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  • 1
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    ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1 (2015)
    Oxford University Press
    Details
    Publication Date: 2015-04-04
    Description: Amyotrophic lateral sclerosis (ALS)-linked mutations in UBQLN2 and some members of the heterogeneous nuclear ribonucleoproteins (hnRNPs) family cause ALS. Most mutations in UBQLN2 are missense mutations that occur in and around a PXX repeat motif located in the central domain of the encoded protein. However, neither the function of the PXX motif nor the mechanism by which mutations in UBQLN2 cause ALS is known. We screened a yeast two-hybrid library using the central domain of ubiquilin-2 hoping to identify proteins whose binding is affected by the UBQLN2 mutations. Three such interactors were identified—hnRNPA1, hnRNPA3 and hnRNPU—all members of the hnRNP family. The interacting region in each of these proteins was their glycine-rich domain, the domain most frequently mutated in hnRNP-related proteins that cause ALS. We focused on hnRNPA1, because a mutation in the protein causes ALS. We confirmed the interaction between wild-type (WT) ubiquilin-2 and hnRNPA1 proteins in vitro and in cells. In contrast, all five ALS mutations in ubiquilin-2 that we examined had reduced binding with WT hnRNPA1. In addition, hnRNPA1 carrying the D262V missense mutation that causes ALS failed to bind WT ubiquilin-2. Overexpression of ubiquilin-2 containing the ALS mutations increased cell death and, for several of the mutants, this correlated with increased translocation of hnRNPA1 to the cytoplasm. Knockdown of ubiquilin-2 led to increased turnover of hnRNPA1, indicating ubiquilin-2 functions to stabilize hnRNPA1. The discovery that ubiquilin-2 interacts with hnRNP proteins and that mutation in either protein disrupts interaction suggests a connection between proteostasis and RNA metabolism.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 2
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    CMIP5 multimodel ensemble projection of storm track change under global warming (2013)
    Wiley
    Details
    Publication Date: 2013-01-03
    Description: [1]  CMIP5 multimodel ensemble projection of midlatitude storm track changes has been examined. Storm track activity is quantified by temporal variance of meridional wind and sea level pressure (psl), as well as cyclone track statistics. For the Southern Hemisphere (SH), CMIP5 models project clear poleward migration, upward expansion, and intensification of the storm track. For the Northern Hemisphere (NH), the models also project some poleward shift and upward expansion of the storm track in the upper troposphere/lower stratosphere, but mainly weakening of the storm track toward its equatorward flank in the troposphere. Consistent with these, CMIP5 models project significant increase in the frequency of extreme cyclones during the SH cool season, but significant decrease in such events in the NH. Comparisons with CMIP3 projections indicate high degrees of consistency for SH projections, but significant differences are found in the NH. Overall, CMIP5 models project larger decrease in storm track activity in the NH troposphere, especially over North America in winter, where psl variance as well as cyclone frequency and amplitude are all projected to decrease significantly. In terms of climatology, similar to CMIP3, most CMIP5 models simulate storm tracks that are too weak and display equatorward biases in their latitude. These biases have also been related to future projections. In the NH, the strength of a model's climatological storm track is negatively correlated with its projected amplitude change under global warming, while in the SH, models with large equatorward biases in storm track latitude tend to project larger poleward shifts.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 3
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    Observed and projected decrease in Northern Hemisphere extratropical cyclone activity in summer and its impacts on maximum temperature (2016)
    Wiley
    Details
    Publication Date: 2016-02-28
    Description: Extratropical cyclones cause much of the high impact weather over the mid-latitudes. With increasing greenhouse gases, enhanced high-latitude warming will lead to weaker cyclone activity. Here we show that between 1979 and 2014, the number of strong cyclones in Northern Hemisphere in summer has decreased at a rate of 4% per decade, with even larger decrease found near northeastern North America. Climate models project a decrease in summer cyclone activity, but the observed decreasing rate is near the fastest projected. Decrease in summer cyclone activity will lead to decrease in cloud cover, giving rise to higher maximum temperature, potentially enhancing the increase in maximum temperature by 0.5 K or more over some regions. We also show that climate models may have biases in simulating the positive relationship between cyclone activity and cloud cover, potentially under-estimating the impacts of cyclone decrease on accentuating the future increase in maximum temperature.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 4
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    Impacts of Background Field Removal on CMIP5 Projected Changes in Pacific Winter Cyclone Activity (2013)
    Wiley
    Details
    Publication Date: 2013-12-11
    Description: [1]  Cyclones are responsible for much of the high impact weather in the extratropics, thus how they will change under global warming is of great concern. Several studies have used the multi-model climate simulations conducted under Phase 5 of the Coupled Model Intercomparison Project (CMIP5) to examine such changes. One study suggested that the frequency of strong cyclones is projected to decrease over the North Pacific, while another concluded that this frequency will increase. [2]  A single tracking algorithm has been used to derive cyclone statistics from 23 CMIP5 simulations using two different definitions of cyclones: cyclones as minima in total sea level pressure (SLP), or cyclones as minima in SLP perturbations about a large scale, low frequency background. When cyclones are defined by total SLP, the frequency of deep cyclones over the Pacific is projected to increase, while if cyclones are defined as perturbations, this frequency is projected to decrease. These differences are shown to be due to a projected deepening of the climatological mean Aleutian low. [3]  In view of these results, it is important to critically assess how cyclones should be defined. Preliminary results suggest that among CMIP5 simulations, over the Pacific, both the projected changes in the frequency of high wind events and mean available potential energy are better correlated with the projected changes in the frequency of cyclones defined as perturbations. It is concluded that more research should be done to quantify and understand the impacts of the different definitions of cyclones.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
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    Predicting human brain activity associated with the meanings of nouns (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-05-31
    Description: The question of how the human brain represents conceptual knowledge has been debated in many scientific fields. Brain imaging studies have shown that different spatial patterns of neural activation are associated with thinking about different semantic categories of pictures and words (for example, tools, buildings, and animals). We present a computational model that predicts the functional magnetic resonance imaging (fMRI) neural activation associated with words for which fMRI data are not yet available. This model is trained with a combination of data from a trillion-word text corpus and observed fMRI data associated with viewing several dozen concrete nouns. Once trained, the model predicts fMRI activation for thousands of other concrete nouns in the text corpus, with highly significant accuracies over the 60 nouns for which we currently have fMRI data.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mitchell, Tom M -- Shinkareva, Svetlana V -- Carlson, Andrew -- Chang, Kai-Min -- Malave, Vicente L -- Mason, Robert A -- Just, Marcel Adam -- New York, N.Y. -- Science. 2008 May 30;320(5880):1191-5. doi: 10.1126/science.1152876.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Tom.Mitchell@cs.cmu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18511683" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Brain/*physiology ; Brain Mapping ; Computational Biology ; Female ; Humans ; *Language ; Magnetic Resonance Imaging ; Male ; Models, Neurological ; Models, Statistical ; Semantics ; Speech Perception/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-08
    Description: The mammalian intestinal tract is colonized by trillions of beneficial commensal bacteria that are anatomically restricted to specific niches. However, the mechanisms that regulate anatomical containment remain unclear. Here, we show that interleukin-22 (IL-22)-producing innate lymphoid cells (ILCs) are present in intestinal tissues of healthy mammals. Depletion of ILCs resulted in peripheral dissemination of commensal bacteria and systemic inflammation, which was prevented by administration of IL-22. Disseminating bacteria were identified as Alcaligenes species originating from host lymphoid tissues. Alcaligenes was sufficient to promote systemic inflammation after ILC depletion in mice, and Alcaligenes-specific systemic immune responses were associated with Crohn's disease and progressive hepatitis C virus infection in patients. Collectively, these data indicate that ILCs regulate selective containment of lymphoid-resident bacteria to prevent systemic inflammation associated with chronic diseases.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659421/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659421/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sonnenberg, Gregory F -- Monticelli, Laurel A -- Alenghat, Theresa -- Fung, Thomas C -- Hutnick, Natalie A -- Kunisawa, Jun -- Shibata, Naoko -- Grunberg, Stephanie -- Sinha, Rohini -- Zahm, Adam M -- Tardif, Melanie R -- Sathaliyawala, Taheri -- Kubota, Masaru -- Farber, Donna L -- Collman, Ronald G -- Shaked, Abraham -- Fouser, Lynette A -- Weiner, David B -- Tessier, Philippe A -- Friedman, Joshua R -- Kiyono, Hiroshi -- Bushman, Frederic D -- Chang, Kyong-Mi -- Artis, David -- 2-P30 CA016520/CA/NCI NIH HHS/ -- AI061570/AI/NIAID NIH HHS/ -- AI074878/AI/NIAID NIH HHS/ -- AI083480/AI/NIAID NIH HHS/ -- AI087990/AI/NIAID NIH HHS/ -- AI095466/AI/NIAID NIH HHS/ -- AI095608/AI/NIAID NIH HHS/ -- AI47619/AI/NIAID NIH HHS/ -- K08 DK093784/DK/NIDDK NIH HHS/ -- K08-DK093784/DK/NIDDK NIH HHS/ -- P30 AI 045008/AI/NIAID NIH HHS/ -- P30DK50306/DK/NIDDK NIH HHS/ -- R01 AI061570/AI/NIAID NIH HHS/ -- R01 AI074878/AI/NIAID NIH HHS/ -- R01 AI095466/AI/NIAID NIH HHS/ -- R01 AI102942/AI/NIAID NIH HHS/ -- R21 AI083480/AI/NIAID NIH HHS/ -- R21 AI087990/AI/NIAID NIH HHS/ -- T32 AI007532/AI/NIAID NIH HHS/ -- T32 AI055428/AI/NIAID NIH HHS/ -- T32 RR007063/RR/NCRR NIH HHS/ -- T32-AI007532/AI/NIAID NIH HHS/ -- T32-AI055428/AI/NIAID NIH HHS/ -- T32-RR007063/RR/NCRR NIH HHS/ -- U01 AI095608/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2012 Jun 8;336(6086):1321-5. doi: 10.1126/science.1222551. Epub 2012 Jun 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22674331" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Alcaligenes/immunology/isolation & purification/*physiology ; Animals ; Bacterial Translocation ; Crohn Disease/immunology/microbiology ; Hepatitis C, Chronic/immunology/microbiology ; Humans ; Immunity, Innate ; Inflammation ; Interleukins/administration & dosage/biosynthesis/*immunology ; Intestines/*immunology/microbiology ; Leukocyte L1 Antigen Complex/metabolism ; Liver/microbiology ; Lymph Nodes/immunology ; Lymphocytes/*immunology ; Lymphoid Tissue/*immunology/*microbiology ; Macaca mulatta ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Spleen/microbiology ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    CMIP5 multimodel ensemble projection of storm track change under global warming (2012)
    Wiley
    Details
    Publication Date: 2012-12-15
    Description: CMIP5 multimodel ensemble projection of midlatitude storm track changes has been examined. Storm track activity is quantified by temporal variance of meridional wind and sea level pressure (psl), as well as cyclone track statistics. For the Southern Hemisphere (SH), CMIP5 models project clear poleward migration, upward expansion, and intensification of the storm track. For the Northern Hemisphere (NH), the models also project some poleward shift and upward expansion of the storm track in the upper troposphere/lower stratosphere, but mainly weakening of the storm track toward its equatorward flank in the troposphere. Consistent with these, CMIP5 models project significant increase in the frequency of extreme cyclones during the SH cool season, but significant decrease in such events in the NH. Comparisons with CMIP3 projections indicate high degrees of consistency for SH projections, but significant differences are found in the NH. Overall, CMIP5 models project larger decrease in storm track activity in the NH troposphere, especially over North America in winter, where psl variance as well as cyclone frequency and amplitude are all projected to decrease significantly. In terms of climatology, similar to CMIP3, most CMIP5 models simulate storm tracks that are too weak and display equatorward biases in their latitude. These biases have also been related to future projections. In the NH, the strength of a model's climatological storm track is negatively correlated with its projected amplitude change under global warming, while in the SH, models with large equatorward biases in storm track latitude tend to project larger poleward shifts.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 8
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    Interannual Modulation of Northern Hemisphere Winter Storm Tracks by the QBO (2018)
    Wiley
    Details
    Publication Date: 2018-03-12
    Description: Storm tracks, defined as the preferred regions of extratropical synoptic-scale disturbances, have remarkable impacts on global weather and climate systems. Causes of interannual storm track variation have been investigated mostly from a troposphere perspective. As shown in this study, Northern Hemisphere winter storm tracks are significantly modulated by the tropical stratosphere through the Quasi-Biennial Oscillation (QBO). The North Pacific storm track (NPST) shifts poleward during the easterly QBO winters associated with a dipole change in the eddy refraction and baroclinicity. The North Atlantic storm track (NAST) varies vertically with a downward shrinking (upward expansion) in easterly (westerly) QBO winters associated with the change of the tropopause height. These results not only fill the knowledge gap of QBO-storm track relationship but also suggest a potential route to improve the seasonal prediction of extratropical storm activities owing to the high predictability of the QBO.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 9
    Electronic Resource
    Electronic Resource
    Three electrodes touch-mode capacitive pressure sensor (1998)
    Springer
    Microsystem technologies 5 (1998), S. 93-99 
    Details
    ISSN: 1432-1858
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Technology
    Notes: Abstract  A three-electrode capacitive pressure sensor for touch-mode operation with sensitivity of 0.030 pF/kPa (or 10.4 mV/kPa using CP-10 C/V converter circuit) in the pressure range of 170–280 kPa is presented with theoretical explanation of experimental results. A special ring structure is designed to integrate a sensing capacitor and a reference capacitor into the same cavity to partially cancel out the temperature effect. A third electrode is included to eliminate two-level connections without reducing its pressure sensitivity. The sensor offers the advantages of simple fabrication processes, planar connections, as well as high sensitivity, near-linear output, and large over-range pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005420050148
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  • 10
    Electronic Resource
    Electronic Resource
    Spectral and inhibitory interactions of methylenedioxyphenyl compounds with southern armyworm (Spodoptera eridania) midgut microsomes
    Amsterdam : Elsevier
    Pesticide Biochemistry and Physiology 15 (1981), S. 32-42 
    Details
    ISSN: 0048-3575
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0048-3575(81)90032-8
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