ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Facilitation of spinal NMDA receptor currents by spillover of synaptically released glycine (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-06-28
    Description: In the mammalian CNS, N-methyl-D-aspartate (NMDA) receptors serve prominent roles in many physiological and pathophysiological processes including pain transmission. For full activation, NMDA receptors require the binding of glycine. It is not known whether the brain uses changes in extracellular glycine to modulate synaptic NMDA responses. Here, we show that synaptically released glycine facilitates NMDA receptor currents in the superficial dorsal horn, an area critically involved in pain processing. During high presynaptic activity, glycine released from inhibitory interneurons escapes the synaptic cleft and reaches nearby NMDA receptors by so-called spillover. In vivo, this process may contribute to the development of inflammatory hyperalgesia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahmadi, Seifollah -- Muth-Selbach, Uta -- Lauterbach, Andreas -- Lipfert, Peter -- Neuhuber, Winfried L -- Zeilhofer, Hanns Ulrich -- New York, N.Y. -- Science. 2003 Jun 27;300(5628):2094-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat Erlangen-Nurnberg, Fahrstrasse 17, D-91054 Erlangen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12829784" target="_blank"〉PubMed〈/a〉
    Keywords: Analgesics/pharmacology ; Animals ; Anterior Horn Cells/drug effects/metabolism ; Diffusion ; Electric Stimulation ; Evoked Potentials/drug effects ; Excitatory Postsynaptic Potentials/drug effects ; Glycine/*metabolism/pharmacology ; In Vitro Techniques ; Interneurons/metabolism ; Neural Inhibition/drug effects ; Opioid Peptides/pharmacology ; Pain Measurement ; Patch-Clamp Techniques ; Posterior Horn Cells/drug effects/*metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/*metabolism ; Serine/pharmacology ; Spinal Cord/drug effects/metabolism ; Synapses/*metabolism ; *Synaptic Transmission/drug effects ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Video-rate far-field optical nanoscopy dissects synaptic vesicle movement (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-02-23
    Description: We present video-rate (28 frames per second) far-field optical imaging with a focal spot size of 62 nanometers in living cells. Fluorescently labeled synaptic vesicles inside the axons of cultured neurons were recorded with stimulated emission depletion (STED) microscopy in a 2.5-micrometer by 1.8-micrometer field of view. By reducing the cross-sectional area of the focal spot by about a factor of 18 below the diffraction limit (260 nanometers), STED allowed us to map and describe the vesicle mobility within the highly confined space of synaptic boutons. Although restricted within boutons, the vesicle movement was substantially faster in nonbouton areas, consistent with the observation that a sizable vesicle pool continuously transits through the axons. Our study demonstrates the emerging ability of optical microscopy to investigate intracellular physiological processes on the nanoscale in real time.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Westphal, Volker -- Rizzoli, Silvio O -- Lauterbach, Marcel A -- Kamin, Dirk -- Jahn, Reinhard -- Hell, Stefan W -- New York, N.Y. -- Science. 2008 Apr 11;320(5873):246-9. doi: 10.1126/science.1154228. Epub 2008 Feb 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of NanoBiophotonics, Max-Planck-Institute for Biophysical Chemistry, Gottingen 37077, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18292304" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Axons/physiology/*ultrastructure ; Cells, Cultured ; Fluorescent Dyes ; Hippocampus/physiology/ultrastructure ; Kinetics ; Microscopy, Fluorescence/*methods ; Movement ; *Nanotechnology ; Optics and Photonics ; Rats ; Synaptic Vesicles/*physiology/*ultrastructure ; Video Recording
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    A 1600 yr seasonally resolved record of decadal-scale flood variability from the Austrian Pre-Alps (2012)
    Geological Society of America (GSA)
    In: Geology
    Details
    Publication Date: 2012-11-01
    Description: We present a record of extreme spring–summer runoff events for the past 1600 yr preserved in the varved sediments of Lake Mondsee (Austrian Pre-Alps). Combined sediment microfacies analyses and high-resolution micro-X-ray fluorescence element scanning allow us to identify 157 detrital event layers deposited in spring–summer and to discriminate between regional flood and local debris flow deposits. Higher spring–summer flood activity with a mean event recurrence of 3–5 yr occurred in several well-confined multidecadal episodes during the Dark Ages Cold Period and Medieval time (A.D. 450–480, 590–640, 700–750, and 1140–1170) as well as during the early Little Ice Age (LIA; A.D. 1300–1330 and 1480–1520). In contrast, lowest spring–summer flood activity with an event recurrence of only 30–100 yr is observed during the Medieval Climate Anomaly (A.D. 1180–1300) and the coldest interval of the LIA (A.D. 1600–1700). These findings indicate a complex relationship between temperature conditions and extreme hydro-meteorological events and suggest that enhanced summer Mediterranean cyclogenesis triggers large-scale floods in the northeast Alps during climatic transitions. The Lake Mondsee data demonstrate the climatic sensitivity of spring–summer floods and prove the potential of varved sediment records to investigate the impact of changing climate boundary conditions on seasonal flood activity for pre-instrumental time.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
    Published by Geological Society of America (GSA)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    STED microscope with Spiral Phase Contrast (2013)
    Springer Nature
    Details
    Publication Date: 2013-06-22
    Description: Stimulated Emission Depletion (STED) microscopy enables superresolution imaging of fluorescently marked nano-structures in vivo. Biological investigations are often hindered by the difficulty of relating super-resolved structures to other non-labeled features. Here we demonstrate that the similarity in optical design of Spiral Phase Contrast (SPC) and STED microscopes allows straightforward implementation of a phase contrast channel into a STED microscope in widefield and scanning modes. This method allows dual imaging and overlay in two contrast modes in fixed and in living specimens, in which double labeling is especially challenging. Living GFP- and YPF-stained neurons are imaged in one label-free phase contrast and one high-resolution STED channel. Furthermore, we implement SPC in widefield and scanning modes demonstrating that scanning confocal SPC yields the highest optical contrast. The latter configuration can provide contour detection or highlights and shadows reminiscent of differential interference contrast. Scientific Reports 3 doi: 10.1038/srep02050
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Method for Determining Overall Performances of Solar Kilns (1987)
    American Society of Mechanical Engineers
    Details
    Publication Date: 1987-02-01
    Description: A theoretical model based on heat and mass transfer equations was developed for determining a reliable comparison between different solar kiln designs. It involves dividing the drying process into two sequential steps, one in which only heat transfer occurs and a second one in which the actual drying process takes place. The model gives an equation for determining the evaporated water in function of the normal drying variables, together with a specially defined parameter which gives account for the air recirculation inside the kiln. The model was validated experimentally for a box-type collector solar kiln operating under constant and falling rate drying periods. It was found that although the model could be applied satisfactorily, the tested design proved to be a very inefficient one, giving low values for the recirculating parameter.
    Print ISSN: 0199-6231
    Electronic ISSN: 1528-8986
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by American Society of Mechanical Engineers
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    Electronic Resource
    Electronic Resource
    Wirtschaftspolitik im Systemvergleich - Dieter Cassel, ed., Munich: Verlag Franz Vahlen, 1984. xv + 383 pp., no index, no price
    Amsterdam : Elsevier
    Journal of Comparative Economics 11 (1987), S. 137-139 
    Details
    ISSN: 0147-5967
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0147-5967(87)90048-5
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    The synthesis of metal coordination polymers using lessons learned from monomeric Werner complexes: chromium(III) β-diketone polymers
    Amsterdam : Elsevier
    Polyhedron 13 (1994), S. 2043-2048 
    Details
    ISSN: 0277-5387
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0277-5387(00)83487-7
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...