Publication Date:
1980-07-25
Description:
Important differences between the metabolic activation of 7,12-dimethylbenz[a]anthracene in intact cellular systems and in liver homogenates suggest that the use of homogenates in conjunction with short-term assays for carcinogens could yield misleading results.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bigger, C A -- Tomaszewski, J E -- Dipple, A -- Lake, R S -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):503-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6771871" target="_blank"〉PubMed〈/a〉
Keywords:
9,10-Dimethyl-1,2-benzanthracene/*metabolism
;
Animals
;
Benz(a)Anthracenes/*metabolism
;
Carcinogens/*metabolism
;
Cells, Cultured
;
DNA/metabolism
;
Deoxyribonucleosides
;
Drug Evaluation, Preclinical/methods
;
Humans
;
Liver/*metabolism
;
Mice
;
Microsomes, Liver/metabolism
;
Rats
;
Skin/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
