Publication Date:
1991-01-25
Description:
CP-96,345, a nonpeptide substance P antagonist, is selective for the tachykinin NK1 receptor. The compound binds to a single population of sites in guinea pig brain and potently inhibits substance P-induced excitation of locus ceruleus neurons. CP-96,345 should be a useful tool for studying the action of substance P in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McLean, S -- Ganong, A H -- Seeger, T F -- Bryce, D K -- Pratt, K G -- Reynolds, L S -- Siok, C J -- Lowe, J A 3rd -- Heym, J -- New York, N.Y. -- Science. 1991 Jan 25;251(4992):437-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Central Research Division, Pfizer Inc., Groton, CT 06340.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1703324" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Animals
;
Autoradiography
;
Binding Sites
;
Binding, Competitive
;
Biphenyl Compounds/*metabolism/pharmacology
;
Brain/*metabolism/radionuclide imaging
;
Corpus Striatum/*metabolism/radionuclide imaging
;
Guinea Pigs
;
Hydrogen-Ion Concentration
;
Male
;
Receptors, Neurokinin-1
;
Receptors, Neurotransmitter/*antagonists & inhibitors/*metabolism
;
Receptors, Tachykinin
;
Spectrophotometry
;
Substance P/metabolism
;
Tachykinins/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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