Publication Date:
1994-03-04
Description:
The 2;5 chromosomal translocation occurs in most anaplastic large-cell non-Hodgkin's lymphomas arising from activated T lymphocytes. This rearrangement was shown to fuse the NPM nucleolar phosphoprotein gene on chromosome 5q35 to a previously unidentified protein tyrosine kinase gene, ALK, on chromosome 2p23. In the predicted hybrid protein, the amino terminus of nucleophosmin (NPM) is linked to the catalytic domain of anaplastic lymphoma kinase (ALK). Expressed in the small intestine, testis, and brain but not in normal lymphoid cells, ALK shows greatest sequence similarity to the insulin receptor subfamily of kinases. Unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morris, S W -- Kirstein, M N -- Valentine, M B -- Dittmer, K G -- Shapiro, D N -- Saltman, D L -- Look, A T -- CA 21765/CA/NCI NIH HHS/ -- KO8 CA 01702/CA/NCI NIH HHS/ -- P01 CA 20180/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1994 Mar 4;263(5151):1281-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Experimental Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8122112" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Base Sequence
;
Brain/enzymology
;
Cell Transformation, Neoplastic
;
Chromosome Walking
;
Chromosomes, Human, Pair 2
;
Chromosomes, Human, Pair 5
;
Cloning, Molecular
;
Gene Expression Regulation, Neoplastic
;
Humans
;
Intestine, Small/enzymology
;
Lymphoma, Large-Cell, Anaplastic/chemistry/enzymology/*genetics
;
Male
;
Molecular Sequence Data
;
Nuclear Proteins/chemistry/*genetics
;
Phosphoproteins/chemistry/*genetics
;
Promoter Regions, Genetic
;
Protein-Tyrosine Kinases/chemistry/*genetics
;
RNA, Messenger/genetics/metabolism
;
Receptor Protein-Tyrosine Kinases
;
Sequence Alignment
;
Signal Transduction
;
Testis/enzymology
;
*Translocation, Genetic
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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