Publication Date:
2009-12-17
Description:
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉HUGO Pan-Asian SNP Consortium -- Abdulla, Mahmood Ameen -- Ahmed, Ikhlak -- Assawamakin, Anunchai -- Bhak, Jong -- Brahmachari, Samir K -- Calacal, Gayvelline C -- Chaurasia, Amit -- Chen, Chien-Hsiun -- Chen, Jieming -- Chen, Yuan-Tsong -- Chu, Jiayou -- Cutiongco-de la Paz, Eva Maria C -- De Ungria, Maria Corazon A -- Delfin, Frederick C -- Edo, Juli -- Fuchareon, Suthat -- Ghang, Ho -- Gojobori, Takashi -- Han, Junsong -- Ho, Sheng-Feng -- Hoh, Boon Peng -- Huang, Wei -- Inoko, Hidetoshi -- Jha, Pankaj -- Jinam, Timothy A -- Jin, Li -- Jung, Jongsun -- Kangwanpong, Daoroong -- Kampuansai, Jatupol -- Kennedy, Giulia C -- Khurana, Preeti -- Kim, Hyung-Lae -- Kim, Kwangjoong -- Kim, Sangsoo -- Kim, Woo-Yeon -- Kimm, Kuchan -- Kimura, Ryosuke -- Koike, Tomohiro -- Kulawonganunchai, Supasak -- Kumar, Vikrant -- Lai, Poh San -- Lee, Jong-Young -- Lee, Sunghoon -- Liu, Edison T -- Majumder, Partha P -- Mandapati, Kiran Kumar -- Marzuki, Sangkot -- Mitchell, Wayne -- Mukerji, Mitali -- Naritomi, Kenji -- Ngamphiw, Chumpol -- Niikawa, Norio -- Nishida, Nao -- Oh, Bermseok -- Oh, Sangho -- Ohashi, Jun -- Oka, Akira -- Ong, Rick -- Padilla, Carmencita D -- Palittapongarnpim, Prasit -- Perdigon, Henry B -- Phipps, Maude Elvira -- Png, Eileen -- Sakaki, Yoshiyuki -- Salvador, Jazelyn M -- Sandraling, Yuliana -- Scaria, Vinod -- Seielstad, Mark -- Sidek, Mohd Ros -- Sinha, Amit -- Srikummool, Metawee -- Sudoyo, Herawati -- Sugano, Sumio -- Suryadi, Helena -- Suzuki, Yoshiyuki -- Tabbada, Kristina A -- Tan, Adrian -- Tokunaga, Katsushi -- Tongsima, Sissades -- Villamor, Lilian P -- Wang, Eric -- Wang, Ying -- Wang, Haifeng -- Wu, Jer-Yuarn -- Xiao, Huasheng -- Xu, Shuhua -- Yang, Jin Ok -- Shugart, Yin Yao -- Yoo, Hyang-Sook -- Yuan, Wentao -- Zhao, Guoping -- Zilfalil, Bin Alwi -- Indian Genome Variation Consortium -- New York, N.Y. -- Science. 2009 Dec 11;326(5959):1541-5. doi: 10.1126/science.1177074.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20007900" target="_blank"〉PubMed〈/a〉
Keywords:
Algorithms
;
Asia
;
Asian Continental Ancestry Group/*genetics/history
;
Bayes Theorem
;
Cluster Analysis
;
*Emigration and Immigration/history
;
Ethnic Groups/*genetics/history
;
Gene Flow
;
Genotype
;
Geography
;
*Haplotypes
;
History, Ancient
;
Humans
;
Language
;
Linguistics
;
Oligonucleotide Array Sequence Analysis
;
Phylogeny
;
*Polymorphism, Single Nucleotide
;
Principal Component Analysis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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