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  • Adult  (423)
  • American Association for the Advancement of Science (AAAS)  (423)
  • American Geophysical Union
  • Annual Reviews
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  • 1985-1989  (87)
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  • 1
    Publication Date: 1988-04-29
    Description: Screening for human T-lymphotropic virus type I (HTLV-I) antibodies was performed on sera from 39,898 blood donors at eight blood centers in geographically distinct areas of the United States. Ten donors (0.025 percent) showed evidence of HTLV-I seropositivity by enzyme immunoassays; this was confirmed by protein immunoblot and radioimmunoprecipitation. Seroprevalence rates ranged from 0 to 0.10 percent at the locations sampled, with HTLV-I antibodies found predominantly in donors from the southeastern and southwestern United States. Matched case-control interviews and laboratory studies were performed on five seropositive women and two seropositive men who participated in an identity-linked collection of sera from a subset of 33,893 donors at six of the eight blood centers. Four of the women and both men are black; one woman is Caucasian. Four of the seven seropositive individuals admitted to prior intravenous drug abuse or sexual contact with an intravenous drug user. Sexual contact with native inhabitants of an HTLV-I endemic area was the only identified risk factor for one male. The distribution of HTLV-I antibodies in this U.S. blood donor sample corroborates the previously reported epidemiology of this agent and suggests that additional donor screening measures, including the testing of donated blood for HTLV-I markers, may be necessary to prevent the spread of HTLV-I to transfusion recipients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, A E -- Fang, C T -- Slamon, D J -- Poiesz, B J -- Sandler, S G -- Darr, W F 2nd -- Shulman, G -- McGowan, E I -- Douglas, D K -- Bowman, R J -- New York, N.Y. -- Science. 1988 Apr 29;240(4852):643-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉American Red Cross Jerome H. Holland Laboratory, Rockville, MD 20855.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2896386" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Antibodies, Viral/*analysis ; *Blood Donors ; Deltaretrovirus/*immunology/isolation & purification ; Deltaretrovirus Infections/diagnosis/*epidemiology/transmission ; Female ; Humans ; Immunoenzyme Techniques ; Immunosorbent Techniques ; Japan ; Male ; Middle Aged ; Risk Factors ; Sexual Partners ; Substance-Related Disorders ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1989-06-16
    Description: Secretory chloride channels can be activated by adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase in normal airway epithelial cells but not in cells from individuals with cystic fibrosis (CF). In excised, inside-out patches of apical membrane of normal human airway cells and airway cells from three patients with CF, the chloride channels exhibited a characteristic outwardly rectifying current-voltage relation and depolarization-induced activation. Channels from normal tissues were activated by both cAMP-dependent protein kinase and protein kinase C. However, chloride channels from CF patients could not be activated by either kinase. Thus, gating of normal epithelial chloride channels is regulated by both cAMP-dependent protein kinase and protein kinase C, and regulation by both kinases is defective in CF.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hwang, T C -- Lu, L -- Zeitlin, P L -- Gruenert, D C -- Huganir, R -- Guggino, W B -- 1-K08-HL02188/HL/NHLBI NIH HHS/ -- R01-DK 39619/DK/NIDDK NIH HHS/ -- R01-HL 40178/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1989 Jun 16;244(4910):1351-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Johns Hopkins University, Baltimore, MD 21205.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2472005" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Chloride Channels ; Chlorides/*physiology ; Cystic Fibrosis/*physiopathology ; Electrophysiology ; Fetus ; Humans ; In Vitro Techniques ; Ion Channels/*physiology ; Membrane Proteins/*physiology ; Protein Kinase C/*physiology ; Protein Kinases/*physiology ; Respiratory System/cytology/physiopathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1989-09-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1989 Sep 15;245(4923):1185.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2781278" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Bone and Bones/*analysis/anatomy & histology ; Female ; *Forensic Medicine ; *Fossils ; Humans ; Infant ; Male ; *Paleontology
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  • 4
    Publication Date: 1989-01-27
    Description: Techniques of gene amplification, molecular cloning, and sequence analysis were used to test for the presence of sequences related to human T-lymphotropic virus type I (HTLV-I) in peripheral blood mononuclear cells of six patients with multiple sclerosis (MS) and 20 normal individuals. HTLV-I sequences were detected in all six MS patients and in one individual from the control group by DNA blot analysis and molecular cloning of amplified DNAs. The viral sequence in MS patients were associated with adherent cell populations consisting predominantly of monocytes and macrophages. Molecular cloning and nucleotide sequence analysis indicated that these amplified viral sequences were related to the HTLV-I proviral genome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reddy, E P -- Sandberg-Wollheim, M -- Mettus, R V -- Ray, P E -- DeFreitas, E -- Koprowski, H -- CA-10815/CA/NCI NIH HHS/ -- NS-11036/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1989 Jan 27;243(4890):529-33.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2536193" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Base Sequence ; Child ; *Cloning, Molecular ; DNA Restriction Enzymes ; DNA, Viral/*genetics ; Female ; *Gene Amplification ; Human T-lymphotropic virus 1/*genetics ; Humans ; Leukocytes, Mononuclear/analysis/microbiology ; Macrophages/analysis/microbiology ; Male ; Molecular Sequence Data ; Multiple Sclerosis/*microbiology ; Nucleic Acid Hybridization ; Oligonucleotide Probes
    Print ISSN: 0036-8075
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1989-10-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frisch, R E -- New York, N.Y. -- Science. 1989 Oct 27;246(4929):432.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2814472" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Body Weight/*physiology ; Cricetinae ; Female ; Fertility/*physiology ; Humans ; Mesocricetus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 1989-08-25
    Description: Blue cone monochromacy is a rare X-linked disorder of color vision characterized by the absence of both red and green cone sensitivities. In 12 of 12 families carrying this trait, alterations are observed in the red and green visual pigment gene cluster. The alterations fall into two classes. One class arose from the wild type by a two-step pathway consisting of unequal homologous recombination and point mutation. The second class arose by nonhomologous deletion of genomic DNA adjacent to the red and green pigment gene cluster. These deletions define a 579-base pair region that is located 4 kilobases upstream of the red pigment gene and 43 kilobases upstream of the nearest green pigment gene; this 579-base pair region is essential for the activity of both pigment genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nathans, J -- Davenport, C M -- Maumenee, I H -- Lewis, R A -- Hejtmancik, J F -- Litt, M -- Lovrien, E -- Weleber, R -- Bachynski, B -- Zwas, F -- New York, N.Y. -- Science. 1989 Aug 25;245(4920):831-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and Genetics, Wilmer Ophthalmologic Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2788922" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Base Sequence ; Child ; Child, Preschool ; Chromosome Deletion ; Color Vision Defects/*genetics ; DNA/analysis ; Female ; Humans ; Male ; Molecular Sequence Data ; Mutation ; Nucleic Acid Hybridization ; Retinal Pigments/genetics ; Thalassemia/genetics ; X Chromosome
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  • 7
    Publication Date: 1989-07-28
    Description: The purine analog 2',3'-dideoxyinosine (ddI), which has anti-retroviral activity in vitro was administered for up to 42 weeks to 26 patients with acquired immunodeficiency syndrome (AIDS) or severe AIDS-related complex (ARC). Ten of these individuals were AZT-intolerant. Eight dose regimens were studied. The drug was orally bioavailable and penetrated into the cerebrospinal fluid (CSF). Comparatively little evidence of an effect against human immunodeficiency virus (HIV) was seen at the lowest four doses. However, patients in the four highest dose groups (ddI at 1.6 milligrams per kilogram intravenously and then greater than or equal to 3.2 milligrams per kilogram orally at least every 12 hours or higher) had increases in their circulating CD4+ T cells (P less than 0.0005), increased CD4/CD8 T cell ratios (P less than 0.01), and, where evaluable, more than an 80% decrease in serum HIV p24 antigen (P less than 0.05). The patients also had evidence of improved immunologic function, had reduced viremic symptomatology, and gained a mean of 1.6 kilogram with these comparatively infrequent dosing schedules (every 8 or 12 hours). The most notable adverse effects directly attributable to ddI administration at the doses used in this study included increases in serum uric acid (due to hypoxanthine release) and mild headaches and insomnia. These results suggest that serious short-term toxicity at therapeutic doses is not an inherent feature in the profile of agents with clinical anti-HIV activity. Further controlled studies to define the safety and efficacy of this agent may be worth considering.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yarchoan, R -- Mitsuya, H -- Thomas, R V -- Pluda, J M -- Hartman, N R -- Perno, C F -- Marczyk, K S -- Allain, J P -- Johns, D G -- Broder, S -- New York, N.Y. -- Science. 1989 Jul 28;245(4916):412-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Clinical Oncology Program, National Cancer Institute, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2502840" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS-Related Complex/*drug therapy/immunology ; Acquired Immunodeficiency Syndrome/*drug therapy/immunology ; Adult ; Antiviral Agents/adverse effects/cerebrospinal fluid/pharmacology/*therapeutic ; use ; Biological Availability ; Clinical Trials as Topic ; Didanosine ; Dideoxynucleosides/adverse effects/cerebrospinal fluid/pharmacology/*therapeutic ; use ; Dose-Response Relationship, Drug ; Female ; HIV/*drug effects ; HIV Antigens/analysis ; HIV Core Protein p24 ; Humans ; Hypersensitivity, Delayed ; Immunity, Cellular ; Leukocyte Count ; Male ; Middle Aged ; Molecular Structure ; Retroviridae Proteins/analysis ; T-Lymphocytes/immunology
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  • 8
    Publication Date: 1989-04-07
    Description: Low-density lipoprotein (LDL) concentrations correlate with risk of coronary heart disease, and genetic variation affecting LDL levels influences atherosclerosis susceptibility. The principal LDL protein is apolipoprotein B (apoB); apoB is not exchangeable between lipoprotein particles and there is only one apoB per LDL particle. Plasma LDL therefore consists of two populations, one containing apoB derived from the maternal and one from the paternal apoB alleles. Products of the apob gene with high or low affinity for the MB-19 monoclonal antibody can be distinguished, and this antibody was used to identify heterozygotes with allele-specific differences in the amount of apoB in their plasma. A family study confirmed that the unequal expression phenotype was inherited in an autosomal dominant manner and was linked to the apob gene locus. Significant apoB genetic variation affecting plasma LDL levels may be more common than previously appreciated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gavish, D -- Brinton, E A -- Breslow, J L -- HL32435/HL/NHLBI NIH HHS/ -- HL33714/HL/NHLBI NIH HHS/ -- HL36461/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1989 Apr 7;244(4900):72-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Rockefeller University, New York 10021.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2565046" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; *Alleles ; Apolipoproteins B/blood/*genetics ; Binding Sites, Antibody ; Child ; Child, Preschool ; Genetic Linkage ; Genotype ; Humans ; Lipoproteins, LDL/blood/*genetics ; Pedigree ; Phenotype ; Polymorphism, Restriction Fragment Length
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-03-04
    Description: Human beings routinely help others to achieve their goals, even when the helper receives no immediate benefit and the person helped is a stranger. Such altruistic behaviors (toward non-kin) are extremely rare evolutionarily, with some theorists even proposing that they are uniquely human. Here we show that human children as young as 18 months of age (prelinguistic or just-linguistic) quite readily help others to achieve their goals in a variety of different situations. This requires both an understanding of others' goals and an altruistic motivation to help. In addition, we demonstrate similar though less robust skills and motivations in three young chimpanzees.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warneken, Felix -- Tomasello, Michael -- New York, N.Y. -- Science. 2006 Mar 3;311(5765):1301-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental and Comparative Psychology, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany. warneken@eva.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16513986" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Altruism ; Animals ; Behavior, Animal ; Child, Preschool ; Female ; *Helping Behavior ; Humans ; Male ; Motivation ; Pan troglodytes/*psychology
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  • 10
    Publication Date: 2006-06-10
    Description: How does the bilingual brain distinguish and control which language is in use? Previous functional imaging experiments have not been able to answer this question because proficient bilinguals activate the same brain regions irrespective of the language being tested. Here, we reveal that neuronal responses within the left caudate are sensitive to changes in the language or the meaning of words. By demonstrating this effect in populations of German-English and Japanese-English bilinguals, we suggest that the left caudate plays a universal role in monitoring and controlling the language in use.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crinion, J -- Turner, R -- Grogan, A -- Hanakawa, T -- Noppeney, U -- Devlin, J T -- Aso, T -- Urayama, S -- Fukuyama, H -- Stockton, K -- Usui, K -- Green, D W -- Price, C J -- 051067/Wellcome Trust/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2006 Jun 9;312(5779):1537-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Department of Imaging Neuroscience, University College London, London WC1N 3BG, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16763154" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Mapping ; Caudate Nucleus/*physiology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; *Multilingualism ; Neurons/physiology ; Positron-Emission Tomography ; Semantics
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-10-21
    Description: Stereotype threat occurs when stereotyped groups perform worse as their group membership is highlighted. We investigated whether stereotype threat is affected by accounts for the origins of stereotypes. In two studies, women who read of genetic causes of sex differences performed worse on math tests than those who read of experiential causes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dar-Nimrod, Ilan -- Heine, Steven J -- R01 MH60155-01A2/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2006 Oct 20;314(5798):435.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of British Columbia, Vancouver, BC V6T 1Z4, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17053140" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Analysis of Variance ; *Aptitude ; Female ; *Genes ; Humans ; *Mathematics ; Sex Characteristics ; *Stereotyping ; Women/*psychology
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-06-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, Leslie -- New York, N.Y. -- Science. 2006 Jun 16;312(5780):1581.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16778026" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Angola/epidemiology ; Child ; *Disease Outbreaks/prevention & control ; Humans ; *Mass Vaccination ; Namibia/epidemiology ; Nigeria/epidemiology ; Poliomyelitis/*epidemiology/*prevention & control/virology ; Poliovirus/genetics ; *Poliovirus Vaccine, Oral
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  • 13
    Publication Date: 2006-02-04
    Description: Few sub-Saharan African countries have witnessed declines in HIV prevalence, and only Uganda has compelling evidence for a decline founded on sexual behavior change. We report a decline in HIV prevalence in eastern Zimbabwe between 1998 and 2003 associated with sexual behavior change in four distinct socioeconomic strata. HIV prevalence fell most steeply at young ages-by 23 and 49%, respectively, among men aged 17 to 29 years and women aged 15 to 24 years-and in more educated groups. Sexually experienced men and women reported reductions in casual sex of 49 and 22%, respectively, whereas recent cohorts reported delayed sexual debut. Selective AIDS-induced mortality contributed to the decline in HIV prevalence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gregson, Simon -- Garnett, Geoffrey P -- Nyamukapa, Constance A -- Hallett, Timothy B -- Lewis, James J C -- Mason, Peter R -- Chandiwana, Stephen K -- Anderson, Roy M -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2006 Feb 3;311(5761):664-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Infectious Disease Epidemiology, Imperial College London, UK. Sajgregson@aol.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16456081" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Cohort Studies ; Condoms ; *Disease Outbreaks/prevention & control ; Emigration and Immigration ; Female ; HIV Infections/*epidemiology/mortality/prevention & control/transmission ; Humans ; Incidence ; Longitudinal Studies ; Male ; Prevalence ; Risk-Taking ; *Sexual Behavior ; Socioeconomic Factors ; Zimbabwe/epidemiology
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  • 14
    Publication Date: 2006-12-13
    Description: Mounting evidence has revealed pathological interactions between HIV and malaria in dually infected patients, but the public health implications of the interplay have remained unclear. A transient almost one-log elevation in HIV viral load occurs during febrile malaria episodes; in addition, susceptibility to malaria is enhanced in HIV-infected patients. A mathematical model applied to a setting in Kenya with an adult population of roughly 200,000 estimated that, since 1980, the disease interaction may have been responsible for 8,500 excess HIV infections and 980,000 excess malaria episodes. Co-infection might also have facilitated the geographic expansion of malaria in areas where HIV prevalence is high. Hence, transient and repeated increases in HIV viral load resulting from recurrent co-infection with malaria may be an important factor in promoting the spread of HIV in sub-Saharan Africa.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abu-Raddad, Laith J -- Patnaik, Padmaja -- Kublin, James G -- P30 AI 27757/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2006 Dec 8;314(5805):1603-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. laith@scharp.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17158329" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Africa South of the Sahara/epidemiology ; Antimalarials/therapeutic use ; Disease Susceptibility ; Endemic Diseases ; Female ; HIV Infections/*complications/*epidemiology/transmission/virology ; HIV-1/physiology ; Humans ; Kenya/epidemiology ; Malaria, Falciparum/*complications/drug therapy/*epidemiology/transmission ; Male ; Mathematics ; Models, Biological ; Prevalence ; Recurrence ; Sexual Behavior ; Viral Load ; Viremia ; Virus Replication
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  • 15
    Publication Date: 2006-09-16
    Description: We observed robust coupling between the high- and low-frequency bands of ongoing electrical activity in the human brain. In particular, the phase of the low-frequency theta (4 to 8 hertz) rhythm modulates power in the high gamma (80 to 150 hertz) band of the electrocorticogram, with stronger modulation occurring at higher theta amplitudes. Furthermore, different behavioral tasks evoke distinct patterns of theta/high gamma coupling across the cortex. The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628289/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628289/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Canolty, R T -- Edwards, E -- Dalal, S S -- Soltani, M -- Nagarajan, S S -- Kirsch, H E -- Berger, M S -- Barbaro, N M -- Knight, R T -- F31DC006762/DC/NIDCD NIH HHS/ -- NS21135/NS/NINDS NIH HHS/ -- R01 DC004855/DC/NIDCD NIH HHS/ -- R01 DC004855-01A1/DC/NIDCD NIH HHS/ -- R01 NS021135/NS/NINDS NIH HHS/ -- R01 NS021135-20/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2006 Sep 15;313(5793):1626-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA. rcanolty@berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16973878" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Attention ; Auditory Perception ; Cognition ; Electrodes, Implanted ; Electrophysiology ; Epilepsy/physiopathology/surgery ; Female ; Humans ; Memory ; *Mental Processes ; Middle Aged ; Neocortex/*physiology ; Psychomotor Performance ; *Theta Rhythm ; Visual Perception
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-06-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, Dennis -- New York, N.Y. -- Science. 2006 Jun 2;312(5778):1298-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16741089" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; *Biomedical Research/trends ; Clinical Trials as Topic ; Embryo Research ; Embryo, Mammalian/cytology ; Financing, Government ; Humans ; Korea ; Myocardial Infarction/therapy ; Nuclear Transfer Techniques ; Research Support as Topic ; Scientific Misconduct ; *Stem Cells
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  • 17
    Publication Date: 2006-02-14
    Description: Cognitive functions dependent on the prefrontal cortex, such as the ability to suppress behavior (response inhibition) and to learn from complex feedback (probabilistic learning), play critical roles in activities of daily life. To what extent do different neurochemical systems modulate these two cognitive functions? Here, using stop-signal and probabilistic learning tasks, we show a double dissociation for the involvement of noradrenaline and serotonin in human cognition. In healthy volunteers, inhibition of central noradrenaline reuptake improved response inhibition but had no effect on probabilistic learning, whereas inhibition of central serotonin reuptake impaired probabilistic learning with no effect on response inhibition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867315/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867315/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chamberlain, Samuel R -- Muller, Ulrich -- Blackwell, Andrew D -- Clark, Luke -- Robbins, Trevor W -- Sahakian, Barbara J -- 076274/Wellcome Trust/United Kingdom -- G0001354/Medical Research Council/United Kingdom -- G0401099/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2006 Feb 10;311(5762):861-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Box 189, Cambridge CB2 2QQ, UK. src33@cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16469930" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Atomoxetine Hydrochloride ; Citalopram/pharmacology ; Double-Blind Method ; Feedback, Psychological ; Humans ; *Inhibition (Psychology) ; Learning/*physiology ; Male ; Neural Inhibition ; Norepinephrine/*physiology ; Prefrontal Cortex/physiology ; Propylamines/pharmacology ; Psychomotor Performance ; Serotonin/*physiology ; Serotonin Uptake Inhibitors/pharmacology
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  • 18
    Publication Date: 2006-01-10
    Description: The pathophysiology of depression remains enigmatic, although abnormalities in serotonin signaling have been implicated. We have found that the serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Svenningsson, Per -- Chergui, Karima -- Rachleff, Ilan -- Flajolet, Marc -- Zhang, Xiaoqun -- El Yacoubi, Malika -- Vaugeois, Jean-Marie -- Nomikos, George G -- Greengard, Paul -- DA10044/DA/NIDA NIH HHS/ -- MH40899/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2006 Jan 6;311(5757):77-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16400147" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Animals ; Annexin A2/genetics/*metabolism ; Antidepressive Agents/pharmacology ; Behavior, Animal/drug effects ; Brain/drug effects/metabolism ; Cell Membrane/metabolism ; Depression/genetics/*metabolism ; Electroconvulsive Therapy ; Female ; Humans ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Middle Aged ; Neurons/metabolism ; Rats ; Receptor, Serotonin, 5-HT1B/*metabolism ; S100 Proteins/genetics/*metabolism ; Serotonin/metabolism/physiology ; Signal Transduction ; Two-Hybrid System Techniques
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  • 19
    Publication Date: 2006-04-15
    Description: Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herbert, Alan -- Gerry, Norman P -- McQueen, Matthew B -- Heid, Iris M -- Pfeufer, Arne -- Illig, Thomas -- Wichmann, H-Erich -- Meitinger, Thomas -- Hunter, David -- Hu, Frank B -- Colditz, Graham -- Hinney, Anke -- Hebebrand, Johannes -- Koberwitz, Kerstin -- Zhu, Xiaofeng -- Cooper, Richard -- Ardlie, Kristin -- Lyon, Helen -- Hirschhorn, Joel N -- Laird, Nan M -- Lenburg, Marc E -- Lange, Christoph -- Christman, Michael F -- CA87969/CA/NCI NIH HHS/ -- K23DK067288/DK/NIDDK NIH HHS/ -- P30DK46200/DK/NIDDK NIH HHS/ -- R01 HD060726/HD/NICHD NIH HHS/ -- R01GM046877/GM/NIGMS NIH HHS/ -- R01HL074166/HL/NHLBI NIH HHS/ -- R01HL54485/HL/NHLBI NIH HHS/ -- R01HL66289/HL/NHLBI NIH HHS/ -- R01MH59532/MH/NIMH NIH HHS/ -- U01HL65899/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2006 Apr 14;312(5771):279-83.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA. aherbert@bu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16614226" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; African Americans ; Alleles ; *Body Mass Index ; Case-Control Studies ; Child ; Cohort Studies ; Europe ; European Continental Ancestry Group ; Female ; Gene Frequency ; Genes, Recessive ; Genetic Predisposition to Disease ; *Genetic Variation ; Genotype ; Haplotypes ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Linkage Disequilibrium ; Male ; Membrane Proteins/genetics ; Models, Genetic ; Obesity/*genetics ; Oligonucleotide Array Sequence Analysis ; *Polymorphism, Single Nucleotide
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-02-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hayes, Richard -- Weiss, Helen -- G0700837/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2006 Feb 3;311(5761):620-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK. richard.hayes@lshtm.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16456070" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Africa South of the Sahara/epidemiology ; Anti-HIV Agents/supply & distribution/therapeutic use ; Circumcision, Male ; *Disease Outbreaks/prevention & control ; Female ; HIV Infections/*epidemiology/prevention & control/transmission ; Humans ; Incidence ; Male ; Prevalence ; Risk-Taking ; *Sexual Behavior ; Zimbabwe/epidemiology
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-07-01
    Description: The study of politics and the life cycle began with a rather single-minded focus on childhood and the family-on the idea, as Tocqueville famously put it, that the entire person could be "seen in the cradle of the child." Politics does begin in childhood, and parents do influence their offspring, but change takes place over the entire span of life. I take up the early emergence of partisanship and essentialism, the formation of generations, politically consequential transitions in adulthood, and the rising of politics and its final decline.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kinder, Donald R -- New York, N.Y. -- Science. 2006 Jun 30;312(5782):1905-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Political Science, University of Michigan, Ann Arbor, MI 48106, USA. drkinder@umich.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16809527" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; *Aging ; Child ; *Culture ; Family ; Humans ; Life Change Events ; Middle Aged ; Parents ; *Politics ; United States
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  • 22
    Publication Date: 2006-09-09
    Description: We used functional magnetic resonance imaging to demonstrate preserved conscious awareness in a patient fulfilling the criteria for a diagnosis of vegetative state. When asked to imagine playing tennis or moving around her home, the patient activated predicted cortical areas in a manner indistinguishable from that of healthy volunteers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Owen, Adrian M -- Coleman, Martin R -- Boly, Melanie -- Davis, Matthew H -- Laureys, Steven -- Pickard, John D -- MC_U105559847/Medical Research Council/United Kingdom -- MC_U105580446/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2006 Sep 8;313(5792):1402.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 2EF, UK. adrian.owen@mrc-cbu.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16959998" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Awareness ; Brain/*physiopathology ; Brain Injuries/physiopathology/*psychology ; Brain Mapping ; *Consciousness ; Female ; Humans ; *Magnetic Resonance Imaging ; Neurons/physiology ; Persistent Vegetative State/physiopathology/*psychology
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  • 23
    Publication Date: 2006-12-16
    Description: Considerable evidence indicates that a stimulus that is subthreshold, and thus consciously invisible, influences brain activity and behavioral performance. However, it is not clear how subthreshold stimuli are processed in the brain. We found that a task-irrelevant subthreshold coherent motion led to a stronger disturbance in task performance than did suprathreshold motion. With the subthreshold motion, activity in the visual cortex measured by functional magnetic resonance imaging was higher, but activity in the lateral prefrontal cortex was lower, than with suprathreshold motion. These results suggest that subthreshold irrelevant signals are not subject to effective inhibitory control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsushima, Yoshiaki -- Sasaki, Yuka -- Watanabe, Takeo -- P41RR14075/RR/NCRR NIH HHS/ -- R01 EY015980/EY/NEI NIH HHS/ -- R21 EY017737/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2006 Dec 15;314(5806):1786-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Boston University, 64 Cummington Street, Boston, MA 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17170308" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Attention ; *Awareness ; Brain Mapping ; Eye Movements ; Humans ; Magnetic Resonance Imaging ; Motion Perception ; Prefrontal Cortex/*physiology ; Sensory Thresholds ; *Task Performance and Analysis ; Visual Cortex/*physiology ; *Visual Perception
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  • 24
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-07-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2006 Jul 28;313(5786):484.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16873653" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/epidemiology/prevention & control ; Adult ; Biomedical Research ; Disease Outbreaks ; HIV Infections/*epidemiology/prevention & control ; Humans ; Prevalence ; South America/epidemiology
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  • 25
    Publication Date: 2006-10-07
    Description: Humans restrain self-interest with moral and social values. They are the only species known to exhibit reciprocal fairness, which implies the punishment of other individuals' unfair behaviors, even if it hurts the punisher's economic self-interest. Reciprocal fairness has been demonstrated in the Ultimatum Game, where players often reject their bargaining partner's unfair offers. Despite progress in recent years, however, little is known about how the human brain limits the impact of selfish motives and implements fair behavior. Here we show that disruption of the right, but not the left, dorsolateral prefrontal cortex (DLPFC) by low-frequency repetitive transcranial magnetic stimulation substantially reduces subjects' willingness to reject their partners' intentionally unfair offers, which suggests that subjects are less able to resist the economic temptation to accept these offers. Importantly, however, subjects still judge such offers as very unfair, which indicates that the right DLPFC plays a key role in the implementation of fairness-related behaviors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knoch, Daria -- Pascual-Leone, Alvaro -- Meyer, Kaspar -- Treyer, Valerie -- Fehr, Ernst -- K24 RR018875/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2006 Nov 3;314(5800):829-32. Epub 2006 Oct 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Empirical Research in Economics, University of Zurich, Blumlisalpstrasse 10, 8006 Zurich, Switzerland. dknoch@iew.unizh.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17023614" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Decision Making ; Functional Laterality ; *Games, Experimental ; Humans ; Interpersonal Relations ; Judgment ; Male ; Prefrontal Cortex/*physiology ; *Social Behavior ; Transcranial Magnetic Stimulation
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  • 26
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2006-07-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2006 Jul 28;313(5786):483.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16873652" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/epidemiology/prevention & control ; Adolescent ; Adult ; Belize/epidemiology ; Female ; HIV Infections/epidemiology/*prevention & control ; Health Education ; Humans ; Juvenile Delinquency/*prevention & control ; Male ; Organizations ; Prevalence ; Prisons ; United Nations ; Violence/*prevention & control
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  • 27
    Publication Date: 2007-12-08
    Description: The role of dopamine in monitoring negative action outcomes and feedback-based learning was tested in a neuroimaging study in humans grouped according to the dopamine D2 receptor gene polymorphism DRD2-TAQ-IA. In a probabilistic learning task, A1-allele carriers with reduced dopamine D2 receptor densities learned to avoid actions with negative consequences less efficiently. Their posterior medial frontal cortex (pMFC), involved in feedback monitoring, responded less to negative feedback than others' did. Dynamically changing interactions between pMFC and hippocampus found to underlie feedback-based learning were reduced in A1-allele carriers. This demonstrates that learning from errors requires dopaminergic signaling. Dopamine D2 receptor reduction seems to decrease sensitivity to negative action consequences, which may explain an increased risk of developing addictive behaviors in A1-allele carriers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klein, Tilmann A -- Neumann, Jane -- Reuter, Martin -- Hennig, Jurgen -- von Cramon, D Yves -- Ullsperger, Markus -- R01MH74457/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2007 Dec 7;318(5856):1642-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. tklein@cbs.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18063800" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Alleles ; *Avoidance Learning ; Basal Ganglia/physiology ; Brain Mapping ; Dopamine/*physiology ; Feedback, Psychological ; Frontal Lobe/*physiology ; Hippocampus/physiology ; Humans ; *Learning ; Magnetic Resonance Imaging ; Male ; Nucleus Accumbens/physiology ; *Polymorphism, Genetic ; Receptors, Dopamine D2/*genetics/metabolism ; *Reinforcement (Psychology) ; Signal Transduction
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  • 28
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-05-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finkel, Elizabeth -- New York, N.Y. -- Science. 2007 May 4;316(5825):677.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17478691" target="_blank"〉PubMed〈/a〉
    Keywords: *Accidents, Occupational/prevention & control ; Adult ; Asphyxia/*etiology ; Australia ; *Containment of Biohazards ; *Environment, Controlled ; Humans ; *Laboratories/standards ; Male
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  • 29
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-06-26
    Description: Negative associations between birth order and intelligence level have been found in numerous studies. The explanation for this relation is not clear, and several hypotheses have been suggested. One family of hypotheses suggests that the relation is due to more-favorable family interaction and stimulation of low-birth-order children, whereas others claim that the effect is caused by prenatal gestational factors. We show that intelligence quotient (IQ) score levels among nearly 250,000 military conscripts were dependent on social rank in the family and not on birth order as such, providing support for a family interaction explanation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kristensen, Petter -- Bjerkedal, Tor -- New York, N.Y. -- Science. 2007 Jun 22;316(5832):1717.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute of Occupational Health, N-0033 Oslo, Norway. petter.kristensen@stami.no〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17588924" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Birth Order ; Child ; Family Characteristics ; Female ; Hierarchy, Social ; Humans ; *Intelligence ; Intelligence Tests ; Interpersonal Relations ; Male ; Military Personnel
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  • 30
    Publication Date: 2007-11-24
    Description: Whether social comparison affects individual well-being is of central importance for understanding behavior in any social environment. Traditional economic theories focus on the role of absolute rewards, whereas behavioral evidence suggests that social comparisons influence well-being and decisions. We investigated the impact of social comparisons on reward-related brain activity using functional magnetic resonance imaging (fMRI). While being scanned in two adjacent MRI scanners, pairs of subjects had to simultaneously perform a simple estimation task that entailed monetary rewards for correct answers. We show that a variation in the comparison subject's payment affects blood oxygenation level-dependent responses in the ventral striatum. Our results provide neurophysiological evidence for the importance of social comparison on reward processing in the human brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fliessbach, K -- Weber, B -- Trautner, P -- Dohmen, T -- Sunde, U -- Elger, C E -- Falk, A -- New York, N.Y. -- Science. 2007 Nov 23;318(5854):1305-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Life and Brain Center Bonn, Department of NeuroCognition and Clinic of Epileptology, Bonn, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18033886" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Analysis of Variance ; Basal Ganglia/blood supply/*physiology ; Brain/blood supply/physiology ; Brain Mapping ; Humans ; Magnetic Resonance Imaging ; Male ; Oxygen/blood ; *Reward ; *Social Perception
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  • 31
    Publication Date: 2007-04-17
    Description: Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646098/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646098/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frayling, Timothy M -- Timpson, Nicholas J -- Weedon, Michael N -- Zeggini, Eleftheria -- Freathy, Rachel M -- Lindgren, Cecilia M -- Perry, John R B -- Elliott, Katherine S -- Lango, Hana -- Rayner, Nigel W -- Shields, Beverley -- Harries, Lorna W -- Barrett, Jeffrey C -- Ellard, Sian -- Groves, Christopher J -- Knight, Bridget -- Patch, Ann-Marie -- Ness, Andrew R -- Ebrahim, Shah -- Lawlor, Debbie A -- Ring, Susan M -- Ben-Shlomo, Yoav -- Jarvelin, Marjo-Riitta -- Sovio, Ulla -- Bennett, Amanda J -- Melzer, David -- Ferrucci, Luigi -- Loos, Ruth J F -- Barroso, Ines -- Wareham, Nicholas J -- Karpe, Fredrik -- Owen, Katharine R -- Cardon, Lon R -- Walker, Mark -- Hitman, Graham A -- Palmer, Colin N A -- Doney, Alex S F -- Morris, Andrew D -- Smith, George Davey -- Hattersley, Andrew T -- McCarthy, Mark I -- 079557/Wellcome Trust/United Kingdom -- 090532/Wellcome Trust/United Kingdom -- G0000934/Medical Research Council/United Kingdom -- G0500070/Medical Research Council/United Kingdom -- G0600705/Medical Research Council/United Kingdom -- G9815508/Medical Research Council/United Kingdom -- MC_U106179471/Medical Research Council/United Kingdom -- MC_U106188470/Medical Research Council/United Kingdom -- Z99 AG999999/Intramural NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2007 May 11;316(5826):889-94. Epub 2007 Apr 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17434869" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue ; Adolescent ; Adult ; Aged ; Alleles ; Birth Weight ; *Body Mass Index ; Case-Control Studies ; Child ; Cohort Studies ; Diabetes Mellitus, Type 2/*genetics ; Female ; *Genetic Predisposition to Disease ; Great Britain ; Homozygote ; Humans ; Infant, Newborn ; Male ; Middle Aged ; Obesity/*genetics ; Overweight/genetics ; *Polymorphism, Single Nucleotide
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  • 32
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2007 Nov 30;318(5855):1360-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18048656" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Anti-HIV Agents/therapeutic use ; Child ; Disease Outbreaks/*statistics & numerical data ; Epidemiologic Methods ; Female ; *Global Health ; HIV Infections/drug therapy/*epidemiology/mortality ; Humans ; Male ; Prevalence ; United Nations
    Print ISSN: 0036-8075
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  • 33
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2007 Dec 7;318(5856):1535.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18063761" target="_blank"〉PubMed〈/a〉
    Keywords: Adalimumab ; Adult ; Antibodies, Monoclonal/*adverse effects/therapeutic use ; Antibodies, Monoclonal, Humanized ; Antirheumatic Agents/*adverse effects/therapeutic use ; Arthritis, Rheumatoid/*therapy ; Clinical Trials as Topic ; Combined Modality Therapy/adverse effects ; Dependovirus/genetics/immunology ; Fatal Outcome ; Female ; Genetic Therapy/*adverse effects ; Genetic Vectors/adverse effects/immunology ; Histoplasmosis/*etiology ; Humans ; Tumor Necrosis Factor-alpha/*antagonists & inhibitors
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  • 34
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-09-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Geddis, Amy E -- Kaushansky, Kenneth -- New York, N.Y. -- Science. 2007 Sep 21;317(5845):1689-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Pediatrics and Medicine, University of California, San Diego, CA 92103-8811, USA. kkaushansky@ucsd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17885117" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Blood Platelets/*cytology ; Humans ; Megakaryocytes/*cytology ; Mice ; Thrombopoiesis/*physiology
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  • 35
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-09-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2007 Sep 21;317(5845):1665.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17885103" target="_blank"〉PubMed〈/a〉
    Keywords: Adalimumab ; Adult ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal, Humanized ; Arthritis, Rheumatoid/immunology/*therapy ; Cause of Death ; Female ; Genetic Therapy/*adverse effects ; Histoplasma ; Histoplasmosis/immunology/mortality ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
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  • 36
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-05-19
    Description: Resistance to certain scientific ideas derives in large part from assumptions and biases that can be demonstrated experimentally in young children and that may persist into adulthood. In particular, both adults and children resist acquiring scientific information that clashes with common-sense intuitions about the physical and psychological domains. Additionally, when learning information from other people, both adults and children are sensitive to the trustworthiness of the source of that information. Resistance to science, then, is particularly exaggerated in societies where nonscientific ideologies have the advantages of being both grounded in common sense and transmitted by trustworthy sources.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bloom, Paul -- Weisberg, Deena Skolnick -- New York, N.Y. -- Science. 2007 May 18;316(5827):996-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Yale University, New Haven, CT 06520, USA. paul.bloom@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17510356" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Biological Evolution ; Brain/physiology ; Child ; *Culture ; Humans ; Intuition ; Learning ; Neurosciences ; Psychology ; *Science/education ; Trust ; United States
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  • 37
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Greg -- New York, N.Y. -- Science. 2007 Nov 9;318(5852):899-900.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17991833" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Adult Stem Cells/chemistry/*cytology ; Animals ; Biomarkers/*analysis ; Brain/cytology/embryology ; Brain Chemistry ; Child ; Fatty Acids/analysis ; Hippocampus/chemistry/*cytology ; Humans ; Magnetic Resonance Spectroscopy/*methods ; Mice ; Rats ; Stem Cells/chemistry/*cytology
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  • 38
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-09-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2007 Sep 21;317(5845):1664.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17885102" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; *Biological Evolution ; Body Size ; Bone and Bones ; Female ; *Fossils ; Georgia (Republic) ; *Hominidae/classification ; Humans ; Male
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  • 39
    Publication Date: 2007-08-25
    Description: Humans normally experience the conscious self as localized within their bodily borders. This spatial unity may break down in certain neurological conditions such as out-of-body experiences, leading to a striking disturbance of bodily self-consciousness. On the basis of these clinical data, we designed an experiment that uses conflicting visual-somatosensory input in virtual reality to disrupt the spatial unity between the self and the body. We found that during multisensory conflict, participants felt as if a virtual body seen in front of them was their own body and mislocalized themselves toward the virtual body, to a position outside their bodily borders. Our results indicate that spatial unity and bodily self-consciousness can be studied experimentally and are based on multisensory and cognitive processing of bodily information.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lenggenhager, Bigna -- Tadi, Tej -- Metzinger, Thomas -- Blanke, Olaf -- New York, N.Y. -- Science. 2007 Aug 24;317(5841):1096-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cognitive Neuroscience, Ecole Polytechnique Federale de Lausanne, Station 15, 1015 Lausanne, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17717189" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Body Image ; Cognition ; Female ; Humans ; Illusions ; Male ; Perceptual Distortion ; Surveys and Questionnaires ; Touch
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  • 40
    Publication Date: 2007-01-16
    Description: Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dina, Christian -- Meyre, David -- Samson, Chantal -- Tichet, Jean -- Marre, Michel -- Jouret, Beatrice -- Charles, Marie Aline -- Balkau, Beverley -- Froguel, Philippe -- New York, N.Y. -- Science. 2007 Jan 12;315(5809):187; author reply 187.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France. dina@good.ibl.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17218508" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Body Mass Index ; Case-Control Studies ; Child ; European Continental Ancestry Group ; Family ; Female ; France ; Gene Frequency ; Genetic Predisposition to Disease ; *Genetic Variation ; Humans ; Intracellular Signaling Peptides and Proteins/*genetics ; Male ; Membrane Proteins/*genetics ; Obesity/*genetics ; *Polymorphism, Single Nucleotide
    Print ISSN: 0036-8075
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  • 41
    Publication Date: 2007-01-16
    Description: Herbert et al. (Reports, 14 April 2006, p. 279) found that the rs7566605 genetic variant, located upstream of the INSIG2 gene, was consistently associated with increased body mass index. However, we found no evidence of association between rs7566605 and body mass index in two large ethnically homogeneous population-based cohorts. On the contrary, an opposite tendency was observed.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719286/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719286/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loos, Ruth J F -- Barroso, Ines -- O'rahilly, Stephen -- Wareham, Nicholas J -- 077016/Wellcome Trust/United Kingdom -- G9824984/Medical Research Council/United Kingdom -- MC_U106179471/Medical Research Council/United Kingdom -- MC_U106188470/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2007 Jan 12;315(5809):187; author reply 187.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Epidemiology Unit, Cambridge, UK. ruth.loos@mrc-epid.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17218509" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Alleles ; *Body Mass Index ; Cohort Studies ; European Continental Ancestry Group ; Female ; Genes, Recessive ; Genetic Predisposition to Disease ; *Genetic Variation ; Genotype ; Humans ; Intracellular Signaling Peptides and Proteins/*genetics ; Male ; Membrane Proteins/*genetics ; Obesity/*genetics ; Polymorphism, Single Nucleotide
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  • 42
    Publication Date: 2007-07-14
    Description: Whether memories can be suppressed has been a controversial issue in psychology and cognitive neuroscience for decades. We found evidence that emotional memories are suppressed via two time-differentiated neural mechanisms: (i) an initial suppression by the right inferior frontal gyrus over regions supporting sensory components of the memory representation (visual cortex, thalamus), followed by (ii) right medial frontal gyrus control over regions supporting multimodal and emotional components of the memory representation (hippocampus, amygdala), both of which are influenced by fronto-polar regions. These results indicate that memory suppression does occur and, at least in nonpsychiatric populations, is under the control of prefrontal regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Depue, Brendan E -- Curran, Tim -- Banich, Marie T -- New York, N.Y. -- Science. 2007 Jul 13;317(5835):215-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Colorado, Boulder, CO 80309, USA. depue@colorado.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17626877" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Amygdala/physiology ; Brain Mapping ; Cognition ; Cues ; *Emotions ; Female ; Frontal Lobe/physiology ; Hippocampus/physiology ; Humans ; Magnetic Resonance Imaging ; Male ; *Memory ; Mental Recall ; Prefrontal Cortex/*physiology ; Pulvinar/physiology ; *Repression, Psychology ; Thinking ; Visual Cortex/physiology
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  • 43
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-08-25
    Description: I report an illusion in which individuals experience that they are located outside their physical bodies and looking at their bodies from this perspective. This demonstrates that the experience of being localized within the physical body can be determined by the visual perspective in conjunction with correlated multisensory information from the body.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ehrsson, H Henrik -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2007 Aug 24;317(5841):1048.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Centre for Neuroimaging, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK. Henrik.Ehrsson@ki.se.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17717177" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Body Image ; Female ; Humans ; Illusions ; Male ; Perceptual Distortion ; Touch
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  • 44
    Publication Date: 2007-01-27
    Description: People typically exhibit greater sensitivity to losses than to equivalent gains when making decisions. We investigated neural correlates of loss aversion while individuals decided whether to accept or reject gambles that offered a 50/50 chance of gaining or losing money. A broad set of areas (including midbrain dopaminergic regions and their targets) showed increasing activity as potential gains increased. Potential losses were represented by decreasing activity in several of these same gain-sensitive areas. Finally, individual differences in behavioral loss aversion were predicted by a measure of neural loss aversion in several regions, including the ventral striatum and prefrontal cortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tom, Sabrina M -- Fox, Craig R -- Trepel, Christopher -- Poldrack, Russell A -- P20 RR020750/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2007 Jan 26;315(5811):515-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of California Los Angeles (UCLA), Franz Hall, Box 951563, Los Angeles, CA 90095-1563, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17255512" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Basal Ganglia/physiology ; Brain/*physiology ; Brain Mapping ; *Decision Making ; Dopamine/physiology ; Female ; Frontal Lobe/physiology ; *Gambling ; Games, Experimental ; Humans ; Magnetic Resonance Imaging ; Male ; Mesencephalon/physiology ; Prefrontal Cortex/physiology ; Probability ; Regression Analysis
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  • 45
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-08-04
    Description: A paradigm shift is occurring in the field of primary immunodeficiencies, with revision of the definition of these conditions and a considerable expansion of their limits. Inborn errors of immunity were initially thought to be confined to a few rare, familial, monogenic, recessive traits impairing the development or function of one or several leukocyte subsets and resulting in multiple, recurrent, opportunistic, and fatal infections in infancy. A growing number of exceptions to each of these conventional qualifications have gradually accumulated. It now appears that most individuals suffer from at least one of a multitude of primary immunodeficiencies, the dissection of which is helping to improve human medicine while describing immunity in natura.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Casanova, Jean-Laurent -- Abel, Laurent -- New York, N.Y. -- Science. 2007 Aug 3;317(5838):617-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale, U550, Paris, France. casanova@necker.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17673650" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Child ; Disease Susceptibility ; Genetic Predisposition to Disease ; Humans ; Immune System/*physiopathology ; Immunity, Active ; Immunity, Innate ; Immunologic Deficiency Syndromes/*genetics/*immunology ; Infant ; Infection/etiology/*immunology ; Mutation ; Phenotype
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  • 46
    Publication Date: 2007-03-03
    Description: Coronary artery disease (CAD) is the leading cause of death worldwide and is commonly caused by a constellation of risk factors called the metabolic syndrome. We characterized a family with autosomal dominant early CAD, features of the metabolic syndrome (hyperlipidemia, hypertension, and diabetes), and osteoporosis. These traits showed genetic linkage to a short segment of chromosome 12p, in which we identified a missense mutation in LRP6, which encodes a co-receptor in the Wnt signaling pathway. The mutation, which substitutes cysteine for arginine at a highly conserved residue of an epidermal growth factor-like domain, impairs Wnt signaling in vitro. These results link a single gene defect in Wnt signaling to CAD and multiple cardiovascular risk factors.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945222/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945222/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mani, Arya -- Radhakrishnan, Jayaram -- Wang, He -- Mani, Alaleh -- Mani, Mohammad-Ali -- Nelson-Williams, Carol -- Carew, Khary S -- Mane, Shrikant -- Najmabadi, Hossein -- Wu, Dan -- Lifton, Richard P -- K08 HD041481/HD/NICHD NIH HHS/ -- K08 HD041481-01/HD/NICHD NIH HHS/ -- P01DK68229/DK/NIDDK NIH HHS/ -- P50 HL55007/HL/NHLBI NIH HHS/ -- R01 AR051476/AR/NIAMS NIH HHS/ -- R01 AR051476-01A1/AR/NIAMS NIH HHS/ -- R01 AR051476-02/AR/NIAMS NIH HHS/ -- R01 AR051476-03/AR/NIAMS NIH HHS/ -- R01 AR051476-04/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2007 Mar 2;315(5816):1278-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, Howard Hughes Medical Institute and Yale University School of Medicine, New Haven, CT 06510, USA. arya.mani@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17332414" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Aged, 80 and over ; Amino Acid Substitution ; Animals ; Chromosomes, Human, Pair 12/genetics ; Coronary Disease/*genetics/metabolism ; Family Health ; Female ; Genetic Linkage ; *Genetic Predisposition to Disease ; Humans ; LDL-Receptor Related Proteins/*genetics/physiology ; Lipids/blood ; Low Density Lipoprotein Receptor-Related Protein-6 ; Male ; Metabolic Syndrome X/*genetics/metabolism ; Mice ; Middle Aged ; *Mutation, Missense ; NIH 3T3 Cells ; Osteoporosis/genetics ; Pedigree ; Risk Factors ; Signal Transduction ; Wnt Proteins/metabolism
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  • 47
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-08-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2008 Aug 1;321(5889):625. doi: 10.1126/science.321.5889.625b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18669831" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; *Aging ; *Athletic Performance ; Child ; Female ; Humans ; Male ; Middle Aged ; *Sports
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 48
    Publication Date: 2008-05-31
    Description: The mapping of numbers onto space is fundamental to measurement and to mathematics. Is this mapping a cultural invention or a universal intuition shared by all humans regardless of culture and education? We probed number-space mappings in the Mundurucu, an Amazonian indigene group with a reduced numerical lexicon and little or no formal education. At all ages, the Mundurucu mapped symbolic and nonsymbolic numbers onto a logarithmic scale, whereas Western adults used linear mapping with small or symbolic numbers and logarithmic mapping when numbers were presented nonsymbolically under conditions that discouraged counting. This indicates that the mapping of numbers onto space is a universal intuition and that this initial intuition of number is logarithmic. The concept of a linear number line appears to be a cultural invention that fails to develop in the absence of formal education.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610411/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610411/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dehaene, Stanislas -- Izard, Veronique -- Spelke, Elizabeth -- Pica, Pierre -- New York, N.Y. -- Science. 2008 May 30;320(5880):1217-20. doi: 10.1126/science.1156540.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM, Cognitive Neuro-imaging Unit, Institut Federatif de Recherche (IFR) 49, Gif sur Yvette, France. stanislas.dehaene@cea.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18511690" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Anthropology, Cultural ; Brazil ; Child ; *Cultural Evolution ; Educational Status ; Female ; Humans ; *Indians, South American ; *Intuition ; Male ; *Mathematics ; Middle Aged
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  • 49
    Publication Date: 2008-06-17
    Description: Process-specific training can improve performance on untrained tasks, but the magnitude of gain is variable and often there is no transfer at all. We demonstrate transfer to a 3-back test of working memory after 5 weeks of training in updating. The transfer effect was based on a joint training-related activity increase for the criterion (letter memory) and transfer tasks in a striatal region that also was recruited pretraining. No transfer was observed to a task that did not engage updating and striatal regions, and age-related striatal changes imposed constraints on transfer. These findings indicate that transfer can occur if the criterion and transfer tasks engage specific overlapping processing components and brain regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dahlin, Erika -- Neely, Anna Stigsdotter -- Larsson, Anne -- Backman, Lars -- Nyberg, Lars -- New York, N.Y. -- Science. 2008 Jun 13;320(5882):1510-2. doi: 10.1126/science.1155466.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Integrative Medical Biology, Umea University, 90187 Umea, Sweden. erika.dahlin@physiol.umu.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18556560" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aging ; Brain Mapping ; Corpus Striatum/*physiology ; Humans ; *Learning ; Magnetic Resonance Imaging ; *Memory ; *Teaching
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  • 50
    Publication Date: 2008-03-01
    Description: Current theories hypothesize that dopamine neuronal firing encodes reward prediction errors. Although studies in nonhuman species provide direct support for this theory, functional magnetic resonance imaging (fMRI) studies in humans have focused on brain areas targeted by dopamine neurons [ventral striatum (VStr)] rather than on brainstem dopaminergic nuclei [ventral tegmental area (VTA) and substantia nigra]. We used fMRI tailored to directly image the brainstem. When primary rewards were used in an experiment, the VTA blood oxygen level-dependent (BOLD) response reflected a positive reward prediction error, whereas the VStr encoded positive and negative reward prediction errors. When monetary gains and losses were used, VTA BOLD responses reflected positive reward prediction errors modulated by the probability of winning. We detected no significant VTA BOLD response to nonrewarding events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉D'Ardenne, Kimberlee -- McClure, Samuel M -- Nystrom, Leigh E -- Cohen, Jonathan D -- F32 MH072141/MH/NIMH NIH HHS/ -- P50 MH062196/MH/NIMH NIH HHS/ -- T32 MH065214/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2008 Feb 29;319(5867):1264-7. doi: 10.1126/science.1150605.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. dardenne@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18309087" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Basal Ganglia/physiology ; Conditioning, Classical ; Cues ; Dopamine/*physiology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Mental Processes/*physiology ; Oxygen/blood ; Probability ; Reinforcement (Psychology) ; *Reward ; Ventral Tegmental Area/*physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 51
    Publication Date: 2008-09-06
    Description: Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined the presence of amplifications and deletions using high-density oligonucleotide arrays, and performed gene expression analyses using next-generation sequencing technologies in 22 human tumor samples. This comprehensive analysis led to the discovery of a variety of genes that were not known to be altered in GBMs. Most notably, we found recurrent mutations in the active site of isocitrate dehydrogenase 1 (IDH1) in 12% of GBM patients. Mutations in IDH1 occurred in a large fraction of young patients and in most patients with secondary GBMs and were associated with an increase in overall survival. These studies demonstrate the value of unbiased genomic analyses in the characterization of human brain cancer and identify a potentially useful genetic alteration for the classification and targeted therapy of GBMs.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820389/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820389/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parsons, D Williams -- Jones, Sian -- Zhang, Xiaosong -- Lin, Jimmy Cheng-Ho -- Leary, Rebecca J -- Angenendt, Philipp -- Mankoo, Parminder -- Carter, Hannah -- Siu, I-Mei -- Gallia, Gary L -- Olivi, Alessandro -- McLendon, Roger -- Rasheed, B Ahmed -- Keir, Stephen -- Nikolskaya, Tatiana -- Nikolsky, Yuri -- Busam, Dana A -- Tekleab, Hanna -- Diaz, Luis A Jr -- Hartigan, James -- Smith, Doug R -- Strausberg, Robert L -- Marie, Suely Kazue Nagahashi -- Shinjo, Sueli Mieko Oba -- Yan, Hai -- Riggins, Gregory J -- Bigner, Darell D -- Karchin, Rachel -- Papadopoulos, Nick -- Parmigiani, Giovanni -- Vogelstein, Bert -- Velculescu, Victor E -- Kinzler, Kenneth W -- 5P50-NS-20023/NS/NINDS NIH HHS/ -- CA09547/CA/NCI NIH HHS/ -- CA108786/CA/NCI NIH HHS/ -- CA11898/CA/NCI NIH HHS/ -- CA121113/CA/NCI NIH HHS/ -- CA43460/CA/NCI NIH HHS/ -- CA57345/CA/NCI NIH HHS/ -- CA62924/CA/NCI NIH HHS/ -- NS052507/NS/NINDS NIH HHS/ -- P50 CA062924/CA/NCI NIH HHS/ -- P50 CA062924-160017/CA/NCI NIH HHS/ -- R01 CA121113/CA/NCI NIH HHS/ -- R01 CA121113-04/CA/NCI NIH HHS/ -- R01 CA140316/CA/NCI NIH HHS/ -- R37 CA043460/CA/NCI NIH HHS/ -- R37 CA043460-27/CA/NCI NIH HHS/ -- R37 CA057345/CA/NCI NIH HHS/ -- R37 CA057345-13/CA/NCI NIH HHS/ -- R37 CA057345-17/CA/NCI NIH HHS/ -- R37 CA057345-18/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2008 Sep 26;321(5897):1807-12. doi: 10.1126/science.1164382. Epub 2008 Sep 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ludwig Center for Cancer Genetics and Therapeutics, and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18772396" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Neoplasms/*genetics/mortality ; Female ; Gene Amplification ; Gene Dosage ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genome, Human ; Glioblastoma/*genetics/mortality ; Humans ; Isocitrate Dehydrogenase/chemistry/*genetics ; Male ; Middle Aged ; *Mutation ; Mutation, Missense ; Oligonucleotide Array Sequence Analysis ; Polymorphism, Single Nucleotide ; Sequence Analysis, DNA ; Signal Transduction ; Survival Rate
    Print ISSN: 0036-8075
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  • 52
    Publication Date: 2008-08-09
    Description: To sustain or repair cooperation during a social exchange, adaptive creatures must understand social gestures and the consequences when shared expectations about fair exchange are violated by accident or intent. We recruited 55 individuals afflicted with borderline personality disorder (BPD) to play a multiround economic exchange game with healthy partners. Behaviorally, individuals with BPD showed a profound incapacity to maintain cooperation, and were impaired in their ability to repair broken cooperation on the basis of a quantitative measure of coaxing. Neurally, activity in the anterior insula, a region known to respond to norm violations across affective, interoceptive, economic, and social dimensions, strongly differentiated healthy participants from individuals with BPD. Healthy subjects showed a strong linear relation between anterior insula response and both magnitude of monetary offer received from their partner (input) and the amount of money repaid to their partner (output). In stark contrast, activity in the anterior insula of BPD participants was related only to the magnitude of repayment sent back to their partner (output), not to the magnitude of offers received (input). These neural and behavioral data suggest that norms used in perception of social gestures are pathologically perturbed or missing altogether among individuals with BPD. This game-theoretic approach to psychopathology may open doors to new ways of characterizing and studying a range of mental illnesses.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105006/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105006/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King-Casas, Brooks -- Sharp, Carla -- Lomax-Bream, Laura -- Lohrenz, Terry -- Fonagy, Peter -- Montague, P Read -- DA11723/DA/NIDA NIH HHS/ -- F32 MH078485/MH/NIMH NIH HHS/ -- MH078485/MH/NIMH NIH HHS/ -- MH52797/MH/NIMH NIH HHS/ -- NS045790/NS/NINDS NIH HHS/ -- R01 DA011723/DA/NIDA NIH HHS/ -- R01 MH052797/MH/NIMH NIH HHS/ -- R01 NS045790/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2008 Aug 8;321(5890):806-10. doi: 10.1126/science.1156902.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Computational Psychiatry Unit and Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18687957" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Borderline Personality Disorder/*physiopathology/*psychology ; Cerebral Cortex/*physiopathology ; *Cooperative Behavior ; Female ; Frontal Lobe/physiopathology ; *Games, Experimental ; Humans ; Magnetic Resonance Imaging ; Male ; Parietal Lobe/physiopathology ; Social Behavior ; Trust/*psychology
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  • 53
    Publication Date: 2008-03-29
    Description: Schizophrenia is a devastating neurodevelopmental disorder whose genetic influences remain elusive. We hypothesize that individually rare structural variants contribute to the illness. Microdeletions and microduplications 〉100 kilobases were identified by microarray comparative genomic hybridization of genomic DNA from 150 individuals with schizophrenia and 268 ancestry-matched controls. All variants were validated by high-resolution platforms. Novel deletions and duplications of genes were present in 5% of controls versus 15% of cases and 20% of young-onset cases, both highly significant differences. The association was independently replicated in patients with childhood-onset schizophrenia as compared with their parents. Mutations in cases disrupted genes disproportionately from signaling networks controlling neurodevelopment, including neuregulin and glutamate pathways. These results suggest that multiple, individually rare mutations altering genes in neurodevelopmental pathways contribute to schizophrenia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, Tom -- McClellan, Jon M -- McCarthy, Shane E -- Addington, Anjene M -- Pierce, Sarah B -- Cooper, Greg M -- Nord, Alex S -- Kusenda, Mary -- Malhotra, Dheeraj -- Bhandari, Abhishek -- Stray, Sunday M -- Rippey, Caitlin F -- Roccanova, Patricia -- Makarov, Vlad -- Lakshmi, B -- Findling, Robert L -- Sikich, Linmarie -- Stromberg, Thomas -- Merriman, Barry -- Gogtay, Nitin -- Butler, Philip -- Eckstrand, Kristen -- Noory, Laila -- Gochman, Peter -- Long, Robert -- Chen, Zugen -- Davis, Sean -- Baker, Carl -- Eichler, Evan E -- Meltzer, Paul S -- Nelson, Stanley F -- Singleton, Andrew B -- Lee, Ming K -- Rapoport, Judith L -- King, Mary-Claire -- Sebat, Jonathan -- HD043569/HD/NICHD NIH HHS/ -- M01 RR000046/RR/NCRR NIH HHS/ -- MH061355/MH/NIMH NIH HHS/ -- MH061464/MH/NIMH NIH HHS/ -- MH061528/MH/NIMH NIH HHS/ -- NS052108/NS/NINDS NIH HHS/ -- R01 HD043569/HD/NICHD NIH HHS/ -- RR000046/RR/NCRR NIH HHS/ -- RR025014/RR/NCRR NIH HHS/ -- U01 MH061355/MH/NIMH NIH HHS/ -- U01 MH061464/MH/NIMH NIH HHS/ -- U01 MH061528/MH/NIMH NIH HHS/ -- U24 NS052108/NS/NINDS NIH HHS/ -- UL1 RR025014/RR/NCRR NIH HHS/ -- Howard Hughes Medical Institute/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2008 Apr 25;320(5875):539-43. doi: 10.1126/science.1155174. Epub 2008 Mar 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Washington, Seattle, WA 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18369103" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age of Onset ; Amino Acid Sequence ; Brain/cytology/*growth & development/metabolism ; Case-Control Studies ; Child ; Excitatory Amino Acid Transporter 1/chemistry/genetics/physiology ; Female ; *Gene Deletion ; *Gene Duplication ; Genetic Predisposition to Disease ; Genome, Human ; Humans ; Male ; Molecular Sequence Data ; *Mutation ; Neurons/cytology/physiology ; Oligonucleotide Array Sequence Analysis ; Polymorphism, Single Nucleotide ; Receptor, Epidermal Growth Factor/chemistry/genetics/physiology ; Receptor, ErbB-4 ; Schizophrenia/*genetics/physiopathology ; Signal Transduction
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  • 54
    Publication Date: 2008-03-01
    Description: Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder characterized pathologically by ubiquitinated TAR DNA binding protein (TDP-43) inclusions. The function of TDP-43 in the nervous system is uncertain, and a mechanistic role in neurodegeneration remains speculative. We identified neighboring mutations in a highly conserved region of TARDBP in sporadic and familial ALS cases. TARDBPM337V segregated with disease within one kindred and a genome-wide scan confirmed that linkage was restricted to chromosome 1p36, which contains the TARDBP locus. Mutant forms of TDP-43 fragmented in vitro more readily than wild type and, in vivo, caused neural apoptosis and developmental delay in the chick embryo. Our evidence suggests a pathophysiological link between TDP-43 and ALS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sreedharan, Jemeen -- Blair, Ian P -- Tripathi, Vineeta B -- Hu, Xun -- Vance, Caroline -- Rogelj, Boris -- Ackerley, Steven -- Durnall, Jennifer C -- Williams, Kelly L -- Buratti, Emanuele -- Baralle, Francisco -- de Belleroche, Jacqueline -- Mitchell, J Douglas -- Leigh, P Nigel -- Al-Chalabi, Ammar -- Miller, Christopher C -- Nicholson, Garth -- Shaw, Christopher E -- G0500289/Medical Research Council/United Kingdom -- G0501573/Medical Research Council/United Kingdom -- G0600974/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2008 Mar 21;319(5870):1668-72. doi: 10.1126/science.1154584. Epub 2008 Feb 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Clinical Neuroscience, King's College London, Medical Research Council (MRC) Centre for Neurodegeneration Research, and Institute of Psychiatry, London, SE5 8AF, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18309045" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Amino Acid Sequence ; Amino Acid Substitution ; Amyotrophic Lateral Sclerosis/*genetics ; Animals ; Apoptosis ; CHO Cells ; Chick Embryo ; Chromosomes, Human, Pair 1/genetics ; Cricetinae ; Cricetulus ; DNA-Binding Proteins/chemistry/*genetics/physiology ; Embryonic Development ; Female ; Humans ; Male ; Microsatellite Repeats ; Middle Aged ; Molecular Sequence Data ; Mutant Proteins/chemistry/physiology ; *Mutation, Missense ; Neurons/cytology/physiology
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  • 55
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-10-25
    Description: "Warmth" is the most powerful personality trait in social judgment, and attachment theorists have stressed the importance of warm physical contact with caregivers during infancy for healthy relationships in adulthood. Intriguingly, recent research in humans points to the involvement of the insula in the processing of both physical temperature and interpersonal warmth (trust) information. Accordingly, we hypothesized that experiences of physical warmth (or coldness) would increase feelings of interpersonal warmth (or coldness), without the person's awareness of this influence. In study 1, participants who briefly held a cup of hot (versus iced) coffee judged a target person as having a "warmer" personality (generous, caring); in study 2, participants holding a hot (versus cold) therapeutic pad were more likely to choose a gift for a friend instead of for themselves.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737341/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737341/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, Lawrence E -- Bargh, John A -- MH-R01-60767/MH/NIMH NIH HHS/ -- R01 MH060767-09/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2008 Oct 24;322(5901):606-7. doi: 10.1126/science.1162548.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Leeds School of Business, University of Colorado at Boulder, UCB 419, Boulder, CO, 80309-0419, USA. lawrence.williams@colorado.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18948544" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Cerebral Cortex/physiology ; Cold Temperature ; Emotions ; Female ; Hot Temperature ; Humans ; *Interpersonal Relations ; Judgment ; Male ; Personality ; Social Behavior ; *Social Perception ; *Thermosensing ; *Trust
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  • 56
    Publication Date: 2008-06-21
    Description: The control of innate immune responses through activation of the nuclear transcription factor NF-kappaB is essential for the elimination of invading microbial pathogens. We showed that the bacterial N-(3-oxo-dodecanoyl) homoserine lactone (C12) selectively impairs the regulation of NF-kappaB functions in activated mammalian cells. The consequence is specific repression of stimulus-mediated induction of NF-kappaB-responsive genes encoding inflammatory cytokines and other immune regulators. These findings uncover a strategy by which C12-producing opportunistic pathogens, such as Pseudomonas aeruginosa, attenuate the innate immune system to establish and maintain local persistent infection in humans, for example, in cystic fibrosis patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kravchenko, Vladimir V -- Kaufmann, Gunnar F -- Mathison, John C -- Scott, David A -- Katz, Alexander Z -- Grauer, David C -- Lehmann, Mandy -- Meijler, Michael M -- Janda, Kim D -- Ulevitch, Richard J -- New York, N.Y. -- Science. 2008 Jul 11;321(5886):259-63. doi: 10.1126/science.1156499. Epub 2008 Jun 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology and Microbial Sciences, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18566250" target="_blank"〉PubMed〈/a〉
    Keywords: 4-Butyrolactone/*analogs & derivatives/physiology ; Adult ; Animals ; Cyclic AMP Response Element-Binding Protein/metabolism ; Cystic Fibrosis/microbiology ; Female ; *Gene Expression Regulation ; Homoserine/*analogs & derivatives/physiology ; Humans ; I-kappa B Kinase/metabolism ; I-kappa B Proteins/metabolism ; Immunity, Innate ; Interferon-gamma/immunology ; Lipopolysaccharides/immunology ; Macrophage Activation ; Macrophages/*immunology/*metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Middle Aged ; NF-kappa B/*metabolism ; Phosphorylation ; Pseudomonas Infections/immunology/microbiology ; Pseudomonas aeruginosa/immunology/*pathogenicity/physiology ; *Signal Transduction ; Toll-Like Receptors/metabolism ; Transcription Factor RelA/metabolism
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  • 57
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-08-09
    Description: Our ability to remember what we have seen is very limited. Most current views characterize this limit as a fixed number of items-only four objects-that can be held in visual working memory. We show that visual memory capacity is not fixed by the number of objects, but rather is a limited resource that is shared out dynamically between all items in the visual scene. This resource can be shifted flexibly between objects, with allocation biased by selective attention and toward targets of upcoming eye movements. The proportion of resources allocated to each item determines the precision with which it is remembered, a relation that we show is governed by a simple power law, allowing quantitative estimates of resource distribution in a scene.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532743/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532743/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bays, Paul M -- Husain, Masud -- 061140/Wellcome Trust/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2008 Aug 8;321(5890):851-4. doi: 10.1126/science.1158023.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK. p.bays@ion.ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18687968" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Attention ; Female ; Fixation, Ocular ; Humans ; Male ; *Memory, Short-Term ; *Mental Recall ; Models, Neurological ; *Saccades ; Vision, Ocular ; *Visual Perception
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  • 58
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-03-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mercer, Jean -- New York, N.Y. -- Science. 2008 Feb 29;319(5867):1185-6; author reply 1185-6. doi: 10.1126/science.319.5867.1185.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18309062" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child, Preschool ; *Cognition ; *Curriculum ; *Early Intervention (Education) ; Faculty ; Humans ; *Interpersonal Relations ; *Schools, Nursery
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  • 59
    Publication Date: 2008-12-17
    Description: Models of cognitive control posit a key modulatory role for the pontine locus coeruleus-norepinephrine (LC-NE) system. In nonhuman primates, phasic LC-NE activity confers adaptive adjustments in cortical gain in task-relevant brain networks, and in performance, on a trial-by-trial basis. This model has remained untested in humans. We used the pharmacological agent modafinil to promote low-tonic/high-phasic LC-NE activity in healthy humans performing a cognitive control task during event-related functional magnetic resonance imaging (fMRI). Modafanil administration was associated with decreased task-independent, tonic LC activity, increased task-related LC and prefrontal cortex (PFC) activity, and enhanced LC-PFC functional connectivity. These results confirm in humans the role of the LC-NE system in PFC function and cognitive control and suggest a mechanism for therapeutic action of procognitive noradrenergic agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Minzenberg, Michael J -- Watrous, Andrew J -- Yoon, Jong H -- Ursu, Stefan -- Carter, Cameron S -- MH059883/MH/NIMH NIH HHS/ -- UL1 RR024146/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2008 Dec 12;322(5908):1700-2. doi: 10.1126/science.1164908.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, USA. michael.minzenberg@ucdmc.ucdavis.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19074351" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Benzhydryl Compounds/administration & dosage/*pharmacology ; Brain Mapping ; Central Nervous System Stimulants/pharmacology ; *Cognition/drug effects ; Female ; Humans ; Locus Coeruleus/drug effects/*physiology ; Magnetic Resonance Imaging ; Male ; Neurons/drug effects/physiology ; Norepinephrine/*metabolism ; Norepinephrine Plasma Membrane Transport Proteins/antagonists & ; inhibitors/metabolism ; Prefrontal Cortex/physiology ; Task Performance and Analysis
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  • 60
    Publication Date: 2008-05-31
    Description: The question of how the human brain represents conceptual knowledge has been debated in many scientific fields. Brain imaging studies have shown that different spatial patterns of neural activation are associated with thinking about different semantic categories of pictures and words (for example, tools, buildings, and animals). We present a computational model that predicts the functional magnetic resonance imaging (fMRI) neural activation associated with words for which fMRI data are not yet available. This model is trained with a combination of data from a trillion-word text corpus and observed fMRI data associated with viewing several dozen concrete nouns. Once trained, the model predicts fMRI activation for thousands of other concrete nouns in the text corpus, with highly significant accuracies over the 60 nouns for which we currently have fMRI data.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mitchell, Tom M -- Shinkareva, Svetlana V -- Carlson, Andrew -- Chang, Kai-Min -- Malave, Vicente L -- Mason, Robert A -- Just, Marcel Adam -- New York, N.Y. -- Science. 2008 May 30;320(5880):1191-5. doi: 10.1126/science.1152876.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Tom.Mitchell@cs.cmu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18511683" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Brain/*physiology ; Brain Mapping ; Computational Biology ; Female ; Humans ; *Language ; Magnetic Resonance Imaging ; Male ; Models, Neurological ; Models, Statistical ; Semantics ; Speech Perception/*physiology
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  • 61
    Publication Date: 2008-08-23
    Description: Common wisdom holds that choice decisions are based on conscious deliberations of the available information about choice options. On the basis of recent insights about unconscious influences on information processing, we tested whether automatic mental associations of undecided individuals bias future choices in a manner such that these choices reflect the evaluations implied by earlier automatic associations. With the use of a computer-based, speeded categorization task to assess automatic mental associations (i.e., associations that are activated unintentionally, difficult to control, and not necessarily endorsed at a conscious level) and self-report measures to assess consciously endorsed beliefs and choice preferences, automatic associations of undecided participants predicted changes in consciously reported beliefs and future choices over a period of 1 week. Conversely, for decided participants, consciously reported beliefs predicted changes in automatic associations and future choices over the same period. These results indicate that decision-makers sometimes have already made up their mind at an unconscious level, even when they consciously indicate that they are still undecided.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galdi, Silvia -- Arcuri, Luciano -- Gawronski, Bertram -- New York, N.Y. -- Science. 2008 Aug 22;321(5892):1100-2. doi: 10.1126/science.1160769.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Psychology and Socialization, University of Padova, Via Venezia 8, 35131 Padova, Italy. silvia.galdi@unipd.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18719288" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Attitude ; *Choice Behavior ; Culture ; *Decision Making ; Female ; Humans ; Longitudinal Studies ; Male ; *Mental Processes ; Middle Aged ; Politics ; *Unconscious (Psychology)
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  • 62
    Publication Date: 2008-02-16
    Description: Alcohol dependence is a major public health challenge in need of new treatments. As alcoholism evolves, stress systems in the brain play an increasing role in motivating continued alcohol use and relapse. We investigated the role of the neurokinin 1 receptor (NK1R), a mediator of behavioral stress responses, in alcohol dependence and treatment. In preclinical studies, mice genetically deficient in NK1R showed a marked decrease in voluntary alcohol consumption and had an increased sensitivity to the sedative effects of alcohol. In a randomized controlled experimental study, we treated recently detoxified alcoholic inpatients with an NK1R antagonist (LY686017; n = 25) or placebo (n = 25). LY686017 suppressed spontaneous alcohol cravings, improved overall well-being, blunted cravings induced by a challenge procedure, and attenuated concomitant cortisol responses. Brain functional magnetic resonance imaging responses to affective stimuli likewise suggested beneficial LY686017 effects. Thus, as assessed by these surrogate markers of efficacy, NK1R antagonism warrants further investigation as a treatment in alcoholism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉George, David T -- Gilman, Jodi -- Hersh, Jacqueline -- Thorsell, Annika -- Herion, David -- Geyer, Christopher -- Peng, Xiaomei -- Kielbasa, William -- Rawlings, Robert -- Brandt, John E -- Gehlert, Donald R -- Tauscher, Johannes T -- Hunt, Stephen P -- Hommer, Daniel -- Heilig, Markus -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2008 Mar 14;319(5869):1536-9. doi: 10.1126/science.1153813. Epub 2008 Feb 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276852" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; *Alcohol Drinking/drug therapy ; Alcoholism/*drug therapy ; Animals ; Behavior, Addictive/drug therapy ; Brain/drug effects/physiology ; Emotions/drug effects ; Ethanol/administration & dosage/pharmacology ; Female ; Humans ; Hydrocortisone/blood ; Magnetic Resonance Imaging ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; *Neurokinin-1 Receptor Antagonists ; Pyridines/administration & dosage/pharmacology/*therapeutic use ; Receptors, Neurokinin-1/deficiency/genetics/*physiology ; Triazoles/administration & dosage/pharmacology/*therapeutic use
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  • 63
    Publication Date: 2009-08-15
    Description: Sleep deprivation can impair human health and performance. Habitual total sleep time and homeostatic sleep response to sleep deprivation are quantitative traits in humans. Genetic loci for these traits have been identified in model organisms, but none of these potential animal models have a corresponding human genotype and phenotype. We have identified a mutation in a transcriptional repressor (hDEC2-P385R) that is associated with a human short sleep phenotype. Activity profiles and sleep recordings of transgenic mice carrying this mutation showed increased vigilance time and less sleep time than control mice in a zeitgeber time- and sleep deprivation-dependent manner. These mice represent a model of human sleep homeostasis that provides an opportunity to probe the effect of sleep on human physical and mental health.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884988/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884988/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉He, Ying -- Jones, Christopher R -- Fujiki, Nobuhiro -- Xu, Ying -- Guo, Bin -- Holder, Jimmy L Jr -- Rossner, Moritz J -- Nishino, Seiji -- Fu, Ying-Hui -- HL059596/HL/NHLBI NIH HHS/ -- MH074924/MH/NIMH NIH HHS/ -- R01 HL059596/HL/NHLBI NIH HHS/ -- R01 HL059596-09/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2009 Aug 14;325(5942):866-70. doi: 10.1126/science.1174443.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, University of California at San Francisco, Mission Bay, 1550 Fourth Street, San Francisco, CA 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19679812" target="_blank"〉PubMed〈/a〉
    Keywords: Activity Cycles/genetics ; Adolescent ; Adult ; Aged ; Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Animals, Genetically Modified ; Basic Helix-Loop-Helix Transcription Factors/chemistry/*genetics/physiology ; Child ; Circadian Rhythm/genetics ; Drosophila/genetics ; Electroencephalography ; Electromyography ; Female ; Homeostasis ; Humans ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Middle Aged ; Molecular Sequence Data ; Pedigree ; Point Mutation ; Sleep/*genetics/physiology ; Sleep Deprivation ; Sleep, REM/genetics/physiology ; Transcription Factors/chemistry/genetics/physiology ; Wakefulness
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  • 64
    Publication Date: 2009-08-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCaw, James M -- McVernon, Jodie -- McBryde, Emma S -- Mathews, John D -- New York, N.Y. -- Science. 2009 Aug 28;325(5944):1071; author reply 1072-3. doi: 10.1126/science.325_1071a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19713508" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; Disease Susceptibility ; Humans ; Immunity ; *Influenza A Virus, H1N1 Subtype/immunology ; Influenza, Human/*epidemiology/*immunology
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  • 65
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-05-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2008 May 2;320(5876):606-7. doi: 10.1126/science.320.5876.606.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18451279" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; Blindness/genetics/*therapy ; Carrier Proteins/genetics ; Child ; Clinical Trials as Topic ; Dogs ; Eye Proteins/genetics ; *Genetic Therapy ; Humans ; Infant ; Male ; Retinal Diseases/genetics/*therapy ; cis-trans-Isomerases
    Print ISSN: 0036-8075
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  • 66
    Publication Date: 2009-05-09
    Description: Throughout the history of mathematics, concepts of number and space have been tightly intertwined. We tested the hypothesis that cortical circuits for spatial attention contribute to mental arithmetic in humans. We trained a multivariate classifier algorithm to infer the direction of an eye movement, left or right, from the brain activation measured in the posterior parietal cortex. Without further training, the classifier then generalized to an arithmetic task. Its left versus right classification could be used to sort out subtraction versus addition trials, whether performed with symbols or with sets of dots. These findings are consistent with the suggestion that mental arithmetic co-opts parietal circuitry associated with spatial coding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knops, Andre -- Thirion, Bertrand -- Hubbard, Edward M -- Michel, Vincent -- Dehaene, Stanislas -- New York, N.Y. -- Science. 2009 Jun 19;324(5934):1583-5. doi: 10.1126/science.1171599. Epub 2009 May 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM, Cognitive Neuroimaging Unit, F-91191 Gif-sur-Yvette, France. knops.andre@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19423779" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Eye Movements/*physiology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; *Mathematics ; Mental Processes/*physiology ; Parietal Lobe/*physiology ; Recruitment, Neurophysiological
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  • 67
    Publication Date: 2009-10-17
    Description: Placebo analgesia is a prime example of the impact that psychological factors have on pain perception. We used functional magnetic resonance imaging of the human spinal cord to test the hypothesis that placebo analgesia results in a reduction of nociceptive processing in the spinal cord. In line with behavioral data that show decreased pain responses under placebo, pain-related activity in the spinal cord is strongly reduced under placebo. These results provide direct evidence for spinal inhibition as one mechanism of placebo analgesia and highlight that psychological factors can act on the earliest stages of pain processing in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eippert, Falk -- Finsterbusch, Jurgen -- Bingel, Ulrike -- Buchel, Christian -- New York, N.Y. -- Science. 2009 Oct 16;326(5951):404. doi: 10.1126/science.1180142.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. f.eippert@uke.uni-hamburg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19833962" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Analgesia/*psychology ; Analgesics/therapeutic use ; Humans ; Lidocaine/therapeutic use ; Magnetic Resonance Imaging ; Male ; Pain/drug therapy/*psychology ; Pain Measurement ; Pain Threshold ; *Placebo Effect ; Placebos/*therapeutic use ; Posterior Horn Cells/physiology ; Spinal Cord/*physiology ; Young Adult
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  • 68
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-08-22
    Description: The criteria to assess public health policies are fundamental to policy optimization. Using a model parametrized with survey-based contact data and mortality data from influenza pandemics, we determined optimal vaccine allocation for five outcome measures: deaths, infections, years of life lost, contingent valuation, and economic costs. We find that optimal vaccination is achieved by prioritization of schoolchildren and adults aged 30 to 39 years. Schoolchildren are most responsible for transmission, and their parents serve as bridges to the rest of the population. Our results indicate that consideration of age-specific transmission dynamics is paramount to the optimal allocation of influenza vaccines. We also found that previous and new recommendations from the U.S. Centers for Disease Control and Prevention both for the novel swine-origin influenza and, particularly, for seasonal influenza, are suboptimal for all outcome measures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Medlock, Jan -- Galvani, Alison P -- New York, N.Y. -- Science. 2009 Sep 25;325(5948):1705-8. doi: 10.1126/science.1175570. Epub 2009 Aug 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520-8034, USA. medlock@clemson.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19696313" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Aged ; Centers for Disease Control and Prevention (U.S.) ; Child ; Child, Preschool ; Disease Outbreaks/*prevention & control ; Health Policy ; Humans ; *Immunization Programs ; Infant ; Influenza A Virus, H1N1 Subtype/immunology ; *Influenza A virus/immunology ; Influenza Vaccines/*administration & dosage/*supply & distribution ; Influenza, Human/epidemiology/mortality/*prevention & control/transmission ; Middle Aged ; Models, Statistical ; United States/epidemiology ; Vaccination ; Young Adult
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  • 69
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-03-03
    Description: In two experiments, children and adults rated pairs of faces from election races. Naive adults judged a pair on competence; after playing a game, children chose who they would prefer to be captain of their boat. Children's (as well as adults') preferences accurately predicted actual election outcomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Antonakis, John -- Dalgas, Olaf -- New York, N.Y. -- Science. 2009 Feb 27;323(5918):1183. doi: 10.1126/science.1167748.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Faculty of Business and Economics, University of Lausanne, 1015 Lausanne, Switzerland. john.antonakis@unil.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19251621" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; *Choice Behavior ; *Face ; Female ; Forecasting ; Games, Experimental ; Humans ; Male ; Middle Aged ; Physiognomy ; *Politics ; Probability ; Regression Analysis ; Young Adult
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  • 70
    Publication Date: 2009-02-07
    Description: Existing research reports inconsistent findings with regard to the effect of color on cognitive task performances. Some research suggests that blue or green leads to better performances than red; other studies record the opposite. Current work reconciles this discrepancy. We demonstrate that red (versus blue) color induces primarily an avoidance (versus approach) motivation (study 1, n = 69) and that red enhances performance on a detail-oriented task, whereas blue enhances performance on a creative task (studies 2 and 3, n = 208 and 118). Further, we replicate these results in the domains of product design (study 4, n = 42) and persuasive message evaluation (study 5, n = 161) and show that these effects occur outside of individuals' consciousness (study 6, n = 68). We also provide process evidence suggesting that the activation of alternative motivations mediates the effect of color on cognitive task performances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mehta, Ravi -- Zhu, Rui Juliet -- New York, N.Y. -- Science. 2009 Feb 27;323(5918):1226-9. doi: 10.1126/science.1169144. Epub 2009 Feb 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sauder School of Business, University of British Columbia, 2053 Main Mall, Vancouver, BC V6T 1Z2, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19197022" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Cognition ; *Color ; Creativity ; Female ; Humans ; Male ; *Mental Processes ; Mental Recall ; Motivation ; *Task Performance and Analysis ; Young Adult
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  • 71
    Publication Date: 2009-05-02
    Description: Schizophrenia is a devastating, highly heritable brain disorder of unknown etiology. Recently, the first common genetic variant associated on a genome-wide level with schizophrenia and possibly bipolar disorder was discovered in ZNF804A (rs1344706). We show, by using an imaging genetics approach, that healthy carriers of rs1344706 risk genotypes exhibit no changes in regional activity but pronounced gene dosage-dependent alterations in functional coupling (correlated activity) of dorsolateral prefrontal cortex (DLPFC) across hemispheres and with hippocampus, mirroring findings in patients, and abnormal coupling of amygdala. Our findings establish disturbed connectivity as a neurogenetic risk mechanism for psychosis supported by genome-wide association, show that rs1344706 or variation in linkage disequilibrium is functional in human brain, and validate the intermediate phenotype strategy in psychiatry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Esslinger, Christine -- Walter, Henrik -- Kirsch, Peter -- Erk, Susanne -- Schnell, Knut -- Arnold, Claudia -- Haddad, Leila -- Mier, Daniela -- Opitz von Boberfeld, Carola -- Raab, Kyeon -- Witt, Stephanie H -- Rietschel, Marcella -- Cichon, Sven -- Meyer-Lindenberg, Andreas -- New York, N.Y. -- Science. 2009 May 1;324(5927):605. doi: 10.1126/science.1167768.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19407193" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Affective Symptoms/genetics/physiopathology ; Bipolar Disorder/genetics/physiopathology ; Brain Mapping ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Hippocampus/*physiology ; Humans ; Kruppel-Like Transcription Factors/*genetics ; Magnetic Resonance Imaging ; Male ; Mental Processes ; Phenotype ; *Polymorphism, Single Nucleotide ; Prefrontal Cortex/*physiology ; Schizophrenia/*genetics/physiopathology
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  • 72
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-09-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, Richard -- New York, N.Y. -- Science. 2009 Sep 18;325(5947):1482-3. doi: 10.1126/science.325_1482.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19762610" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Antibodies, Viral/biosynthesis ; Child ; China/epidemiology ; Disease Outbreaks/*prevention & control ; Humans ; Influenza A Virus, H1N1 Subtype/*immunology ; *Influenza Vaccines/administration & dosage/immunology/supply & distribution ; Influenza, Human/epidemiology/*prevention & control ; *Mass Vaccination
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  • 73
    Publication Date: 2009-04-11
    Description: Heterozygous mutations in the gene encoding isocitrate dehydrogenase-1 (IDH1) occur in certain human brain tumors, but their mechanistic role in tumor development is unknown. We have shown that tumor-derived IDH1 mutations impair the enzyme's affinity for its substrate and dominantly inhibit wild-type IDH1 activity through the formation of catalytically inactive heterodimers. Forced expression of mutant IDH1 in cultured cells reduces formation of the enzyme product, alpha-ketoglutarate (alpha-KG), and increases the levels of hypoxia-inducible factor subunit HIF-1alpha, a transcription factor that facilitates tumor growth when oxygen is low and whose stability is regulated by alpha-KG. The rise in HIF-1alpha levels was reversible by an alpha-KG derivative. HIF-1alpha levels were higher in human gliomas harboring an IDH1 mutation than in tumors without a mutation. Thus, IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251015/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251015/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhao, Shimin -- Lin, Yan -- Xu, Wei -- Jiang, Wenqing -- Zha, Zhengyu -- Wang, Pu -- Yu, Wei -- Li, Zhiqiang -- Gong, Lingling -- Peng, Yingjie -- Ding, Jianping -- Lei, Qunying -- Guan, Kun-Liang -- Xiong, Yue -- R01 CA068377/CA/NCI NIH HHS/ -- R01 CA068377-14/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2009 Apr 10;324(5924):261-5. doi: 10.1126/science.1170944.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular and Cell Biology Laboratory, Institute of Biomedical Sciences, Fudan University, 130 Dong-An Road, Shanghai 200032, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19359588" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Astrocytoma/genetics/metabolism ; Biocatalysis ; Brain Neoplasms/*genetics/metabolism ; Cell Line ; Child ; Female ; Gene Expression Regulation, Neoplastic ; Genes, Tumor Suppressor ; Glioblastoma/genetics/metabolism ; Glioma/*genetics/metabolism ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & ; inhibitors/genetics/*metabolism ; Isocitrate Dehydrogenase/chemistry/*genetics/*metabolism ; Ketoglutaric Acids/metabolism ; Male ; Middle Aged ; Mutant Proteins/chemistry/metabolism ; Oligodendroglioma/genetics/metabolism ; Oxalates/pharmacology ; Protein Multimerization
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  • 74
    Publication Date: 2009-10-17
    Description: Words, grammar, and phonology are linguistically distinct, yet their neural substrates are difficult to distinguish in macroscopic brain regions. We investigated whether they can be separated in time and space at the circuit level using intracranial electrophysiology (ICE), namely by recording local field potentials from populations of neurons using electrodes implanted in language-related brain regions while people read words verbatim or grammatically inflected them (present/past or singular/plural). Neighboring probes within Broca's area revealed distinct neuronal activity for lexical (approximately 200 milliseconds), grammatical (approximately 320 milliseconds), and phonological (approximately 450 milliseconds) processing, identically for nouns and verbs, in a region activated in the same patients and task in functional magnetic resonance imaging. This suggests that a linguistic processing sequence predicted on computational grounds is implemented in the brain in fine-grained spatiotemporally patterned activity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030760/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030760/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sahin, Ned T -- Pinker, Steven -- Cash, Sydney S -- Schomer, Donald -- Halgren, Eric -- HD18381/HD/NICHD NIH HHS/ -- NS18741/NS/NINDS NIH HHS/ -- NS44623/NS/NINDS NIH HHS/ -- P41 RR014075/RR/NCRR NIH HHS/ -- P41 RR014075-02/RR/NCRR NIH HHS/ -- P41-RR14075/RR/NCRR NIH HHS/ -- R01 HD018381-18/HD/NICHD NIH HHS/ -- R01 NS018741/NS/NINDS NIH HHS/ -- R01 NS018741-22/NS/NINDS NIH HHS/ -- R01 NS044623/NS/NINDS NIH HHS/ -- R01 NS044623-03/NS/NINDS NIH HHS/ -- T32 MH070328-03/MH/NIMH NIH HHS/ -- T32-MH070328/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2009 Oct 16;326(5951):445-9. doi: 10.1126/science.1174481.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Radiology, University of California-San Diego, La Jolla, CA 92037, USA. sahin@post.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19833971" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Brain Mapping ; Electrodes, Implanted ; Electrophysiological Phenomena ; Epilepsy/physiopathology ; Female ; Frontal Lobe/*physiology ; Humans ; *Language ; *Linguistics ; Magnetic Resonance Imaging ; Mental Processes/*physiology ; Middle Aged ; Neurons/*physiology ; Speech/*physiology ; Time Factors
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  • 75
    Publication Date: 2009-07-18
    Description: Adults with Asperger syndrome can understand mental states such as desires and beliefs (mentalizing) when explicitly prompted to do so, despite having impairments in social communication. We directly tested the hypothesis that such individuals nevertheless fail to mentalize spontaneously. To this end, we used an eye-tracking task that has revealed the spontaneous ability to mentalize in typically developing infants. We showed that, like infants, neurotypical adults' (n = 17 participants) eye movements anticipated an actor's behavior on the basis of her false belief. This was not the case for individuals with Asperger syndrome (n = 19). Thus, these individuals do not attribute mental states spontaneously, but they may be able to do so in explicit tasks through compensatory learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Senju, Atsushi -- Southgate, Victoria -- White, Sarah -- Frith, Uta -- G0701484/Medical Research Council/United Kingdom -- PTA 037-27-0107/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2009 Aug 14;325(5942):883-5. doi: 10.1126/science.1176170. Epub 2009 Jul 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Brain and Cognitive Development, Birkbeck, University of London, London, UK. a.senju@bbk.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19608858" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Asperger Syndrome/*psychology ; Comprehension ; Female ; Fixation, Ocular ; Humans ; Interpersonal Relations ; Learning ; Male ; *Mental Processes ; Middle Aged ; Psychological Tests ; Psychological Theory ; Saccades ; Young Adult
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  • 76
    Publication Date: 2009-12-08
    Description: Several common genetic variations have been associated with type 2 diabetes, but the exact disease mechanisms are still poorly elucidated. Using congenic strains from the diabetic Goto-Kakizaki rat, we identified a 1.4-megabase genomic locus that was linked to impaired insulin granule docking at the plasma membrane and reduced beta cell exocytosis. In this locus, Adra2a, encoding the alpha2A-adrenergic receptor [alpha(2A)AR], was significantly overexpressed. Alpha(2A)AR mediates adrenergic suppression of insulin secretion. Pharmacological receptor antagonism, silencing of receptor expression, or blockade of downstream effectors rescued insulin secretion in congenic islets. Furthermore, we identified a single-nucleotide polymorphism in the human ADRA2A gene for which risk allele carriers exhibited overexpression of alpha(2A)AR, reduced insulin secretion, and increased type 2 diabetes risk. Human pancreatic islets from risk allele carriers exhibited reduced granule docking and secreted less insulin in response to glucose; both effects were counteracted by pharmacological alpha(2A)AR antagonists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosengren, Anders H -- Jokubka, Ramunas -- Tojjar, Damon -- Granhall, Charlotte -- Hansson, Ola -- Li, Dai-Qing -- Nagaraj, Vini -- Reinbothe, Thomas M -- Tuncel, Jonatan -- Eliasson, Lena -- Groop, Leif -- Rorsman, Patrik -- Salehi, Albert -- Lyssenko, Valeriya -- Luthman, Holger -- Renstrom, Erik -- New York, N.Y. -- Science. 2010 Jan 8;327(5962):217-20. doi: 10.1126/science.1176827. Epub 2009 Nov 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lund University Diabetes Centre, Malmo, SE-20502 Malmo, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965390" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adrenergic alpha-2 Receptor Agonists ; Adrenergic alpha-2 Receptor Antagonists ; Adrenergic alpha-Agonists/pharmacology ; Adrenergic alpha-Antagonists/pharmacology ; Adult ; Aged ; Animals ; Animals, Congenic ; Blood Glucose/metabolism ; Cell Membrane/metabolism ; Cyclic AMP/metabolism ; Diabetes Mellitus, Type 2/*genetics/metabolism ; Exocytosis ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Insulin/blood/*secretion ; Insulin-Secreting Cells/*secretion ; Middle Aged ; Polymorphism, Single Nucleotide ; RNA Interference ; Rats ; Rats, Inbred Strains ; Receptors, Adrenergic, alpha-2/*genetics/*metabolism ; Risk Factors ; Secretory Vesicles/metabolism ; Up-Regulation ; Young Adult
    Print ISSN: 0036-8075
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  • 77
    Publication Date: 2005-11-19
    Description: The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for schizophrenia, but its mechanistic role in the disorder is unknown. Here we report that the gene encoding phosphodiesterase 4B (PDE4B) is disrupted by a balanced translocation in a subject diagnosed with schizophrenia and a relative with chronic psychiatric illness. The PDEs inactivate adenosine 3',5'-monophosphate (cAMP), a second messenger implicated in learning, memory, and mood. We show that DISC1 interacts with the UCR2 domain of PDE4B and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and an increase in PDE4B activity. We propose a mechanistic model whereby DISC1 sequesters PDE4B in resting cells and releases it in an activated state in response to elevated cAMP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Millar, J Kirsty -- Pickard, Benjamin S -- Mackie, Shaun -- James, Rachel -- Christie, Sheila -- Buchanan, Sebastienne R -- Malloy, M Pat -- Chubb, Jennifer E -- Huston, Elaine -- Baillie, George S -- Thomson, Pippa A -- Hill, Elaine V -- Brandon, Nicholas J -- Rain, Jean-Christophe -- Camargo, L Miguel -- Whiting, Paul J -- Houslay, Miles D -- Blackwood, Douglas H R -- Muir, Walter J -- Porteous, David J -- G8604010/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1187-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, UK. Kirsty.Millar@ed.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293762" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-AMP Phosphodiesterases/*genetics/metabolism ; Adult ; Affective Disorders, Psychotic/genetics/metabolism ; Animals ; Cadherins/genetics ; Cell Line ; Chromosomes, Human, Pair 1 ; Chromosomes, Human, Pair 16 ; Cyclic AMP/*metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Enzyme Activation ; Genetic Predisposition to Disease ; Humans ; Male ; Nerve Tissue Proteins/*genetics/metabolism ; Protein Binding ; Rats ; Schizophrenia/enzymology/*genetics/metabolism ; *Signal Transduction ; Translocation, Genetic
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  • 78
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guzman, Maria G -- New York, N.Y. -- Science. 2005 Sep 2;309(5740):1495-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Virology Department, PAHO/WHO Collaborating Center for Viral Diseases, Instituto de Medicina Tropical "Pedro Kouri" Autopista Novia del Mediodia, Km 1/2, Post Office Box Mariano 13, Habana, Cuba. lupe@ipk.sld.cu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141052" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cuba/epidemiology ; Dengue/epidemiology/prevention & control/virology ; Dengue Virus/chemistry/immunology ; Humans ; Risk Factors ; Severe Dengue/*epidemiology ; Viral Vaccines
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  • 79
    Publication Date: 2005-02-01
    Description: Obesity occurs when energy intake exceeds energy expenditure. Humans expend energy through purposeful exercise and through changes in posture and movement that are associated with the routines of daily life [called nonexercise activity thermogenesis (NEAT)]. To examine NEAT's role in obesity, we recruited 10 lean and 10 mildly obese sedentary volunteers and measured their body postures and movements every half-second for 10 days. Obese individuals were seated, on average, 2 hours longer per day than lean individuals. Posture allocation did not change when the obese individuals lost weight or when lean individuals gained weight, suggesting that it is biologically determined. If obese individuals adopted the NEAT-enhanced behaviors of their lean counterparts, they might expend an additional 350 calories (kcal) per day.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, James A -- Lanningham-Foster, Lorraine M -- McCrady, Shelly K -- Krizan, Alisa C -- Olson, Leslie R -- Kane, Paul H -- Jensen, Michael D -- Clark, Matthew M -- DK56650/DK/NIDDK NIH HHS/ -- DK63226/DK/NIDDK NIH HHS/ -- DK66270/DK/NIDDK NIH HHS/ -- M01 RR00585/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2005 Jan 28;307(5709):584-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA. Jim@Mayo.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15681386" target="_blank"〉PubMed〈/a〉
    Keywords: Activities of Daily Living ; Adult ; *Body Weight ; Energy Intake ; *Energy Metabolism ; Female ; Humans ; Locomotion ; Male ; Middle Aged ; *Motor Activity ; *Movement ; Obesity/*physiopathology ; Overnutrition ; Pilot Projects ; *Posture ; *Thermogenesis ; Weight Gain ; Weight Loss
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  • 80
    Publication Date: 2005-04-02
    Description: We analyzed the mortality impacts and greenhouse gas (GHG) emissions produced by household energy use in Africa. Under a business-as-usual (BAU) scenario, household indoor air pollution will cause an estimated 9.8 million premature deaths by the year 2030. Gradual and rapid transitions to charcoal would delay 1.0 million and 2.8 million deaths, respectively; similar transitions to petroleum fuels would delay 1.3 million and 3.7 million deaths. Cumulative BAU GHG emissions will be 6.7 billion tons of carbon by 2050, which is 5.6% of Africa's total emissions. Large shifts to the use of fossil fuels would reduce GHG emissions by 1 to 10%. Charcoal-intensive future scenarios using current practices increase emissions by 140 to 190%; the increase can be reduced to 5 to 36% using currently available technologies for sustainable production or potentially reduced even more with investment in technological innovation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bailis, Robert -- Ezzati, Majid -- Kammen, Daniel M -- P01-AG17625/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2005 Apr 1;308(5718):98-103.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Energy and Resources Group, University of California, Berkeley, CA 94720-3050, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15802601" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Africa South of the Sahara ; *Air Pollution, Indoor/adverse effects/prevention & control ; *Biomass ; Carbon Dioxide ; Charcoal ; Child ; Costs and Cost Analysis ; Databases, Factual ; *Energy-Generating Resources/economics ; Female ; Forecasting ; Fossil Fuels ; *Greenhouse Effect ; Humans ; Mortality/trends ; *Petroleum ; Public Health/trends ; Pulmonary Disease, Chronic Obstructive/*mortality ; Respiratory Tract Infections/*mortality ; Rural Population ; Urban Population ; Wood
    Print ISSN: 0036-8075
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  • 81
    Publication Date: 2005-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, Dennis -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1027.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718437" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Asia, Southeastern/epidemiology ; Cambodia/epidemiology ; Disease Outbreaks/veterinary ; Female ; Humans ; *Influenza A virus ; Influenza in Birds/*epidemiology ; Influenza, Human/*epidemiology/transmission/*virology ; Male ; *Population Surveillance ; Poultry
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  • 82
    Publication Date: 2005-03-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mann, Charles C -- New York, N.Y. -- Science. 2005 Mar 18;307(5716):1716-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15774742" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Age Factors ; Aged ; Body Mass Index ; Child ; Female ; Humans ; Incidence ; Life Expectancy/*trends ; Male ; Mortality ; Obesity/complications/*epidemiology ; Public Health ; United States/epidemiology
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  • 83
    Publication Date: 2005-12-13
    Description: Much is known about how people make decisions under varying levels of probability (risk). Less is known about the neural basis of decision-making when probabilities are uncertain because of missing information (ambiguity). In decision theory, ambiguity about probabilities should not affect choices. Using functional brain imaging, we show that the level of ambiguity in choices correlates positively with activation in the amygdala and orbitofrontal cortex, and negatively with a striatal system. Moreover, striatal activity correlates positively with expected reward. Neurological subjects with orbitofrontal lesions were insensitive to the level of ambiguity and risk in behavioral choices. These data suggest a general neural circuit responding to degrees of uncertainty, contrary to decision theory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, Ming -- Bhatt, Meghana -- Adolphs, Ralph -- Tranel, Daniel -- Camerer, Colin F -- P01 NS19632/NS/NINDS NIH HHS/ -- R01 MH067681/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1680-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Humanities and Social Sciences, 228-77, California Institute of Technology, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339445" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Amygdala/physiology ; Brain/*physiology ; Brain Diseases/physiopathology/psychology ; Brain Mapping ; Confidence Intervals ; Corpus Striatum/physiology ; *Decision Making ; Decision Theory ; Female ; Frontal Lobe/physiology ; Games, Experimental ; Humans ; Likelihood Functions ; Magnetic Resonance Imaging ; Male ; *Mental Processes ; Probability ; Reward ; Risk ; *Uncertainty
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  • 84
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Russo, Tommaso -- Volterra, Virginia -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):56; author reply 56.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Philosophy, University of Calabria, Via Piero Bucci, 87036 Rende (CS), Italy. t.russo@mclink.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994513" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; Communication ; Deafness ; Gestures ; Humans ; Language ; *Learning ; Linguistics ; Nicaragua ; *Sign Language ; Speech
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  • 85
    Publication Date: 2005-10-01
    Description: Intraoperative electrical stimulation, which temporarily inactivates restricted regions during brain surgery, can map cognitive functions in humans with spatiotemporal resolution unmatched by other methods. Using this technique, we found that stimulation of the right inferior parietal lobule or the caudal superior temporal gyrus, but not of its rostral portion, determined rightward deviations on line bisection. However, the strongest shifts occurred with subcortical stimulation. Fiber tracking identified the stimulated site as a section of the superior occipitofrontal fasciculus, a poorly known parietal-frontal pathway. These findings suggest that parietal-frontal communication is necessary for the symmetrical processing of the visual scene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thiebaut de Schotten, Michel -- Urbanski, Marika -- Duffau, Hugues -- Volle, Emmanuelle -- Levy, Richard -- Dubois, Bruno -- Bartolomeo, Paolo -- New York, N.Y. -- Science. 2005 Sep 30;309(5744):2226-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM Unit 610, Assistance Publique-Hopitaux de Paris, Hopital de la Salpetriere, 75013 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16195465" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Awareness/*physiology ; Brain Mapping ; Brain Neoplasms/surgery ; Electric Stimulation ; Female ; Frontal Lobe/*physiology ; Glioma/surgery ; Humans ; Male ; Nerve Net/*physiology ; Neural Pathways/*physiology ; Parietal Lobe/*physiology ; Perceptual Disorders/physiopathology ; Space Perception/*physiology ; Temporal Lobe/physiology
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  • 86
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Aug 5;309(5736):860.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16081704" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/epidemiology/*prevention & control ; Adult ; Biomedical Research/ethics ; *Circumcision, Male ; Global Health ; Humans ; Male ; Publishing/standards ; South Africa
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  • 87
    Publication Date: 2005-03-19
    Description: Type VII collagen defects cause recessive dystrophic epidermolysis bullosa (RDEB), a blistering skin disorder often accompanied by epidermal cancers. To study the role of collagen VII in these cancers, we examined Ras-driven tumorigenesis in RDEB keratinocytes. Cells devoid of collagen VII did not form tumors in mice, whereas those retaining a specific collagen VII fragment (the amino-terminal noncollagenous domain NC1) were tumorigenic. Forced NC1 expression restored tumorigenicity to collagen VII-null epidermis in a non-cell-autonomous fashion. Fibronectin-like sequences within NC1 (FNC1) promoted tumor cell invasion in a laminin 5-dependent manner and were required for tumorigenesis. Tumor-stroma interactions mediated by collagen VII thus promote neoplasia, and retention of NC1 sequences in a subset of RDEB patients may contribute to their increased susceptibility to squamous cell carcinoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ortiz-Urda, Susana -- Garcia, John -- Green, Cheryl L -- Chen, Lei -- Lin, Qun -- Veitch, Dallas P -- Sakai, Lynn Y -- Lee, Hyangkyu -- Marinkovich, M Peter -- Khavari, Paul A -- AR43799/AR/NIAMS NIH HHS/ -- AR44012/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Mar 18;307(5716):1773-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15774758" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; Antibodies/immunology ; Apoptosis ; Carcinoma, Squamous Cell/etiology/*physiopathology ; Cell Adhesion Molecules/immunology/metabolism ; Cell Proliferation ; Cell Transformation, Neoplastic ; Child ; Collagen Type VII/chemistry/*genetics/immunology/*physiology ; Disease Susceptibility ; Epidermolysis Bullosa Dystrophica/complications/*genetics/metabolism/pathology ; Female ; *Genes, ras ; Humans ; I-kappa B Proteins/genetics/metabolism ; Keratinocytes/*metabolism/pathology ; Male ; Mice ; Mice, SCID ; Middle Aged ; Mutation ; Neoplasm Invasiveness ; Protein Structure, Tertiary ; Skin Neoplasms/etiology/pathology/*physiopathology
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  • 88
    Publication Date: 2005-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freyd, Jennifer J -- Putnam, Frank W -- Lyon, Thomas D -- Becker-Blease, Kathryn A -- Cheit, Ross E -- Siegel, Nancy B -- Pezdek, Kathy -- R01 HD047290/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2005 Apr 22;308(5721):501.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Oregon, Eugene, OR, 97403-1227, USA. jjf@dynamic. uoregon.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15845837" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; *Child Abuse, Sexual/economics/prevention & control/psychology/statistics & ; numerical data ; Cost-Benefit Analysis ; Education ; Education, Medical ; Education, Professional ; Humans ; Interdisciplinary Communication ; Memory ; Mental Health Services ; Public Policy ; *Research ; United States
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):38-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210512" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Advisory Committees ; *Contraceptives, Postcoital/adverse effects ; *Drug Approval ; Female ; Humans ; *Levonorgestrel/adverse effects ; *Nonprescription Drugs/adverse effects ; Politics ; Sexual Behavior ; United States ; *United States Food and Drug Administration
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  • 90
    Publication Date: 2005-04-02
    Description: Neuronal groups can interact with each other even if they are widely separated. One group might modulate its firing rate or its internal oscillatory synchronization to influence another group. We propose that coherence between two neuronal groups is a mechanism of efficient interaction, because it renders mutual input optimally timed and thereby maximally effective. Modulations of subjects' readiness to respond in a simple reaction-time task were closely correlated with the strength of gamma-band (40 to 70 hertz) coherence between motor cortex and spinal cord neurons. This coherence may contribute to an effective corticospinal interaction and shortened reaction times.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schoffelen, Jan-Mathijs -- Oostenveld, Robert -- Fries, Pascal -- New York, N.Y. -- Science. 2005 Apr 1;308(5718):111-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉F. C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EK Nijmegen, Netherlands. jan.schoffelen@fcdonders.ru.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15802603" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Adult ; Electromyography ; Female ; Humans ; Magnetoencephalography ; Male ; Motor Cortex/*physiology ; Motor Neurons/*physiology ; Photic Stimulation ; Psychomotor Performance ; *Reaction Time ; Spinal Cord/*physiology
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  • 91
    Publication Date: 2005-08-27
    Description: We have explored the use of embryonic stem cells as an alternative to oocytes for reprogramming human somatic nuclei. Human embryonic stem (hES) cells were fused with human fibroblasts, resulting in hybrid cells that maintain a stable tetraploid DNA content and have morphology, growth rate, and antigen expression patterns characteristic of hES cells. Differentiation of hybrid cells in vitro and in vivo yielded cell types from each embryonic germ layer. Analysis of genome-wide transcriptional activity, reporter gene activation, allele-specific gene expression, and DNA methylation showed that the somatic genome was reprogrammed to an embryonic state. These results establish that hES cells can reprogram the transcriptional state of somatic nuclei and provide a system for investigating the underlying mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cowan, Chad A -- Atienza, Jocelyn -- Melton, Douglas A -- Eggan, Kevin -- New York, N.Y. -- Science. 2005 Aug 26;309(5739):1369-73.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Harvard Stem Cell Institute, Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16123299" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Biomarkers/analysis ; Cell Cycle ; Cell Differentiation ; *Cell Fusion ; Cell Line ; Cell Nucleus/*physiology ; Cell Shape ; Cell Transplantation ; Chromosomes, Human/genetics ; Embryo, Mammalian/*cytology ; Epigenesis, Genetic ; Female ; Fibroblasts/cytology/*physiology ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Humans ; Hybrid Cells/cytology/*physiology ; Male ; Mice ; Mice, Nude ; Phenotype ; Pluripotent Stem Cells/cytology/*physiology ; Polyploidy ; Teratoma/pathology ; Transcription, Genetic ; Transcriptional Activation ; Transfection
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  • 92
    Publication Date: 2005-12-24
    Description: Here we describe a functional magnetic resonance imaging study of humans engaged in memory search during a free recall task. Patterns of cortical activity associated with the study of three categories of pictures (faces, locations, and objects) were identified by a pattern-classification algorithm. The algorithm was used to track the reappearance of these activity patterns during the recall period. The reappearance of a given category's activity pattern correlates with verbal recalls made from that category and precedes the recall event by several seconds. This result is consistent with the hypothesis that category-specific activity is cueing the memory system to retrieve studied items.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Polyn, Sean M -- Natu, Vaidehi S -- Cohen, Jonathan D -- Norman, Kenneth A -- MH070177-01/MH/NIMH NIH HHS/ -- R01MH052864/MH/NIMH NIH HHS/ -- R01MH069456/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2005 Dec 23;310(5756):1963-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA. polyn@psych.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16373577" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Algorithms ; Brain/*physiology ; *Brain Mapping ; Female ; Form Perception/physiology ; Humans ; Magnetic Resonance Imaging ; Male ; Memory/*physiology ; Mental Recall/physiology ; Space Perception/physiology
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  • 93
    Publication Date: 2005-08-06
    Description: Functional magnetic resonance imaging (fMRI) is an important tool for investigating human brain function, but the relationship between the hemodynamically based fMRI signals in the human brain and the underlying neuronal activity is unclear. We recorded single unit activity and local field potentials in auditory cortex of two neurosurgical patients and compared them with the fMRI signals of 11 healthy subjects during presentation of an identical movie segment. The predicted fMRI signals derived from single units and the measured fMRI signals from auditory cortex showed a highly significant correlation (r = 0.75, P 〈 10(-47)). Thus, fMRI signals can provide a reliable measure of the firing rate of human cortical neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mukamel, Roy -- Gelbard, Hagar -- Arieli, Amos -- Hasson, Uri -- Fried, Itzhak -- Malach, Rafael -- New York, N.Y. -- Science. 2005 Aug 5;309(5736):951-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16081741" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Auditory Cortex/*physiology ; Brain Mapping ; Epilepsy/physiopathology ; Evoked Potentials, Auditory ; Female ; Humans ; *Magnetic Resonance Imaging ; Middle Aged ; Motion Pictures as Topic ; Neurons/*physiology ; Oxygen/blood
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  • 94
    Publication Date: 2005-08-05
    Description: Highly pathogenic avian influenza A (subtype H5N1) is threatening to cause a human pandemic of potentially devastating proportions. We used a stochastic influenza simulation model for rural Southeast Asia to investigate the effectiveness of targeted antiviral prophylaxis, quarantine, and pre-vaccination in containing an emerging influenza strain at the source. If the basic reproductive number (R0) was below 1.60, our simulations showed that a prepared response with targeted antivirals would have a high probability of containing the disease. In that case, an antiviral agent stockpile on the order of 100,000 to 1 million courses for treatment and prophylaxis would be sufficient. If pre-vaccination occurred, then targeted antiviral prophylaxis could be effective for containing strains with an R0 as high as 2.1. Combinations of targeted antiviral prophylaxis, pre-vaccination, and quarantine could contain strains with an R(0) as high as 2.4.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Longini, Ira M Jr -- Nizam, Azhar -- Xu, Shufu -- Ungchusak, Kumnuan -- Hanshaoworakul, Wanna -- Cummings, Derek A T -- Halloran, M Elizabeth -- R01-AI32042/AI/NIAID NIH HHS/ -- U01-GM070749/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Aug 12;309(5737):1083-7. Epub 2005 Aug 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, N.E., Atlanta, GA 30322, USA. longini@sph.emory.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16079251" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Antiviral Agents/*therapeutic use ; Asia, Southeastern/epidemiology ; Child ; Child, Preschool ; Disease Outbreaks/*prevention & control ; Humans ; Immunization Programs ; Infant ; *Influenza A virus/immunology ; *Influenza Vaccines ; Influenza, Human/epidemiology/*prevention & control/transmission/virology ; Models, Statistical ; *Quarantine ; Stochastic Processes ; Thailand/epidemiology ; Time Factors ; Vaccination
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  • 95
    Publication Date: 2005-09-06
    Description: The determination of the chimpanzee genome sequence provides a means to study both structural and functional aspects of the evolution of the human genome. Here we compare humans and chimpanzees with respect to differences in expression levels and protein-coding sequences for genes active in brain, heart, liver, kidney, and testis. We find that the patterns of differences in gene expression and gene sequences are markedly similar. In particular, there is a gradation of selective constraints among the tissues so that the brain shows the least differences between the species whereas liver shows the most. Furthermore, expression levels as well as amino acid sequences of genes active in more tissues have diverged less between the species than have genes active in fewer tissues. In general, these patterns are consistent with a model of neutral evolution with negative selection. However, for X-chromosomal genes expressed in testis, patterns suggestive of positive selection on sequence changes as well as expression changes are seen. Furthermore, although genes expressed in the brain have changed less than have genes expressed in other tissues, in agreement with previous work we find that genes active in brain have accumulated more changes on the human than on the chimpanzee lineage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Khaitovich, Philipp -- Hellmann, Ines -- Enard, Wolfgang -- Nowick, Katja -- Leinweber, Marcus -- Franz, Henriette -- Weiss, Gunter -- Lachmann, Michael -- Paabo, Svante -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1850-4. Epub 2005 Sep 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141373" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Amino Acid Sequence ; Animals ; Base Sequence ; Child ; Chromosomes, Human, X/genetics ; Chromosomes, Mammalian/genetics ; *Evolution, Molecular ; Female ; *Gene Expression ; Gene Expression Profiling ; Gene Expression Regulation ; *Genome ; *Genome, Human ; Heart/physiology ; Humans ; Kidney/physiology ; Liver/physiology ; Male ; Middle Aged ; Models, Genetic ; Oligonucleotide Array Sequence Analysis ; Organ Specificity ; Pan troglodytes/*genetics ; Prefrontal Cortex/physiology ; Promoter Regions, Genetic ; Proteins/genetics ; Selection, Genetic ; Sequence Analysis, DNA ; Species Specificity ; Testis/physiology ; *Transcription, Genetic ; X Chromosome/genetics
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  • 96
    Publication Date: 2005-10-08
    Description: Most people hold beliefs about personality characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal experience, stereotypes with a "kernel of truth," or inaccurate stereotypes. We obtained national character ratings of 3989 people from 49 cultures and compared them with the average personality scores of culture members assessed by observer ratings and self-reports. National character ratings were reliable but did not converge with assessed traits. Perceptions of national character thus appear to be unfounded stereotypes that may serve the function of maintaining a national identity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775052/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775052/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Terracciano, A -- Abdel-Khalek, A M -- Adam, N -- Adamovova, L -- Ahn, C-k -- Ahn, H-n -- Alansari, B M -- Alcalay, L -- Allik, J -- Angleitner, A -- Avia, M D -- Ayearst, L E -- Barbaranelli, C -- Beer, A -- Borg-Cunen, M A -- Bratko, D -- Brunner-Sciarra, M -- Budzinski, L -- Camart, N -- Dahourou, D -- De Fruyt, F -- de Lima, M P -- del Pilar, G E H -- Diener, E -- Falzon, R -- Fernando, K -- Fickova, E -- Fischer, R -- Flores-Mendoza, C -- Ghayur, M A -- Gulgoz, S -- Hagberg, B -- Halberstadt, J -- Halim, M S -- Hrebickova, M -- Humrichouse, J -- Jensen, H H -- Jocic, D D -- Jonsson, F H -- Khoury, B -- Klinkosz, W -- Knezevic, G -- Lauri, M A -- Leibovich, N -- Martin, T A -- Marusic, I -- Mastor, K A -- Matsumoto, D -- McRorie, M -- Meshcheriakov, B -- Mortensen, E L -- Munyae, M -- Nagy, J -- Nakazato, K -- Nansubuga, F -- Oishi, S -- Ojedokun, A O -- Ostendorf, F -- Paulhus, D L -- Pelevin, S -- Petot, J-M -- Podobnik, N -- Porrata, J L -- Pramila, V S -- Prentice, G -- Realo, A -- Reategui, N -- Rolland, J-P -- Rossier, J -- Ruch, W -- Rus, V S -- Sanchez-Bernardos, M L -- Schmidt, V -- Sciculna-Calleja, S -- Sekowski, A -- Shakespeare-Finch, J -- Shimonaka, Y -- Simonetti, F -- Sineshaw, T -- Siuta, J -- Smith, P B -- Trapnell, P D -- Trobst, K K -- Wang, L -- Yik, M -- Zupancic, A -- McCrae, R R -- Z99 AG999999/Intramural NIH HHS/ -- ZIA AG000180-25/Intramural NIH HHS/ -- ZIA AG000180-26/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):96-100.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute on Aging, NIH, DHHS, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. terraccianoa@grc.nia.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210536" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Character ; Cross-Cultural Comparison ; *Culture ; *Ethnic Groups ; Female ; Humans ; Male ; *Personality ; Personality Assessment ; Reproducibility of Results ; Social Perception ; Stereotyping ; Surveys and Questionnaires
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  • 97
    Publication Date: 2005-07-16
    Description: In everyday life, the successful monitoring of behavior requires continuous updating of the effectiveness of motor acts; one crucial step is becoming aware of the movements one is performing. We studied the anatomical distribution of lesions in right-brain-damaged hemiplegic patients, who obstinately denied their motor impairment, claiming that they could move their paralyzed limbs. Denial was associated with lesions in areas related to the programming of motor acts, particularly Brodmann's premotor areas 6 and 44, motor area 4, and the somatosensory cortex. This association suggests that monitoring systems may be implemented within the same cortical network that is responsible for the primary function that has to be monitored.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berti, A -- Bottini, G -- Gandola, M -- Pia, L -- Smania, N -- Stracciari, A -- Castiglioni, I -- Vallar, G -- Paulesu, E -- New York, N.Y. -- Science. 2005 Jul 15;309(5733):488-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Psychology Department and Center for Cognitive Science, University of Turin, Via Po 14, 10123 Turin, Italy. berti@psych.unito.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16020740" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Aged, 80 and over ; *Awareness ; Brain Damage, Chronic/pathology/*physiopathology ; Brain Mapping ; Frontal Lobe/pathology/physiopathology ; Hemiplegia/*physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor Activity ; Motor Cortex/pathology/*physiopathology ; Movement ; Nerve Net/physiology ; Perceptual Disorders/pathology/*physiopathology ; Prefrontal Cortex/pathology/physiopathology ; Somatosensory Cortex/*physiopathology
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  • 98
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Apr 29;308(5722):618-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860602" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Cervical Intraepithelial Neoplasia/prevention & control ; Clinical Trials as Topic ; Condylomata Acuminata/prevention & control ; Developed Countries ; Developing Countries ; Drug Approval ; Drug Industry ; Female ; Humans ; Immunization Programs ; Male ; Papillomaviridae/*immunology ; Papillomavirus Infections/*prevention & control/transmission ; Uterine Cervical Neoplasms/*prevention & control/*virology ; Vaccines, Synthetic ; *Viral Vaccines/administration & dosage/adverse effects/immunology
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  • 99
    Publication Date: 2005-01-08
    Description: Segmental duplications in the human genome are selectively enriched for genes involved in immunity, although the phenotypic consequences for host defense are unknown. We show that there are significant interindividual and interpopulation differences in the copy number of a segmental duplication encompassing the gene encoding CCL3L1 (MIP-1alphaP), a potent human immunodeficiency virus-1 (HIV-1)-suppressive chemokine and ligand for the HIV coreceptor CCR5. Possession of a CCL3L1 copy number lower than the population average is associated with markedly enhanced HIV/acquired immunodeficiency syndrome (AIDS) susceptibility. This susceptibility is even greater in individuals who also possess disease-accelerating CCR5 genotypes. This relationship between CCL3L1 dose and altered HIV/AIDS susceptibility points to a central role for CCL3L1 in HIV/AIDS pathogenesis and indicates that differences in the dose of immune response genes may constitute a genetic basis for variable responses to infectious diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gonzalez, Enrique -- Kulkarni, Hemant -- Bolivar, Hector -- Mangano, Andrea -- Sanchez, Racquel -- Catano, Gabriel -- Nibbs, Robert J -- Freedman, Barry I -- Quinones, Marlon P -- Bamshad, Michael J -- Murthy, Krishna K -- Rovin, Brad H -- Bradley, William -- Clark, Robert A -- Anderson, Stephanie A -- O'connell, Robert J -- Agan, Brian K -- Ahuja, Seema S -- Bologna, Rosa -- Sen, Luisa -- Dolan, Matthew J -- Ahuja, Sunil K -- AI043279/AI/NIAID NIH HHS/ -- AI046326/AI/NIAID NIH HHS/ -- MH069270/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2005 Mar 4;307(5714):1434-40. Epub 2005 Jan 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Veterans Administration Research Center for AIDS and HIV-1 Infection, South Texas Veterans Health Care System, and Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15637236" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Animals ; Chemokines, CC/*genetics/metabolism ; Child ; Cohort Studies ; Continental Population Groups/genetics ; Disease Progression ; Ethnic Groups/genetics ; Female ; *Gene Dosage ; *Gene Duplication ; *Genetic Predisposition to Disease ; Genotype ; HIV Infections/epidemiology/*genetics/*immunology/virology ; *HIV-1/metabolism ; Humans ; Male ; Middle Aged ; Pan troglodytes/genetics ; Phenotype ; Public Health ; Receptors, CCR5/genetics/metabolism ; Selection, Genetic
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  • 100
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-05-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 May 20;308(5725):1096-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15905368" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Blastocyst/*cytology ; Cell Line ; Child ; Child, Preschool ; *Cloning, Organism/ethics/methods ; Embryo Research/ethics ; Female ; Humans ; Korea ; Male ; Middle Aged ; Oocytes ; Politics ; *Research Embryo Creation/ethics/methods ; *Stem Cells ; Tissue Donors ; United States
    Print ISSN: 0036-8075
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