Abstract
Signals mediated by the T cell receptor (TCR) are required for thymocyte maturation and selection. To examine the role of TCR zeta chain signals in development, TCR expression was restored in zeta-deficient mice with transgenic zeta chains that partially or completely lacked sequences required for signal transduction. The zeta chain played a role in thymic development by promoting TCR surface expression, but zeta-mediated signals were not essential because TCRs that contained signaling-deficient zeta chains promoted T cell maturation and transduced signals associated with thymic selection.
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, CD / analysis
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Antigens, CD / genetics
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Antigens, Differentiation, T-Lymphocyte / analysis
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CD4 Antigens / analysis
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CD5 Antigens
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CD8 Antigens / analysis
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DNA-Binding Proteins*
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Down-Regulation
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Gene Expression
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Homeodomain Proteins*
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Lectins, C-Type
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Lymph Nodes / immunology
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Membrane Proteins / genetics
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Membrane Proteins / physiology*
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Mice
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Mice, Transgenic
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Molecular Sequence Data
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Proteins / genetics
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Receptors, Antigen, T-Cell / genetics
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Receptors, Antigen, T-Cell / physiology*
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Signal Transduction
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
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Thymus Gland / immunology
Substances
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Antigens, CD
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Antigens, Differentiation, T-Lymphocyte
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CD4 Antigens
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CD5 Antigens
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CD69 antigen
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CD8 Antigens
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DNA-Binding Proteins
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Homeodomain Proteins
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Lectins, C-Type
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Membrane Proteins
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Proteins
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RNA, Messenger
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Rag2 protein, mouse
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Receptors, Antigen, T-Cell
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V(D)J recombination activating protein 2
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antigen T cell receptor, zeta chain
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RAG-1 protein