Publication Date:
1980-08-22
Description:
The binding of [6-alanine]gonadotropin-releasing hormone to pituitary plasma membranes increased threefold between metestrus and early proestrus in female rats. Receptor numbers fell rapidly on the afternoon of proestrus coincident with the preovulatory gonadotropin surge. The numbers of receptors for gonadotropin-releasing hormone were positively correlated with concentrations of estradiol in serum; this pattern may be a necessary component of increased pituitary sensitivty to gonadotropin-releasing hormone observed during proestrus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Savoy-Moore, R T -- Schwartz, N B -- Duncan, J A -- Marshall, J C -- New York, N.Y. -- Science. 1980 Aug 22;209(4459):942-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250218" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Membrane/metabolism
;
Estradiol/blood
;
*Estrus
;
Feedback
;
Female
;
Follicle Stimulating Hormone/blood
;
Gonadotropin-Releasing Hormone/analogs & derivatives/*metabolism
;
Kinetics
;
Luteinizing Hormone/blood
;
Pituitary Gland, Anterior/*metabolism
;
Pregnancy
;
Progesterone/blood
;
Rats
;
Receptors, Cell Surface/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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