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  • 1
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    Pigment epithelium-derived factor: a potent inhibitor of angiogenesis (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-10
    Description: In the absence of disease, the vasculature of the mammalian eye is quiescent, in part because of the action of angiogenic inhibitors that prevent vessels from invading the cornea and vitreous. Here, an inhibitor responsible for the avascularity of these ocular compartments is identified as pigment epithelium-derived factor (PEDF), a protein previously shown to have neurotrophic activity. The amount of inhibitory PEDF produced by retinal cells was positively correlated with oxygen concentrations, suggesting that its loss plays a permissive role in ischemia-driven retinal neovascularization. These results suggest that PEDF may be of therapeutic use, especially in retinopathies where pathological neovascularization compromises vision and leads to blindness.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dawson, D W -- Volpert, O V -- Gillis, P -- Crawford, S E -- Xu, H -- Benedict, W -- Bouck, N P -- New York, N.Y. -- Science. 1999 Jul 9;285(5425):245-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology-Immunology, Department of Pathology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10398599" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Antibodies/immunology ; Cattle ; Cells, Cultured ; Chemotaxis/drug effects ; Culture Media, Conditioned ; Endothelial Growth Factors/metabolism ; Endothelium, Vascular/cytology/drug effects/physiology ; Eye/blood supply ; *Eye Proteins ; Humans ; Lymphokines/metabolism ; Mice ; Neovascularization, Pathologic/*drug therapy/metabolism/pathology ; Neovascularization, Physiologic/*drug effects ; *Nerve Growth Factors ; Oxygen/physiology ; Proteins/genetics/immunology/*pharmacology/*physiology ; RNA, Messenger/genetics/metabolism ; Rats ; Retina/*metabolism/pathology ; Retinal Neovascularization/*drug therapy ; Retinal Vessels/growth & development ; Serpins/genetics/immunology/*pharmacology/*physiology ; Tumor Cells, Cultured ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Synthesis of many different types of organic small molecules using one automated process (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-03-15
    Description: Small-molecule synthesis usually relies on procedures that are highly customized for each target. A broadly applicable automated process could greatly increase the accessibility of this class of compounds to enable investigations of their practical potential. Here we report the synthesis of 14 distinct classes of small molecules using the same fully automated process. This was achieved by strategically expanding the scope of a building block-based synthesis platform to include even C(sp3)-rich polycyclic natural product frameworks and discovering a catch-and-release chromatographic purification protocol applicable to all of the corresponding intermediates. With thousands of compatible building blocks already commercially available, many small molecules are now accessible with this platform. More broadly, these findings illuminate an actionable roadmap to a more general and automated approach for small-molecule synthesis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687482/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687482/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Junqi -- Ballmer, Steven G -- Gillis, Eric P -- Fujii, Seiko -- Schmidt, Michael J -- Palazzolo, Andrea M E -- Lehmann, Jonathan W -- Morehouse, Greg F -- Burke, Martin D -- GM080436/GM/NIGMS NIH HHS/ -- GM090153/GM/NIGMS NIH HHS/ -- R01 GM080436/GM/NIGMS NIH HHS/ -- R01 GM090153/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2015 Mar 13;347(6227):1221-6. doi: 10.1126/science.aaa5414.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute (HHMI), Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. ; Howard Hughes Medical Institute (HHMI), Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. mdburke@illinois.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25766227" target="_blank"〉PubMed〈/a〉
    Keywords: Automation ; Boronic Acids/chemistry ; Chemistry Techniques, Synthetic/instrumentation/*methods ; Cyclization ; Molecular Structure ; Organic Chemicals/*chemical synthesis/chemistry/isolation & purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Applications of Fluorine in Medicinal Chemistry (2015)
    American Chemical Society (ACS)
    Details
    Publication Date: 2015-07-24
    Description: Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00258
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 4
    Electronic Resource
    Electronic Resource
    Nuclear magnetic relaxation in a 1-d semiconductor (K-TCNQ)
    Amsterdam : Elsevier
    Physica B+C 90 (1977), S. 154-178 
    Details
    ISSN: 0378-4363
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-4363(77)90104-8
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  • 5
    Electronic Resource
    Electronic Resource
    A self-consistent analysis for two-dimensional hydrodynamics
    Amsterdam : Elsevier
    Physica A: Statistical Mechanics and its Applications 98 (1979), S. 261-273 
    Details
    ISSN: 0378-4371
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-4371(79)90177-8
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  • 6
    Electronic Resource
    Electronic Resource
    A conjecture about two-dimensional hydrodynamics
    Amsterdam : Elsevier
    Physics Letters A 63 (1977), S. 101-102 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(77)90214-6
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  • 7
    Electronic Resource
    Electronic Resource
    Nuclear magnetic relaxation dispersion of silica particle suspensions
    Amsterdam : Elsevier
    Journal of Magnetic Resonance (1969) 77 (1988), S. 19-32 
    Details
    ISSN: 0022-2364
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0022-2364(88)90028-5
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  • 8
    Electronic Resource
    Electronic Resource
    Relaxation of water adsorbed on the surface of silica powder
    Amsterdam : Elsevier
    Journal of Magnetic Resonance (1969) 59 (1984), S. 437-445 
    Details
    ISSN: 0022-2364
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0022-2364(84)90076-3
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  • 9
    Electronic Resource
    Electronic Resource
    The optokinetic reflex in the cat: Modeling and computer simulation (1984)
    Springer
    Biological cybernetics 50 (1984), S. 135-141 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract After a brief comparative review of the dynamic characteristics of the optokinetic reflex (OKR) in different species and after a brief description of the main anatomical structures involved in this reflex, a mathematical model of the OKR in the cat is presented. The experimental results obtained by Godaux and Vanderkelen (1984) in the normal and in the totally cerebellectomized cat were used to validate the model and to obtain an estimation of its parameters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00337160
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  • 10
    Electronic Resource
    Electronic Resource
    An elastic, plastic theory of longitudinal growth stresses (1979)
    Springer
    Wood science and technology 13 (1979), S. 97-115 
    Details
    ISSN: 1432-5225
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Summary The problem of predicting the distribution of longitudinal growth stresses in a symmetrical, standing, woody stem is treated. It is assumed that coupling effects between longitudinal and transverse stress components are negligible so that the longitudinal stress distribution can be determined independently. One novel feature introduced in this analysis is that the material behaviour is assummed to be elastic, plastic rather than wholly elastic as in previous analyses of this problem. This assumption successfully limits the maximum intensity of the longitudinal compressive stress near the center of the stem. Another novel feature of the present analysis is that the initial, longitudinal, tensile stress at the periphery of the stem varies inversely with the size of the stem rather than being assumed constant as in previous analyses. Results obtained from this analysis are compared with previously published experimental data for curvatures and length changes of strips cut from diametral planks. The agreement is very good with the length change data over a wide range of stem sizes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00368603
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