Publication Date:
1999-02-26
Description:
Cell proliferation and differentiation are regulated by growth regulatory factors such as transforming growth factor-beta (TGF-beta) and the liphophilic hormone vitamin D. TGF-beta causes activation of SMAD proteins acting as coactivators or transcription factors in the nucleus. Vitamin D controls transcription of target genes through the vitamin D receptor (VDR). Smad3, one of the SMAD proteins downstream in the TGF-beta signaling pathway, was found in mammalian cells to act as a coactivator specific for ligand-induced transactivation of VDR by forming a complex with a member of the steroid receptor coactivator-1 protein family in the nucleus. Thus, Smad3 may mediate cross-talk between vitamin D and TGF-beta signaling pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yanagisawa, J -- Yanagi, Y -- Masuhiro, Y -- Suzawa, M -- Watanabe, M -- Kashiwagi, K -- Toriyabe, T -- Kawabata, M -- Miyazono, K -- Kato, S -- New York, N.Y. -- Science. 1999 Feb 26;283(5406):1317-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10037600" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bone Morphogenetic Protein Receptors
;
Bone Morphogenetic Proteins/pharmacology
;
COS Cells
;
Calcitriol/*metabolism/pharmacology
;
Cell Nucleus/metabolism
;
DNA-Binding Proteins/*metabolism
;
Histone Acetyltransferases
;
Ligands
;
Nuclear Receptor Coactivator 1
;
Phosphorylation
;
Receptor Cross-Talk
;
Receptors, Calcitriol/*metabolism
;
Receptors, Cell Surface/metabolism
;
*Receptors, Growth Factor
;
Receptors, Retinoic Acid/metabolism
;
Receptors, Transforming Growth Factor beta/metabolism
;
Recombinant Fusion Proteins/metabolism
;
Retinoid X Receptors
;
Signal Transduction
;
Smad3 Protein
;
Trans-Activators/*metabolism
;
Transcription Factors/metabolism
;
*Transcriptional Activation
;
Transfection
;
Transforming Growth Factor beta/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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