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  • 1
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    Requirement for the SLP-76 adaptor GADS in T cell development (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-03-10
    Description: GADS is an adaptor protein implicated in CD3 signaling because of its ability to link SLP-76 to LAT. A GADS-deficient mouse was generated by gene targeting, and the function of GADS in T cell development and activation was examined. GADS- CD4-CD8- thymocytes exhibited a severe block in proliferation but still differentiated into mature T cells. GADS- thymocytes failed to respond to CD3 cross-linking in vivo and were impaired in positive and negative selection. Immunoprecipitation experiments revealed that the association between SLP-76 and LAT was uncoupled in GADS- thymocytes. These observations indicate that GADS is a critical adaptor for CD3 signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoder, J -- Pham, C -- Iizuka, Y M -- Kanagawa, O -- Liu, S K -- McGlade, J -- Cheng, A M -- New York, N.Y. -- Science. 2001 Mar 9;291(5510):1987-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11239162" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptor Proteins, Signal Transducing ; Animals ; Antigens, CD3/metabolism ; Carrier Proteins/*metabolism ; Cell Differentiation ; Cell Division ; Cell Lineage ; Cell Size ; Female ; Gene Targeting ; Lymphocyte Activation ; Male ; *Membrane Proteins ; Mice ; Mice, Transgenic ; Phosphoproteins/*metabolism ; Phosphorylation ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction ; Spleen/cytology/immunology ; T-Lymphocytes/*cytology/immunology ; Thymus Gland/cytology/immunology ; src Homology Domains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-06-26
    Description: The integrity of polarized epithelia is critical for development and human health. Many questions remain concerning the full complement and the function of the proteins that regulate cell polarity. Here we report that the Drosophila FERM proteins Yurt (Yrt) and Coracle (Cora) and the membrane proteins Neurexin IV (Nrx-IV) and Na(+),K(+)-ATPase are a new group of functionally cooperating epithelial polarity proteins. This 'Yrt/Cora group' promotes basolateral membrane stability and shows negative regulatory interactions with the apical determinant Crumbs (Crb). Genetic analyses indicate that Nrx-IV and Na(+),K(+)-ATPase act together with Cora in one pathway, whereas Yrt acts in a second redundant pathway. Moreover, we show that the Yrt/Cora group is essential for epithelial polarity during organogenesis but not when epithelial polarity is first established or during terminal differentiation. This property of Yrt/Cora group proteins explains the recovery of polarity in embryos lacking the function of the Lethal giant larvae (Lgl) group of basolateral polarity proteins. We also find that the mammalian Yrt orthologue EPB41L5 (also known as YMO1 and Limulus) is required for lateral membrane formation, indicating a conserved function of Yrt proteins in epithelial polarity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Laprise, Patrick -- Lau, Kimberly M -- Harris, Kathryn P -- Silva-Gagliardi, Nancy F -- Paul, Sarah M -- Beronja, Slobodan -- Beitel, Greg J -- McGlade, C Jane -- Tepass, Ulrich -- England -- Nature. 2009 Jun 25;459(7250):1141-5. doi: 10.1038/nature08067.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19553998" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Adhesion Molecules, Neuronal/genetics/*metabolism ; Cell Line ; Cell Polarity ; Drosophila Proteins/genetics/*metabolism ; Drosophila melanogaster/*embryology/enzymology/genetics/metabolism ; Epithelium/embryology/*physiology ; Gene Knockdown Techniques ; Membrane Proteins/genetics/*metabolism ; Mutation ; Phenotype ; Sodium-Potassium-Exchanging ATPase/genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    EU innovation must benefit society (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van den Hove, Sybille -- McGlade, Jacqueline -- Depledge, Michael H -- England -- Nature. 2011 Jun 8;474(7350):161. doi: 10.1038/474161a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21654790" target="_blank"〉PubMed〈/a〉
    Keywords: Conservation of Natural Resources/trends ; *Diffusion of Innovation ; *European Union ; Health ; Humans ; *Social Responsibility
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Policy: social responsibility for new technologies (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-05-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGlade, Jacqueline -- Quist, David -- Gee, David -- England -- Nature. 2013 May 16;497(7449):317. doi: 10.1038/497317a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23676744" target="_blank"〉PubMed〈/a〉
    Keywords: Environmental Exposure/adverse effects ; Humans ; *Risk Management ; Safety ; *Technology ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Development: Time to leave GDP behind (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-01-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Costanza, Robert -- Kubiszewski, Ida -- Giovannini, Enrico -- Lovins, Hunter -- McGlade, Jacqueline -- Pickett, Kate E -- Ragnarsdottir, Kristin Vala -- Roberts, Debra -- De Vogli, Roberto -- Wilkinson, Richard -- England -- Nature. 2014 Jan 16;505(7483):283-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24436983" target="_blank"〉PubMed〈/a〉
    Keywords: Conservation of Natural Resources/statistics & numerical data ; Environment ; Gross Domestic Product/statistics & numerical data/*trends ; Humans ; Life Expectancy ; Personal Satisfaction ; *Quality of Life ; Socioeconomic Factors ; Sociology/*methods
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Fluorescence-line-narrowed spectra of polycyclic aromatic carcinogen-DNA adducts (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-20
    Description: The laser excited fluorescence-line-narrowed spectrum of DNA modified with (+/-)-r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), the ultimate carcinogenic metabolite of benzo[a]pyrene (BP), has been obtained in a water-glycerol-ethanol glass at 4.2 K. The spectrum was well resolved and highly characteristic of the chromophore. Comparisons were made between the spectrum of this modified DNA and the isolated deoxyguanosine-BPDE adduct and a series of other 7,8,9,10-tetrahydro-BP (THBP) derivatives. 9-Hydroxy-BP 4,5-oxide, which is also involved in the binding of BP to DNA, and THBP have very similar conventional broadband fluorescence spectra. However, the fluorescence-line-narrowed spectra of their derivatives were readily distinguishable either as individual components or as mixtures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heisig, V -- Jeffrey, A M -- McGlade, M J -- Small, G J -- CA 021111/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):289-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6422551" target="_blank"〉PubMed〈/a〉
    Keywords: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide ; Benzopyrenes/*metabolism ; Carcinogens/*metabolism ; DNA/*metabolism ; Deoxyguanosine/analogs & derivatives ; *Dihydroxydihydrobenzopyrenes ; *Spectrometry, Fluorescence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
    Electronic Resource
    Electronic Resource
    Increases in terrestrial carbon storage from the Last Glacial Maximum to the present (1990)
    [s.l.] : Nature Publishing Group
    Nature 348 (1990), S. 711-714 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We used published palynological, pedological and sedimentological data to produce global maps of vegetation and ice cover at 18kyr, which we compare with present natural vegetation (the vegetation types which it is thought would exist without human influence, under present climate conditions). ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/348711a0
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  • 8
    Electronic Resource
    Electronic Resource
    Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases (1992)
    [s.l.] : Nature Publishing Group
    Nature 360 (1992), S. 689-692 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In Rat-2 cells transformed by v-src or v-fps, and in epidermal growth factor (EGF)-stimulated cells, the 46 and 52K She pro-teins (p46shc, p52shc) become phosphorylated on tyrosine1'2. A minor and variably expressed 66K protein, encoded by a distinct she transcript1, is also tyrosine ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/360689a0
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  • 9
    Electronic Resource
    Electronic Resource
    Ecology, thermodynamics and H.T. Odum's conjectures (1993)
    Springer
    Oecologia 93 (1993), S. 582-596 
    Details
    ISSN: 1432-1939
    Keywords: Critique ; Systems ecology ; Energy numeraire ; Exergy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The central rôle of energy in all life processes has led to the development of numerous hypotheses, conjectures and theories on the relationships between thermodynamics and ecological processes. In this paper we examine the theoretical and empirical support for these developments, and in particular for the widely published set of thermodynamic conjectures developed by H.T. Odum, in which the maximum power principle is put forward as a generic feature of evolution in ecosystems. Although they are widely used, we argue that many of the ecological studies that have adopted the ideas encapsulated in Odum's work have done so without being aware of some of the fundamental problems underlying this approach. We discuss alternative ways in which a general available-work concept could be constructed for use as a numeraire in an energy-centered ecological theory or paradigm. In so doing, we examine what is meant by material accessibility and energy stocks and flows with respect to traditional food web and food chain theories, and relate these to results from the evolutionary dynamics of ecosystems. We conclude that the various forms and uses of energy bound up in essential ecosystem processes present a formidable obstacle to obtaining an operational definition of a general, aggregated available-work concept, a prerequisite for the systems approach of Odum and others. We also show that the prototypical derivations of the maximum power principle, and its interpretation, are contradicted on many scales both by empirical data and models, thereby invalidating the maximum power principle as a general principle of ecological evolution. The conclusions point to the fundamental problem of trying to describe ecosystems in a framework which has a one-dimensional currency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00328969
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  • 10
    Electronic Resource
    Electronic Resource
    Evolutionary drive: The effect of microscopic diversity, error making, and noise (1987)
    Springer
    Foundations of physics 17 (1987), S. 723-738 
    Details
    ISSN: 1572-9516
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In order to model any macroscopic system, it is necessary to aggregate both spatially and taxonomically. If average processes are assumed, then kinetic equations of “population dynamics” can be derived. Much effort has gone into showing the important effects introduced by non-average effects (fluctuations) in generating symmetry-breaking transitions and creating structure and form. However, the effects of microscopic diversity have been largely neglected. We show that evolution will select for populations which retain “variability,” even though this is, at any given time, loss-making, predicting that we shall not observe populations with “optimal behavior,” but populations which can “learn.” This lesser short-term efficiency may be why natural diversity is so great. Evolution is seen to be “driven” by the noise to which it leads.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01889545
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