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  • 1
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    American Physical Society (APS)
    Publication Date: 2013-09-25
    Description: Author(s): T. Y. Chen and C. L. Chien A Reply to the Comment by M. Eschrig et al. [Phys. Rev. Lett. 111, 139704] Published Tue Sep 24, 2013
    Keywords: Comments
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 2
    Publication Date: 2012-10-04
    Description: Author(s): T. Y. Chen, Z. Tesanovic, and C. L. Chien We present a unified formalism of Andreev reflection of a partial polarized current at a ferromagnet/superconductor interface instead of assuming a linear combination of unpolarized and polarized currents. The Andreev reflection is limited by the states of minority spins and the extra majority spins... [Phys. Rev. Lett. 109, 146602] Published Wed Oct 03, 2012
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 3
    Publication Date: 2015-12-02
    Description: G-quadruplex (G4) is a promising target for anti-cancer treatment. In this paper, we provide the first evidence supporting the presence of G4 in the mitochondrial DNA (mtDNA) of live cells. The molecular engineering of a fluorescent G4 ligand, 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide (BMVC), can change its major cellular localization from the nucleus to the mitochondria in cancer cells, while remaining primarily in the cytoplasm of normal cells. A number of BMVC derivatives with sufficient mitochondrial uptake can induce cancer cell death without damaging normal cells. Fluorescence studies of these anti-cancer agents in live cells and in isolated mitochondria from HeLa cells have demonstrated that their major target is mtDNA. In this study, we use fluorescence lifetime imaging microscopy to verify the existence of mtDNA G4s in live cells. Bioactivity studies indicate that interactions between these anti-cancer agents and mtDNA G4 can suppress mitochondrial gene expression. This work underlines the importance of fluorescence in the monitoring of drug-target interactions in cells and illustrates the emerging development of drugs in which mtDNA G4 is the primary target.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 4
    Publication Date: 2012-08-28
    Description: Author(s): T. Y. Chen, M. J. Erickson, P. A. Crowell, and C. Leighton Although pinning of domain walls in ferromagnets is ubiquitous, the absence of an appropriate characterization tool has limited the ability to correlate the physical and magnetic microstructures of ferromagnetic films with specific pinning mechanisms. Here, we show that the pinning of a magnetic vor... [Phys. Rev. Lett. 109, 097202] Published Mon Aug 27, 2012
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 5
    Publication Date: 2012-08-25
    Description: : S -nitrosylation (SNO), a selective and reversible protein post-translational modification that involves the covalent attachment of nitric oxide (NO) to the sulfur atom of cysteine, critically regulates protein activity, localization and stability. Due to its importance in regulating protein functions and cell signaling, a mass spectrometry-based proteomics method rapidly evolved to increase the dataset of experimentally determined SNO sites. However, there is currently no database dedicated to the integration of all experimentally verified S -nitrosylation sites with their structural or functional information. Thus, the dbSNO database is created to integrate all available datasets and to provide their structural analysis. Up to April 15, 2012, the dbSNO has manually accumulated 〉3000 experimentally verified S -nitrosylated peptides from 219 research articles using a text mining approach. To solve the heterogeneity among the data collected from different sources, the sequence identity of these reported S -nitrosylated peptides are mapped to the UniProtKB protein entries. To delineate the structural correlation and consensus motif of these SNO sites, the dbSNO database also provides structural and functional analyses, including the motifs of substrate sites, solvent accessibility, protein secondary and tertiary structures, protein domains and gene ontology. Availability : The dbSNO is now freely accessible via http://dbSNO.mbc.nctu.edu.tw . The database content is regularly updated upon collecting new data obtained from continuously surveying research articles. Contacts: francis@saturn.yu.edu.tw or yujuchen@gate.sinica.edu.tw Supplementary Information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
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  • 6
    Publication Date: 2012-09-08
    Description: Author(s): S. Y. Huang, X. Fan, D. Qu, Y. P. Chen, W. G. Wang, J. Wu, T. Y. Chen, J. Q. Xiao, and C. L. Chien Platinum (Pt) metal, being nonmagnetic and with a strong spin-orbit coupling interaction, has been central in detecting the pure spin current and establishing most of the recent spin-based phenomena. Magnetotransport measurements, both electrical and thermal, conclusively show strong ferromagnetic c... [Phys. Rev. Lett. 109, 107204] Published Fri Sep 07, 2012
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 7
    Publication Date: 2012-05-17
    Description: Author(s): T. Y. Chen, A. T. Galkiewicz, and P. A. Crowell The dynamics of a magnetic vortex are influenced profoundly by nonlinear effects at large and small amplitudes. For example, a strongly driven magnetic vortex is unstable with respect to internal deformation, leading to reversal of its core magnetization. At small amplitudes, a nonlinear response is... [Phys. Rev. B 85, 180406] Published Wed May 16, 2012
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 8
    Publication Date: 2015-03-24
    Description: Thermoelectric coolers based on the Peltier effect have been utilized to control temperature gradient to study thermal effects in both bulk and thin film samples. The temperature gradient is controlled by two coolers and the polarity of the thermal gradient can be reversed by reversing an electric driven voltage. With appropriate controlled thermal gradient using this technique, the Nernst and the Seebeck effects can be measured in both bulk and thin film samples free of spurious contributions. In an arbitrary direction of thermal gradient, the Seebeck and the Nernst components can be decomposed from the measured signal based on the symmetry of the effects in a magnetic field.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
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  • 9
    Publication Date: 2014-08-06
    Description: : S -glutathionylation, the reversible protein posttranslational modification (PTM) that generates a mixed disulfide bond between glutathione and cysteine residue, critically regulates protein activity, stability and redox regulation. Due to its importance in regulating oxidative/nitrosative stress and balance in cellular response, a number of methods have been rapidly developed to study S -glutathionylation, thus expanding the dataset of experimentally determined glutathionylation sites. However, there is currently no database dedicated to the integration of all experimentally verified S -glutathionylation sites along with their characteristics or structural or functional information. Thus, the dbGSH database has been created to integrate all available datasets and to provide the relevant structural analysis. As of January 31, 2014, dbGSH has manually collected 〉2200 experimentally verified S -glutathionylated peptides from 169 research articles using a text-mining approach. To solve the problem of heterogeneity of the data collected from different sources, the sequence identity of the reported S -glutathionylated peptides is mapped to UniProtKB protein entries. To delineate the structural correlations and consensus motifs of these S -glutathionylation sites, the dbGSH database also provides structural and functional analyses, including the motifs of substrate sites, solvent accessibility, protein secondary and tertiary structures, protein domains and gene ontology. Availability and implementation: dbGSH is now freely accessible at http://csb.cse.yzu.edu.tw/dbGSH/ . The database content is regularly updated with new data collected by the continuous survey of research articles. Contact: francis@saturn.yzu.edu.tw or yujuchen@gate.sinica.edu.tw Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
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  • 10
    Publication Date: 2008-06-06
    Description: Since the discovery of superconductivity in the high-transition-temperature (high-T(c)) copper oxides two decades ago, it has been firmly established that the CuO(2) plane is essential for superconductivity and gives rise to a host of other very unusual properties. A new family of superconductors with the general composition of LaFeAsO(1-x)F(x) has recently been discovered and the conspicuous lack of the CuO(2) planes raises the tantalizing question of a different pairing mechanism in these oxypnictides. The superconducting gap (its magnitude, structure, and temperature dependence) is intimately related to pairing. Here we report the observation of a single gap in the superconductor SmFeAsO(0.85)F(0.15) with T(c) = 42 K as measured by Andreev spectroscopy. The gap value of 2Delta = 13.34 +/- 0.3 meV gives 2Delta/k(B)T(c) = 3.68 (where k(B) is the Boltzmann constant), close to the Bardeen-Cooper-Schrieffer (BCS) prediction of 3.53. The gap decreases with temperature and vanishes at T(c) in a manner consistent with the BCS prediction, but dramatically different from that of the pseudogap behaviour in the copper oxide superconductors. Our results clearly indicate a nodeless gap order parameter, which is nearly isotropic in size across different sections of the Fermi surface, and are not compatible with models involving antiferromagnetic fluctuations, strong correlations, the t-J model, and the like, originally designed for the high-T(c) copper oxides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, T Y -- Tesanovic, Z -- Liu, R H -- Chen, X H -- Chien, C L -- England -- Nature. 2008 Jun 26;453(7199):1224-7. doi: 10.1038/nature07081. Epub 2008 Jun 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18528330" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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