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  • 1
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    Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-08-04
    Description: One of the most dominant influences in the patterning of multicellular embryos is exerted by the Hedgehog (Hh) family of secreted signaling proteins. Here, we identify a segment polarity gene in Drosophila melanogaster, skinny hedgehog (ski), and show that its product is required in Hh-expressing cells for production of appropriate signaling activity in embryos and in the imaginal precursors of adult tissues. The ski gene encodes an apparent acyltransferase, and we provide genetic and biochemical evidence that Hh proteins from ski mutant cells retain carboxyl-terminal cholesterol modification but lack amino-terminal palmitate modification. Our results suggest that ski encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of Hh, and further demonstrate that this lipid modification is required for the embryonic and larval patterning activities of the Hh signal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chamoun, Z -- Mann, R K -- Nellen, D -- von Kessler, D P -- Bellotto, M -- Beachy, P A -- Basler, K -- New York, N.Y. -- Science. 2001 Sep 14;293(5537):2080-4. Epub 2001 Aug 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut fur Molekularbiologie and Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11486055" target="_blank"〉PubMed〈/a〉
    Keywords: Acylation ; Acyltransferases/chemistry/*genetics/*metabolism ; Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Body Patterning ; Cholesterol/metabolism ; *Drosophila Proteins ; Drosophila melanogaster/embryology/*genetics/growth & development/metabolism ; Gene Expression ; Genes, Insect ; Hedgehog Proteins ; Insect Proteins/chemistry/genetics/*metabolism ; Molecular Sequence Data ; Mutation ; Palmitic Acid/*metabolism ; Protein Structure, Tertiary ; *Signal Transduction ; Transgenes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-06-14
    Description: Drosophila limb development is organized by interactions between anterior and posterior compartment cells. Posterior cells continuously express and require engrailed (en) and secrete Hedgehog (Hh) protein. Anterior cells express the zinc-finger protein Cubitus interruptus (Ci). It is now shown that anterior cells lacking ci express hh and adopt posterior properties without expressing en. Increased levels of Ci can induce the expression of the Hh target gene decapentaplegic (dpp) in a Hh-independent manner. Thus, expression of Ci in anterior cells controls limb development (i) by restricting hh secretion to posterior cells and (ii) by conferring competence to respond to Hh by mediating the transduction of this signal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dominguez, M -- Brunner, M -- Hafen, E -- Basler, K -- New York, N.Y. -- Science. 1996 Jun 14;272(5268):1621-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Zoologisches Institut, Universitat Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658135" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA-Binding Proteins/genetics/*physiology ; Drosophila/embryology/genetics ; *Drosophila Proteins ; *Embryonic Induction ; Female ; Gene Expression Regulation, Developmental ; Hedgehog Proteins ; Insect Hormones/genetics/physiology ; Male ; Membrane Proteins/genetics/physiology ; Models, Biological ; Mutagenesis ; Proteins/*physiology ; Receptors, Cell Surface ; *Signal Transduction ; Transcription Factors ; Zinc Fingers/genetics/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Ubiquitous expression of sevenless: position-dependent specification of cell fate (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-02-17
    Description: Specification of cell fate in the compound eye of Drosophila appears to be controlled entirely by cell interactions. The sevenless gene is required for the correct determination of one of the eight photoreceptor cells (R7) in each ommatidium. It encodes a transmembrane protein with a tyrosine kinase domain and is expressed transiently on a subpopulation of ommatidial precursor cells including the R7 precursors. It is shown here that heat shock-induced indiscriminate expression of a sevenless complementary DNA throughout development can correctly specify R7 cell identity without affecting the development of other cells. Furthermore, discontinuous supply of sevenless protein during eye development leads to the formation of mosaic eyes containing stripes of sevenless+ and sevenless- ommatidia, suggesting that R7 cell fate can be specified only within a relatively short period during ommatidial assembly. These results support the hypothesis that the specification of cell fate by position depends on the interaction of a localized signal with a receptor present on many undifferentiated cells, and that the mere presence of the receptor alone is not sufficient to specify cell fate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Basler, K -- Hafen, E -- New York, N.Y. -- Science. 1989 Feb 17;243(4893):931-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Zoologisches Institut, Universitat Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2493159" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication ; Drosophila melanogaster/anatomy & histology/*genetics ; Eye/anatomy & histology/metabolism ; *Genes ; Heat-Shock Proteins/genetics ; Mutation ; Promoter Regions, Genetic ; Protein-Tyrosine Kinases/genetics ; RNA, Messenger/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Cell biology. Cytonemes show their colors (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Affolter, Markus -- Basler, Konrad -- New York, N.Y. -- Science. 2011 Apr 15;332(6027):312-3. doi: 10.1126/science.1205971.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biozentrum der Universitat Basel, CH-4056 Basel, Switzerland. markus.affolter@unibas.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21493848" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication ; Drosophila/*cytology/metabolism ; Drosophila Proteins/*metabolism ; Fibroblast Growth Factors/metabolism ; Ligands ; Protein-Serine-Threonine Kinases/*metabolism ; Protein-Tyrosine Kinases/*metabolism ; Pseudopodia/*physiology/*ultrastructure ; Receptor, Epidermal Growth Factor/metabolism ; Receptors, Cell Surface/*metabolism ; Receptors, Fibroblast Growth Factor/*metabolism ; *Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Comment on "Dynamics of dpp signaling and proliferation control" (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-28
    Description: Wartlick et al. (Research Articles, 4 March 2011, p. 1154) reported that growth rates in the Drosophila wing disc correlate with increasing Dpp signaling levels, suggesting that the rate of Dpp increase determines the cell-cycle length. Contradicting their model, we found that cells in which the increase of Dpp signaling levels was genetically abrogated grew at rates comparable to those of wild-type cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwank, Gerald -- Yang, Schu-Fee -- Restrepo, Simon -- Basler, Konrad -- New York, N.Y. -- Science. 2012 Jan 27;335(6067):401; author reply 401. doi: 10.1126/science.1210997.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22282789" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Proliferation ; Drosophila Proteins/*metabolism ; Drosophila melanogaster/*growth & development/*metabolism ; Intercellular Signaling Peptides and Proteins/*metabolism ; *Signal Transduction ; Wings, Animal/*growth & development/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    An ancient defense system eliminates unfit cells from developing tissues during cell competition (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-12-06
    Description: Developing tissues that contain mutant or compromised cells present risks to animal health. Accordingly, the appearance of a population of suboptimal cells in a tissue elicits cellular interactions that prevent their contribution to the adult. Here we report that this quality control process, cell competition, uses specific components of the evolutionarily ancient and conserved innate immune system to eliminate Drosophila cells perceived as unfit. We find that Toll-related receptors (TRRs) and the cytokine Spatzle (Spz) lead to NFkappaB-dependent apoptosis. Diverse "loser" cells require different TRRs and NFkappaB factors and activate distinct pro-death genes, implying that the particular response is stipulated by the competitive context. Our findings demonstrate a functional repurposing of components of TRRs and NFkappaB signaling modules in the surveillance of cell fitness during development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meyer, S N -- Amoyel, M -- Bergantinos, C -- de la Cova, C -- Schertel, C -- Basler, K -- Johnston, L A -- P40OD018537/OD/NIH HHS/ -- R01 GM078464/GM/NIGMS NIH HHS/ -- R01-GM084947/GM/NIGMS NIH HHS/ -- R21 HD067918/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2014 Dec 5;346(6214):1258236. doi: 10.1126/science.1258236.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. ; Department of Genetics and Development, Columbia University, New York, NY 10032, USA. ; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. konrad.basler@imls.uzh.ch lj180@columbia.edu. ; Department of Genetics and Development, Columbia University, New York, NY 10032, USA. konrad.basler@imls.uzh.ch lj180@columbia.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25477468" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis/genetics/*immunology ; Cell Communication/*immunology ; Drosophila Proteins/genetics/metabolism ; Drosophila melanogaster/cytology/genetics/growth & development ; Immunity, Innate/genetics/*immunology ; Mutation ; NF-kappa B/genetics/*metabolism ; Neuropeptides/genetics ; Toll-Like Receptors/genetics/*metabolism ; Transcription Factors/metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-04-16
    Description: Disruption of epithelial polarity is a key event in the acquisition of neoplastic growth. JNK signalling is known to play an important part in driving the malignant progression of many epithelial tumours, although the link between loss of polarity and JNK signalling remains elusive. In a Drosophila genome-wide genetic screen designed to identify molecules implicated in neoplastic growth, we identified grindelwald (grnd), a gene encoding a transmembrane protein with homology to members of the tumour necrosis factor receptor (TNFR) superfamily. Here we show that Grnd mediates the pro-apoptotic functions of Eiger (Egr), the unique Drosophila TNF, and that overexpression of an active form of Grnd lacking the extracellular domain is sufficient to activate JNK signalling in vivo. Grnd also promotes the invasiveness of Ras(V12)/scrib(-/-) tumours through Egr-dependent Matrix metalloprotease-1 (Mmp1) expression. Grnd localizes to the subapical membrane domain with the cell polarity determinant Crumbs (Crb) and couples Crb-induced loss of polarity with JNK activation and neoplastic growth through physical interaction with Veli (also known as Lin-7). Therefore, Grnd represents the first example of a TNFR that integrates signals from both Egr and apical polarity determinants to induce JNK-dependent cell death or tumour growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andersen, Ditte S -- Colombani, Julien -- Palmerini, Valentina -- Chakrabandhu, Krittalak -- Boone, Emilie -- Rothlisberger, Michael -- Toggweiler, Janine -- Basler, Konrad -- Mapelli, Marina -- Hueber, Anne-Odile -- Leopold, Pierre -- England -- Nature. 2015 Jun 25;522(7557):482-6. doi: 10.1038/nature14298. Epub 2015 Apr 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] University of Nice-Sophia Antipolis, Institute of Biology Valrose, Parc Valrose, 06108 Nice, France [2] CNRS, Institute of Biology Valrose, Parc Valrose, 06108 Nice, France [3] INSERM, Institute of Biology Valrose, Parc Valrose, 06108 Nice, France [4] Genetics and Physiology of Growth laboratory, Institute of Biology Valrose, Parc Valrose, 06108 Nice, France. ; Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy. ; 1] University of Nice-Sophia Antipolis, Institute of Biology Valrose, Parc Valrose, 06108 Nice, France [2] CNRS, Institute of Biology Valrose, Parc Valrose, 06108 Nice, France [3] INSERM, Institute of Biology Valrose, Parc Valrose, 06108 Nice, France [4] Death receptors Signalling and Cancer Therapy laboratory, Institute of Biology Valrose, Parc Valrose, 06108 Nice, France. ; Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25874673" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Apoptosis/genetics ; Cell Adhesion Molecules/metabolism ; Cell Division/genetics ; *Cell Polarity/genetics ; Cell Transformation, Neoplastic/genetics ; Disease Models, Animal ; Drosophila Proteins/chemistry/deficiency/genetics/*metabolism ; Drosophila melanogaster/*cytology/enzymology/genetics/*metabolism ; Female ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; MAP Kinase Signaling System ; Male ; Matrix Metalloproteinase 1/metabolism ; Membrane Proteins/chemistry/deficiency/genetics/*metabolism ; Molecular Sequence Data ; Neoplasm Invasiveness/genetics ; Neoplasms/enzymology/genetics/*metabolism/*pathology ; Receptors, Tumor Necrosis Factor/chemistry/genetics/*metabolism ; ras Proteins/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 8
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    Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-04-03
    Description: The determination of cell fates during the assembly of the ommatidia in the compound eye of Drosophila appears to be controlled by cell-cell interactions. In this process, the sevenless gene is essential for the development of a single type of photoreceptor cell. In the absence of proper sevenless function the cells that would normally become the R7 photoreceptors instead become nonneuronal cells. Previous morphological and genetic analysis has indicated that the product of the sevenless gene is involved in reading or interpreting the positional information that specifies this particular developmental pathway. The sevenless gene has now been isolated and characterized. The data indicate that sevenless encodes a transmembrane protein with a tyrosine kinase domain. This structural similarity between sevenless and certain hormone receptors suggests that similar mechanisms are involved in developmental decisions based on cell-cell interaction and physiological or developmental changes induced by diffusible factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hafen, E -- Basler, K -- Edstroem, J E -- Rubin, G M -- GM32795/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1987 Apr 3;236(4797):55-63.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2882603" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Chromosome Mapping ; Cloning, Molecular ; DNA Restriction Enzymes ; Drosophila melanogaster/*embryology/genetics ; Eye/cytology/embryology ; Gene Expression Regulation ; Genes ; *Genes, Homeobox ; Growth Substances/physiology ; Membrane Proteins/genetics ; Phenotype ; Protein-Tyrosine Kinases/*genetics/physiology ; Receptors, Cell Surface/*genetics/physiology ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
    Electronic Resource
    Electronic Resource
    Compartment boundarles and the control of Drosophila limb pattern by bedgebog protein
    Amsterdam : Elsevier
    Trends in Genetics 10 (1994), S. 187 
    Details
    ISSN: 0168-9525
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9525(94)90253-4
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  • 10
    Electronic Resource
    Electronic Resource
    Sevenless and Drosophila eye development: a tyrosine kinase controls cell fate
    Amsterdam : Elsevier
    Trends in Genetics 4 (1988), S. 74-79 
    Details
    ISSN: 0168-9525
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0168-9525(88)90044-3
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