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  • 1
    Publication Date: 2015-06-24
    Description: The Ni atom at the catalytic center of [NiFe] hydrogenases is incorporated by a Ni-metallochaperone, HypA, and a GTPase/ATPase, HypB. We report the crystal structures of the transient complex formed between HypA and ATPase-type HypB (HypBAT) with Ni ions. Transient association between HypA and HypBAT is controlled by the ATP...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 2
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    In:  J. Seismol. Soc. Japan, Hannover, Akad. Nauk SSSR, vol. 16, no. 2, pp. 181-187, pp. B06304, (ISSN: 1340-4202)
    Publication Date: 1963
    Keywords: Earthquake ; Low frequency ... ; Surface waves ; Source parameters ; Fault plane solution, focal mechanism ; Seismology
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  • 3
    Publication Date: 2016-06-15
    Description: Invariant natural killer T (iNKT) cells are a subset of innate-like T cells that act as important mediators of immune responses. In particular, iNKT cells have the ability to immediately produce large amounts of IFN-γ upon activation and thus initiate immune responses in various pathological conditions. However, molecular mechanisms that...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 4
    Publication Date: 2011-04-01
    Description: Carbon isotope exchange between calcite and graphite is a useful and reliable geothermometer for medium- to high-grade marbles. However, in rare instances, such as at Naxos, Greece, apparent disequilibrium carbon isotope fractionation between calcite and graphite has been previously reported. In this study, new results are presented on the morphological features, X-ray diffraction studies, Raman spectroscopic studies, and carbon isotope studies of graphite. Three morphologically distinct graphite types are identified. The first type is fine grained with distinct polygonal crystal aggregates having smooth pinacoid faces. The second type consists of large botryoidal aggregates with typical crystal overgrowth features, and the third type is "normal" large platy crystals associated with phlogopite. Graphite morphological features using an FE-SEM suggests that the botryoidal aggregates are composed of complexly intergrown and stacked graphite layers, comprised of cone-helix structures. Different types of graphite display distinct Lc(002) and DG values as well as a sharp first-order Raman peak at ~1580 cm-1 with disordered bands. The presence of Raman disordered bands in fine-grained well-crystallized graphite is attributed to edge effects. Carbon isotope analysis of graphite reveals that marble with fine-grained well-crystallized graphite show a consistent isotope fractionation with the calcite, which perfectly match temperature estimates based on the mineral isograds. In contrast, coarse botryoidal graphite gives heterogeneous carbon isotope values (about a few per mill) and show anomalous carbon isotope fractionation between the calcite and graphite. The graphite associated with phlogopite also shows variations in the carbon isotope values. Combining morphologic, crystallographic, and carbon isotopic data we conclude that the variations in carbon isotopic composition were caused by the overgrowth of graphite on the preexisting grain and that morphological observations and structural characterizations of graphite crystals is a key for predicting isotopic equilibration during metamorphism.
    Print ISSN: 0003-004X
    Electronic ISSN: 1945-3027
    Topics: Geosciences
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  • 5
    Publication Date: 2019
    Electronic ISSN: 2397-3366
    Topics: Physics
    Published by Springer Nature
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  • 6
    Publication Date: 2001-06-02
    Description: Transcription elongation by RNA polymerase II (RNAPII) is negatively regulated by the human factors DRB-sensitivity inducing factor (DSIF) and negative elongation factor (NELF). A 66-kilodalton subunit of NELF (NELF-A) shows limited sequence similarity to hepatitis delta antigen (HDAg), the viral protein required for replication of hepatitis delta virus (HDV). The host RNAPII has been implicated in HDV replication, but the detailed mechanism and the role of HDAg in this process are not understood. We show that HDAg binds RNAPII directly and stimulates transcription by displacing NELF and promoting RNAPII elongation. These results suggest that HDAg may regulate RNAPII elongation during both cellular messenger RNA synthesis and HDV RNA replication.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamaguchi, Y -- Filipovska, J -- Yano, K -- Furuya, A -- Inukai, N -- Narita, T -- Wada, T -- Sugimoto, S -- Konarska, M M -- Handa, H -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):124-7. Epub 2001 May 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Frontier Collaborative Research Center, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama 226-8503, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11387440" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; Consensus Sequence/genetics ; Enzyme Activation ; HeLa Cells ; Hepatitis Antigens/chemistry/*metabolism ; *Hepatitis Delta Virus/chemistry/genetics/metabolism ; Hepatitis delta Antigens ; Humans ; Molecular Sequence Data ; Protein Binding ; Protein Subunits ; RNA Polymerase II/*metabolism ; RNA, Viral/biosynthesis/genetics ; Sequence Alignment ; Templates, Genetic ; Transcription Factors/antagonists & inhibitors/chemistry/metabolism ; *Transcription, Genetic ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2014-11-08
    Description: Extragalactic background light (EBL) anisotropy traces variations in the total production of photons over cosmic history and may contain faint, extended components missed in galaxy point-source surveys. Infrared EBL fluctuations have been attributed to primordial galaxies and black holes at the epoch of reionization (EOR) or, alternately, intrahalo light (IHL) from stars tidally stripped from their parent galaxies at low redshift. We report new EBL anisotropy measurements from a specialized sounding rocket experiment at 1.1 and 1.6 micrometers. The observed fluctuations exceed the amplitude from known galaxy populations, are inconsistent with EOR galaxies and black holes, and are largely explained by IHL emission. The measured fluctuations are associated with an EBL intensity that is comparable to the background from known galaxies measured through number counts and therefore a substantial contribution to the energy contained in photons in the cosmos.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zemcov, Michael -- Smidt, Joseph -- Arai, Toshiaki -- Bock, James -- Cooray, Asantha -- Gong, Yan -- Kim, Min Gyu -- Korngut, Phillip -- Lam, Anson -- Lee, Dae Hee -- Matsumoto, Toshio -- Matsuura, Shuji -- Nam, Uk Won -- Roudier, Gael -- Tsumura, Kohji -- Wada, Takehiko -- New York, N.Y. -- Science. 2014 Nov 7;346(6210):732-5. doi: 10.1126/science.1258168.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA 91125, USA. Jet Propulsion Laboratory (JPL), National Aeronautics and Space Administration (NASA), Pasadena, CA 91109, USA. ; Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. Department of Physics and Astronomy, University of California, Irvine, CA 92697, USA. ; Department of Space Astronomy and Astrophysics, Institute of Space and Astronautical Science (ISAS), Japan Aerospace Exploration Agency (JAXA), Sagamihara, Kanagawa 252-5210, Japan. Department of Physics, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan. ; Department of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA 91125, USA. Jet Propulsion Laboratory (JPL), National Aeronautics and Space Administration (NASA), Pasadena, CA 91109, USA. jjb@astro.caltech.edu. ; Department of Physics and Astronomy, University of California, Irvine, CA 92697, USA. ; Department of Physics and Astronomy, Seoul National University, Seoul 151-742, Korea. ; Jet Propulsion Laboratory (JPL), National Aeronautics and Space Administration (NASA), Pasadena, CA 91109, USA. Department of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA 91125, USA. ; Department of Physics and Astronomy, University of California, Los Angeles, CA 90095, USA. Department of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA 91125, USA. ; Korea Astronomy and Space Science Institute (KASI), Daejeon 305-348, Korea. ; Department of Space Astronomy and Astrophysics, Institute of Space and Astronautical Science (ISAS), Japan Aerospace Exploration Agency (JAXA), Sagamihara, Kanagawa 252-5210, Japan. Institute of Astronomy and Astrophysics, Academia Sinica, Taipei 10617, Taiwan, Republic of China. ; Department of Space Astronomy and Astrophysics, Institute of Space and Astronautical Science (ISAS), Japan Aerospace Exploration Agency (JAXA), Sagamihara, Kanagawa 252-5210, Japan. ; Jet Propulsion Laboratory (JPL), National Aeronautics and Space Administration (NASA), Pasadena, CA 91109, USA. ; Frontier Research Institute for Interdisciplinary Science, Tohoku University, Sendai, Miyagi, 980-8578, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25378620" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 1997-08-22
    Description: The roots of plants normally carry small hairs arranged in a regular pattern. Transfer DNA-tagged lines of Arabidopsis thaliana included a mutant with few, randomly distributed root hairs. The mutated gene CAPRICE (CPC) encoded a protein with a Myb-like DNA binding domain typical of transcription factors involved in animal and plant development. Analysis in combination with other root hair mutations showed that CPC may work together with the TTG gene and upstream of the GL2 gene. Transgenic plants overexpressing CPC had more root hairs and fewer trichomes than normal. Thus, the CPC gene determines the fate of epidermal cell differentiation in Arabidopsis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wada, T -- Tachibana, T -- Shimura, Y -- Okada, K -- New York, N.Y. -- Science. 1997 Aug 22;277(5329):1113-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division I of Gene Expression and Regulation, National Institute for Basic Biology, Okazaki, 444, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9262483" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Arabidopsis/*cytology/*genetics ; *Arabidopsis Proteins ; Cell Differentiation ; Crosses, Genetic ; DNA-Binding Proteins/chemistry/*genetics/physiology ; Genes, Plant ; Homeodomain Proteins/genetics ; Molecular Sequence Data ; Mutation ; Oncogenes ; Phenotype ; Plant Proteins/genetics ; Plant Roots/*cytology/genetics ; Plants, Genetically Modified ; Proto-Oncogene Proteins/chemistry/genetics ; Proto-Oncogene Proteins c-myb ; Trans-Activators/chemistry/genetics ; Transcription Factors/chemistry/*genetics/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2003-05-24
    Description: Meiosis is a critical stage of gametogenesis in which alignment and synapsis of chromosomal pairs occur, allowing for the recombination of maternal and paternal genomes. Here we show that FK506 binding protein (Fkbp6) localizes to meiotic chromosome cores and regions of homologous chromosome synapsis. Targeted inactivation of Fkbp6 in mice results in aspermic males and the absence of normal pachytene spermatocytes. Moreover, we identified the deletion of Fkbp6 exon 8 as the causative mutation in spontaneously male sterile as/as mutant rats. Loss of Fkbp6 results in abnormal pairing and misalignments between homologous chromosomes, nonhomologous partner switches, and autosynapsis of X chromosome cores in meiotic spermatocytes. Fertility and meiosis are normal in Fkbp6 mutant females. Thus, Fkbp6 is a component of the synaptonemal complex essential for sex-specific fertility and for the fidelity of homologous chromosome pairing in meiosis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882960/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882960/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crackower, Michael A -- Kolas, Nadine K -- Noguchi, Junko -- Sarao, Renu -- Kikuchi, Kazuhiro -- Kaneko, Hiroyuki -- Kobayashi, Eiji -- Kawai, Yasuhiro -- Kozieradzki, Ivona -- Landers, Rushin -- Mo, Rong -- Hui, Chi-Chung -- Nieves, Edward -- Cohen, Paula E -- Osborne, Lucy R -- Wada, Teiji -- Kunieda, Tetsuo -- Moens, Peter B -- Penninger, Josef M -- 38103/Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2003 May 23;300(5623):1291-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), c/o Dr. Bohrgasse 7, 1030, Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12764197" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Apoptosis ; Chromosome Pairing/*physiology ; Cloning, Molecular ; Exons ; Female ; Fertility/*physiology ; Gene Targeting ; Humans ; Infertility, Male/genetics/*physiopathology ; Male ; *Meiosis ; Mice ; Molecular Sequence Data ; Mutation ; Nuclear Proteins/genetics/metabolism ; Oogenesis ; Ovary/physiology ; Prophase ; Rats ; Sequence Deletion ; Spermatids/physiology ; Spermatocytes/physiology/ultrastructure ; Spermatogenesis ; Synaptonemal Complex/*physiology ; Tacrolimus Binding Proteins/chemistry/*genetics/*physiology ; Testis/physiology ; X Chromosome/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2018-07-03
    Description: ELYS determines the subcellular localizations of Nucleoporins (Nups) during interphase and mitosis. We made loss-of-function mutations of Elys in Drosophila melanogaster and found that ELYS is dispensable for zygotic viability and male fertility but the maternal supply is necessary for embryonic development. Subsequent to fertilization, mitotic progression of the embryos produced by the mutant females is severely disrupted at the first cleavage division, accompanied by irregular behavior of mitotic centrosomes. The Nup160 introgression from D. simulans shows close resemblance to that of the Elys mutations, suggesting a common role for those proteins in the first cleavage division. Our genetic experiments indicated critical interactions between ELYS and three Nup107–160 subcomplex components; hemizygotes of either Nup37 , Nup96 or Nup160 were lethal in the genetic background of the Elys mutation. Not only Nup96 and Nup160 but also Nup37 of D. simulans behave as recessive hybrid incompatibility genes with D. melanogaster . An evolutionary analysis indicated positive natural selection in the ELYS-like domain of ELYS. Here we propose that genetic incompatibility between Elys and Nups may lead to reproductive isolation between D. melanogaster and D. simulans , although direct evidence is necessary.
    Electronic ISSN: 2160-1836
    Topics: Biology
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