Publication Date:
2001-08-18
Description:
B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thompson, J S -- Bixler, S A -- Qian, F -- Vora, K -- Scott, M L -- Cachero, T G -- Hession, C -- Schneider, P -- Sizing, I D -- Mullen, C -- Strauch, K -- Zafari, M -- Benjamin, C D -- Tschopp, J -- Browning, J L -- Ambrose, C -- New York, N.Y. -- Science. 2001 Sep 14;293(5537):2108-11. Epub 2001 Aug 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA., The Institute of Biochemistry, University of Lausanne, CH-1066, Epalinges, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11509692" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
B-Cell Activating Factor
;
B-Cell Activation Factor Receptor
;
B-Cell Maturation Antigen
;
B-Lymphocytes/immunology/metabolism/*physiology
;
Cell Line
;
Chromosome Mapping
;
Chromosomes, Human, Pair 22
;
Cloning, Molecular
;
Homeostasis
;
Humans
;
Ligands
;
Lymphoid Tissue/metabolism
;
Male
;
Membrane Proteins/*metabolism
;
Mice
;
Mice, Inbred A
;
Mice, Inbred C57BL
;
Molecular Sequence Data
;
RNA, Messenger/chemistry/genetics/metabolism
;
Receptors, Tumor Necrosis Factor/chemistry/genetics/*metabolism
;
Recombinant Fusion Proteins/metabolism
;
Signal Transduction
;
Transfection
;
Transmembrane Activator and CAML Interactor Protein
;
Tumor Necrosis Factor-alpha/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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