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  • 1
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    Control of synaptic strength by glial TNFalpha (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-03-23
    Description: Activity-dependent modulation of synaptic efficacy in the brain contributes to neural circuit development and experience-dependent plasticity. Although glia are affected by activity and ensheathe synapses, their influence on synaptic strength has largely been ignored. Here, we show that a protein produced by glia, tumor necrosis factor alpha (TNFalpha), enhances synaptic efficacy by increasing surface expression of AMPA receptors. Preventing the actions of endogenous TNFalpha has the opposite effects. Thus, the continual presence of TNFalpha is required for preservation of synaptic strength at excitatory synapses. Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beattie, Eric C -- Stellwagen, David -- Morishita, Wade -- Bresnahan, Jacqueline C -- Ha, Byeong Keun -- Von Zastrow, Mark -- Beattie, Michael S -- Malenka, Robert C -- DA00439/DA/NIDA NIH HHS/ -- MH063394/MH/NIMH NIH HHS/ -- NS 31193/NS/NINDS NIH HHS/ -- NS38079/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2002 Mar 22;295(5563):2282-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA. beattie.2@osu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11910117" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD/pharmacology ; Astrocytes/*metabolism ; Cells, Cultured ; Culture Media, Conditioned/pharmacology ; Gene Expression Regulation/drug effects ; Hippocampus/cytology/metabolism ; Neuronal Plasticity/drug effects ; Neurons/drug effects/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA/metabolism ; Receptors, Tumor Necrosis Factor ; Receptors, Tumor Necrosis Factor, Type I ; Synapses/drug effects/*metabolism ; Synaptic Transmission/drug effects ; Tumor Necrosis Factor-alpha/antagonists & inhibitors/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Cleavage of amyloid beta peptide during constitutive processing of its precursor (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-06-01
    Description: The amyloid beta peptide (A beta P) is a small fragment of the much larger, broadly distributed amyloid precursor protein (APP). Abundant A beta P deposition in the brains of patients with Alzheimer's disease suggests that altered APP processing may represent a key pathogenic event. Direct protein structural analyses showed that constitutive processing in human embryonic kidney 293 cells cleaves APP in the interior of the A beta P, thus preventing A beta P deposition. A deficiency of this processing event may ultimately prove to be the etiological event in Alzheimer's disease that gives rise to senile plaque formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Esch, F S -- Keim, P S -- Beattie, E C -- Blacher, R W -- Culwell, A R -- Oltersdorf, T -- McClure, D -- Ward, P J -- New York, N.Y. -- Science. 1990 Jun 1;248(4959):1122-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Athena Neurosciences, Incorporated, South San Francisco, CA 94080.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2111583" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amyloid/isolation & purification/*metabolism ; Amyloid beta-Protein Precursor ; Humans ; Molecular Sequence Data ; Peptide Fragments/isolation & purification ; Protein Precursors/isolation & purification/*metabolism ; Protein Processing, Post-Translational/*physiology ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Dynamin-dependent endocytosis of ionotropic glutamate receptors (1999)
    National Academy of Sciences
    Details
    Publication Date: 1999-11-23
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    Design of a multivariable integrated control for a supersonic propulsion system (1980)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: An inlet/engine/nozzle integrated control mode for the propulsion system of an advanced supersonic commercial aircraft was studied. Results show that integration of these control functions can result in both operational and performance benefits for the propulsion system. For example, this integrated control mode may make it possible to minimize the use of inlet bypass doors for shock position control. This may be of benefit to the aircraft as a result of minimizing: (1) bypass bleed drag effects; (2) perturbations to the aircraft resulting from the side thrust effect of the bypass bleeds; and (3) potential unstarts of the inlet. A conceptual integrated control mode was developed which makes use of many cross coupling paths between inlet and engine control variables and inlet and engine sensed variables. A multivariable control design technique based upon linear quadratic regulator theory was applied to designing the feedback gains for this control to allow a simulation evaluation of the benefits of the integrated control mode.
    Keywords: AIRCRAFT PROPULSION AND POWER
    Type: NASA. Lewis Research Center Propulsion Controls, 1979; p 35-47
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 5
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    Propulsion control technology (1984)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: A brief discussion of digital jet engine control systems is given. Performance tests, systems integration, and redundancy are discussed.
    Keywords: AIRCRAFT PROPULSION AND POWER
    Type: NASA. Langley Research Center NASA Aircraft Controls Research, 1983; p 585-592
    Format: application/pdf
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  • 6
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    HYTESS: A hypothetical turbofan engine simplified simulation (1984)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: A users manual for a hypothetical turbofan engine simplified simulation is presented. This digital simulation exists as FORTRAN source code. The program is self-contained and was developed to offer those interested in engine dynamics and controls research an efficient, realistic, and easily used engine simulation. The engine is modeled using a state space formulation. Matrix elements within the linear state space structure are nonlinear functions of various engine variables.
    Keywords: AIRCRAFT PROPULSION AND POWER
    Type: NASA-TM-83561 , E-1940 , NAS 1.15:83561
    Format: application/pdf
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  • 7
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    Preliminary study, analysis and design for a power switch for digital engine actuators (1979)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: Innovative control configurations using high temperature switches to operate actuator driving solenoids were studied. The impact on engine control system life cycle costs and reliability of electronic control and (ECU) heat dissipation due to power conditioning and interface drivers were addressed. Various power supply and actuation schemes were investigated, including optical signal transmission and electronics on the actuator, engine driven alternator, and inside the ECU. The use of a switching shunt power conditioner results in the most significant decrease in heat dissipation within the ECU. No overall control system reliability improvement is projected by the use of remote high temperature switches for solenoid drivers.
    Keywords: ELECTRONICS AND ELECTRICAL ENGINEERING
    Type: NASA-CR-159559 , NAS 1.26:159559 , PWA-5643-6
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 8
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    Sensor failure detection system (1981)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: Advanced concepts for detecting, isolating, and accommodating sensor failures were studied to determine their applicability to the gas turbine control problem. Five concepts were formulated based upon such techniques as Kalman filters and a screening process led to the selection of one advanced concept for further evaluation. The selected advanced concept uses a Kalman filter to generate residuals, a weighted sum square residuals technique to detect soft failures, likelihood ratio testing of a bank of Kalman filters for isolation, and reconfiguring of the normal mode Kalman filter by eliminating the failed input to accommodate the failure. The advanced concept was compared to a baseline parameter synthesis technique. The advanced concept was shown to be a viable concept for detecting, isolating, and accommodating sensor failures for the gas turbine applications.
    Keywords: AIRCRAFT PROPULSION AND POWER
    Type: NASA-CR-165515 , PWA-5736-17
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  • 9
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    Sensor failure detection for jet engines (1983)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: Revisions to the advanced sensor failure detection, isolation, and accommodation (DIA) algorithm, developed under the sensor failure detection system program were studied to eliminate the steady state errors due to estimation filter biases. Three algorithm revisions were formulated and one revision for detailed evaluation was chosen. The selected version modifies the DIA algorithm to feedback the actual sensor outputs to the integral portion of the control for the nofailure case. In case of a failure, the estimates of the failed sensor output is fed back to the integral portion. The estimator outputs are fed back to the linear regulator portion of the control all the time. The revised algorithm is evaluated and compared to the baseline algorithm developed previously.
    Keywords: QUALITY ASSURANCE AND RELIABILITY
    Type: NASA-CR-168190 , NAS 1.26:168190 , PWA-5891-18
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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