Publication Date:
2001-02-24
Description:
Neuroscience research is shedding light on how neurons delegate their protein synthesis, shipping some messenger RNAs out to the dendrites, where they are translated to protein under the control of local synapses. Indeed, it appears that finely controlled, decentralized protein production may contribute to learning and memory in a way that neuroscientists could scarcely have imagined 20 years ago. As researchers presss on, they are filling in a picture of a complex loop of communication and supply, with synapses acting as local managers wielding more power than anyone might have imagined, to get what they need for carrying out the critical task of storing memories.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 2000 Oct 27;290(5492):736-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11184205" target="_blank"〉PubMed〈/a〉
Keywords:
3' Untranslated Regions
;
Animals
;
Calcium-Calmodulin-Dependent Protein Kinase Type 2
;
Calcium-Calmodulin-Dependent Protein Kinases/biosynthesis/metabolism
;
Cell Nucleus/metabolism
;
Dendrites/*metabolism
;
*Drosophila Proteins
;
Gene Expression Regulation
;
Learning/*physiology
;
Long-Term Potentiation
;
Memory/*physiology
;
Muscle Proteins/biosynthesis/genetics
;
*Protein Biosynthesis
;
RNA, Messenger/genetics/metabolism
;
RNA-Binding Proteins/metabolism
;
Ribosomes/metabolism
;
Synapses/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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