Publication Date:
1980-03-28
Description:
The food dye erythrosine (Erythrosin B; FD & C No. 3) was applied to isolated neuromuscular synapses in the frog, and its effects on the spontaneous quantal release of acetylcholine were examined with electrophysiological techniques. At concentrations of 10 muM or greater this anionic dye produced an irreversible, dose-dependent increase in neurotransmitter release. This increase did not depend on the presence of calcium ions in the bathing medium. These increase did not depend on the presence of calcium ions in the bathing medium. These results suggest that erythrosine might prove a useful pharmacological tool for studying the process of transmitter release, but that its use as a food additive should be reexamined.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Augustine, G J Jr -- Levitan, H -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1489-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6244619" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Anura
;
Calcium/physiology
;
Erythrosine/*pharmacology
;
Fluoresceins/*pharmacology
;
Kinetics
;
Membrane Potentials/drug effects
;
Motor Endplate/drug effects
;
Neuromuscular Junction/*drug effects
;
Rana pipiens
;
Stimulation, Chemical
;
Synaptic Transmission/*drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
