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  • Mice  (83)
  • Kinetics  (23)
  • Rats, Inbred Strains
  • American Association for the Advancement of Science (AAAS)  (104)
  • Annual Reviews
  • Blackwell Publishing Ltd
  • 1980-1984  (104)
  • 1955-1959
  • 1930-1934
  • 1980  (104)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (104)
  • Annual Reviews
  • Blackwell Publishing Ltd
  • Springer  (10)
  • Wiley-Blackwell  (1)
Years
  • 1980-1984  (104)
  • 1955-1959
  • 1930-1934
Year
  • 1
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    L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-02
    Description: The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase activity associated with early embryogenesis in the mouse and arrests embryonic development at that stage. Contragestational effects were confirmed in the rat and rabbit. An increase in L-ornithine decarboxylase activity that leads to a rapid increase in putrescine concentration appears to be essential during a critical period after implantation for continued mammalian embryonal growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fozard, J R -- Part, M L -- Prakash, N J -- Grove, J -- Schechter, P J -- Sjoerdsma, A -- Koch-Weser, J -- New York, N.Y. -- Science. 1980 May 2;208(4443):505-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6768132" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosylmethionine Decarboxylase/metabolism ; Animals ; Carboxy-Lyases/*physiology ; Eflornithine ; Embryo, Mammalian/drug effects/*physiology ; Female ; Gestational Age ; Mice ; Ornithine/*analogs & derivatives/pharmacology ; Ornithine Decarboxylase/*physiology ; Ornithine Decarboxylase Inhibitors ; Polyamines/metabolism ; Pregnancy ; Rabbits ; Rats ; Uterus/drug effects/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Doridosine: a new hypotensive N-methylpurine riboside from the nudibranch Anisodoris nobilis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: A new N-methylpurine riboside (doridosine), probably N1-Methylisoguanosine, was isolated from the digestive glands of a nudibranch. Doridosine produces prolonged hypotension and bradycardia in anesthetized rats, decreases the rate and the amplitude of contraction of guinea pig atria in vitro, and causes the heart rate in anesthetized mice to be reduced by 50 percent for many hours after which the animals recover completely.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fuhrman, F A -- Fuhrman, G J -- Kim, Y H -- Pavelka, L A -- Mosher, H S -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):193-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350655" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antihypertensive Agents/*isolation & purification ; Guanosine/*analogs & derivatives/isolation & purification/pharmacology ; Guinea Pigs ; Heart Rate/drug effects ; Mice ; Mollusca/analysis ; Rats
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Survival of mice receiving melanoma transplants is promoted by hydroquinone (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-25
    Description: In BALB/c female mice with melanoma transplants, the incidence of "takes" is decreased and survival is increased by hydroquinone, a melanocytolytic agent. The mechanism of drug action is suggested by via DNA. The significant and high degree of positive response to hydroquinone treatment in vivo is encouraging for the clinical management of melanoma with melanocytolytic agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chavin, W -- Jelonek, E J Jr -- Reed, A H -- Binder, L R -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):408-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7367868" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Hydroquinones/metabolism/*therapeutic use ; Melanocytes/metabolism ; Melanoma/*drug therapy ; Mice ; Neoplasm Transplantation ; Neoplasms, Experimental/drug therapy
    Print ISSN: 0036-8075
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  • 4
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    Single-nutrient microbial competition: qualitative agreement between experimental and theoretically forecast outcomes (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-28
    Description: When microbial strains compete for the same limiting nutrient in continuous culture, resource-based competition theory predicts that only one strain will survive and all others will die out. The surviving strain expected from theory will be the one with the smallest subsistence or "break-even" concentration of the limiting resource, a concentration defined by the J parameter. This prediction has been confirmed in the case of auxotrophic bacterial strains competing for limiting tryptophan. Because the value of J can be measured on the strains grown alone, the theory can predict the qualitative outcomes of mixed-growth competition in advance of actual competition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hansen, S R -- Hubbell, S P -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6767274" target="_blank"〉PubMed〈/a〉
    Keywords: Bacteria/*growth & development ; Culture Media ; Drug Resistance, Microbial ; Escherichia coli/growth & development ; Kinetics ; Models, Theoretical ; Nalidixic Acid/pharmacology ; Nutritional Physiological Phenomena ; Pseudomonas aeruginosa/growth & development ; Tryptophan/metabolism
    Print ISSN: 0036-8075
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  • 5
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    Testosterone-mediated sexual dimorphism of mitochondria and lysosomes in mouse kidney proximal tubules (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-29
    Description: In kidney proximal tubules of male mice the mitochondria are larger and more electron-lucent, autophagic vacuoles and lysosomes (predominantly myeloid bodies) more numerous and voluminous, and exocytosed intraluminal myeloid bodies more common than in females. Males also have higher kidney activities of mitochondrial cytochrome c oxidase and lysosomal hydrolases, and excrete larger quantities of hydrolases and protein in the urine. Orchiectomy evokes the feminine pattern whereas testosterone administration induces the male pattern. Endogenous testosterone modulates mitochondrial structure and function and enhances the activity of the lysosomal-vacuolar system in proximal tubule cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koenig, H -- Goldstone, A -- Blume, G -- Lu, C Y -- New York, N.Y. -- Science. 1980 Aug 29;209(4460):1023-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403864" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; Enzymes/urine ; Female ; Kidney/drug effects ; Kidney Tubules, Proximal/*ultrastructure ; Lysosomes/drug effects/enzymology ; Male ; Mice ; Mitochondria/drug effects/enzymology ; Organ Size/drug effects ; Sex Differentiation/*drug effects ; Testosterone/*pharmacology
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  • 6
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    Tooth induction in chick epithelium: expression of quiescent genes for enamel synthesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-29
    Description: Intraocular grafts of chick epithelium combined with mouse molar mesenchyme produced a variety of dental structures including perfectly formed crowns with differentiated ameloblasts depositing enamel matrix. The results suggest that the loss of teeth in Aves did not result from a loss of genetic coding for enamel synthesis in the oral epithelium but from an alteration in the tissue interactions requisite for odontogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kollar, E J -- Fisher, C -- New York, N.Y. -- Science. 1980 Feb 29;207(4434):993-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352302" target="_blank"〉PubMed〈/a〉
    Keywords: *Amelogenesis ; Animals ; Chick Embryo/*cytology ; Culture Techniques ; Dental Enamel Proteins/*biosynthesis/genetics ; Embryonic Induction ; Epithelial Cells ; Genes ; Mandible/cytology ; Mesoderm/cytology ; Mice ; *Odontogenesis
    Print ISSN: 0036-8075
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  • 7
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    Role of the spleen in the growth of a murine B cell leukemia (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-04
    Description: A spontaneous B cell leukemia (BCL1) grew progressively in normal BALB/c mice after injection of tumor cells but did not grow in splenectomized recipients. Despite the absence of progressive tumor growth, residual tumor cells with malignant potential were found in the peripheral blood of the splenectomized animals. Splenectomy performed after injection of tumor cells but before the development of marked leukocytosis also prevented progressive tumor growth and death of the host. Thus the spleen appears to be necessary for progressive proliferation of this lymphocytic leukemia early after passage in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kotzin, B L -- Strober, S -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):59-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6965803" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*pathology ; Disease Models, Animal ; Female ; Leukemia, Experimental/etiology/physiopathology ; Leukemia, Lymphoid/*etiology/physiopathology ; Mice ; Mice, Inbred BALB C ; Spleen/*physiology ; Splenectomy
    Print ISSN: 0036-8075
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  • 8
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    Prolongation of islet xenograft survival without continuous immunosuppression (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: The survival of isolated rat islets transplanted into diabetic mice was prolonged markedly by maintaining the rat islets in vitro at 24 degrees C for 7 days before transplantation and administering to the recipients a single injection of antiserum to mouse and rat lymphocytes shortly before transplantation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lacy, P E -- Davie, J M -- Finke, E H -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):283-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6770465" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Glucose/analysis ; Cell Survival ; Cells, Cultured ; Diabetes Mellitus, Experimental/*therapy ; *Immunosuppression ; *Islets of Langerhans Transplantation ; Lymphocytes/immunology ; Male ; Mice ; Mice, Inbred BALB C ; Rats ; Transplantation, Heterologous ; Transplantation, Isogeneic
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  • 9
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    Phenacetin safety (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macklin, A W -- Welch, R M -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):129-30, 132.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350647" target="_blank"〉PubMed〈/a〉
    Keywords: Aminopyrine/adverse effects/toxicity ; Animals ; Humans ; Mice ; Mutagens ; Phenacetin/administration & dosage/*adverse effects/toxicity ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 10
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    Immunoglobulin gene rearrangement in immature B cells (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: Two types of immature B cells, namely fetal liver hybridomas and the leukemic cell line 70Z/3, both of which have cytoplasmic mu chains but no light chains, were examined for DNA rearrangements of their light chain and heavy chain immunoglobulin genes. In the fetal liver hybridomas, which were constructed from fetal liver cells and a tumor cell, no light chain gene rearrangement was observed, whereas in the 70Z/3 cell line a kappa light chain rearrangement probably occurred. The results suggest that, although the lack of light chain synthesis can be due to a lack of gene rearrangement, there may also be transcriptional regulation, which may also be important for the expression of light chain immunoglobulins in immature B cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maki, R -- Kearney, J -- Paige, C -- Tonegawa, S -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1366-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6774416" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*immunology ; Genes ; Hybrid Cells/immunology ; Immunoglobulin Constant Regions/genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin Light Chains/*genetics ; Immunoglobulin Variable Region/genetics ; Immunoglobulin kappa-Chains/*genetics ; Immunoglobulin mu-Chains/*genetics ; Leukemia, Experimental/*immunology ; Liver/*embryology ; Mice ; Recombination, Genetic ; Transcription, Genetic
    Print ISSN: 0036-8075
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  • 11
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    Mapping of heavy chain genes for mouse immunoglobulins M and D (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: A single DNA fragment containing both mu and delta immunoglobulin heavy chain genes has been cloned from normal BALB/c mouse liver DNA with a new lambda phage vector Charon 28. The physical distance between the membrane terminal exon of mu and the first domain of delta is 2466 base pairs, with delta on the 3' side of mu. A single transcript could contain a variable region and both mu and delta constant regions. The dual expression of immunoglobulins M and D on spleen B cells may be due to alternate splicing of this transcript.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, C P -- Tucker, P W -- Mushinski, J F -- Blattner, F R -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1348-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6774414" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/immunology ; Chromosome Deletion ; *Genes ; Immunoglobulin Constant Regions/genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin delta-Chains/*genetics ; Immunoglobulin mu-Chains/*genetics ; Liver/physiology ; Membrane Proteins/genetics ; Mice ; Myeloma Proteins/genetics ; Plasmids ; RNA, Messenger/genetics ; Recombination, Genetic
    Print ISSN: 0036-8075
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  • 12
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    Selective inhibition of glycoprotein and membrane protein of vesicular stomatitis virus from interferon-treated cells (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-01
    Description: A 200-fold inhibition in the titer of infectious vesicular stomatitis virus (VSV) was produced in cultures of Ly cells treated with 30 reference units of interferon per milliliter. Virus particle production, as measured by VSV particle-associated transcriptase, or nucleocapsid protein was inhibited by a maximum of tenfold. The glycoprotein and membrane protein content was reduced in VSV derived from interferon-treated cells. Thus interferon-treated cells may have produced VSV particles with low infectivity, which may be related to the reduced amount of glycoprotein incorporated into such particles. These findings resemble those reported in interferon-treated cells infected with murine leukemia viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maheshwari, R K -- Jay, F T -- Friedman, R M -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):540-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243416" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Defective Viruses/growth & development ; Glycoproteins/*biosynthesis ; Interferons/*pharmacology ; Membrane Proteins/*biosynthesis ; Mice ; RNA, Viral/metabolism ; Vesicular stomatitis Indiana virus/*growth & development ; Viral Proteins/*biosynthesis ; Virus Replication/*drug effects
    Print ISSN: 0036-8075
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  • 13
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    (-)Pentobarbital opens ion channels of long duration in cultured mouse spinal neurons (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Intracellular recordings from voltage-clamped mouse spinal neurons in tissue culture were used to study the membrane mechanisms underlying inhibitory responses to gamma-aminobutyric acid and the (-) isomer of pentobarbital. Fluctuation analysis suggested that both substances activated ion channels in the membranes. However, the channels activated by pentobarbital remained open five times longer than those activated by gamma-aminobutyric acid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mathers, D A -- Barker, J L -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):507-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6248961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/drug effects/physiology ; Cells, Cultured ; Ion Channels/drug effects/*physiology ; Membrane Potentials/drug effects ; Mice ; Neurons/drug effects/*physiology ; Pentobarbital/*pharmacology ; Spinal Cord/*physiology ; gamma-Aminobutyric Acid/pharmacology
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  • 14
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    Vesicle targeting: timed release and specificity for leukocytes in mice by subcutaneous injection (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-18
    Description: When unilamellar vesicles were administered subcutaneously in mice, the half-time for the destruction of the vesicles varied from 12 to 600 hours, depending on their composition. The vesicles tested consisted of distearoyl phosphatidylcholine, cholesterol, and certain sugar and amino-sugar derivatives of cholesterol. Vesicle with amino-sugar derivatives showed the greatest longevity and became localized with high specificity in aggregates of polymorphonuclear leukocytes. A substantial delay between the time that the vesicles broke open and the time that labels contained in the vesicles were excreted suggests that the vesicles undergo endocytosis before destruction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mauk, M R -- Gamble, R C -- Baldeschwieler, J D -- New York, N.Y. -- Science. 1980 Jan 18;207(4428):309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350660" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cholesterol/analogs & derivatives ; Endocytosis ; Liposomes/*therapeutic use ; Lysosomes/metabolism ; Metabolic Clearance Rate ; Mice ; Neutrophils/*metabolism ; Phosphatidylcholines ; Structure-Activity Relationship
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  • 15
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    Mebendazole therapy of parenteral trichinellosis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-14
    Description: Mebendazole was highly effective against the helminth parasite Trichinella spiralis in mice subjected to a 3-day course of treatment during the invasive and encystment phases of experimental trichinellosis. When treatment began either 2 or 4 weeks after the mice were inoculated with parasites, the number of larvae developing in the host musculature was greatly reduced by twice-daily oral administration of 3.125, 6.25, or 12.5 milligrams of mebendazole per kilogram of body weight.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCracken, R O -- Taylor, D D -- New York, N.Y. -- Science. 1980 Mar 14;207(4436):1220-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355285" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Animals ; Benzimidazoles/*therapeutic use ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Larva ; Male ; Mebendazole/administration & dosage/*therapeutic use ; Mice ; Muscles/parasitology ; Trichinella/drug effects ; Trichinellosis/*drug therapy
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  • 16
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    The heart is a target organ for androgen (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-15
    Description: Autoradiographic and biochemical analyses of the hearts of female rhesus monkeys and baboons indicate that atrial and ventricular myocardial cells contain androgen receptors. Although the specific effects of nuclear uptake and retention of androgen on the function of heart muscle cells are not known, the presence of this receptor suggests that sex steroid hormones may affect myocardial function directly and may explain some of the peculiar differences in heart disease between men and women.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGill, H C Jr -- Anselmo, V C -- Buchanan, J M -- Sheridan, P J -- New York, N.Y. -- Science. 1980 Feb 15;207(4432):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6766222" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/*metabolism ; Animals ; Coronary Disease/*etiology ; Dihydrotestosterone/metabolism ; Estradiol/metabolism ; Female ; Haplorhini ; Kinetics ; Macaca mulatta ; Myocardium/*metabolism ; Papio ; Receptors, Androgen/*metabolism ; Receptors, Steroid/*metabolism ; Sex Factors
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  • 17
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    Insertion of a new gene of viral origin into bone marrow cells of mice (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-30
    Description: DNA containing the herpes simplex virus thymidine kinase (HSVtk) gene was used to transform wild-type tk+ mouse L cells to a tk++ status in vitro using methotrexate as a selective agent. HSVtk DNA was also used to transform mouse bone marrow cells in vitro. Transformed marrow cells injected into irradiated and methotrexate-treated recipient mice gave rise to proliferating cells which in some cases dominated the marrow population and which contained HSVtk gene sequences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mercola, K E -- Stang, H D -- Browne, J -- Salser, W -- Cline, M J -- New York, N.Y. -- Science. 1980 May 30;208(4447):1033-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6246577" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow/*enzymology ; Bone Marrow Transplantation ; DNA, Viral/analysis ; Drug Resistance ; *Genes, Viral ; L Cells (Cell Line) ; Methotrexate/pharmacology ; Mice ; Simplexvirus/enzymology/*genetics ; Species Specificity ; Thymidine Kinase/*genetics ; *Transformation, Genetic
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  • 18
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    J genes for heavy chain immunoglobulins of mouse (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-05
    Description: A 15,8-kilobase pair fragment of BALB/c mouse liver DNA, cloned in the Charon 4A lambda phage vector system, was shown to contain the mu heavy chain constant region (CHmu) gene for the mouse immunoglobulin M. In addition, this fragment of DNA contains at least two J genes, used to code for the carboxyl terminal portion of heavy chain variable regions. These genes are located in genomic DNA about eight kilobase pairs to the 5' side of the CHmu gene. The complete nucleotide sequence of a 1120-base pair stretch of DNA that includes the two J genes has been determined.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newell, N -- Richards, J E -- Tucker, P W -- Blattner, F R -- New York, N.Y. -- Science. 1980 Sep 5;209(4461):1128-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250219" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Binding Sites, Antibody/*genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Genes ; Genetic Linkage ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulin mu-Chains/*genetics ; Mice
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  • 19
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    Gene affecting superoxide dismutase activity linked to the histocompatibility complex in H-2 congenic mice (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: The activity of cyanide-sensitive, Cu-Zn superoxide dismutase (SOD) was studied in liver sytosols from H-2 congenic strains of mice. Higher SOD activity was found in livers of mice having H-2b/A.BY, B10, and C3H.SW/haplotypes than in those of H-2a, H-2k and H-2d haplotypes. Segregation studies supported these correlations. In H-2 recombinant strains of mice, the genes influencing the liver SOD activity occur, as ascertained by mapping techniques, at or near the H-2d region of the major histocompatibility complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Novak, R -- Bosze, Z -- Matkovics, B -- Fachet, J -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):86-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350646" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Genes ; Genes, Regulator ; Genetic Linkage ; H-2 Antigens/*genetics ; Liver/enzymology ; *Major Histocompatibility Complex ; Mice ; Superoxide Dismutase/*genetics
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  • 20
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    Substance P: does it produce analgesia or hyperalgesia? (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-18
    Description: In the hot plate test, substance P given intravenously at doses of 5 x 10-5 and 5 x 10-4 gram per kilogram caused analgesia, while lower doses caused hyperalgesia. The influence of substance P on nociception depended on the individual mouse's sensitivity to pain (control response latency). Analgesia was produced by substance P administered to mice with high sensitivity to thermic stimulation, whereas hyperalgesia occurred in mice whose control latencies were longer than normal. This result is interpreted as an indication that substance P is capable of normalizing responsiveness to pain and could be classified as a regulatory peptide.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oehme, P -- Hilse, H -- Morgenstern, E -- Gores, E -- New York, N.Y. -- Science. 1980 Apr 18;208(4441):305-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6154313" target="_blank"〉PubMed〈/a〉
    Keywords: Acetates ; Animals ; Dose-Response Relationship, Drug ; Hot Temperature ; Hyperalgesia/*chemically induced ; Hyperesthesia/*chemically induced ; Mice ; Nociceptors/drug effects ; Pain/*physiopathology ; Perception/*drug effects ; Receptors, Drug/physiology ; Substance P/*pharmacology
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  • 21
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    Calcium regulation during stimulus-secretion coupling: continuous measurement of intracellular calcium activities (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Accurate measurements of intracellular calcium activities in salivary gland epithelial cells of the insect Phormia regina were obtained with microelectrodes in which N,N'-di(11-ethoxycarbonyl)undecyl-N,N'-4,5-tetramethyl-3,6-dioxaoctane diacid diamide wsa incorporated in a liquid membrane system. When calibrated in solutions approximating the ionic concentration of the cell interior, these microelectrodes gave rapid stable responses that were linear functions of the logarithm of calcium activities and were not affected by potassium, sodium and magnesium. Continuous monitoring of calcium activities during serotonin-induced saliva release provided direct evidence of hormonal influence on transmembrane calcium movement and spontaneous regulation of intracellular calcium by stimulated cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Doherty, J -- Youmans, S J -- Armstrong, W M -- Stark, R J -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):510-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394518" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Calcium/*metabolism ; Diptera/*metabolism ; Epithelium/metabolism ; Kinetics ; Magnesium/pharmacology ; Microelectrodes ; Salivary Glands/drug effects/*metabolism ; Serotonin/pharmacology
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  • 22
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    Human monoclonal antibody against Forssman antigen (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-10-31
    Description: Hybrid cells formed between human lymphocytes and mouse myeloma cells produce human immunoglobulin in culture. Stable antibody-producing cell lines can be isolated after multiple cycles of low-density passage, cloning, and continued selection for immunoglobulin production. The origin and characteristics of a hybrid of human and mouse cells is described. This hybrid produces high concentrations (8.3 micrograms per milliliter) of human immunoglobulin M reactive with the terminal disaccharide of the Forssman glycolipid. These findings point to the potential use of human-mouse hybrid cells as a source of human monoclonal antibodies for therapeutic and diagnostic purposes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nowinski, R -- Berglund, C -- Lane, J -- Lostrom, M -- Bernstein, I -- Young, W -- Hakomori, S I -- Hill, L -- Cooney, M -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):537-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423202" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; Antibody Formation ; Antibody Specificity ; Cells, Cultured ; Clone Cells/immunology ; *Forssman Antigen ; Humans ; Hybrid Cells/immunology ; Immunoglobulin M/biosynthesis ; Mice
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  • 23
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    alpha-Lactalbumin-casein induction in virgin mouse mammary explants: dose-dependent differential action of cortisol (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-21
    Description: The interplay of insulin, cortisol, and prolactin induces synthesis of casein and alpha-lactalbumin in cultured mammary explants from mature virgin mice. A striking difference has been found between the optimal concentrations of cortisol required for maximal induction of the two milk proteins in vitro: 3 x 10(-8) molar for alpha-lactalbumin and 3 x 10(-6) molar for casein. Moreover, 10(-7) to 10(-5) molar cortisol caused progressive inhibition of alpha-lactalbumin accumulation. Such differential actions of cortisol may partly account for the asynchronous synthesis of the two proteins during pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ono, M -- Oka, T -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1367-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6986657" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caseins/*biosynthesis ; Dose-Response Relationship, Drug ; Drug Interactions ; Female ; Hydrocortisone/*pharmacology ; Insulin/pharmacology ; Lactalbumin/*biosynthesis ; Mammary Glands, Animal/drug effects/*metabolism ; Mice ; Organ Culture Techniques ; Pregnancy ; Prolactin/pharmacology
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  • 24
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    Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-14
    Description: A 15.0-kilobase (kb) Eco RI DNA fragment from normal mouse Balb/c genomic DNA that contains sequences (sarc) homologous to the acquired cell sequences (src) of Moloney sarcoma virus (MSV) has been cloned in phage lambda. The sarc region (1.2 to 1.3 kb) of the 15.0-kb cell fragment is indistinguishable from the src region of two isolates of MSV as judged by heteroduplex and restriction endonuclease analyses. The cellular sequences flanking sarc show no homology to other MSV sequences. Whereas cloned subgenomic portions of MSV that contain src transformed NIH-3T3 cells in vitro, the cloned sarc fragment is inactive.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oskarsson, M -- McClements, W L -- Blair, D G -- Maizel, J V -- Vande Woude, G F -- New York, N.Y. -- Science. 1980 Mar 14;207(4436):1222-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243788" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Chromosome Mapping ; DNA Restriction Enzymes ; *Genes ; *Genes, Viral ; Mice ; Mice, Inbred BALB C/*genetics ; Moloney murine leukemia virus/*genetics ; Nucleic Acid Hybridization
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  • 25
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    Cytosolic and microsomal epoxide hydrolases: differential properties in mammalian liver (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-28
    Description: The epoxide hydrolase activities of the 100,000 g pellet (microsomal) and 100,00 g soluble (cystosolic) fractions of mouse, rat, and guinea pig liver were measured with three closely related compounds used as substrates. Differences between the species in the distribution of the cytosolic and microsomal hydrolases and in their substrate specificities and pH optima demonstrate why epoxide hydrolase activity in the cytosolic fraction was not detected earlier in spie of intensive work on the microsomal epoxide hydrolase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ota, K -- Hammock, B D -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1479-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361100" target="_blank"〉PubMed〈/a〉
    Keywords: Allyl Compounds ; Animals ; Benzene ; Cytosol/enzymology ; Epoxide Hydrolases/*metabolism ; Guinea Pigs ; Hydrogen-Ion Concentration ; Liver/*enzymology/ultrastructure ; Mice ; Microsomes, Liver/enzymology ; Rats ; Styrenes ; Substrate Specificity
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  • 26
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    Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: The human genes for growth hormone (GH), chorionic somatomammotropin (CSH), and a third growth hormone-like gene (GHL) have been located on chromosome 17 in humans. DNA fragments of 2.6, 2.8, and 9.5 kilobase pairs containing GH, CSH, and GHL, respectively, were identified in human genomic DNA, and a 7.5-kilobase DNA fragment related to growth hormone DNA sequences was found in mouse cells. In somatic hybrids of human and mouse cells containing reduced numbers of human chromosomes, but a normal complement of mouse chromosomes, the mouse, 7.5-kolobase DNA fragment was always present, whereas the 2.6-, 2.8-, and 9.5-kilobase human fragments were present only when human chromosome 17 was also present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Owerbach, D -- Rutter, W J -- Martial, J A -- Baxter, J D -- Shows, T B -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):289-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384802" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; *Chromosomes, Human, 16-18 ; *DNA/metabolism ; *Genes ; Growth Hormone/*biosynthesis ; Humans ; Hybrid Cells/metabolism ; Mice ; Placental Lactogen/*biosynthesis ; Translocation, Genetic
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  • 27
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    Opiate analgesia: evidence for mediation by a subpopulation of opiate receptors (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-02
    Description: Naloxazone, a hydrazone derivative of the opiate antagonist naloxone, has a high affinity for opiate receptor binding sites. Naloxazone injections reduce opiate receptor binding to extensively washed mouse brain membranes for more than 24 hours, suggesting that the effect is irreversible. High-affinity binding sites are abolished by this treatment, whereas low-affinity sites are unaffected. Naloxazone treatment blocks the analgesic effects of morphine for at least 24 hours but does not prevent death from high doses of morphine. Thus analgesic but nonlethal opiate effects may be mediated by the high-affinity subpopulation of opiate receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pasternak, G W -- Childers, S R -- Snyder, S H -- New York, N.Y. -- Science. 1980 May 2;208(4443):514-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6245448" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites/drug effects ; Brain/metabolism ; Mice ; Morphine/pharmacology/toxicity ; Naloxone/adverse effects/*analogs & derivatives/pharmacology ; Receptors, Opioid/classification/*drug effects/physiology
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  • 28
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    Nerve terminals are as metabolically different as the muscle fibers they innervate (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-21
    Description: The rate at which glucose enters nerve terminals in muscle was estimated indirectly by measuring changes in miniature end-plate potential frequency D-Glucose entered nerve terminals in muscles with a fast twitch more rapidly than it entered those with a slow twitch. This suggests that nerve terminals in fast- and slow-twitch muscles differ in their rate of metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickett, J B -- New York, N.Y. -- Science. 1980 Nov 21;210(4472):927-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434009" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; Diaphragm/innervation ; Glucose/*metabolism ; Kinetics ; Membrane Potentials ; Nerve Endings/*metabolism ; Neuromuscular Junction/*metabolism ; Osmolar Concentration ; Rats
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  • 29
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    Estrogen and the growth of breast cancer: new evidence suggests indirect action (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-08
    Description: The growth of the MCF-7 human breast cancer cell line is unresponsive to the presence of estrogen in culture media. Paradoxically, in nude mice, growth of these cells and formation of solid tumors are dependent on estrogen. Tumors fail to develop in ovariectomized mice, but do develop in intact mice and in ovariectomized mice given estrogen. Primary cultures derived from MCF-7 tumors revert to unresponsiveness to estrogen. However, when these cultures are again transplanted into nude mice, estrogen is required for tumor formation. The continuous culture, the solid tumor, and the primary cultures therefrom have similar estrogen-binding capacities and affinities. These results indicate that mammary carcinoma cell growth in vivo is subject to inhibition that can be overcome by estrogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shafie, S M -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):701-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6994231" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/metabolism/*physiopathology ; Castration ; Cell Division/drug effects ; Cell Line ; Cytosol/metabolism ; Estradiol/metabolism/*pharmacology ; Female ; Humans ; Insulin/pharmacology ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Receptors, Estrogen/metabolism ; Transplantation, Heterologous
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  • 30
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    Correction of enzyme deficiency in mice by allogeneic bone marrow transplantation with total lymphoid irradiation (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-05
    Description: Enzyme deficiency was corrected in mice after allogeneic bone marrow transplantation with occurrence of graft versus host disease. beta-Glucuronidase-deficient C3H/HeJ mice were treated with total lymphoid irradiation. Normal bone marrow cells (30 X 10(6)) from BALB/c to C3H/HeJ chimeras (〉90 percent circulating donor-type cells) without graft versus host disease. beta-Glucuronidase activity increases to normal levels in all chimeras as measured in the liver and in the plasma. Activity was maintained throughout an observation period of 7 months.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slavin, S -- Yatziv, S -- A1 15387/PHS HHS/ -- New York, N.Y. -- Science. 1980 Dec 5;210(4474):1150-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7003711" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow Transplantation ; Glucuronidase/blood/*deficiency ; Liver/enzymology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Radiation Chimera ; Transplantation, Homologous
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  • 31
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    Neurobiology of amnesia (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Squire, L R -- Davis, H P -- Spanis, C W -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):836-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7190729" target="_blank"〉PubMed〈/a〉
    Keywords: Amnesia/*physiopathology ; Amnesia, Retrograde/*physiopathology ; Animals ; Brain Chemistry ; Catecholamines/metabolism ; Cycloheximide/pharmacology ; Humans ; Memory/drug effects ; Mice ; Nerve Tissue Proteins/biosynthesis ; Phenoxybenzamine/pharmacology
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  • 32
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    Pituitary gonadotropin-releasing hormone receptors during the rat estrous cycle (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-22
    Description: The binding of [6-alanine]gonadotropin-releasing hormone to pituitary plasma membranes increased threefold between metestrus and early proestrus in female rats. Receptor numbers fell rapidly on the afternoon of proestrus coincident with the preovulatory gonadotropin surge. The numbers of receptors for gonadotropin-releasing hormone were positively correlated with concentrations of estradiol in serum; this pattern may be a necessary component of increased pituitary sensitivty to gonadotropin-releasing hormone observed during proestrus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Savoy-Moore, R T -- Schwartz, N B -- Duncan, J A -- Marshall, J C -- New York, N.Y. -- Science. 1980 Aug 22;209(4459):942-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250218" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/metabolism ; Estradiol/blood ; *Estrus ; Feedback ; Female ; Follicle Stimulating Hormone/blood ; Gonadotropin-Releasing Hormone/analogs & derivatives/*metabolism ; Kinetics ; Luteinizing Hormone/blood ; Pituitary Gland, Anterior/*metabolism ; Pregnancy ; Progesterone/blood ; Rats ; Receptors, Cell Surface/*metabolism
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  • 33
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    Glucan-induced modification of murine viral hepatitis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-04
    Description: Glucan, a macrophage stimulant, was evaluated for its ability to alter survival and phagocytic dysfunction in mice challenged with mouse hepatitis virus strain MHV-A59. Administration of glucan before the mice were challenged with the virus significantly prolonged median survival time but did not modify overall mortality compared with control mice given dextrose. Maximal effectiveness was achieved when glucan was administered both before and after the viral challenge. In contrast to the marked hepatic parenchymal cell necrosis observed in the control mice, glucan-treated mice exhibited reduced pathology. Intraperitoneal administration of MHV-A59 resulted in a significant depression of phagocytic activity compared with controls that were not exposed to the virus. The enhancement in phagocytic function in glucan-treated control mice was unaltered in virus-challenged, glucan-treated mice. Thus glucan is capable of increasing survival, inhibiting hepatic necrosis, and maintaining an activated state of phagocytic activity in mice challenged with MHV-A59. Macrophage stimulants may have a significant role in the modification of virally induced hepatic lesions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, D L -- Di Luzio, N R -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):67-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361108" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Glucans/*pharmacology/therapeutic use ; Hepatitis, Viral, Animal/drug therapy/*immunology/mortality ; Liver/pathology ; Macrophages/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Phagocytosis/*drug effects
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    Latency of herpes simplex virus in absence of neutralizing antibody: model for reactivation (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-28
    Description: Mice inoculated with herpes simplex virus (type 1) by the lip or corneal route and then passively immunized with rabbit antibody to herpes simplex virus developed a latent infection in the trigeminal ganglia within 96 hours. Neutralizing antibody to herpes simplex virus was cleared from the circulation and could not be detected in most of these mice after 2 months. Examination of ganglia from the antibody-negative mice revealed latent virus in over 90 percent of the animals, indicating that serum neutralizing antibody is not necessary to maintain the latent state. When the lips or corneas of these mice were traumatized, viral reactivation occurred in up to 90 percent of the mice, as demonstrated by the appearance of neutralizing antibody. This study provides a model for identifying factors that trigger viral reactivation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sekizawa, T -- Openshaw, H -- Wohlenberg, C -- Notkins, A L -- New York, N.Y. -- Science. 1980 Nov 28;210(4473):1026-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254149" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/*metabolism ; Antigens, Viral/analysis ; Disease Models, Animal ; Ganglia/microbiology ; Herpes Simplex/*immunology ; Immune Tolerance ; Immunization, Passive ; Mice ; Simplexvirus/*growth & development/immunology ; *Virus Activation
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    Hemoglobin switching: a cellular model (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: Regulation of hemoglobin synthesis depends in part on the population of cells available for erythroid differentiation. Mouse erythroleukemia cells were cloned, and the clones were induced with dimethyl sulfoxide to test the relative induction of beta minor and beta major synthesis. Cells of line 745 produced approximately 35 percent beta minor after induction, and 39 clones of line 745 produced from 23 to 61 percent beta minor. Further subcloning of the clone that produced 61 percent beta minor led to three subclones, all of which produced more than 90 percent beta minor. Thus one kind of hemoglobin regulation occurs at the cellular level.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alter, B P -- Goff, S C -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):647-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6928071" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Line ; Clone Cells/metabolism ; Dimethyl Sulfoxide/pharmacology ; Globins/*biosynthesis/genetics ; Leukemia, Erythroblastic, Acute/metabolism ; Mice
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  • 36
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    Neurotransmitter release from a vertebrate neuromuscular synapse affected by a food dye (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-03-28
    Description: The food dye erythrosine (Erythrosin B; FD & C No. 3) was applied to isolated neuromuscular synapses in the frog, and its effects on the spontaneous quantal release of acetylcholine were examined with electrophysiological techniques. At concentrations of 10 muM or greater this anionic dye produced an irreversible, dose-dependent increase in neurotransmitter release. This increase did not depend on the presence of calcium ions in the bathing medium. These increase did not depend on the presence of calcium ions in the bathing medium. These results suggest that erythrosine might prove a useful pharmacological tool for studying the process of transmitter release, but that its use as a food additive should be reexamined.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Augustine, G J Jr -- Levitan, H -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1489-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6244619" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anura ; Calcium/physiology ; Erythrosine/*pharmacology ; Fluoresceins/*pharmacology ; Kinetics ; Membrane Potentials/drug effects ; Motor Endplate/drug effects ; Neuromuscular Junction/*drug effects ; Rana pipiens ; Stimulation, Chemical ; Synaptic Transmission/*drug effects
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    Polyamine metabolism: a potential therapeutic target in trypanosomes (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-17
    Description: alpha-Difluoromethylornithine (RMI 71,782), a specific irreversible inhibitor of the first step in polyamine biosynthesis, that is, the formation of putrescine from ornithine by ornithine decarboxylase, cures mice infected with a virulent, rodent-passaged strain of Trypanosoma brucei brucei. This parasite is closely related to the trypanosomes that cause human sleeping sickness. The drug, which is remarkably nontoxic, was effective when administered in drinking water or by intubation. The ability of the compound to inhibit ornithine decarboxylase in vitro was demonstrated by the reduced amounts of putrescine synthesized from tritiated ornithine in Trypanosoma brucei suspensions. These observations direct attention to polyamine metabolism as a target for chemotherapy of parasitic diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bacchi, C J -- Nathan, H C -- Hutner, S H -- McCann, P P -- Sjoerdsma, A -- AI 13801/AI/NIAID NIH HHS/ -- AI 13852/AI/NIAID NIH HHS/ -- FR-05596/PHS HHS/ -- New York, N.Y. -- Science. 1980 Oct 17;210(4467):332-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6775372" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Eflornithine ; Mice ; Ornithine/analogs & derivatives/metabolism/pharmacology ; Ornithine Decarboxylase Inhibitors ; Polyamines/*metabolism ; *Trypanocidal Agents ; Trypanosoma brucei brucei/drug effects/metabolism ; Trypanosomiasis, African/*drug therapy
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    Picrotoxin convulsions involve synaptic and nonsynaptic mechanisms on cultured mouse spinal neurons (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-30
    Description: The cellular mechanisms underlying picrotoxin-induced convulsive activity were studied by using mouse spinal neurons growing in tissue culture. Picrotoxin-induced convulsive activity in most but not all of the cells studied. The activity could be inverted by polarizing to positive potentials and eliminated either by decreasing the ratio of calcium to magnesium or by applying tetrodotoxin. When applied locally to individual cells, picrotoxin lowered spike threshold and induced spontaneous firing in some but not all cells tested. The results suggest that picrotoxin-induced convulsive activity involves rapidly summating synaptic activity which may be evoked by high-frequency repetitive firing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barker, J L -- MacDonald, J F -- New York, N.Y. -- Science. 1980 May 30;208(4447):1054-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375918" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Calcium/pharmacology ; Cells, Cultured ; Magnesium/pharmacology ; Membrane Potentials/drug effects ; Mice ; Picrotoxin/*pharmacology ; Seizures/*chemically induced ; Spinal Cord/*drug effects/physiology ; Synapses/*drug effects
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    Age-related changes in passive avoidance retention: modulation with dietary choline (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartus, R T -- Dean, R L -- Goas, J A -- Lippa, A S -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384805" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Aging ; Animals ; Avoidance Learning/*drug effects ; Choline/administration & dosage/*pharmacology ; Mice ; Mice, Inbred Strains ; Time Factors
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    Antibody to spermine: a natural biological constituent (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-06
    Description: A protein that binds spermine specifically was separated from normal rabbit serum by affinity chromatography. Immunoelectrophoresis, the Ouchterlony immunodiffusion test, and gradient gel electrophoresis indicated that this protein has immunoglobulin characteristics and consists of several populations of antibodies to spermine. These were sequentially released from Sepharose-spermine gel by step-wise elution with solutions ranging in pH from 4 to 1. The binding constants varied from 5.0 x 10(8) to 11.1 x 10(8) liters per mole. These globulins did not react with monoacetylputrescine, L-ornithine, L-lysine, and histamine. Negligible cross-reactivity was detected with spermidine, putrescine, N8-monoacetylspermidine, cadaverine, and diaminopropane. Since perturbations in polyamine metabolism have been identified in several diseases, the study of extracellular polyamine homeostasis may reveal an important regulatory function for this protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartos, D -- Bartos, F -- Campbell, R A -- Grettie, D P -- Smejtek, P -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1178-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375929" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/*isolation & purification ; Binding Sites, Antibody ; Chromatography, Affinity ; Homeostasis ; Immunoglobulin G/isolation & purification ; Kinetics ; Rabbits ; Spermine/*immunology/metabolism
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    Mouse leukemia: therapy with monoclonal antibodies against a thymus differentiation antigen (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: Monoclonal antibodies against a thymus cell differentiation antigen (Thy-1.1) were effective in the therapy of a transplanted mouse leukemia. Passive immunization resulted in high titers of cytotoxic antibody in the serum of treated mice and the suppression of metastatic tumor cells. The tumor-suppressive effects of the monoclonal antibodies were amplified by the administration of exogenous complement. This combined antibody and complement therapy resulted in the cure of leukemia in a significant proportion of the treated animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernstein, I D -- Tam, M R -- Nowinski, R C -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):68-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6965328" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Specificity ; Antigens, Surface ; Antilymphocyte Serum/*therapeutic use ; Cell Differentiation ; Clone Cells/immunology ; Cytotoxicity, Immunologic ; Immunotherapy ; Leukemia, Experimental/surgery/*therapy ; Mice ; Mice, Inbred Strains ; Neoplasm Metastasis ; T-Lymphocytes/*immunology
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  • 42
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    Limitations of metabolic activation systems used with in vitro tests for carcinogens (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-07-25
    Description: Important differences between the metabolic activation of 7,12-dimethylbenz[a]anthracene in intact cellular systems and in liver homogenates suggest that the use of homogenates in conjunction with short-term assays for carcinogens could yield misleading results.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bigger, C A -- Tomaszewski, J E -- Dipple, A -- Lake, R S -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):503-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6771871" target="_blank"〉PubMed〈/a〉
    Keywords: 9,10-Dimethyl-1,2-benzanthracene/*metabolism ; Animals ; Benz(a)Anthracenes/*metabolism ; Carcinogens/*metabolism ; Cells, Cultured ; DNA/metabolism ; Deoxyribonucleosides ; Drug Evaluation, Preclinical/methods ; Humans ; Liver/*metabolism ; Mice ; Microsomes, Liver/metabolism ; Rats ; Skin/metabolism
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    Electrophoretic injection of a fluorescent dye into giant mitochondria and mitoplasts (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-09-12
    Description: Studies of the electrical properties of giant mitochondria and mitoplasts with microelectrodes have indicated that there are no significant metabolically dependent membrane potentials. The internal location of the microelectrode has been confirmed by electrophoretically microinjecting the water-soluble dye Lucifer yellow CH into giant mitochondria or mitoplasts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowman, C -- Tedeschi, H -- New York, N.Y. -- Science. 1980 Sep 12;209(4462):1251-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403882" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Electrophoresis ; Fluorescent Dyes/*administration & dosage ; Membrane Potentials ; Mice ; Microelectrodes ; Mitochondria, Liver/*physiology/ultrastructure
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  • 44
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    Histamine-mediated delayed permeability response after scald burn inhibited by cimetidine or cold-water treatment (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-15
    Description: Scald injury to one ear of the hairless mouse induced significant (P 〈 .05) delayed edema formation in remote, uninjured skin. This remote edema formation was completely inhibited by immediate cold-water treatment of the scalded ear. Cold-water treatment significantly reduced histamine loss from the scalded ear, and the edema-inhibiting effect of the treatment could be mimicked by treating the animal prior to injury with the H2-histamine receptor antagonist cimetidine or a drug that causes histamine depletion. These observations suggest (i) that a histamine-mediated, delayed permeability response occurs after thermal injury that causes remote edema formation and (ii) that one mechanism of remote edema inhibition by cold-water treatment is the prevention of histamine release from thermally injured tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boykin, J V Jr -- Eriksson, E -- Sholley, M M -- Pittman, R N -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):815-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6157189" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Burns/complications/physiopathology/*therapy ; Cell Membrane Permeability ; Cimetidine/*pharmacology ; *Cold Temperature ; Edema/etiology/physiopathology ; Guanidines/*pharmacology ; Histamine Release/*drug effects ; Indomethacin/pharmacology ; Male ; Mice ; Receptors, Histamine H2/physiology
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  • 45
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    Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-07-11
    Description: The high-affinity binding of triatiated imipramine to platelet membranes was compared in samples from 16 untreated depressed women and 21 age-matched controls of the same sex. The maximal binding in the depressed group was significantly lower than that of the controls, although the affinity constants were similar. These results suggest that binding of tritiated imipramine in human platelets may represent a biochemical index of depression, possibly reflecting similar changes in the brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Briley, M S -- Langer, S Z -- Raisman, R -- Sechter, D -- Zarifian, E -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):303-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384806" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Blood Platelets/*analysis ; Cell Membrane/metabolism ; Depression/*blood ; Humans ; Imipramine/*blood ; Kinetics ; Middle Aged ; Receptors, Drug/*metabolism
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    Inhibition of cell motility by interferon (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-05-02
    Description: Interferon derived from human leukocytes, human fibroblasts, and mouse fibroblasts was found to inhibit the motility of cultured cells. It inhibits the tumor-induced motility of capillary endothelial cells as well as the spontaneous migration of other cell types. The ability of a given preparation of interferon to inhibit the motility of a given cell type is proportional to its antiviral activity in that particular cell type. Antiserum to human leukocyte interferon neutralizes both the motility-inhibitory activity and the antiviral activity of this preparation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brouty-Boye, D -- Zetter, B R -- New York, N.Y. -- Science. 1980 May 2;208(4443):516-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6154315" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antineoplastic Agents ; Antiviral Agents ; Capillaries/cytology ; Cattle ; *Cell Movement ; Cells, Cultured/physiology ; Endothelium/cytology ; Fibroblasts ; Humans ; Interferons/*pharmacology ; Leukocytes/physiology ; Mice ; Neoplasms/pathology
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  • 47
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    Excitatory and inhibitory effects of serotonin on sensorimotor reactivity measured with acoustic startle (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-07-25
    Description: Serotonin infused into the lateral ventricle in rats produced a dose-dependent depression of the acoustic startle reflex. When infused onto the spinal cord, serotonin produced a dose-dependent increase in startle. Thus the same neurotransmitter can modulate the same behavior in opposite ways, depending on which part of the central nervous system is involved.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, M -- Strachan, D I -- Kass, E -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):521-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394520" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Kinetics ; Male ; Rats ; Reflex, Acoustic/*drug effects ; Reflex, Startle/*drug effects ; Serotonin/*pharmacology
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  • 48
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    gamma-Glutamyl transpeptidase in isolated brain endothelial cells: induction by glial cells in vitro (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-02-08
    Description: The endothelia of microvessels isolated from mouse brain by mechanical means are rich in gamma-glutamyl transpeptidase; however, the enzyme often disappears when the cells migrate or proliferate from the microvessel isolates. In an endothelial cell line derived from similar isolates and negative for gamma-glutamyl transpeptidase, the enzyme could be induced in the endothelial cells when they were cocultured with glial cells. Thus there may be a requirement for continuous induction of gamma-glutamyl transpeptidase in brain microvessels by adjacent glial cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeBault, L E -- Cancilla, P A -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):653-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6101511" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*blood supply ; Capillaries/*enzymology ; Cells, Cultured ; Endothelium/enzymology ; Enzyme Induction ; Glioma/physiopathology ; Mice ; Neuroglia/*physiology ; Rats ; gamma-Glutamyltransferase/*biosynthesis
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    Epidermal growth factor is a major growth-promoting agent in human milk (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-10-10
    Description: Human milk stimulates DNA synthesis in cell cultures in which growth has been arrested. The mitogenic activity of milk is neutralized by the addition of antibody to human epidermal growth factor. The results identify epidermal growth factor as a major growth-promoting agent in breast milk.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carpenter, G -- CA24071/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 10;210(4466):198-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6968093" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division/drug effects ; Cells, Cultured ; DNA/biosynthesis ; Epidermal Growth Factor/analysis/*pharmacology ; Female ; Humans ; Mice ; Milk, Human/analysis/*physiology ; Mitogens ; Peptides/*pharmacology
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    Postsynaptic transmission block can cause terminal sprouting of a motor nerve (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: Sprouting of mouse soleus motor nerve terminals can be evoked by daily intramuscular injections of purified alpha-bungarotoxin. This finding supports the hypothesis that an important stimulus to terminal sprouting in partial denervation and presynaptic nerve blockade is a product of inactive muscle fibers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holland, R L -- Brown, M C -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):649-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243417" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Botulinum Toxins/pharmacology ; Bungarotoxins/*pharmacology ; Female ; Mice ; Motor Endplate/drug effects ; Motor Neurons/*growth & development ; Muscles/innervation ; Neuromuscular Junction/*physiology ; Receptors, Cholinergic/drug effects ; Synaptic Transmission/*drug effects
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    Gene transfer given a new twist (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):386-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6929109" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow Cells ; Cell Survival/drug effects ; *DNA, Recombinant ; Drug Resistance ; Genetic Engineering/*methods ; Methotrexate/*pharmacology ; Mice ; Selection, Genetic
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    Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-12
    Description: Vasoactive intestinal peptide, a smooth-muscle relaxant neuropeptide with neurotransmitter properties, was relaxed during electrical field stimulation of guinea pig trachea. The amount released correlated with the degree of relaxation, and the release was blocked by tetrodotoxin. Prior incubation of the trachea with antiserum to vasoactive intestinal peptide reduced the relaxation. Thus vasoactive intestinal peptide may mediate the nonadrenergic relaxation of tracheal smooth muscle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsuzaki, Y -- Hamasaki, Y -- Said, S I -- HL-14187/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1252-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254154" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/*physiology ; Animals ; Antigen-Antibody Reactions ; Electric Stimulation ; Female ; Gastrointestinal Hormones/*physiology ; Humans ; Mice ; *Muscle Contraction ; *Muscle Relaxation ; Muscle, Smooth/drug effects ; Neural Inhibition ; Synaptic Transmission ; Tetrodotoxin/pharmacology ; Trachea/*innervation ; Vasoactive Intestinal Peptide/immunology/*physiology
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    Tumor-promoting phorbol esters stimulate hematopoietic colony formation in vitro (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-04-25
    Description: Tumor-promoting phorbol esters stimulated mouse bone marrow cells to form myeloid colonies in agar cultures without added colony-stimulating factors. The colony-stimulating ability of various phorbol esters correlated well with their ability to promote skin tumors in vivo. These results suggest that phorbol esters mimic the action of specific colony-stimulating factors that regulate growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stuart, R K -- Hamilton, J A -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):402-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6245446" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division/drug effects ; Cells, Cultured ; *Colony-Forming Units Assay ; Colony-Stimulating Factors/pharmacology ; Dose-Response Relationship, Drug ; Hematopoietic Stem Cells/*drug effects ; Macrophages/physiology ; Mice ; Monocytes/physiology ; Phorbol Esters/pharmacology ; Phorbols/*pharmacology ; Receptors, Cell Surface/drug effects ; Structure-Activity Relationship ; Tetradecanoylphorbol Acetate/*pharmacology
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    Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-01-04
    Description: Hybrid cells secreting antibodies against sporozoites of Plasmodium berghei were obtained by fusion of plasmacytoma cells with immune murine spleen cells. The monoclonal antibodies bound to a protein with an apparent molecular weight of 44,000 (Pb44), which envelopes the surface membrane of sporozoites. Incubation of sporozoites in vitro with antibodies to Pb44 abolished their infectivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoshida, N -- Nussenzweig, R S -- Potocnjak, P -- Nussenzweig, V -- Aikawa, M -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985745" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; Antigens, Surface ; Clone Cells/immunology ; Hybrid Cells/immunology ; Malaria/*immunology ; Membrane Proteins/immunology ; Mice ; Molecular Weight ; Myeloma Proteins/immunology ; Neoplasms, Experimental/immunology ; Plasmacytoma/immunology ; Plasmodium berghei/*immunology ; Spleen/immunology
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    DNA sequences mediating class switching in alpha-immunoglobulins (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: Immunoglobulin class switching involves specific DNA rearrangements of the gene segments coding for heavy chain constant regions (CH) during B lymphocyte differentiation. In two different cases of C mu to C alpha switching examined here (T15 and M603) and one taken from the literature (MC101), three different sites on the 5' side of C mu and three different sites on the 5' side of C alpha are joined together in the process of CH switching. The sequences surrounding the three germ-line C alpha sites of recombination are highly conserved blocks of 30 nucleotides that may serve as recognition sequences for CH switching to the C alpha gene. This putative recognition sequence is repeated 17 times in approximately 1400 nucleotides of the germ-line Calpha 5' flanking sequence. The lack of homology between this C alpha sequence and sequences reported for the C gamma 1 and C gamma 2b switch sites suggests that heavy chain switching is mediated by class-specific recognition sequences and, presumably, class-specific regulatory mechanisms. In addition, it appears that in one example (MC101) CH switching progressed from C mu to C alpha to C gamma 1. This switching pathway may present difficulties for the simple deletional model of CH switching.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, M M -- Kim, S K -- Hood, L E -- AI 09072/AI/NIAID NIH HHS/ -- GM 07616/GM/NIGMS NIH HHS/ -- PCM76-81546/PC/NCI NIH HHS/ -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1360-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6774415" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*immunology ; Base Sequence ; DNA/genetics ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin Variable Region/genetics ; Immunoglobulin alpha-Chains/*genetics ; Immunoglobulin mu-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Myeloma Proteins/genetics ; Recombination, Genetic
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    Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-22
    Description: Two coronaviruses were isolated from brain material obtained at autopsy from two multiple sclerosis patients. The viruses were neutralized by serum and spinal fluid from these patients. Although most of the population have antibody to these virus isolates, multiple sclerosis patients have slightly higher concentrations of serum antibody than controls. The results suggest that coronaviruses should be considered as one additional virus with a potential implication in the etiology of multiple sclerosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burks, J S -- DeVald, B L -- Jankovsky, L D -- Gerdes, J C -- New York, N.Y. -- Science. 1980 Aug 22;209(4459):933-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403860" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Animals ; Antibodies, Viral/analysis ; Brain/*microbiology ; Cells, Cultured ; Coronaviridae/immunology/*isolation & purification ; Female ; Freezing ; Humans ; Male ; Mice ; Middle Aged ; Multiple Sclerosis/*microbiology/pathology
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    Insulin receptors in hepatocytes: postreceptor events mediate down regulation (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-28
    Description: Down regulation of the insulin receptor of primary cultures of rat hepatocytes occurs in the presence of insulin and several agents with insulin-like activity, which act through or distal to the insulin receptor. These findings indicate that the interaction of insulin with its specific binding site is not in itself sufficient to down-regulate this receptor and that one or more steps subsequent to this interaction are necessary. Thus, down regulation may be a complex biological response to insulin, and if a cell were resistant to this effect of insulin, our data may explain how target cells from a patient or animal can have a normal number of receptors in the presence of increased concentrations of circulating insulin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caro, J F -- Amatruda, J M -- AM 00366/AM/NIADDK NIH HHS/ -- AM 20948/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1980 Nov 28;210(4473):1029-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7001632" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Insulin/metabolism ; Kinetics ; Liver/*metabolism ; Male ; Peroxides/pharmacology ; Rats ; Receptor, Insulin/drug effects/immunology/*metabolism ; Spermine/pharmacology ; Vitamin K/pharmacology
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    Subcellular origin of cholinergic transmitter release from mouse brain (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-11-07
    Description: Samples of minced mouse forebrain were treated in a way that resulted in a high ratio of false cholinergic transmitter (acetylhomocholine) to true transmitter (acetylcholine) in a synaptic vesicle fraction, and a low ratio of false to true transmitter in the nerve terminal cytoplasm. The spontaneous release of cholinergic transmitters from this minced tissue occurred independently of calcium and had a ratio of false to true transmitter similar to that of the cytoplasm, whereas the evoked transmitter release required calcium and had a ratio of false to true transmitter similar to that of the vesicular fraction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carroll, P T -- Aspry, J M -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):641-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7433989" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/analogs & derivatives/*metabolism ; Animals ; Brain/*metabolism ; Calcium/physiology ; Cytoplasm/metabolism ; Exocytosis/drug effects ; Lithium/pharmacology ; Magnesium/physiology ; Male ; Mice ; Potassium/pharmacology ; Synaptic Vesicles/metabolism
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    Asymmetrically permeable membrane channels in cell junction (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-02-15
    Description: Asymmetric membrane junctions were formed in culture by pairing two cell types which, in their respective homologous junctions, have cell-cell channels of different permselectivities. The channels in the asymmetric junction, presumably made of unequal channel precursors, displayed directional permselectivity; fluorescent labeled glutamic acid (700 daltons), but not smaller and less polar permeant molecules, traversed the junction more readily in one direction than in the other. The favored direction was the one where the permeant passed first through the cell membrane that would have the less restrictive channels in a homologous junction. This directional selectivity requires no electric field across the junction and is thus distinct from a rectifying junction. The physiological potential of such directional molecular sieving for partitioning communication between tissue cells of different function and developmental fate are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flagg-Newton, J L -- Loewenstein, W R -- New York, N.Y. -- Science. 1980 Feb 15;207(4432):771-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352287" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; *Cell Communication ; Cell Line ; Cell Membrane Permeability ; Fluorescent Dyes ; Intercellular Junctions/*physiology ; Ion Channels/*physiology/ultrastructure ; Membrane Potentials ; Mice
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    Therapy of spontaneous metastases by intravenous injection of liposomes containing lymphokines (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-06-27
    Description: Mice of two different strains were injected subcutaneously with spontaneously metastasizing syngeneic melanomas. After 4 to 6 weeks, the local tumors were removed and, 3 days after surgery, treatment of the metastases was initiated. The treatment consisted of intravenous injections of liposomes containing lymphokines or control supernatant fluids. Liposomes were injected twice weekly for 3 weeks, and the mice were killed 2 weeks later. Seventy-three percent of the mice injected with liposomes containing lymphokines were free of metastases, whereas only 10 percent of the mice treated with control liposomes were tumor-free. These experiments suggest that this form of therapy may provide a valuable addition to the more conventional approaches to the eradication of cancer metastases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fidler, I J -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1469-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384789" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Liposomes/*therapeutic use ; Lymphokines/*therapeutic use ; Melanoma/*drug therapy ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; *Neoplasm Metastasis ; Neoplasms, Experimental/drug therapy ; Species Specificity
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    1 alpha, 25-Dihydroxyvitamin D3 nuclear receptors in pituitary (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-09-12
    Description: Specific binding of 1 alpha,25-dihydroxyvitamin D(3) was found in nuclear and cytosol fractions of the bovine pituitary. For nuclear binding. the dissociation constant was 0.1 namomole per liter, and maximum binding was 104 femtomoles per milligram of protein. In competition studies, 25-hydroxyvitamin D(3) was 300 times weaker than 1 alpha,25-dihydroxyvitamin D(3). The existence of high-affinity sites supports a physiologic role for 1 alpha,25-dihydroxyvitamin D(3) in the pituitary.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gelbard, H A -- Stern, P H -- U'Prichard, D C -- New York, N.Y. -- Science. 1980 Sep 12;209(4462):1247-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250221" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/metabolism ; Cattle ; Cell Nucleus/metabolism ; Cholecalciferol/*metabolism ; Cytosol/metabolism ; Dihydroxycholecalciferols/*metabolism ; Hydroxycholecalciferols/*metabolism ; Kinetics ; Pituitary Gland/*metabolism/ultrastructure ; Receptors, Drug/*metabolism
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    Human cutaneous lieshmania in a mouse macrophage line: propagation and isolation of intracellular parasites (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-09-12
    Description: A mouse macrophage line, J774G8, supports continuous and prolific intracellular growth of Leishmania mexicana amazonensis, the etiological agent of a South American cutaneous leishmaniasis. The intracellular parasites from these infected cultures can be isolated with high recovery rate and purity by simple Percoll gradient centrifugation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chang, K P -- New York, N.Y. -- Science. 1980 Sep 12;209(4462):1240-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403880" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Disease Models, Animal ; Humans ; Leishmania/growth & development ; Leishmaniasis/*parasitology/pathology ; Macrophages/*parasitology ; Mice
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    Strain dependence of the antiproliferative action of interferon on murine erythroid precursors (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-07-11
    Description: Electrophoretically pure mouse interferon inhibits erythropoietin-dependent proliferation of committed erythroid precursors (CFU-E) obtained either from adult mouse bone marrow or from 14-day fetal mouse livers. The degree of inhibition is significantly influenced by the genotype of the cell donor; about ten times as much interferon is required to inhibit proliferation of CFU-E from C57BL/6 than is needed for comparable inhibition of CFU-E from BALB/c or Swiss mice. These strain-dependent results point to the existence of genes that influence the degree of the inhibitory effect of interferon on cell multiplication.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallien-Lartigue, O -- Carrez, D -- De Maeyer, E -- De Maeyer-Guignard, J -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):292-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6155700" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow/drug effects/*physiology ; Cell Division/drug effects ; Embryo, Mammalian ; Erythropoiesis/*drug effects ; Female ; Interferons/*pharmacology ; Liver/drug effects/physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Species Specificity
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    New protein sequenator with increased sensitivity (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-02-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hunkapiller, M W -- Hood, L E -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):523-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352258" target="_blank"〉PubMed〈/a〉
    Keywords: *Amino Acid Sequence ; Animals ; Humans ; Mice ; *Proteins/genetics
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    Role of nitrogen dioxide in the biosynthesis of nitraosamines in mice (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-03-28
    Description: Groups of three to four mice were gavaged with aqueous solutions of 2 milligrams of morpholine, after which they were exposed to nitrogen dioxide in inhalation chambers at concentrations of 0.2 to 50 parts per million for up to 4 hours. At sequential intervals during the exposure, mice were frozen and pulverized in liquid nitrogen, and the mice powder was extracted with ice-cold 35 percent aqueous methanol and dichloromethane; organic-phase concentrates were analyzed for N-nitrosomorpholine with a thermal energy analyzer interfaced to a gas chromatograph. The N-nitrosomorpholine yields, ranging up to about 2.3 micrograms per mouse, were time-dependent relative to the duration of exposure to nitrogen dioxide and dose-dependent relative to the concentrations of nitrogen dioxide; control levels (in mice that were gavaged with morpholine or distilled water and then exposed to air instead of nitrogen dioxide) were less than 5 nanograms per mouse. These preliminary studies demonstrate the in vivo nitrosating potential of nitrogen oxides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iqbal, Z M -- Dahl, K -- Epstein, S S -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1475-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361099" target="_blank"〉PubMed〈/a〉
    Keywords: Amines/metabolism ; Animals ; Ascorbic Acid/pharmacology ; Biotransformation ; Dose-Response Relationship, Drug ; Mice ; Morpholines/*metabolism ; Nitrogen Dioxide/antagonists & inhibitors/*metabolism ; Nitrosamines/*metabolism ; Time Factors
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    Natural killer cells help defend the body (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-11-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):624-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159684" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Humans ; Immunity, Cellular ; *Immunity, Innate ; Interferons/physiology ; Killer Cells, Natural/*immunology ; Mice ; Mice, Nude/immunology ; Neoplasms/*immunology ; Neoplasms, Experimental/immunology ; Virus Diseases/*immunology
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    Cell variants showing differential susceptibility to ultraviolet light--induced transformation (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Six variant clones isolated from a subclone of BALB/3T3-A31 clone were classified into three groups according to their different susceptibilities to cell transformation by ultraviolet light irradiation: highly susceptible, intermediately susceptible, and resistant. All variant clones showed similar susceptibility to cytotoxic effects induced by ultraviolet light.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kakunaga, T -- Crow, J D -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):505-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394516" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic/*radiation effects ; Clone Cells ; Dose-Response Relationship, Radiation ; Genetic Variation ; Mice ; Transformation, Genetic/*radiation effects ; *Ultraviolet Rays
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    Hybridomas revisited (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-17
    Description: In the report by John C. Behrendt et al. "Aeromagnetic and radio echo ice-sounding measurements show much greater area of the Dufek Intrusion, Antarctica" (29 Aug., p. 1014), the word "expedition" should have read "exploitation" in line 13 of the first paragraph on page 1014. Also, in line 2 of the next to last paragraph on page 1016, "50 to 60 cm/sec(2)" should have read "50 to 60 (cm sec(2)) x 10(-3)."〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koprowski, H -- Croce, C -- New York, N.Y. -- Science. 1980 Oct 17;210(4467):248.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423184" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; Antibodies, Viral ; Cell Line ; *Clone Cells ; Mice ; *Patents as Topic ; Plasmacytoma/immunology
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    Absence of cross-tolerance to heroin in morphine-tolerant mice (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-04
    Description: Mice implanted with morphine pellets demonstrated a 30-fold increase in tolerance to subcutaneously administered morphine but showed no cross-tolerance to subcutaneously administered heroin. When given morphine intracerebroventricularly, the mice showed no tolerance to morphine or cross-tolerance to heroin. These observations depended on the presence of the morphine pellet. If the pellets were removed prior to determinations of potency, the expected responses--tolerance to morphine and cross-tolerance to heroin--were obtained. The blood-brain barrier may be a prime site for the expression of morphine tolerance in mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lange, D G -- Roerig, S C -- Fujimoto, J M -- Wang, R I -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):72-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361110" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood-Brain Barrier/drug effects ; Drug Interactions ; Drug Tolerance ; Heroin/administration & dosage/*pharmacology ; Mice ; Morphine/administration & dosage/*pharmacology
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  • 70
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    Assignment of the murine interferon sensitivity and cytoplasmic superoxide dismutase genes to chromosome 16 (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: Both hybrids of mouse and human microcells and whole cell hybrids generated by the fusion of primary mouse cells and SV40-transformed human fibroblasts were used to establish the syntenic association of the murine cytoplasmic superoxide dismutase and the interferon sensitivity genes on mouse chromosome 16. This assignment adds two new markers to chromosome 16 and provides another example of an evolutionarily conserved linkage. This finding also provides an animal model both for cellular responsiveness to interferon and for Down's syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, P F -- Slate, D L -- Lawyer, F C -- Ruddle, F H -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):285-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6155698" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Viral ; *Chromosomes, Human, 16-18 ; *Genes ; Humans ; Hybrid Cells/drug effects/*physiology ; Interferons/*pharmacology ; Karyotyping ; Mice ; Simian virus 40 ; Superoxide Dismutase/*genetics
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  • 71
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    Time: a new parameter for kinetic measurements in flow cytometry (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: The measure of time was used as an additional parameter on an existing flow cytometer to study the kinetics of enzyme activities and cell-stain interactions. By correlating all fluorescent signals from single cells with time, the dynamics of a reaction can be followed for several minutes. This advanced application of flow cytometry is easily implemented and can be incorporated into any flow cytometer that has two-parameter analysis capability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, J C -- Swartzendruber, D E -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):199-201.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6153131" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cells, Cultured/enzymology ; Computers ; Cricetinae ; *Cytological Techniques ; DNA/metabolism ; Esterases/metabolism ; Kinetics ; Mice ; Spectrometry, Fluorescence/methods ; Staining and Labeling
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  • 72
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    Opiate receptor function may be modulated through an oxidation-reduction mechanism (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-06
    Description: Cupric ion, a thiol oxidant, caused naloxone-reversible analgesia when injected intracerebroventricularly in mice; its potency was close to that of morphine. Dithiothreitol, a thiol reductant, reversed the analgesia induced by cupric ion and antagonized analgesia induced by morphine. Oxidized dithiothreitol had no effect. These findings, together with evidence for redox modification of opiate receptor binding in vitro, suggest that a mechanism of oxidation-reduction of thiols may modulate opiate receptor function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marzullo, G -- Hine, B -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6246583" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; Copper/antagonists & inhibitors/*pharmacology ; Dithiothreitol/pharmacology ; Male ; Mice ; Naloxone/pharmacology ; Oxidation-Reduction ; Pain/*physiopathology ; Rats ; Receptors, Opioid/drug effects/*physiology ; Sulfhydryl Compounds/pharmacology ; Zinc/pharmacology
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    New techniques for selective immune suppression increase transplant odds (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T A 2nd -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):44-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6774417" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antilymphocyte Serum/therapeutic use ; Blood Transfusion ; Bone Marrow Transplantation ; Cyclosporins ; Drainage ; *Graft Survival/drug effects ; Haplorhini ; Heart Transplantation ; Humans ; Immunosuppression/*methods ; Immunosuppressive Agents/therapeutic use ; Infection Control ; Kidney Transplantation ; Lung Transplantation ; Lymphatic System/radiation effects ; Lymphocyte Depletion ; Mice ; Peptides, Cyclic/therapeutic use ; Rats ; T-Lymphocytes/drug effects/immunology ; Thoracic Duct/surgery ; Transplantation, Homologous
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  • 74
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    Effective pulmonary ventilation with small-volume oscillations at high frequency (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-01
    Description: At high oscillation frequencies (4 to 30 hertz), effective alveolar ventilation can be achieved with tidal volumes much smaller than the anatomic dead space. An explanation of this phenomenon is given in terms of the combined effects of diffusion and convection and in terms of data consistent with the hypothesis. Theory and experimental results both show that the significant variable determining the effectiveness of gas exchange is the amplitude of the oscillatory flow rate independent of the individual values of frequency and stroke volume.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slutsky, A S -- Drazen, F M -- Ingram, R H Jr -- Kamm, R D -- Shapiro, A H -- Fredberg, J J -- Loring, S H -- Lehr, J -- New York, N.Y. -- Science. 1980 Aug 1;209(4456):609-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6771872" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Dioxide/metabolism ; Diffusion ; Dogs ; Kinetics ; Mathematics ; Oscillometry ; Pulmonary Alveoli/*physiology ; *Respiration
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  • 75
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    Endocytotic sucrose uptake in Amoeba proteus induced with the calcium ionophore A23187 (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-08
    Description: The calcium ionophore A23187 brings about an influx of calcium and uptake of sucrose by endocytosis in Amoeba proteus. The amount of endocytotic sucrose uptake elicited by the ionophore depends upon the external calcium ion concentration. Calcium ion movements may serve to couple the surface phase of endocytosis with cytoplasmic uptake of the endocytotic inducer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prusch, R D -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):691-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6771873" target="_blank"〉PubMed〈/a〉
    Keywords: Amoeba/drug effects/*metabolism ; Animals ; Anti-Bacterial Agents/*pharmacology ; Biological Transport/drug effects ; Calcimycin/*pharmacology ; Calcium/metabolism ; Endocytosis/*drug effects ; Kinetics ; Sucrose/*metabolism
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  • 76
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    At least three human type alpha interferons: structure of alpha 2 (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: The sequence of a human leukocyte-derived complementary DNA (cDNA), Hif-2h, which directs the formation in Escherichia coli of a polypeptide, IFN-alpha 1, with interferon (IFN) activity has been described. A second IFN cDNA, Hif-SN206, which also elicits synthesis of a biologically active IFN, IFN-alpha 2, is described in this article. Whereas IFN-alpha 2 is twice as active on human as on bovine cells, IFN-alpha 1 is 10 to 20 times more active on bovine than on human cells. As deduced from the cDNA's, the messenger RNA's for the two IFN's differ in length and in 20 percent of the nucleotides; the mature IFN polypeptides differ in 17 percent of the amino acids. Both IFN-alpha 1 and IFN-alpha 2 differ from the lymphoblastoid IFN described by others. Therefore, at least three different IFN-alpha genes are expressed in man; studies on genomic DNA reveal the presence of at least eight IFN-related genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Streuli, M -- Nagata, S -- Weissmann, C -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1343-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6158094" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; DNA, Recombinant ; Escherichia coli/genetics ; Genes ; Humans ; *Interferons/genetics ; Leukocytes ; Lymphocytes ; Mice ; RNA, Messenger/genetics ; Structure-Activity Relationship
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    Biochemical analysis of human T lymphocyte differentiation antigens T4 and T5 (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-25
    Description: Two major functionally distinct T cell subsets in man have been defined with heteroantiserums and monoclonal antibodies directed against stable cell surface antigens that appear during thymic ontogeny. A monoclonal antibody to T4 antigen (anti-T4) is reactive with the peripheral inducer T cell population while a monoclonal antibody to T5 antigen (anti-T5) is reactive with the cytotoxic and suppressor population. Immunoprecipitation and electrophoresis on sodium dodecyl sulfate polyacrylamide gel were used to show that on human thymocytes or peripheral T cells the T4 antigen is a single 62,000-dalton glycoprotein while the T5 antigen is a complex of two glycoproteins, one being 30,000 daltons and the other 32,000 daltons. Similar glycoproteins have been isolated with antibodies to murine Lyt 1 and Lyt 2,3 antigens. Both the antigens defining the phenotypes of inducer and suppressor populations in man and mouse are structurally homologous.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Terhorst, C -- van Agthoven, A -- Reinherz, E -- Schlossman, S -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):520-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6967228" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Antigens, Surface/*analysis ; Electrophoresis, Polyacrylamide Gel ; Glycoproteins/analysis ; Humans ; Mice ; Molecular Weight ; T-Lymphocytes/*immunology ; Thymus Gland/immunology
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    Mouse interferons: amino terminal amino acid sequences of various species (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-01
    Description: Mouse interferons of three size classes (A, 35,000 to 40,000 daltons; B, 26,000 to 33,000 daltons; and C, 20,000 daltons) were purified from Ehrlich ascites tumor cells infected with Newcastle disease virus. The sequences of the first 24 amino acids (No. 17 has not been identified) of interferons A and B are identical. The sequence of the first 20 amino acids of interferon C differs from that of A and B in 18 positions. There is partial homology in amino terminal sequence between mouse interferons A (or B) and a human fibroblast interferon and between mouse interferon C and a human lymphoblastoid interferon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taira, H -- Broeze, R J -- Jayaram, B M -- Lengyel, P -- Hunkapiller, M W -- Hood, L E -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):528-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352261" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Biological Evolution ; Carcinoma, Ehrlich Tumor/analysis ; Cells, Cultured ; Glycoproteins/analysis ; *Interferons/genetics ; Mice ; Molecular Weight
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    Niemann-Pick disease: a genetic model in Siamese cats (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-27
    Description: Three Siamese cats were found to have a progressive neurological disease that became obvious when they were 4 to 5 months of age. Their brains contained an excess of GM2 and GM3 gangliosides, and their livers a nine- to tenfold excess of sphingomyelin and cholesterol. A total deficiency of lysosomal (pH 5.0) sphingomyelinase was found in the leukocytes, liver, and brain of the cats, although the activity of the microsomal (pH 7.4, magnesium-dependent) sphingomyelinase was normal in brain. These cats appear to have a genetic disease identical to Niemann-Pick disease type A.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wenger, D A -- Sattler, M -- Kudoh, T -- Snyder, S P -- Kingston, R S -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1471-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7189903" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/enzymology ; Brain Chemistry ; Cat Diseases/enzymology/*genetics ; Cats ; *Disease Models, Animal ; Gangliosides/analysis ; Humans ; Kinetics ; Liver/analysis ; Niemann-Pick Diseases/enzymology/*genetics ; Phospholipids/analysis ; Sphingomyelin Phosphodiesterase/analysis
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    UCLA gene therapy racked by friendly fire (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):509-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6932738" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Cells ; Ethics Committees, Research ; Gene Expression Regulation ; *Genes ; Genetic Engineering/*methods ; Globins/*genetics ; Humans ; Mice ; Risk Assessment ; Thalassemia/*genetics ; Universities
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  • 81
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    Modulation of epidermal growth factor receptors on 3T3 cells by platelet-derived growth factor (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-12-19
    Description: Platelet-derived growth factor does not compete with epidermal growth factor (EGF) for binding to EGF receptors on the murine 3T3 cell surface, but it modulates EGF receptors in two ways: (i) it induces a transient down regulation of EGF receptors and (ii) it inhibits EGF-induced down regulation of EGF receptors. These data suggest a common cellular internalization mechanism for the receptors for both hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wrann, M -- Fox, C F -- Ross, R -- AM-25826/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 19;210(4476):1363-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding, Competitive ; Blood Platelets/*physiology ; Cell Line ; Endocytosis ; Epidermal Growth Factor/*metabolism ; Growth Substances/*pharmacology ; Mice ; Peptides/*metabolism/*pharmacology ; Platelet-Derived Growth Factor ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/*drug effects/metabolism
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    Relation of mammalian sperm chromatin heterogeneity to fertility (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-12-05
    Description: Flow cytometry of heated sperm nuclei revealed a significant decrease in resistance to in situ denaturation of spermatozoal DNA in samples from bulls, mice, and humans of low or questionable fertility when compared with others of high fertility. Since thermal denaturation of DNA in situ depends on chromatin structure, it is assumed that changes in sperm chromatin conformation may be related to the diminished fertility. Flow cytometry of heated sperm nuclei may provide a new and independent determinant of male fertility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Evenson, D P -- Darzynkiewicz, Z -- Melamed, M R -- New York, N.Y. -- Science. 1980 Dec 5;210(4474):1131-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444440" target="_blank"〉PubMed〈/a〉
    Keywords: Acridine Orange ; Animals ; Cattle ; Cell Nucleus/ultrastructure ; Chromatin/*ultrastructure ; *Fertility ; Hot Temperature ; Humans ; Infertility, Male/*pathology ; Male ; Mice ; Nucleic Acid Denaturation ; Sperm Head/*ultrastructure ; Spermatozoa/*physiology/*ultrastructure ; Zinc/deficiency
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  • 83
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    Factors influencing the inhibitory effect of selenium on mice inoculated with Ehrlich ascites tumor cells (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-15
    Description: Selenium, administered to mice with Ehrlich ascites tumors, effectively limited tumor growth. The response was dependent on the chemical form and dose of selenium administered. At the doses administered, there were no detectable adverse effects to the host.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greeder, G A -- Milner, J A -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):825-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7406957" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinoma, Ehrlich Tumor/*drug therapy/pathology ; Cell Line ; Cell Membrane Permeability ; Cystine/analogs & derivatives ; Dose-Response Relationship, Drug ; Male ; Mice ; Neoplasm Transplantation ; Selenium/*administration & dosage/metabolism/therapeutic use ; Selenomethionine/administration & dosage
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  • 84
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    Pentobarbital: stereospecific actions of (+) and (-) isomers revealed on cultured mammalian neurons (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: Stereoisomers of the barbiturate anesthetic pentobarbital were applied to mouse spinal neurons growing in tissue culture. Intracellular recordings of neuronal membrane properties revealed that the (+) and (-) isomers caused direct changes in membrane potential and conductance on some but not all of the cells tested. The action of the (+) isomer was predominantly excitatory, whereas the (-) isomer produced predominantly inhibitory responses. The (-) isomer was considerably more effective in potentiating inhibitory responses to the transmitter gamma-aminobutyric acid. The results show that pentobarbital has multiple effects on neuronal excitability and demonstrate the presence of stereospecific sites of barbiturate action on central neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, L Y -- Barker, J L -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):195-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350656" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Electric Conductivity ; Membrane Potentials/drug effects ; Mice ; Neural Inhibition/drug effects ; Neurons/*drug effects ; Pentobarbital/*pharmacology ; Spinal Cord/embryology ; Stereoisomerism ; Structure-Activity Relationship
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  • 85
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    Monozygotic twin formation in mouse embryos in vitro (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-01
    Description: Monozygotic twins developed from cultured murine blastocysts at the ratio of approximately 1:100. The locus at which the denuded blastocysts attached to the culture dish was usually a random section of their mural trophoblasts, in which case single egg cylinders developed unilaterally. However, in those few blastocysts attaching with their antipolar mural trophoblasts, the inner cell mass became subdivided into two parts because of restrictions imposed on its growth by the apically situated polar trophoblasts and the plastic substrate. Each subdivision apparently incorporated totipotent cells, resulting in the bilateral formation of two egg cylinders sharing the same ectoplacental cone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, Y C -- Gonda, M A -- New York, N.Y. -- Science. 1980 Aug 1;209(4456):605-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7190325" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/physiology ; Culture Media ; Embryo, Mammalian/*physiology ; Female ; Fertilization in Vitro ; Mice ; Pregnancy ; *Twins ; *Twins, Monozygotic
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  • 86
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    Fluorescent light induces malignant transformation in mouse embryo cell cultures (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-14
    Description: Fluorescent light induced a dose-dependent malignant transformation in mouse C3H10T1/2 cells. A plateau in the dose-response curve for transformation was correlated with that observed with ultraviolet light exposure. The similarity in the two dose-response patterns suggests that similar molecular processes may be involved in the induction of malignant transformation by the two types of radiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, A R -- Ritter, M A -- Little, J B -- New York, N.Y. -- Science. 1980 Mar 14;207(4436):1209-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355282" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Survival/radiation effects ; Cell Transformation, Neoplastic/*radiation effects ; Cells, Cultured ; DNA/radiation effects ; Dose-Response Relationship, Radiation ; Embryo, Mammalian/radiation effects ; Fluorescence ; *Light ; Mice ; Pyrimidine Dimers/radiation effects ; Ultraviolet Rays
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  • 87
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    Sodium-calcium exchange in rabbit heart muscle cells: direct measurement of sarcoplasmic Ca2+ activity (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-08
    Description: Calcium ion-selective microelectrodes made with Simon's neutral carrier were used to measure simultaneously sarcoplasmic Ca2+ activity (aiCa) and resting tension (Tr) of rabbit ventricular muscle during reduction and restoration of external sodium ion concentration, [Na]0. Under the same experimental conditions the change in contractile tension (Ta) also measured. In resting muscle the aiCa was 38 +/- 17 nanomolar (mean +/- standard deviation; N = 10). The reduction of [Na]O from 153 to 20 millimolar led to about a threefold increase in aiCa with parallel increases in Tr and Ta. The time course of the change in aiCa was similar to that of the changes in Tr and Ta. The results are consistent with an important role of the sodium-calcium exchange system for regulating sarcoplasmic Ca2+ activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, C O -- Uhm, D Y -- Dresdner, K -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):699-701.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394527" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Calcium/*metabolism ; Heart Ventricles/metabolism ; Kinetics ; Membrane Potentials/drug effects ; Microelectrodes ; Myocardium/*metabolism ; Rabbits ; Sarcoplasmic Reticulum/drug effects/*metabolism ; Sodium/*metabolism/pharmacology
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  • 88
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    Neuronal control of acetylcholine receptor turnover rate at a vertebrate neuromuscular junction (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-31
    Description: The turnover rate of acetylcholine receptors at neuromuscular junctions in mice increases progressively after denervation and, after 15 days, reaches a half-time of 30 z 5 hours. Denervation thus causes the clustered junctional acetylcholine receptors to assume the rapid turnover characteristic of extrajunctional receptors before innervation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levitt, T A -- Loring, R H -- Salpeter, M M -- NS 09315-10/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 31;210(4469):550-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7423205" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bungarotoxins/metabolism ; Kinetics ; Mice ; Motor Neurons/*physiology ; Muscle Denervation ; Neuromuscular Junction/*metabolism ; Receptors, Cholinergic/*metabolism ; Receptors, Nicotinic/metabolism
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  • 89
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    Mouse globin system: a functional and evolutionary analysis (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-09-19
    Description: Structural and functional analysis of the mouse alpha-globin and beta-globin genes reveals that the globin genes are encoded in discontinous bits of coding information and that each gene locus is much more complex than was originally supposed. Each seems to consist of an array of several authentic genes as well as several apparently inactive pseudogenes. Comparison of the sequences of some of these genes to one another indicates that chromosomal DNA is a dynamic structure. Flanking and intervening sequences change in two ways: quickly, by duplication and extensive insertions and deletions, and slowly, by point mutation. Active coding sequences are usually limited to the slower mode of evolution. In addition to identifying fast and slow modes of evolution, it has also been possible to test the function of several signals that surround these genes and to identify those that appear to play a role in gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leder, P -- Hansen, J N -- Konkel, D -- Leder, A -- Nishioka, Y -- Talkington, C -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1336-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7414319" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Biological Evolution ; Genes ; Globins/*genetics ; Mice ; Nucleic Acid Hybridization ; Nucleic Acid Precursors/genetics ; RNA, Messenger/genetics/metabolism
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  • 90
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    Survival of Escherichia coli host-vector systems in the mammalian intestine (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-07-18
    Description: Survival in the mouse and human intestine of Escherichia coli host-vector systems used and proposed for recombinant DNA technology was assessed. There was no detectable survival of severely disabled E. coli K12 strain X1776 in mice or in human subjects 24 hours after ingestion. The same strain bearing the plasmid pBR322, however, was recovered from human subjects for 4 days in amounts of six organisms for every million ingested. Nondisabled E. coli K12 strain X1666, with or without pBR322, survived in 10(4)-fold greater numbers and for 2 days longer, with better recovery of the plasmid-containing derivative. Although the plasmid-bearing strains were recovered for longer periods, no intestinal colonization was noted. Despite the presence of pBR322 for a maximum of 6 days in the human intestine, there was no evidence that it was transferred from either bacterial host to endogenous aerobic fecal bacteria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, S B -- Marshall, B -- Rowse-Eagle, D -- Onderdonk, A -- New York, N.Y. -- Science. 1980 Jul 18;209(4454):391-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6992276" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA, Recombinant/metabolism ; Escherichia coli/*physiology ; Humans ; Intestines/*microbiology ; Mice ; Plasmids ; Species Specificity
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  • 91
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    Teratocarcinomas and mammalian embryogenesis (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-15
    Description: In the last decade there has emerged an appreciation of the remarkable similarity between the cells that give rise to teratocarcinomas in mice and the cells that give rise to the developing mouse embryo. The resemblance is so close that in certain instances the tumor stem cells can join with their embryonic counterparts and develop into a completely normal mouse. The availability of stem cell lines isolated from mouse teratocarcinomas has made possible a number of new biochemical, immunological, and genetic approahes to the study of early mammalian development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, G R -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):768-76.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250214" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Neoplasm/genetics ; Antigens, Surface/genetics ; Antigens, Viral/genetics ; Blastocyst/cytology ; Cell Differentiation ; Cell Transformation, Viral ; Cells, Cultured ; Chimera ; Embryo, Mammalian/*cytology ; Endoderm/cytology ; Mice ; Simian virus 40 ; Teratoma/immunology/*pathology
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  • 92
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    Lactate dehydrogenases of Atlantic hagfish: physiological and evolutionary implications of a primitive heart isozyme (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-02-15
    Description: Isozymes of lactate dehydrogenase from heart and muscle of Atlantic hagfish show less functional divergence than those from other fishes and higher vertebrates. The enzyme from hagfish heart (B4) displays a higher Michaelis constant for pyruvate and lower substrate inhibition at moderate pyruvate concentrations than heart isozymes from other species. These properties support the hypothesis that the ancestral vertebrate lactate dehydrogenase was a muscle (A4)-type enzyme and also suggest a role for the B4 enzyme in the unusual physiology of hagfish cardiac tissue which functions under sustained hypoxic conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sidell, B D -- Beland, K F -- New York, N.Y. -- Science. 1980 Feb 15;207(4432):769-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352286" target="_blank"〉PubMed〈/a〉
    Keywords: Anaerobiosis ; Animals ; *Biological Evolution ; Energy Metabolism ; Fishes/genetics/*physiology ; Genes ; Isoenzymes ; Kinetics ; L-Lactate Dehydrogenase/*genetics/metabolism ; Muscles/*enzymology ; Myocardium/enzymology ; Pyruvates/metabolism
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  • 93
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    Electrophysiological correlates of ethanol-induced sedation in differentially sensitive lines of mice (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-12-05
    Description: Acute electrophysiological effects of ethanol were studied in two lines of mice that differ markedly in their response to the soporific effects of systemic alcohol administration. Cerebellar Purkinje neurons from the genetic line that had long sleep times were one to two orders of magnitude more sensitive to the depressant effects of locally administered ethanol than those from the line that had short sleep times. The data suggest that there are genetically determined specificities in the acute effects of ethanol on central neurons and that such specificities might be used to determine which regions of the cerebellum participate in differences in behavioral responses to this substance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sorensen, S -- Palmer, M -- Dunwiddie, T -- Hoffer, B -- AA-03527/AA/NIAAA NIH HHS/ -- GM-01983/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 5;210(4474):1143-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444444" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/*drug effects ; Animals ; Behavior, Animal/physiology ; Dose-Response Relationship, Drug ; Ethanol/*pharmacology ; Heart Conduction System/*drug effects ; Mice ; Mice, Mutant Strains ; Neural Inhibition/drug effects ; Purkinje Fibers/*drug effects
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  • 94
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    Persistence of crystallin messenger RNA's with reduced translation in hereditary cataracts in mice (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-21
    Description: In vitro translation experiments showed that the lens fiber cells of two hereditary cataracts in mice (Nakano and Philly) possessed a full complement of crystallin messenger RNA's, despite severely reduced synthesis of crystallin in these cells. The reduction in synthesis in the lens fiber cells correlated with the increase in Na+ and the decrease in K+, which occurs during cataractogenesis. In contrast to the fiber cells, the epithelial cells continued to synthesize crystallins in the cataractous lenses. Crystallin synthesis was stimulated in the fiber cells by raising the K+ concentration and lowering the Na+ concentration in the cultured lenses. The reduction in crystallin synthesis in the initial stages of cataractogenesis in the Nakano and Philly lenses thus appears to be due to poor utilization of crystallin messenger RNA's in the fiber cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shinohara, T -- Piatigorsky, J -- New York, N.Y. -- Science. 1980 Nov 21;210(4472):914-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434006" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cataract/genetics/*metabolism ; Crystallins/biosynthesis/*genetics ; Disease Models, Animal ; Mice ; Mice, Mutant Strains/metabolism ; Potassium/metabolism ; Protein Biosynthesis ; RNA, Messenger/*metabolism ; Sodium/metabolism
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  • 95
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    Bone cancer from radium: canine dose response explains data for mice and humans (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-04-04
    Description: Analysis of lifetime studies of 243 beagles with skeletal burdens of radium-226 shows that the distribution of bone cancers clusters about a linear function of the logarithms of radiation dose rate to the skeleton and time from exposure until death. Similar relations displaced by species-dependent response ratios also provide satisfactory descriptions of the reported data on deaths from primary bone cancers in people and mice exposed to radium-226. The median cumulative doses (or times) leading to death from bone tumors are 2.9 times larger for dogs than for mice and 3.6 times larger for people than for dogs. These response ratios are well correlated with the normal life expectancies. The cumulative radiation dose required to give significant risk of bone cancer is found to be much less at lower dose rates than at higher rates, but the time required for the tumors to be manifested is longer. At low dose rates, this time exceeds the normal life-span and appears as a practical threshold, which for bone cancer is estimated to occur at an average cumulative radiation dose to the skeleton of about 50 to 110 rads for the three species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raabe, O G -- Book, S A -- Parks, N J -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):61-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361106" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Neoplasms/*etiology/mortality ; *Disease Models, Animal ; *Dogs ; *Dose-Response Relationship, Radiation ; Humans ; Mice ; Neoplasms, Radiation-Induced/*etiology ; Radium/*adverse effects ; Species Specificity
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  • 96
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    Sodium-calcium exchange activity generates a current in cardiac membrane vesicles (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-06-27
    Description: Sarcolemmal membrane vesicles isolated from canine ventricular tissue accumulate calcium through the sodium-calcium exchange system when an outwardly directed sodium gradient is generated across the vesicle membrane. Moreover, calcium uptake under these conditions is accompanied by the transient accumulation of the lipophilic cation tetraphenylphosphonium. Since the distribution of tetraphenylphosphonium across biological membranes reflects the magnitude and direction of transmembrane potential differences and the characteristics of the transient accumulation of this cation closely resemble those of sodium-calcium exchange activity, it is concluded that a membrane potential, interior negative, is produced during calcium accumulation through the exchange system. Thus, the operation of the sodium-calcium exchange system generates a current in cardiac membrane vesicles, suggesting that three or more sodium ions exchange for each calcium ion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reeves, J P -- Sutko, J L -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1461-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384788" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Transport, Active/drug effects ; Calcium/*metabolism ; Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology ; Cell Membrane/drug effects/*metabolism ; Heart/*physiology ; Kinetics ; Membrane Potentials/drug effects ; Myocardium/*metabolism ; Onium Compounds/metabolism ; *Organophosphorus Compounds ; Sodium/*metabolism ; Valinomycin/pharmacology
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    N-Formylmethionyl peptide receptors on equine leukocytes initiate secretion but not chemotaxis (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-07-25
    Description: The chemotaxis of leukocytes appears to be initiated by the binding of chemotactic factors to the surface of these cells. N-Formylated peptides induce chemotaxis and lysosomal enzyme secretion of leukocytes; because these peptides are available in a purified radiolabeled form, they have been useful in the characterization of receptors for chemotactic factors. Equine polymorphonuclear leukocytes secrete lysosomal enzymes but do not exhibit chemotaxis in respone to the N-formylated peptides, even though they have a high-affinity cell surface receptor for these agents. The specificity of the equine receptor resembles the specificity of the receptor on chemotactically responsive leukocytes from other species. Equine polymorphonuclear leukocytes may thus be an excellent model for the study of the events that lead to a biological response following receptor occupancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snyderman, R -- Pike, M C -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):493-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6248959" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chemotaxis ; Horses ; Kinetics ; Leukocytes/*physiology/secretion ; Oligopeptides/blood/*physiology ; Receptors, Cell Surface/*physiology ; Receptors, Formyl Peptide ; Structure-Activity Relationship
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  • 98
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    Erythroid differentiation of clonal Rauscher erythroleukemia cells in response to erythropoietin or dimethyl sulfoxide (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-03
    Description: Clonal lines of Rauscher erythroleukemia cells exhibited selective responses to two inducers of differentiation, erythropoietin and dimethyl sulfoxide. There were substantial quantitiative differences between clones that reponded to both inducers. Several clones differentiated only in response to erythropoietin. Erythropoietin stimulated cell proliferation and differentiation whereas dimethyl sulfoxide inhibited proliferation, suggesting dissimilar modes of action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sytkowski, A J -- Salvado, A J -- Smith, G M -- McIntyre, C J -- deBoth, N J -- CA-18662/CA/NCI NIH HHS/ -- CA-26105/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):74-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6932101" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/*drug effects ; Cell Division/drug effects ; Clone Cells/drug effects ; Dimethyl Sulfoxide/*pharmacology ; Erythropoietin/*pharmacology ; Hemoglobins/biosynthesis ; Leukemia, Erythroblastic, Acute/*pathology ; Leukemia, Experimental/pathology ; Mice ; Rauscher Virus
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  • 99
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    Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: Cromolyn inhibited histamine release from mast cells that was induced by a classic secretagogue and correspondingly increased incorporation of radioactive phosphate into a 78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering the phosphorylation of a protein involved in the regulation of secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Theoharides, T C -- Sieghart, W -- Greengard, P -- Douglas, W W -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):80-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6153130" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Cromolyn Sodium/*pharmacology ; Histamine Release/*drug effects ; Kinetics ; Mast Cells/*drug effects/immunology/metabolism ; Molecular Weight ; Phosphoproteins/*metabolism ; Phosphorylation ; Rats ; p-Methoxy-N-methylphenethylamine/antagonists & inhibitors
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  • 100
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    Energy requirement for nitrogen fixation in actinorhizal and legume root nodules (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-07-11
    Description: The ratio of respiration to nitrogenase activity was measured in five species of actinorhizal root nodules and eight species of legume nodules. The two types of nodules could not be distinguished on the basis of this ratio; this evidence thus indicates that the energy cost of nitrogen fixation is similar for both.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tjepkema, J D -- Winship, L J -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):279-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384801" target="_blank"〉PubMed〈/a〉
    Keywords: Actinomycetales/metabolism ; Kinetics ; *Nitrogen Fixation ; Plants/*metabolism ; Rhizobium/metabolism ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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