of angiogenic inhibitors that prevent vessels from invading the cornea and vitreous. Here, an inhibitor responsible for the avascularity of these ocular compartments is identified as pigment epithelium-derived factor (PEDF), a protein previously shown to have neurotrophic activity. The amount of inhibitory PEDF produced by retinal cells was positively correlated with oxygen concentrations, suggesting that its loss plays a permissive role in ischemia-driven retinal neovascularization. These results suggest that PEDF may be of therapeutic use, especially in retinopathies where pathological neovascularization compromises vision and leads to blindness.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dawson, D W -- Volpert, O V -- Gillis, P -- Crawford, S E -- Xu, H -- Benedict, W -- Bouck, N P -- New York, N.Y. -- Science. 1999 Jul 9;285(5425):245-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology-Immunology, Department of Pathology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10398599" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Antibodies/immunology ; Cattle ; Cells, Cultured ; Chemotaxis/drug effects ; Culture Media, Conditioned ; Endothelial Growth Factors/metabolism ; Endothelium, Vascular/cytology/drug effects/physiology ; Eye/blood supply ; *Eye Proteins ; Humans ; Lymphokines/metabolism ; Mice ; Neovascularization, Pathologic/*drug therapy/metabolism/pathology ; Neovascularization, Physiologic/*drug effects ; *Nerve Growth Factors ; Oxygen/physiology ; Proteins/genetics/immunology/*pharmacology/*physiology ; RNA, Messenger/genetics/metabolism ; Rats ; Retina/*metabolism/pathology ; Retinal Neovascularization/*drug therapy ; Retinal Vessels/growth & development ; Serpins/genetics/immunology/*pharmacology/*physiology ; Tumor Cells, Cultured ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 53
    facet.materialart.
    Unknown
    Focal adhesion motility revealed in stationary fibroblasts (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-05
    Description: Focal adhesions (FAs) are clustered integrins and associated proteins that mediate cell adhesion and signaling. A green fluorescent protein-beta1 integrin chimera was used to label FAs in living cells. In stationary cells, FAs were highly motile, moving linearly for several plaque lengths toward the cell center. FA motility was independent of cell density and resulted from contraction of associated actin fibers. In migrating cells, FAs were stationary and only moved in the tail. FA motility in stationary cells suggests that cell movement may be regulated by a clutch-like mechanism by which the affinity of integrins to substrate may be altered in response to migratory cues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smilenov, L B -- Mikhailov, A -- Pelham, R J -- Marcantonio, E E -- Gundersen, G G -- GM42026/GM/NIGMS NIH HHS/ -- GM44585/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1999 Nov 5;286(5442):1172-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Columbia University, New York, NY 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10550057" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Actins/physiology ; Animals ; Antigens, CD29/*metabolism ; *Cell Adhesion ; Cell Count ; Cell Line ; *Cell Movement ; Fibroblasts/*cytology/metabolism ; Fluorescence ; Green Fluorescent Proteins ; Luminescent Proteins ; Mice ; Microscopy, Interference ; Rats ; Recombinant Fusion Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 54
    facet.materialart.
    Unknown
    Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-01-05
    Description: Programmed cell death (apoptosis) occurs during normal development of the central nervous system. However, the mechanisms that determine which neurons will succumb to apoptosis are poorly understood. Blockade of N-methyl-D-aspartate (NMDA) glutamate receptors for only a few hours during late fetal or early neonatal life triggered widespread apoptotic neurodegeneration in the developing rat brain, suggesting that the excitatory neurotransmitter glutamate, acting at NMDA receptors, controls neuronal survival. These findings may have relevance to human neurodevelopmental disorders involving prenatal (drug-abusing mothers) or postnatal (pediatric anesthesia) exposure to drugs that block NMDA receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ikonomidou, C -- Bosch, F -- Miksa, M -- Bittigau, P -- Vockler, J -- Dikranian, K -- Tenkova, T I -- Stefovska, V -- Turski, L -- Olney, J W -- AG 11355/AG/NIA NIH HHS/ -- DA 05072/DA/NIDA NIH HHS/ -- MH 38894/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1999 Jan 1;283(5398):70-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatric Neurology, Charite-Virchow Clinics, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany. hrissanthi.ikonomidou@charite.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9872743" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Apoptosis ; Brain/*cytology/drug effects/embryology/growth & development ; Calcium Channel Blockers/pharmacology ; Dizocilpine Maleate/pharmacology ; Dopamine Antagonists/pharmacology ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Antagonists/pharmacology ; Fetus ; Haloperidol/pharmacology ; Immunohistochemistry ; In Situ Nick-End Labeling ; Microscopy, Electron ; Muscarinic Antagonists/pharmacology ; *Nerve Degeneration ; Neurons/*cytology/drug effects/metabolism ; Quinoxalines/pharmacology ; Rats ; Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors/metabolism ; Scopolamine Hydrobromide/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 55
    facet.materialart.
    Unknown
    Building neural representations of habits (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-27
    Description: Memories for habits and skills ("implicit or procedural memory") and memories for facts ("explicit or episodic memory") are built up in different brain systems and are vulnerable to different neurodegenerative disorders in humans. So that the striatum-based mechanisms underlying habit formation could be studied, chronic recordings from ensembles of striatal neurons were made with multiple tetrodes as rats learned a T-maze procedural task. Large and widely distributed changes in the neuronal activity patterns occurred in the sensorimotor striatum during behavioral acquisition, culminating in task-related activity emphasizing the beginning and end of the automatized procedure. The new ensemble patterns remained stable during weeks of subsequent performance of the same task. These results suggest that the encoding of action in the sensorimotor striatum undergoes dynamic reorganization as habit learning proceeds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jog, M S -- Kubota, Y -- Connolly, C I -- Hillegaart, V -- Graybiel, A M -- R03 MH57878/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1999 Nov 26;286(5445):1745-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉London Health Sciences Center, London, Ontario N6A 5A5, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10576743" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Behavior, Animal ; Brain Mapping ; Corpus Striatum/*physiology ; Electrodes, Implanted ; Evoked Potentials ; *Habits ; Locomotion ; *Maze Learning ; Memory/physiology ; Motor Activity ; Neurons/physiology ; Rats ; Reaction Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 56
    facet.materialart.
    Unknown
    Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-13
    Description: A mechanism by which the Ras-mitogen-activated protein kinase (MAPK) signaling pathway mediates growth factor-dependent cell survival was characterized. The MAPK-activated kinases, the Rsks, catalyzed the phosphorylation of the pro-apoptotic protein BAD at serine 112 both in vitro and in vivo. The Rsk-induced phosphorylation of BAD at serine 112 suppressed BAD-mediated apoptosis in neurons. Rsks also are known to phosphorylate the transcription factor CREB (cAMP response element-binding protein) at serine 133. Activated CREB promoted cell survival, and inhibition of CREB phosphorylation at serine 133 triggered apoptosis. These findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bonni, A -- Brunet, A -- West, A E -- Datta, S R -- Takasu, M A -- Greenberg, M E -- NIHP30-HD18655/HD/NICHD NIH HHS/ -- P01 HD 24926/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1999 Nov 12;286(5443):1358-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Neuroscience, Children's Hospital, and Department of Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10558990" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Apoptosis ; Brain-Derived Neurotrophic Factor/pharmacology ; Carrier Proteins/genetics/metabolism ; *Cell Survival ; Cells, Cultured ; Cerebellum/cytology ; Cyclic AMP Response Element-Binding Protein/metabolism ; Enzyme Activation ; Enzyme Inhibitors/pharmacology ; Flavonoids/pharmacology ; Insulin-Like Growth Factor I/pharmacology ; MAP Kinase Kinase 1 ; *MAP Kinase Signaling System ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors/metabolism ; Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism ; Mutation ; Neurons/*cytology/metabolism ; Phosphorylation ; Phosphoserine/metabolism ; *Protein-Serine-Threonine Kinases ; Rats ; Rats, Long-Evans ; Recombinant Fusion Proteins/metabolism ; Ribosomal Protein S6 Kinases/genetics/*metabolism ; *Transcription, Genetic ; Transfection ; bcl-Associated Death Protein ; ras Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 57
    facet.materialart.
    Unknown
    Dissecting dendrite dynamics (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, S J -- New York, N.Y. -- Science. 1999 Mar 19;283(5409):1860-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA. sjsmith@leland.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10206891" target="_blank"〉PubMed〈/a〉
    Keywords: 2-Amino-5-phosphonovalerate/pharmacology ; Action Potentials ; Animals ; Dendrites/*physiology/ultrastructure ; Excitatory Amino Acid Antagonists/pharmacology ; Glutamic Acid/metabolism ; Hippocampus/cytology ; Microscopy, Fluorescence ; Neurons/physiology/ultrastructure ; Pseudopodia/*physiology/ultrastructure ; Rats ; Receptors, N-Methyl-D-Aspartate/*physiology ; Synapses/*physiology/ultrastructure ; Synaptic Membranes/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 58
    facet.materialart.
    Unknown
    The role of local actin instability in axon formation (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-03-19
    Description: The role of localized instability of the actin network in specifying axonal fate was examined with the use of rat hippocampal neurons in culture. During normal neuronal development, actin dynamics and instability polarized to a single growth cone before axon formation. Consistently, global application of actin-depolymerizing drugs and of the Rho-signaling inactivator toxin B to nonpolarized cells produced neurons with multiple axons. Moreover, disruption of the actin network in one individual growth cone induced its neurite to become the axon. Thus, local instability of the actin network restricted to a single growth cone is a physiological signal specifying neuronal polarization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bradke, F -- Dotti, C G -- New York, N.Y. -- Science. 1999 Mar 19;283(5409):1931-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉European Molecular Biology Laboratory, Cell Biology Programme, Meyerhofstrasse 1, 69012 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10082468" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/metabolism/*physiology ; Animals ; Axons/*physiology/ultrastructure ; *Bacterial Proteins ; Bacterial Toxins/pharmacology ; Bicyclo Compounds, Heterocyclic/pharmacology ; Cell Polarity ; Cells, Cultured ; Cytochalasin D/pharmacology ; GTP Phosphohydrolases/antagonists & inhibitors/metabolism ; Growth Cones/drug effects/*physiology/ultrastructure ; Hippocampus ; Microtubules/physiology/ultrastructure ; Neurites/*physiology/ultrastructure ; Phenotype ; Pseudopodia/drug effects/ultrastructure ; Rats ; Signal Transduction ; Thiazoles/pharmacology ; Thiazolidines
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 59
    facet.materialart.
    Unknown
    Precisely localized LTD in the neocortex revealed by infrared-guided laser stimulation (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-03
    Description: In a direct approach to elucidate the origin of long-term depression (LTD), glutamate was applied onto dendrites of neurons in rat neocortical slices. An infrared-guided laser stimulation was used to release glutamate from caged glutamate in the focal spot of an ultraviolet laser. A burst of light flashes caused an LTD-like depression of glutamate receptor responses, which was highly confined to the region of "tetanic" stimulation (〈10 micrometers). A similar depression of glutamate receptor responses was observed during LTD of synaptic transmission. A spatially highly specific postsynaptic mechanism can account for the LTD induced by glutamate release.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dodt, H -- Eder, M -- Frick, A -- Zieglgansberger, W -- New York, N.Y. -- Science. 1999 Oct 1;286(5437):110-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany. dodt@mpipsykl.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10506556" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dizocilpine Maleate/pharmacology ; Electric Stimulation ; Excitatory Amino Acid Antagonists/pharmacology ; Excitatory Postsynaptic Potentials ; Glutamates/pharmacology ; Glutamic Acid/metabolism ; In Vitro Techniques ; Infrared Rays ; Lasers ; Microscopy, Video ; Neocortex/cytology/*physiology ; *Neuronal Plasticity ; Patch-Clamp Techniques ; Photolysis ; Pyramidal Cells/*physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, Glutamate/*metabolism ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/metabolism ; Synapses/*physiology ; *Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 60
    facet.materialart.
    Unknown
    Neuroscience. Early insult rewires pain circuits (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-12
    Description: On page 628, neuroscientists report that painful stimuli delivered to rats shortly after birth permanently rewire the spinal cord circuits that respond to pain. Not only do the circuits contain more axons, but the axons extend to more areas of the spinal cord than they normally would. The results should help convince skeptics of the importance of managing pain in human infants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helmuth, L -- New York, N.Y. -- Science. 2000 Jul 28;289(5479):521-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10939955" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways ; Aging ; Animals ; Animals, Newborn ; Axons/*physiology ; Hindlimb/innervation ; Humans ; Infant, Newborn ; Inflammation/physiopathology ; *Pain ; Pain Threshold ; Rats ; Sciatic Nerve/*anatomy & histology/physiology ; Spinal Cord/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 61
    facet.materialart.
    Unknown
    Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-05-20
    Description: A hippocampal pyramidal neuron receives more than 10(4) excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that the protein complement (and thus function) of each synapse can be regulated on the basis of activity. Here, local postsynaptic protein synthesis, triggered by synaptic activation of metabotropic glutamate receptors, was found to modify synaptic transmission within minutes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huber, K M -- Kayser, M S -- Bear, M F -- New York, N.Y. -- Science. 2000 May 19;288(5469):1254-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Neuroscience, Brown University, Providence, RI 02912, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10818003" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/pharmacology ; Animals ; Anisomycin/pharmacology ; Dendrites/drug effects/*metabolism ; Electric Stimulation ; Excitatory Amino Acid Antagonists/pharmacology ; Hippocampus/*metabolism/physiology ; Methoxyhydroxyphenylglycol/analogs & derivatives/pharmacology ; Nerve Tissue Proteins/antagonists & inhibitors/*biosynthesis/genetics ; Neural Inhibition/drug effects/*physiology ; Protein Biosynthesis/drug effects ; Protein Synthesis Inhibitors/pharmacology ; RNA, Messenger/metabolism ; Rats ; Receptors, Metabotropic Glutamate/*physiology ; Synaptic Transmission/drug effects/physiology ; Xanthenes/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 62
    facet.materialart.
    Unknown
    Learning-induced LTP in neocortex (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-10-20
    Description: The hypothesis that learning occurs through long-term potentiation (LTP)- and long-term depression (LTD)-like mechanisms is widely held but unproven. This hypothesis makes three assumptions: Synapses are modifiable, they modify with learning, and they strengthen through an LTP-like mechanism. We previously established the ability for synaptic modification and a synaptic strengthening with motor skill learning in horizontal connections of the rat motor cortex (MI). Here we investigated whether learning strengthened these connections through LTP. We demonstrated that synapses in the trained MI were near the ceiling of their modification range, compared with the untrained MI, but the range of synaptic modification was not affected by learning. In the trained MI, LTP was markedly reduced and LTD was enhanced. These results are consistent with the use of LTP to strengthen synapses during learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rioult-Pedotti, M S -- Friedman, D -- Donoghue, J P -- NS27164/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2000 Oct 20;290(5491):533-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Brown University, Providence, RI 02912, USA. mengia_rioult@brown.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11039938" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Electric Stimulation ; Female ; Learning/*physiology ; Long-Term Potentiation/*physiology ; Models, Neurological ; Motor Cortex/*physiology ; Motor Skills ; Neuronal Plasticity ; Rats ; Rats, Sprague-Dawley ; Synapses/*physiology ; Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 63
    facet.materialart.
    Unknown
    Neurobiology. Receptors as kissing cousins (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-04-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Milligan, G -- New York, N.Y. -- Science. 2000 Apr 7;288(5463):65-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Scotland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10766637" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclase Inhibitors ; Adenylyl Cyclases/metabolism ; Animals ; Cell Line ; Cerebral Cortex/metabolism ; Corpus Striatum/metabolism ; Dimerization ; Energy Transfer ; Fluorescence ; GTP-Binding Proteins/*metabolism ; Ligands ; Rats ; Receptor Cross-Talk ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/agonists/*metabolism ; Receptors, Dopamine D5 ; Receptors, GABA-A/metabolism ; Receptors, Somatostatin/agonists/*metabolism ; Signal Transduction ; Somatostatin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 64
    facet.materialart.
    Unknown
    Evolution. Parasites make scaredy-rats foolhardy (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zimmer, C -- New York, N.Y. -- Science. 2000 Jul 28;289(5479):525-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10939959" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; Biological Evolution ; *Fear ; Female ; Humans ; Male ; *Personality ; Rats ; Toxoplasma/*physiology ; Toxoplasmosis, Animal/parasitology/*psychology ; Toxoplasmosis, Cerebral/parasitology/*psychology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 65
    facet.materialart.
    Unknown
    Laboratory animals. Researchers fight plan to regulate mice, birds (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, D -- New York, N.Y. -- Science. 2000 Oct 6;290(5489):23.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11183138" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Testing Alternatives/*legislation & jurisprudence ; Animal Welfare/*legislation & jurisprudence ; Animals ; *Animals, Laboratory ; Birds ; Mice ; Rats ; United States ; United States Department of Agriculture/*legislation & jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 66
    facet.materialart.
    Unknown
    Neurobiology. A new clue to how alcohol damages brains (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 2000 Feb 11;287(5455):947-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10691562" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Benzodiazepines/adverse effects/toxicity ; Brain/cytology/*drug effects/growth & development ; Ethanol/blood/*toxicity ; Female ; Humans ; Infant, Newborn ; Nerve Degeneration ; Neurons/cytology/*drug effects ; Pregnancy ; Rats ; Receptors, GABA/*drug effects/metabolism ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*drug effects/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 67
    facet.materialart.
    Unknown
    Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-11-10
    Description: Reciprocal gene activation and restriction during cell type differentiation from a common lineage is a hallmark of mammalian organogenesis. A key question, then, is whether a critical transcriptional activator of cell type-specific gene targets can also restrict expression of the same genes in other cell types. Here, we show that whereas the pituitary-specific POU domain factor Pit-1 activates growth hormone gene expression in one cell type, the somatotrope, it restricts its expression from a second cell type, the lactotrope. This distinction depends on a two-base pair spacing in accommodation of the bipartite POU domains on a conserved growth hormone promoter site. The allosteric effect on Pit-1, in combination with other DNA binding factors, results in the recruitment of a corepressor complex, including nuclear receptor corepressor N-CoR, which, unexpectedly, is required for active long-term repression of the growth hormone gene in lactotropes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scully, K M -- Jacobson, E M -- Jepsen, K -- Lunyak, V -- Viadiu, H -- Carriere, C -- Rose, D W -- Hooshmand, F -- Aggarwal, A K -- Rosenfeld, M G -- R01 DK18477/DK/NIDDK NIH HHS/ -- R01 DK54802/DK/NIDDK NIH HHS/ -- R01 GM49327/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2000 Nov 10;290(5494):1127-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Endocrinology and Metabolism, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11073444" target="_blank"〉PubMed〈/a〉
    Keywords: Allosteric Regulation ; Animals ; Base Sequence ; Binding Sites ; Cell Line ; Conserved Sequence ; Crystallization ; DNA/*metabolism ; DNA-Binding Proteins/chemistry/genetics/*metabolism ; Female ; *Gene Expression Regulation ; Genes, Reporter ; Growth Hormone/*genetics ; Male ; Mice ; Mice, Transgenic ; Models, Molecular ; Molecular Sequence Data ; Nuclear Proteins/genetics/metabolism ; Nuclear Receptor Co-Repressor 1 ; Pituitary Gland/cytology/*metabolism ; Prolactin/*genetics ; Promoter Regions, Genetic ; Protein Conformation ; Protein Structure, Tertiary ; Rats ; Repressor Proteins/chemistry/genetics/*metabolism ; Transcription Factor Pit-1 ; Transcription Factors/chemistry/genetics/*metabolism ; Transcriptional Activation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 68
    facet.materialart.
    Unknown
    Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-02-11
    Description: DARPP-32, a dopamine- and adenosine 3',5'-monophosphate (cAMP)-regulated phosphoprotein (32 kilodaltons in size), is an obligate intermediate in progesterone (P)-facilitated sexual receptivity in female rats and mice. The facilitative effect of P on sexual receptivity in female rats was blocked by antisense oligonucleotides to DARPP-32. Homozygous mice carrying a null mutation for the DARPP-32 gene exhibited minimal levels of P-facilitated sexual receptivity when compared to their wild-type littermates. P significantly increased hypothalamic cAMP levels and cAMP-dependent protein kinase activity. These increases were not inhibited by a D1 subclass dopamine receptor antagonist. P also enhanced phosphorylation of DARPP-32 on threonine 34 in the hypothalamus of mice. DARPP-32 activation is thus an obligatory step in progestin receptor regulation of sexual receptivity in rats and mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mani, S K -- Fienberg, A A -- O'Callaghan, J P -- Snyder, G L -- Allen, P B -- Dash, P K -- Moore, A N -- Mitchell, A J -- Bibb, J -- Greengard, P -- O'Malley, B W -- MH49662/MH/NIMH NIH HHS/ -- MH57442/MH/NIMH NIH HHS/ -- NS 35457/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 2000 Feb 11;287(5455):1053-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. smani@bcm.tmc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10669419" target="_blank"〉PubMed〈/a〉
    Keywords: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology ; Animals ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Dopamine/pharmacology ; Dopamine Agonists/pharmacology ; Dopamine and cAMP-Regulated Phosphoprotein 32 ; Female ; Hypothalamus/metabolism ; Injections, Intraventricular ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; *Nerve Tissue Proteins ; Oligonucleotides, Antisense/pharmacology ; Phosphoproteins/genetics/*metabolism ; Phosphorylation ; Posture ; Progesterone/*pharmacology ; Proteins/genetics/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Progesterone/metabolism ; Serotonin/pharmacology ; Sexual Behavior, Animal/*drug effects ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 69
    facet.materialart.
    Unknown
    An early taste of things to come (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-09-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marcus, M -- New York, N.Y. -- Science. 2000 Sep 15;289(5486):1878.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11012357" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/physiology ; Embryonic and Fetal Development ; Female ; *Food Preferences/physiology ; Humans ; Rats ; *Taste
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 70
    facet.materialart.
    Unknown
    A transcriptional switch mediated by cofactor methylation (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-11-10
    Description: We describe a molecular switch based on the controlled methylation of nucleosome and the transcriptional cofactors, the CREB-binding proteins (CBP)/p300. The CBP/p300 methylation site is localized to an arginine residue that is essential for stabilizing the structure of the KIX domain, which mediates CREB recruitment. Methylation of KIX by coactivator-associated arginine methyltransferase 1 (CARM1) blocks CREB activation by disabling the interaction between KIX and the kinase inducible domain (KID) of CREB. Thus, CARM1 functions as a corepressor in cyclic adenosine monophosphate signaling pathway via its methyltransferase activity while acting as a coactivator for nuclear hormones. These results provide strong in vivo and in vitro evidence that histone methylation plays a key role in hormone-induced gene activation and define cofactor methylation as a new regulatory mechanism in hormone signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, W -- Chen, H -- Du, K -- Asahara, H -- Tini, M -- Emerson, B M -- Montminy, M -- Evans, R M -- 9R01DK57978/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2507-11. Epub 2001 Nov 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gene Expression Laboratory, Department of Biological Chemistry, University of California Davis Cancer Center/Basic Science, Sacramento, CA 95817, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11701890" target="_blank"〉PubMed〈/a〉
    Keywords: Acetyltransferases/metabolism ; Amino Acid Sequence ; Animals ; Apoptosis ; Cell Line ; Cyclic AMP Response Element-Binding Protein/metabolism ; Dimerization ; E1A-Associated p300 Protein ; *Gene Expression Regulation ; Genes, Reporter ; Histone Acetyltransferases ; Histones/metabolism ; Methylation ; Molecular Sequence Data ; Nerve Growth Factor/pharmacology ; Nuclear Proteins/chemistry/*metabolism ; PC12 Cells ; Protein Structure, Tertiary ; Protein-Arginine N-Methyltransferases/*metabolism ; Rats ; Receptors, Retinoic Acid/*metabolism ; Recombinant Fusion Proteins/metabolism ; Retinoid X Receptors ; *Saccharomyces cerevisiae Proteins ; Signal Transduction ; Somatostatin/genetics ; Trans-Activators/chemistry/*metabolism ; Transcription Factors/metabolism ; *Transcription, Genetic ; Transcriptional Activation ; Transfection ; Tretinoin/metabolism/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 71
    facet.materialart.
    Unknown
    Molecular mechanisms of the biological clock in cultured fibroblasts (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-04-17
    Description: In mammals, the central circadian pacemaker resides in the hypothalamic suprachiasmatic nucleus (SCN), but circadian oscillators also exist in peripheral tissues. Here, using wild-type and cryptochrome (mCry)-deficient cell lines derived from mCry mutant mice, we show that the peripheral oscillator in cultured fibroblasts is identical to the oscillator in the SCN in (i) temporal expression profiles of all known clock genes, (ii) the phase of the various mRNA rhythms (i.e., antiphase oscillation of Bmal1 and mPer genes), (iii) the delay between maximum mRNA levels and appearance of nuclear mPER1 and mPER2 protein, (iv) the inability to produce oscillations in the absence of functional mCry genes, and (v) the control of period length by mCRY proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yagita, K -- Tamanini, F -- van Der Horst, G T -- Okamura, H -- New York, N.Y. -- Science. 2001 Apr 13;292(5515):278-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, Chuo-ku, Kobe 650-0017, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11303101" target="_blank"〉PubMed〈/a〉
    Keywords: ARNTL Transcription Factors ; Animals ; Basic Helix-Loop-Helix Transcription Factors ; Biological Clocks/*genetics ; CLOCK Proteins ; Cell Cycle Proteins ; Cell Line ; Cell Nucleus/metabolism ; Circadian Rhythm/*genetics ; Cryptochromes ; *DNA-Binding Proteins ; *Drosophila Proteins ; Endothelin-1/pharmacology ; *Eye Proteins ; Fibroblasts/*physiology ; Flavoproteins/genetics/metabolism ; Gene Expression Profiling ; *Gene Expression Regulation ; Nuclear Proteins/genetics/metabolism ; Period Circadian Proteins ; *Photoreceptor Cells, Invertebrate ; RNA, Messenger/genetics/metabolism ; Rats ; Receptors, G-Protein-Coupled ; Suprachiasmatic Nucleus/metabolism ; Time Factors ; Trans-Activators/genetics/metabolism ; Transcription Factors/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 72
    facet.materialart.
    Unknown
    Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-05
    Description: We show that high doses of salicylates reverse hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents by sensitizing insulin signaling. Activation or overexpression of the IkappaB kinase beta (IKKbeta) attenuated insulin signaling in cultured cells, whereas IKKbeta inhibition reversed insulin resistance. Thus, IKKbeta, rather than the cyclooxygenases, appears to be the relevant molecular target. Heterozygous deletion (Ikkbeta+/-) protected against the development of insulin resistance during high-fat feeding and in obese Lep(ob/ob) mice. These findings implicate an inflammatory process in the pathogenesis of insulin resistance in obesity and type 2 diabetes mellitus and identify the IKKbeta pathway as a target for insulin sensitization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yuan, M -- Konstantopoulos, N -- Lee, J -- Hansen, L -- Li, Z W -- Karin, M -- Shoelson, S E -- AI43477/AI/NIAID NIH HHS/ -- DK45493/DK/NIDDK NIH HHS/ -- DK51729/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2001 Aug 31;293(5535):1673-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11533494" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Aspirin/administration & dosage/*pharmacology ; Blood Glucose/metabolism ; Cell Line ; Dietary Fats/*administration & dosage ; Gene Deletion ; Gene Targeting ; Glucose Tolerance Test ; I-kappa B Kinase ; Insulin/administration & dosage/blood/*metabolism/pharmacology ; *Insulin Resistance ; Lipids/blood ; Liver/metabolism ; Male ; Mice ; Mice, Obese ; Muscles/metabolism ; Obesity/metabolism/*physiopathology ; Phosphorylation ; Prostaglandin-Endoperoxide Synthases/genetics/metabolism ; Protein-Serine-Threonine Kinases/antagonists & inhibitors/genetics/*metabolism ; Rats ; Rats, Zucker ; Receptor, Insulin/metabolism ; Signal Transduction ; Sodium Salicylate/administration & dosage/*pharmacology ; Tumor Necrosis Factor-alpha/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 73
    facet.materialart.
    Unknown
    Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-01-06
    Description: Most traditional cytotoxic anticancer agents ablate the rapidly dividing epithelium of the hair follicle and induce alopecia (hair loss). Inhibition of cyclin-dependent kinase 2 (CDK2), a positive regulator of eukaryotic cell cycle progression, may represent a therapeutic strategy for prevention of chemotherapy-induced alopecia (CIA) by arresting the cell cycle and reducing the sensitivity of the epithelium to many cell cycle-active antitumor agents. Potent small-molecule inhibitors of CDK2 were developed using structure-based methods. Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the animals. Thus, inhibition of CDK2 represents a potentially useful approach for the prevention of CIA in cancer patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, S T -- Benson, B G -- Bramson, H N -- Chapman, D E -- Dickerson, S H -- Dold, K M -- Eberwein, D J -- Edelstein, M -- Frye, S V -- Gampe Jr, R T -- Griffin, R J -- Harris, P A -- Hassell, A M -- Holmes, W D -- Hunter, R N -- Knick, V B -- Lackey, K -- Lovejoy, B -- Luzzio, M J -- Murray, D -- Parker, P -- Rocque, W J -- Shewchuk, L -- Veal, J M -- Walker, D H -- Kuyper, L F -- New York, N.Y. -- Science. 2001 Jan 5;291(5501):134-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cancer Biology, Glaxo Wellcome Research and Development, Research Triangle Park, NC 27709, USA. std41085@glaxowellcome.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11141566" target="_blank"〉PubMed〈/a〉
    Keywords: Alopecia/*chemically induced/*prevention & control ; Animals ; Animals, Newborn ; Antineoplastic Agents/*toxicity ; Antineoplastic Combined Chemotherapy Protocols/toxicity ; Apoptosis/drug effects ; *CDC2-CDC28 Kinases ; Cell Cycle/drug effects ; Cell Line ; Cyclin-Dependent Kinase 2 ; Cyclin-Dependent Kinases/*antagonists & inhibitors/metabolism ; Cyclophosphamide/toxicity ; Cytoprotection/drug effects ; DNA/biosynthesis ; Doxorubicin/toxicity ; Drug Design ; Enzyme Inhibitors/chemical synthesis/chemistry/*pharmacology ; Epithelium/drug effects ; Etoposide/toxicity ; Hair Follicle/cytology/*drug effects ; Humans ; Indoles/chemical synthesis/chemistry/*pharmacology ; Mice ; Mice, SCID ; Phosphorylation ; Protein-Serine-Threonine Kinases/*antagonists & inhibitors/metabolism ; Rats ; Retinoblastoma Protein/metabolism ; Scalp/transplantation ; Sulfonamides/chemical synthesis/chemistry/*pharmacology ; Transplantation, Heterologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 74
    facet.materialart.
    Unknown
    Neuroscience. A kinase to dampen the effects of cocaine? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-04-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gupta, A -- Tsai, L H -- New York, N.Y. -- Science. 2001 Apr 13;292(5515):236-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11305318" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cocaine/*pharmacology ; Corpus Striatum/*drug effects/metabolism ; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors/metabolism ; Cyclin-Dependent Kinase 5 ; Cyclin-Dependent Kinases/antagonists & inhibitors/genetics/*metabolism ; Dopamine/metabolism ; Dopamine Uptake Inhibitors/*pharmacology ; Dopamine and cAMP-Regulated Phosphoprotein 32 ; Mice ; Mice, Knockout ; Motor Activity/drug effects ; Nerve Tissue Proteins/metabolism ; Neurons/metabolism ; Phosphoprotein Phosphatases/antagonists & inhibitors/metabolism ; Phosphoproteins/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 75
    facet.materialart.
    Unknown
    Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-06-02
    Description: The GGAs are a multidomain protein family implicated in protein trafficking between the Golgi and endosomes. Here, the VHS domain of GGA2 was shown to bind to the acidic cluster-dileucine motif in the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR). Receptors with mutations in this motif were defective in lysosomal enzyme sorting. The hinge domain of GGA2 bound clathrin, suggesting that GGA2 could be a link between cargo molecules and clathrin-coated vesicle assembly. Thus, GGA2 binding to the CI-MPR is important for lysosomal enzyme targeting.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhu, Y -- Doray, B -- Poussu, A -- Lehto, V P -- Kornfeld, S -- R01 CA-08759/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2001 Jun 1;292(5522):1716-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11387476" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Vesicular Transport ; Amino Acid Motifs ; Amino Acid Sequence ; Animals ; *Carrier Proteins ; Cations ; Clathrin/metabolism ; Dipeptides/chemistry/metabolism ; L Cells (Cell Line) ; Lysosomes/*enzymology ; Mice ; Molecular Sequence Data ; Mutation ; Protein Sorting Signals ; Protein Structure, Tertiary ; *Protein Transport ; Proteins/chemistry/genetics/*metabolism ; Rats ; Receptor, IGF Type 2/*chemistry/genetics/*metabolism ; Recombinant Fusion Proteins/chemistry/metabolism ; Solubility ; Transcription Factor AP-1/metabolism ; Transport Vesicles/metabolism ; Two-Hybrid System Techniques ; trans-Golgi Network/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 76
    facet.materialart.
    Unknown
    Dominant-negative mutants of a toxin subunit: an approach to therapy of anthrax (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-04-28
    Description: The protective antigen moiety of anthrax toxin translocates the toxin's enzymic moieties to the cytosol of mammalian cells by a mechanism that depends on its ability to heptamerize and insert into membranes. We identified dominant-negative mutants of protective antigen that co-assemble with the wild-type protein and block its ability to translocate the enzymic moieties across membranes. These mutants strongly inhibited toxin action in cell culture and in an animal intoxication model, suggesting that they could be useful in therapy of anthrax.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sellman, B R -- Mourez, M -- Collier, R J -- 5T32AI07410/AI/NIAID NIH HHS/ -- R37-AI22021/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2001 Apr 27;292(5517):695-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11326092" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthrax/*drug therapy ; *Antigens, Bacterial ; Bacterial Toxins/*antagonists & inhibitors/*genetics/metabolism/toxicity ; CHO Cells ; Cell Membrane/metabolism ; Cricetinae ; Endocytosis ; Genes, Dominant ; Male ; *Mutation ; Protein Transport ; Rats ; Rats, Inbred F344 ; Receptors, Peptide/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 77
    facet.materialart.
    Unknown
    Control of synapse number by glia (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-07
    Description: Although astrocytes constitute nearly half of the cells in our brain, their function is a long-standing neurobiological mystery. Here we show by quantal analyses, FM1-43 imaging, immunostaining, and electron microscopy that few synapses form in the absence of glial cells and that the few synapses that do form are functionally immature. Astrocytes increase the number of mature, functional synapses on central nervous system (CNS) neurons by sevenfold and are required for synaptic maintenance in vitro. We also show that most synapses are generated concurrently with the development of glia in vivo. These data demonstrate a previously unknown function for glia in inducing and stabilizing CNS synapses, show that CNS synapse number can be profoundly regulated by nonneuronal signals, and raise the possibility that glia may actively participate in synaptic plasticity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ullian, E M -- Sapperstein, S K -- Christopherson, K S -- Barres, B A -- NS10784/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2001 Jan 26;291(5504):657-61.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stanford University School of Medicine, Department of Neurobiology, Fairchild Science Building, Stanford, CA 94305-5125, USA. emu@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11158678" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/*physiology ; Calcium/metabolism ; *Calcium-Binding Proteins ; Cell Communication ; Cells, Cultured ; Coculture Techniques ; Excitatory Postsynaptic Potentials ; Fluorescent Dyes/metabolism ; Glutamic Acid/pharmacology ; Ionomycin/pharmacology ; Membrane Glycoproteins/metabolism ; Microscopy, Electron ; Nerve Tissue Proteins/metabolism ; Neuronal Plasticity ; Patch-Clamp Techniques ; Pyridinium Compounds/metabolism ; Quaternary Ammonium Compounds/metabolism ; Rats ; Rats, Sprague-Dawley ; Retinal Ganglion Cells/*physiology/ultrastructure ; Superior Colliculi/embryology/growth & development/ultrastructure ; Synapses/*physiology/ultrastructure ; Synaptic Transmission ; Synaptic Vesicles/metabolism ; Synaptophysin/metabolism ; Synaptotagmins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 78
    facet.materialart.
    Unknown
    Dendrodendritic inhibition through reversal of dopamine transport (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-29
    Description: Synapses in the central nervous system are usually defined by presynaptic exocytotic release sites and postsynaptic differentiations. We report here a demonstration of dendrodendritic inhibition that does not engage a conventional synapse. Using amperometric and patch-clamp recordings in rat brain slices of the substantia nigra, we found that blockade of the dopamine transporter abolished the dendritic release of dopamine and the resulting self-inhibition. These findings demonstrate that dendrodendritic autoinhibition entails the carrier-mediated release of dopamine rather than conventional exocytosis. This suggests that some widely used antidepressants that inhibit the dopamine transporter may benefit patients in the early stages of Parkinson's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Falkenburger, B H -- Barstow, K L -- Mintz, I M -- R01-3445/PHS HHS/ -- New York, N.Y. -- Science. 2001 Sep 28;293(5539):2465-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology and Experimental Therapeutics, Boston University Medical Center, Boston, MA 02118, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11577238" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Calcium/metabolism ; Carrier Proteins/antagonists & inhibitors/*metabolism ; Dendrites/*metabolism ; Dopamine/*metabolism ; Dopamine D2 Receptor Antagonists ; Dopamine Plasma Membrane Transport Proteins ; Electric Stimulation ; Electrophysiology ; Evoked Potentials/drug effects ; Excitatory Postsynaptic Potentials ; Exocytosis ; Glutamic Acid/pharmacology ; Humans ; In Vitro Techniques ; *Membrane Glycoproteins ; Membrane Potentials ; *Membrane Transport Proteins ; *Nerve Tissue Proteins ; Neural Inhibition ; Neurons/metabolism ; Parkinson Disease/drug therapy/metabolism ; Patch-Clamp Techniques ; Piperazines/pharmacology ; Rats ; Receptors, Dopamine D2/metabolism ; Sodium/metabolism ; Substantia Nigra/cytology/*metabolism ; Subthalamic Nucleus/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 79
    facet.materialart.
    Unknown
    Impulsive choice induced in rats by lesions of the nucleus accumbens core (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-05-26
    Description: Impulsive choice is exemplified by choosing a small or poor reward that is available immediately, in preference to a larger but delayed reward. Impulsive choice contributes to drug addiction, attention-deficit/hyperactivity disorder, mania, and personality disorders, but its neuroanatomical basis is unclear. Here, we show that selective lesions of the nucleus accumbens core induce persistent impulsive choice in rats. In contrast, damage to two of its afferents, the anterior cingulate cortex and medial prefrontal cortex, had no effect on this capacity. Thus, dysfunction of the nucleus accumbens core may be a key element in the neuropathology of impulsivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cardinal, R N -- Pennicott, D R -- Sugathapala, C L -- Robbins, T W -- Everitt, B J -- G9537855/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2001 Jun 29;292(5526):2499-501. Epub 2001 May 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK. rudolf.cardinal@pobox.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11375482" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Attention ; Attention Deficit Disorder with Hyperactivity ; Behavior, Animal ; Brain Mapping ; *Choice Behavior ; Disease Models, Animal ; Gyrus Cinguli/physiology ; *Impulsive Behavior ; Motor Activity ; Nucleus Accumbens/*physiology/surgery ; Prefrontal Cortex/physiology ; Random Allocation ; Rats ; Reinforcement (Psychology) ; Reward
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 80
    facet.materialart.
    Unknown
    Relapse to cocaine-seeking after hippocampal theta burst stimulation (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-05-12
    Description: Treatment efforts for cocaine addiction are hampered by high relapse rates. To map brain areas underlying relapse, we used electrical brain stimulation and intracranial injection of pharmacological compounds after extinction of cocaine self-administration behavior in rats. Electrical stimulation of the hippocampus containing glutamatergic fibers, but not the medial forebrain bundle containing dopaminergic fibers, elicited cocaine-seeking behavior dependent on glutamate in the ventral tegmental area. This suggests a role for glutamatergic neurotransmission in relapse to cocaine abuse. The medial forebrain bundle electrodes supported intense electrical self-stimulation. These findings suggest a dissociation of neural systems subserving positive reinforcement (self-stimulation) and incentive motivation (relapse).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vorel, S R -- Liu, X -- Hayes, R J -- Spector, J A -- Gardner, E L -- New York, N.Y. -- Science. 2001 May 11;292(5519):1175-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA. robvorel@hotmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11349151" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cocaine/administration & dosage/pharmacology ; Cocaine-Related Disorders/*physiopathology/prevention & control ; Conditioning, Operant/drug effects/physiology ; Dopamine/physiology ; Electric Stimulation ; Electrodes ; Excitatory Amino Acid Agonists/pharmacology ; Excitatory Amino Acid Antagonists/pharmacology ; Extinction, Psychological/drug effects/physiology ; Glutamic Acid/*physiology ; Hippocampus/cytology/*physiology ; Injections, Intravenous ; Kynurenic Acid/pharmacology ; Medial Forebrain Bundle/cytology/drug effects/physiology ; Memory/physiology ; N-Methylaspartate/pharmacology ; Rats ; Rats, Long-Evans ; Recurrence ; Reward ; Self Administration ; Synaptic Transmission/drug effects ; *Theta Rhythm ; Ventral Tegmental Area/cytology/drug effects/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 81
    facet.materialart.
    Unknown
    Neurobiology. Total recall-the memory of addiction (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nestler, E J -- New York, N.Y. -- Science. 2001 Jun 22;292(5525):2266-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390--9070, USA. eric.nestler@utsouthwestern.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11423644" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/drug effects/physiology/physiopathology ; Calcium/metabolism ; Calcium Signaling ; Cocaine/*pharmacology ; Cocaine-Related Disorders/*physiopathology ; Dopamine/metabolism ; Glutamic Acid/metabolism ; Hippocampus/physiology ; *Long-Term Potentiation ; Memory/*physiology ; Neurons/*drug effects/physiology ; Rats ; Receptors, AMPA/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synaptic Transmission/drug effects ; Ventral Tegmental Area/*drug effects/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 82
    facet.materialart.
    Unknown
    Drug addiction. Zapping memory center triggers drug craving (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 2001 May 11;292(5519):1039.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11352038" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cocaine/administration & dosage/pharmacology ; Cocaine-Related Disorders/*physiopathology ; Conditioning, Operant/drug effects/physiology ; Dopamine/physiology ; Electric Stimulation ; Extinction, Psychological/drug effects/physiology ; Glutamic Acid/*physiology ; Hippocampus/drug effects/*physiology ; Injections, Intravenous ; Medial Forebrain Bundle/drug effects/physiology ; Memory/*physiology ; Rats ; Recurrence ; Reward ; Self Administration ; Ventral Tegmental Area/drug effects/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 83
    facet.materialart.
    Unknown
    Animal welfare. Congress clears way for rodent rules (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-11-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, D -- New York, N.Y. -- Science. 2001 Nov 23;294(5547):1637.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11721028" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Experimentation ; Animal Rights/economics/legislation & jurisprudence ; Animal Welfare/economics/*legislation & jurisprudence ; Animals ; Birds ; Government ; *Government Regulation ; Housing, Animal/economics/legislation & jurisprudence ; Mice ; *Models, Animal ; Rats ; Research Design/legislation & jurisprudence ; *Rodentia ; United States ; United States Department of Agriculture/*legislation & jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 84
    facet.materialart.
    Unknown
    The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-11-27
    Description: Multiple sclerosis is a demyelinating disease, characterized by inflammation in the brain and spinal cord, possibly due to autoimmunity. Large-scale sequencing of cDNA libraries, derived from plaques dissected from brains of patients with multiple sclerosis (MS), indicated an abundance of transcripts for osteopontin (OPN). Microarray analysis of spinal cords from rats paralyzed by experimental autoimmune encephalomyelitis (EAE), a model of MS, also revealed increased OPN transcripts. Osteopontin-deficient mice were resistant to progressive EAE and had frequent remissions, and myelin-reactive T cells in OPN-/- mice produced more interleukin 10 and less interferon-gamma than in OPN+/+ mice. Osteopontin thus appears to regulate T helper cell-1 (TH1)-mediated demyelinating disease, and it may offer a potential target in blocking development of progressive MS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chabas, D -- Baranzini, S E -- Mitchell, D -- Bernard, C C -- Rittling, S R -- Denhardt, D T -- Sobel, R A -- Lock, C -- Karpuj, M -- Pedotti, R -- Heller, R -- Oksenberg, J R -- Steinman, L -- New York, N.Y. -- Science. 2001 Nov 23;294(5547):1731-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology and Neurological Sciences, Beckman Center for Molecular Medicine, B002, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11721059" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Encephalomyelitis, Autoimmune, ; Experimental/genetics/immunology/metabolism/pathology ; Expressed Sequence Tags ; Gene Deletion ; *Gene Expression Profiling ; Gene Library ; Humans ; Inflammation/genetics/immunology/metabolism/pathology ; Interferon-gamma/genetics/metabolism ; Interleukin-10/genetics/metabolism ; Lymphocyte Activation ; Mice ; Mice, Knockout ; Multiple Sclerosis/*genetics/immunology/*metabolism/pathology ; Oligonucleotide Array Sequence Analysis ; Osteopontin ; RNA, Messenger/genetics/metabolism ; Rats ; Sialoglycoproteins/deficiency/genetics/*metabolism ; Spinal Cord/metabolism ; Th1 Cells/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 85
    facet.materialart.
    Unknown
    Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-11-03
    Description: In the exocytosis of neurotransmitter, fusion pore opening represents the first instant of fluid contact between the vesicle lumen and extracellular space. The existence of the fusion pore has been established by electrical measurements, but its molecular composition is unknown. The possibility that synaptotagmin regulates fusion pores was investigated with amperometry to monitor exocytosis of single dense-core vesicles. Overexpression of synaptotagmin I prolonged the time from fusion pore opening to dilation, whereas synaptotagmin IV shortened this time. Both synaptotagmin isoforms reduced norepinephrine flux through open fusion pores. Thus, synaptotagmin interacts with fusion pores, possibly by associating with a core complex of membrane proteins and/or lipid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, C T -- Grishanin, R -- Earles, C A -- Chang, P Y -- Martin, T F -- Chapman, E R -- Jackson, M B -- New York, N.Y. -- Science. 2001 Nov 2;294(5544):1111-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Wisconsin Medical School, University of Wisconsin, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11691996" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Calcium Channels, P-Type/metabolism ; Calcium Channels, Q-Type/metabolism ; *Calcium-Binding Proteins ; Cell Membrane Structures/*metabolism ; Chromogranins/metabolism ; Electrophysiology ; *Exocytosis ; Kinetics ; *Membrane Fusion ; Membrane Glycoproteins/*metabolism ; Membrane Potentials ; Nerve Tissue Proteins/*metabolism ; Neurotransmitter Agents/*metabolism ; Norepinephrine/metabolism ; PC12 Cells ; Protein Isoforms ; Rats ; Recombinant Fusion Proteins/metabolism ; Secretory Vesicles/*metabolism ; Synaptic Transmission ; Synaptic Vesicles/metabolism ; Synaptotagmin I ; Synaptotagmins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 86
    facet.materialart.
    Unknown
    Compartmentalized and binary behavior of terminal dendrites in hippocampal pyramidal neurons (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-22
    Description: The dendritic arbor of pyramidal neurons is not a monolithic structure. We show here that the excitability of terminal apical dendrites differs from that of the apical trunk. In response to fluorescence-guided focal photolysis of caged glutamate, individual terminal apical dendrites generated cadmium-sensitive all-or-none responses that were subthreshold for somatic action potentials. Calcium transients produced by all-or-none responses were not restricted to the sites of photolysis, but occurred throughout individual distal dendritic compartments, indicating that electrogenesis is mediated primarily by voltage-gated calcium channels. Compartmentalized and binary behavior of parallel-connected terminal dendrites can greatly expand the computational power of a single neuron.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wei, D S -- Mei, Y A -- Bagal, A -- Kao, J P -- Thompson, S M -- Tang, C M -- New York, N.Y. -- Science. 2001 Sep 21;293(5538):2272-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11567143" target="_blank"〉PubMed〈/a〉
    Keywords: 2-Amino-5-phosphonovalerate/pharmacology ; Action Potentials ; Animals ; Cadmium/pharmacology ; Calcium/metabolism ; Calcium Channels/metabolism ; Calcium Signaling ; Cesium/pharmacology ; Dendrites/*physiology ; Egtazic Acid/analogs & derivatives/pharmacology ; Glutamates ; Hippocampus/*cytology/physiology ; Light ; Organ Culture Techniques ; Patch-Clamp Techniques ; Photolysis ; Pyramidal Cells/drug effects/*physiology/ultrastructure ; Quinoxalines/pharmacology ; Rats ; Receptors, AMPA/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Tetrodotoxin/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 87
    facet.materialart.
    Unknown
    Wording blurs survey on animal protection (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-03-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garrison, H H -- New York, N.Y. -- Science. 2001 Feb 9;291(5506):986-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11232582" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Welfare/*legislation & jurisprudence ; Animals ; *Animals, Laboratory ; Birds ; Mice ; Rats ; *Research Personnel ; Surveys and Questionnaires ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 88
    facet.materialart.
    Unknown
    Cell biology. Fusion without SNAREs? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-11-03
    Description: Highly orchestrated molecular rearrangements are required for two membranes to fuse, as happens, for example, during neurotransmitter release into the synapse. In an elegant Perspective, Scales et al. discuss two studies (Schoch et al., Wang et al.) that shed new light on the protein interactions involved in membrane fusion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scales, S J -- Finley, M F -- Scheller, R H -- New York, N.Y. -- Science. 2001 Nov 2;294(5544):1015-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genentech Inc., South San Francisco, CA 94080, USA. sscales@gene.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11691976" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Calcium Signaling ; *Calcium-Binding Proteins ; Catecholamines/metabolism ; Cell Membrane/metabolism ; Cells, Cultured ; Electrophysiology ; *Membrane Fusion ; Membrane Glycoproteins/*physiology ; Membrane Proteins/*physiology ; Mice ; Nerve Tissue Proteins/*physiology ; Neurotransmitter Agents/metabolism ; PC12 Cells ; Phospholipids/metabolism ; Protein Isoforms ; R-SNARE Proteins ; Rats ; SNARE Proteins ; Secretory Vesicles/*metabolism ; Synapses/physiology ; Synaptic Transmission ; Synaptic Vesicles/*metabolism ; Synaptotagmins ; *Vesicular Transport Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 89
    facet.materialart.
    Unknown
    Microbiology. Fighting anthrax with a mutant toxin (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olsnes, S -- Wesche, J -- New York, N.Y. -- Science. 2001 Apr 27;292(5517):647-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Institute for Cancer Research, Norwegian Radium Hospital, Oslo, Norway. olsnes@radium.uio.no〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11330322" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthrax/*drug therapy ; *Antigens, Bacterial ; Bacterial Toxins/*antagonists & inhibitors/*genetics/metabolism/toxicity ; Cell Membrane/metabolism ; Cytoplasm/metabolism ; Endocytosis ; *Mutation ; Protein Transport ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 90
    facet.materialart.
    Unknown
    TRP-PLIK, a bifunctional protein with kinase and ion channel activities (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-13
    Description: We cloned and characterized a protein kinase and ion channel, TRP-PLIK. As part of the long transient receptor potential channel subfamily implicated in control of cell division, it is a protein that is both an ion channel and a protein kinase. TRP-PLIK phosphorylated itself, displayed a wide tissue distribution, and, when expressed in CHO-K1 cells, constituted a nonselective, calcium-permeant, 105-picosiemen, steeply outwardly rectifying conductance. The zinc finger containing alpha-kinase domain was functional. Inactivation of the kinase activity by site-directed mutagenesis and the channel's dependence on intracellular adenosine triphosphate (ATP) demonstrated that the channel's kinase activity is essential for channel function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Runnels, L W -- Yue, L -- Clapham, D E -- New York, N.Y. -- Science. 2001 Feb 9;291(5506):1043-7. Epub 2001 Jan 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Cardiology, Department of Neurobiology, Harvard Medical School, 1309 Enders Building, 320 Longwood Avenue, Children's Hospital, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11161216" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Amino Acid Motifs ; Amino Acid Sequence ; Animals ; CHO Cells ; Calcium/metabolism ; Catalytic Domain ; Cations/metabolism ; Cell Line ; Cricetinae ; DNA, Complementary ; Electric Conductivity ; Humans ; Ion Channels/chemistry/*genetics/*metabolism ; *Membrane Proteins ; Mice ; Molecular Sequence Data ; Mutation ; Myelin Basic Protein/metabolism ; Patch-Clamp Techniques ; Phosphorylation ; Protein Kinases/chemistry/*genetics/*metabolism ; Protein-Serine-Threonine Kinases ; Rats ; Recombinant Fusion Proteins/chemistry/metabolism ; TRPM Cation Channels ; Transfection ; Two-Hybrid System Techniques ; Type C Phospholipases/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 91
    facet.materialart.
    Unknown
    Entrainment of the circadian clock in the liver by feeding (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-13
    Description: Circadian rhythms of behavior are driven by oscillators in the brain that are coupled to the environmental light cycle. Circadian rhythms of gene expression occur widely in peripheral organs. It is unclear how these multiple rhythms are coupled together to form a coherent system. To study such coupling, we investigated the effects of cycles of food availability (which exert powerful entraining effects on behavior) on the rhythms of gene expression in the liver, lung, and suprachiasmatic nucleus (SCN). We used a transgenic rat model whose tissues express luciferase in vitro. Although rhythmicity in the SCN remained phase-locked to the light-dark cycle, restricted feeding rapidly entrained the liver, shifting its rhythm by 10 hours within 2 days. Our results demonstrate that feeding cycles can entrain the liver independently of the SCN and the light cycle, and they suggest the need to reexamine the mammalian circadian hierarchy. They also raise the possibility that peripheral circadian oscillators like those in the liver may be coupled to the SCN primarily through rhythmic behavior, such as feeding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokkan, K A -- Yamazaki, S -- Tei, H -- Sakaki, Y -- Menaker, M -- MH 56647/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2001 Jan 19;291(5503):490-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, P.O. Box 400328, Charlottesville, VA 22904-4328, USA. mm7e@virginia.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11161204" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; *Circadian Rhythm ; Corticosterone/blood/pharmacology ; Culture Techniques ; Eating ; Female ; *Food ; *Gene Expression Regulation ; Genes, Reporter ; Liver/*physiology ; Luciferases/genetics ; Lung/physiology ; Male ; Motor Activity ; Organ Specificity ; Rats ; Suprachiasmatic Nucleus/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 92
    facet.materialart.
    Unknown
    BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-09-14
    Description: Mutations in the BRCA2 (breast cancer susceptibility gene 2) tumor suppressor lead to chromosomal instability due to defects in the repair of double-strand DNA breaks (DSBs) by homologous recombination, but BRCA2's role in this process has been unclear. Here, we present the 3.1 angstrom crystal structure of a approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif. We also (i) demonstrate that this BRCA2 domain binds single-stranded DNA, (ii) present its 3.5 angstrom structure bound to oligo(dT)9, (iii) provide data that implicate the HTH motif in dsDNA binding, and (iv) show that BRCA2 stimulates RAD51-mediated recombination in vitro. These findings establish that BRCA2 functions directly in homologous recombination and provide a structural and biochemical basis for understanding the loss of recombination-mediated DSB repair in BRCA2-associated cancers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, Haijuan -- Jeffrey, Philip D -- Miller, Julie -- Kinnucan, Elspeth -- Sun, Yutong -- Thoma, Nicolas H -- Zheng, Ning -- Chen, Phang-Lang -- Lee, Wen-Hwa -- Pavletich, Nikola P -- New York, N.Y. -- Science. 2002 Sep 13;297(5588):1837-48.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Sloan-Kettering Division, Joan and Sanford I. Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12228710" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; BRCA2 Protein/*chemistry/genetics/*metabolism ; Binding Sites ; Crystallography, X-Ray ; DNA/metabolism ; *DNA Repair ; DNA, Single-Stranded/*metabolism ; DNA-Binding Proteins/metabolism ; Genes, BRCA2 ; Helix-Turn-Helix Motifs ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Mice ; Molecular Sequence Data ; Mutation ; Proteasome Endopeptidase Complex ; Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Proteins/chemistry/*metabolism ; Rad51 Recombinase ; Rats ; *Recombination, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 93
    facet.materialart.
    Unknown
    Protein structure. Harmless proteins twist into troublemakers (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-04-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2002 Apr 5;296(5565):28-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11934996" target="_blank"〉PubMed〈/a〉
    Keywords: Amyloid beta-Peptides/chemistry ; Animals ; Humans ; Mice ; Protein Conformation ; *Protein Folding ; *Protein Structure, Quaternary ; Proteins/*chemistry ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 94
    facet.materialart.
    Unknown
    Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-03-02
    Description: The second messenger cyclic adenosine monophosphate (cAMP) is the most important modulator of sympathetic control over cardiac contractility. In cardiac myocytes and many other cell types, however, cAMP transduces the signal generated upon stimulation of various receptors and activates different cellular functions, raising the issue of how specificity can be achieved. In the general field of signal transduction, the view is emerging that specificity is guaranteed by tight localization of signaling events. Here, we show that in neonatal rat cardiac myocytes, beta-adrenergic stimulation generates multiple microdomains with increased concentration of cAMP in correspondence with the region of the transverse tubule/junctional sarcoplasmic reticulum membrane. The restricted pools of cAMP show a range of action as small as approximately 1 micrometer, and free diffusion of the second messenger is limited by the activity of phosphodiesterases. Furthermore, we demonstrate that such gradients of cAMP specifically activate a subset of protein kinase A molecules anchored in proximity to the T tubule.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zaccolo, Manuela -- Pozzan, Tullio -- TCP00089/Telethon/Italy -- New York, N.Y. -- Science. 2002 Mar 1;295(5560):1711-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomedical Sciences and Venetian Institute for Molecular Medicine, University of Padua, Via Orus 2, 35129 Padua, Italy. manuela.zaccolo@unipd.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11872839" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Methyl-3-isobutylxanthine/pharmacology ; A Kinase Anchor Proteins ; Adaptor Proteins, Signal Transducing ; Animals ; Animals, Newborn ; Cells, Cultured ; Colforsin/pharmacology ; Cyclic AMP/*metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Fluorescence ; Green Fluorescent Proteins ; Intracellular Membranes/metabolism ; Kinetics ; Luminescent Proteins ; Myocardium/*cytology/*metabolism/ultrastructure ; Norepinephrine/pharmacology ; Phosphodiesterase Inhibitors/pharmacology ; Proto-Oncogene Proteins/pharmacology ; Rats ; Receptors, Adrenergic, beta/*metabolism ; Recombinant Fusion Proteins/metabolism ; Sarcoplasmic Reticulum/*metabolism ; Second Messenger Systems ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 95
    facet.materialart.
    Unknown
    Partitioning of the matrix fraction of the Golgi apparatus during mitosis in animal cells (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-02-02
    Description: The Golgi apparatus is partitioned during mitosis in animal cells by a process of fragmentation, dispersal, and reassembly in each daughter cell. We fractionated the Golgi apparatus in vivo using the drug brefeldin A or a dominant-negative mutant of the Sar1p protein. After these treatments, Golgi enzymes moved back to the endoplasmic reticulum, leaving behind a matrix of Golgi structural proteins. Under these conditions, cells still entered and exited mitosis normally, and their Golgi matrix partitioned in a manner very similar to that of the complete organelle. Thus, the matrix may be the partitioning unit of the Golgi apparatus and may carry the Golgi enzyme-containing membranes into the daughter cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seemann, Joachim -- Pypaert, Marc -- Taguchi, Tomohiko -- Malsam, Jorg -- Warren, Graham -- New York, N.Y. -- Science. 2002 Feb 1;295(5556):848-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, Post Office Box 208002, New Haven, CT 06520-8002, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11823640" target="_blank"〉PubMed〈/a〉
    Keywords: Anaphase ; Animals ; Autoantigens ; Brefeldin A/pharmacology ; Cell Line ; Endoplasmic Reticulum/enzymology ; Golgi Apparatus/*metabolism/ultrastructure ; HeLa Cells ; Humans ; Interphase ; Intracellular Membranes/metabolism/ultrastructure ; Mannosidases/metabolism ; Membrane Proteins/metabolism ; Metaphase ; Microscopy, Electron ; Microscopy, Fluorescence ; *Mitosis ; Monomeric GTP-Binding Proteins/pharmacology ; N-Acetylglucosaminyltransferases/metabolism ; Protein Disulfide-Isomerases/metabolism ; Rats ; *Saccharomyces cerevisiae Proteins ; Telophase ; Vesicular Transport Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 96
    facet.materialart.
    Unknown
    Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-03-09
    Description: Time courses of translocation of fluorescently conjugated proteins to the plasma membrane were simultaneously measured in thousands of individual rat basophilic leukemia cells. We found that the C2 domain---a calcium-sensing, lipid-binding protein module that is an essential regulator of protein kinase C and numerous other proteins---targeted proteins to the plasma membrane transiently if calcium was released from internal stores, and persistently in response to entry of extracellular calcium across the plasma membrane. The C2 domain translocation time courses of stimulated cells clustered into only two primary modes. Hence, the reversible recruitment of families of signaling proteins from one cellular compartment to another is a rapid bifurcation mechanism for inducing discrete states of cellular signaling networks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teruel, Mary N -- Meyer, Tobias -- CA83229/CA/NCI NIH HHS/ -- GM062144/GM/NIGMS NIH HHS/ -- HG00057/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2002 Mar 8;295(5561):1910-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Pharmacology, Stanford University Medical School, 269 Campus Drive, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11884760" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Proteins ; Calcium/*metabolism ; *Calcium Signaling ; Cell Membrane/*metabolism ; Cytosol/metabolism ; Fluorescence ; Fluorescent Dyes ; Isoenzymes/chemistry/*metabolism ; Kinetics ; Luminescent Proteins ; Platelet Activating Factor/pharmacology ; Protein Binding ; Protein Kinase C/chemistry/*metabolism ; Protein Structure, Tertiary ; *Protein Transport ; Rats ; Receptors, Cell Surface/*metabolism ; Recombinant Fusion Proteins/metabolism ; Software ; Thapsigargin/pharmacology ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 97
    facet.materialart.
    Unknown
    Development. Putting the brakes on regeneration (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-06-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKerracher, Lisa -- Ellezam, Benjamin -- New York, N.Y. -- Science. 2002 Jun 7;296(5574):1819-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departement de Pathologie et Biologie Cellulaire, Universite de Montreal, 2900 Edouard-Montpetit, Montreal, Quebec, H3T 1J4 Canada. mckerral@patho.umontreal.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12052945" target="_blank"〉PubMed〈/a〉
    Keywords: Amacrine Cells/*physiology ; Animals ; Axonal Transport ; Axons/*physiology ; *Cell Communication ; Cell Differentiation ; Cell Polarity ; Cells, Cultured ; Coculture Techniques ; Dendrites/*physiology ; Embryo, Mammalian ; Nerve Crush ; *Nerve Regeneration ; Optic Nerve/cytology/physiology ; Peripheral Nerves/transplantation ; Rats ; Retinal Ganglion Cells/*physiology ; Signal Transduction ; Spinal Cord/cytology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 98
    facet.materialart.
    Unknown
    Biodegradable, elastic shape-memory polymers for potential biomedical applications (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-04-27
    Description: The introduction of biodegradable implant materials as well as minimally invasive surgical procedures in medicine has substantially improved health care within the past few decades. This report describes a group of degradable thermoplastic polymers that are able to change their shape after an increase in temperature. Their shape-memory capability enables bulky implants to be placed in the body through small incisions or to perform complex mechanical deformations automatically. A smart degradable suture was created to illustrate the potential of these shape-memory thermoplastics in biomedical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lendlein, Andreas -- Langer, Robert -- New York, N.Y. -- Science. 2002 May 31;296(5573):1673-6. Epub 2002 Apr 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉mnemoScience GmbH, Pauwelsstrabetae 19, D-52074 Aachen, Germany. a.lendlein@mnemoscience.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11976407" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biocompatible Materials/chemical synthesis/chemistry ; Chemistry, Physical ; Dioxanes/chemistry ; Elasticity ; Elastomers ; Isocyanates/chemistry ; Mechanics ; Physicochemical Phenomena ; Polyesters/chemistry ; *Polymers/chemical synthesis/chemistry ; *Prostheses and Implants ; Rats ; Stress, Mechanical ; *Sutures ; Temperature ; Thermodynamics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 99
    facet.materialart.
    Unknown
    Correlated bursts of activity in the neonatal hippocampus in vivo (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-06-18
    Description: The behavior of immature cortical networks in vivo remains largely unknown. Using multisite extracellular and patch-clamp recordings, we observed recurrent bursts of synchronized neuronal activity lasting 0.5 to 3 seconds that occurred spontaneously in the hippocampus of freely moving and anesthetized rat pups. The influence of slow rhythms (0.33 and 0.1 hertz) and the contribution of both gamma-aminobutyric acid A-mediated and glutamate receptor-mediated synaptic signals in the generation of hippocampal bursts was reminiscent of giant depolarizing potentials observed in vitro. This earliest pattern, which diversifies during the second postnatal week, could provide correlated activity for immature neurons and may underlie activity-dependent maturation of the hippocampal network.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leinekugel, Xavier -- Khazipov, Rustem -- Cannon, Robert -- Hirase, Hajime -- Ben-Ari, Yehezkel -- Buzsaki, Gyorgy -- FO6 TW02290/TW/FIC NIH HHS/ -- N0T 43994/PHS HHS/ -- NS 34994/NS/NINDS NIH HHS/ -- NS 43157/NS/NINDS NIH HHS/ -- RR09754/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2002 Jun 14;296(5575):2049-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INMED, Institut National de la Sante et de la Recherche Medicale (INSERM) U29, Avenue de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12065842" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Evoked Potentials ; Hippocampus/*physiology ; Neurons/*physiology ; Patch-Clamp Techniques ; Pyramidal Cells/physiology ; Rats ; Rats, Wistar ; Receptors, GABA-A/physiology ; Receptors, Glutamate/physiology ; Synapses/physiology ; Synaptic Transmission ; gamma-Aminobutyric Acid/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 100
    facet.materialart.
    Unknown
    Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-09-28
    Description: Unc104/KIF1A belongs to a class of monomeric kinesin motors that have been thought to possess an unusual motility mechanism. Unlike the unidirectional motion driven by the coordinated actions of the two heads in conventional kinesins, single-headed KIF1A was reported to undergo biased diffusional motion along microtubules. Here, we show that Unc104/KIF1A can dimerize and move unidirectionally and processively with rapid velocities characteristic of transport in living cells. These results suggest that Unc104/KIF1A operates in vivo by a mechanism similar to conventional kinesin and that regulation of motor dimerization may be used to control transport by this class of kinesins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tomishige, Michio -- Klopfenstein, Dieter R -- Vale, Ronald D -- AR42895/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2002 Sep 27;297(5590):2263-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Howard Hughes Medical Institute and the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12351789" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins/chemistry/physiology ; Diffusion ; Dimerization ; Humans ; Kinesin/*chemistry/physiology ; Liposomes ; Microtubules/*physiology ; Molecular Motor Proteins/*chemistry/*physiology ; Molecular Sequence Data ; Movement ; Mutation ; Nerve Tissue Proteins/*chemistry/*physiology ; Protein Structure, Tertiary ; Rats ; Recombinant Fusion Proteins/chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...