Publication Date:
1999-10-16
Description:
Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human beta-defensins are also chemotactic for immature dendritic cells and memory T cells. Human beta-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. The beta-defensin-induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the chemokine ligand for CCR6, to CCR6-transfected cells was competitively displaced by beta-defensin. Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, D -- Chertov, O -- Bykovskaia, S N -- Chen, Q -- Buffo, M J -- Shogan, J -- Anderson, M -- Schroder, J M -- Wang, J M -- Howard, O M -- Oppenheim, J J -- N01-CO-56000/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1999 Oct 15;286(5439):525-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Intramural Research Support Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10521347" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies/immunology
;
Binding, Competitive
;
Cell Line
;
Chemokine CCL20
;
Chemokines, CC/metabolism/pharmacology
;
Chemotaxis
;
Chemotaxis, Leukocyte
;
Defensins
;
Dendritic Cells/*immunology
;
Humans
;
*Immunity, Active
;
*Immunity, Innate
;
Immunologic Memory
;
*Macrophage Inflammatory Proteins
;
Pertussis Toxin
;
Proteins/pharmacology/*physiology
;
Receptors, CCR6
;
Receptors, Chemokine/genetics/*metabolism
;
Recombinant Proteins/pharmacology
;
T-Lymphocyte Subsets/*immunology
;
Transfection
;
Virulence Factors, Bordetella/pharmacology
;
*beta-Defensins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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